Spatial Atlas for Mapping Vascular Microcalcification Using 18F-NaF PET/CT: Application in Hyperphosphatemic Familial Tumoral Calcinosis
CONCLUSIONS: This technique affords the ability to visualize spatial patterns of the active microcalcification process in the peripheral vasculature. Further, this technique affords the ability to track microcalcifications at precise locations not only across time but also across subjects. This technique is readily adaptable to other diseases of vascular calcification and may represent a significant advance in the field of vascular biology.PMID:38660800 | DOI:10.1161/ATVBAHA.123.320455 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Aaron J Sheppard Elizabeth H Theng Sriram S Paravastu Natalia M Wojnowski Faraz Farhadi Michael A Morris Iris R Hartley Rachel I Gafni Kelly L Roszko Michael T Collins Babak Saboury Source Type: research
Multicenter comparative study on the usefulness of the optimal electrosurgical unit setting in endoscopic papillectomy for ampullary neoplasms (with video)
ConclusionsThe risks of pancreatitis and residual lesions after EP may be lower when the VIO electrosurgical unit is used with the optimal setting. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - April 25, 2024 Category: Gastroenterology Authors: Kenjiro Yamamoto,
Takao Itoi,
Akio Katanuma,
Tatsuya Ishii,
Eisuke Iwasaki,
Shintaro Kawasaki,
Takayoshi Tsuchiya,
Ryosuke Tonozuka,
Kazumasa Nagai,
Shuntaro Mukai Tags: ORIGINAL ARTICLE Source Type: research
Letter to the editor regarding “MRI-based endplate bone quality score independently predicts cage subsidence following transforaminal lumbar interbody fusion” by Chen et al.
We read with great interest the article by Chen et al [1] that used the MRI-based Endplate Bone Quality (EBQ) score as an independent predictor of cage subsidence in patients after transforaminal lumbar interbody fusion (TLIF) surgery. This retrospective study was conducted on 280 adult patients who underwent single-segment TLIF for degenerative lumbar spine disease and aimed to investigate the predictive value of MRI-based EBQ scores for cage subsidence. The study found that cage subsidence, observed in 42 patients, was associated with visibly reduced bone density as measured by quantitative computed tomography, and the m...
Source: The Spine Journal - April 25, 2024 Category: Orthopaedics Authors: Hidetaka Mochizuki, Masatsugu Tsukamoto, Tadatsugu Morimoto, Hirohito Hirata, Tomohito Yoshihara, Masaaki Mawatari Tags: Letters to the Editor Source Type: research
Characteristic Single Photon Emission Computed Tomography-Computed Tomography Findings in Lower Extremity Lymphedema: Comparison to Indocyanine Green Lymphography
Lymphatic Research and Biology, Ahead of Print. (Source: Lymphatic Research and Biology)
Source: Lymphatic Research and Biology - April 25, 2024 Category: Biology Authors: Hayahito Sakai Toko Miyazaki Maya Kanasaki Reiko Tsukuura Takumi Yamamoto Source Type: research
Recent Progress in Synthesis of 99mTc-labeled Complexes with Nitroimidazoles as SPECT Probes for Targeting Tumor Hypoxia
AbstractThe majority of solid tumors have hypoxia, or low oxygen levels, which is one of the hallmarks of cancer. Hypoxia was found to relate to cancer metastases and resistance to therapies, therefore, detection of hypoxia plays an important role in the process of cancer prognosis and treatment. Single-photon emission computed tomography (SPECT) is a non-invasive imaging technique using gamma-emitting radiopharmaceuticals to visualize biological activities within the body. SPECT is also applied for the detection of tumor hypoxia with the development of hypoxia-targeting radiopharmaceuticals. Radiopharmaceuticals containin...
Source: Nuclear Medicine and Molecular Imaging - April 25, 2024 Category: Nuclear Medicine Source Type: research
Treatment Response Imaging in Prostate Cancer
This study will review the different criteria for imaging treatment response on conventional and advanced molecular imaging for different therapies, and the future perspective in posttherapy imaging. (Source: PET Clinics)
Source: PET Clinics - April 25, 2024 Category: Radiology Authors: Mina Swiha, Andrei Gafita, Andrew Nguyen, Louise Emmett Source Type: research
Exploring the relationship between pericoronary inflammation and microvascular function
Inflammation is a key driver of atherosclerotic plaque development and progression. Pericoronary adipose tissue (PCAT) attenuation index is a novel non-invasive marker obtained from computed tomography coronary angiography (CTCA) that is a surrogate for the degree of coronary inflammation.1 Atheroma contain by-products of lipid metabolism, especially oxidised LDL and reactive oxygen species that are released into the downstream coronary circulation with consequent potential to affect endothelial function and microcirculatory tone. (Source: Journal of Cardiovascular Computed Tomography)
Source: Journal of Cardiovascular Computed Tomography - April 25, 2024 Category: Radiology Authors: Harsh V. Thakkar, Jasmine Chan, Andrea Comella, Abdul R. Ihdayhid, Michael Michail, Nitesh Nerlekar, Adam J. Brown Tags: Correspondence Source Type: research
Predictive role of ureteral wall thickness and patient characteristics in endoscopic treatment outcomes for ureteral stricture disease following stone surgery
ConclusionsOur current results indicated that assessment of UWT value at the obstructing stone could be helpful enough to predict the likelihood of failure following endoscopic management of strictures with high sensitivity and specificity. Evaluation of this particular parameter could let the endourologists to look for more rational treatment alternatives with necessary measures taken on time. (Source: World Journal of Urology)
Source: World Journal of Urology - April 25, 2024 Category: Urology & Nephrology Source Type: research
Development and evaluation of two open-source nnU-Net models for automatic segmentation of lung tumors on PET and CT images with and without respiratory motion compensation
ConclusionsPerformance evaluation demonstrated that the automatic segmentation models have the potential to achieve accuracy comparable to manual segmentation and thus hold promise for clinical application. The resulting models can be freely downloaded and employed to support the integration of 3D- or 4D- PET/CT and to facilitate the evaluation of its impact on lung cancer clinical practice.Clinical relevance statementWe provide two open-source nnU-Net models for the automatic segmentation of lung tumors on PET/CT to facilitate the optimal integration of biological and anatomical information in clinical practice. The model...
Source: European Radiology - April 25, 2024 Category: Radiology Source Type: research
Subclinical Atherosclerosis to Guide Treatment in Dyslipidemia and Diabetes Mellitus
AbstractPurpose of ReviewDyslipidemia and type 2 diabetes mellitus are two common conditions that are associated with an increased risk of atherosclerotic cardiovascular disease (ASCVD). In this review, we aimed to provide an in-depth and contemporary review of non-invasive approaches to assess subclinical atherosclerotic burden, predict cardiovascular risk, and guide appropriate treatment strategies. We focused this paper on two main imaging modalities: coronary artery calcium (CAC) score and computed tomography coronary angiography.Recent FindingsRecent longitudinal studies have provided stronger evidence on the relation...
Source: Current Atherosclerosis Reports - April 25, 2024 Category: Cardiology Source Type: research
A rationally designed nuclei-targeting FAPI 04-based molecular probe with enhanced tumor uptake for PET/CT and fluorescence imaging
ConclusionsThe NOTA-FAPI-MB was successfully synthesized, in which FAPI and MB simultaneously contributed to the targeting effect. Notably, the nuclear delivery mechanism of the probes improved intracellular retention time and targeting efficacy, broadening the imaging time window for fluorescence imaging. In vivo PET/CT demonstrated favorable performance of NOTA-FAPI-MB compared to [18F]F-FDG. This study highlights the significance of fluorescence imaging as an adjunct technique to PET/CT. Furthermore, the encouraging results obtained from the imaging of human HCC tissues hold promise for the potential application of NOTA...
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 24, 2024 Category: Nuclear Medicine Source Type: research
The accuracy and intra- and interobserver variability of PSMA PET/CT for the local staging of primary prostate cancer
ConclusionIn a large, multicentre study evaluating 600 patients with newly diagnosed intermediate and high-risk PCa, we showed that PSMA PET/CT may have a value in local tumour staging when pathological tumour stage in the radical prostatectomy specimen was used as the reference standard. The intra-observer and interobserver variability of assessment of tumour extent on PSMA PET/CT was moderate to substantial. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 24, 2024 Category: Nuclear Medicine Source Type: research
The scimitar-cat Homotherium from the submerged continental shelf of the Gulf Coast of Texas
We report on a new record of Homotherium based on a fragmentary premaxilla-maxilla discovered on McFaddin Beach, Texas, along the Gulf of Mexico. Skeletal remains of extinct, Pleistocene vertebrates accumulate on McFaddin Beach. Those fossils appear to originate from submerged deposits on the continental shelf in the Gulf of Mexico, an area that was subaerially exposed in the Late Pleistocene during glacial intervals. Marine erosion and transport altered the externally visible morphology of the current specimen, obscuring and/or damaging taxonomically informative details of the preserved dentition. However, high-resolution...
Source: Anatomical Record - April 24, 2024 Category: Anatomy Authors: John A Moretti Deanna Flores Christopher J Bell Will Godwin Adam Hartstone-Rose Patrick J Lewis Source Type: research
Comparison of novel PSMA-targeting [ < sup > 177 < /sup > Lu]Lu-P17-087 with its albumin binding derivative [ < sup > 177 < /sup > Lu]Lu-P17-088 in metastatic castration-resistant prostate cancer patients: a first-in-human study
CONCLUSION: [177Lu]Lu-P17-088 and [177Lu]Lu-P17-087 displayed different pharmacokinetics but excellent PSMA-targeting dose delivery in mCRPC patients. These two agents are promising RLT agents for personalized treatment of mCRPC. Further studies with increased dose and frequency of RLT are warranted to evaluate the potential therapeutic efficacy.TRIAL REGISTRATION: 177Lu-P17-087/177Lu-P17-088 in Patients with Metastatic Castration-resistant Prostate Cancer (NCT05603559, Registered at 25 October, 2022). URL OF REGISTRY: https://classic.CLINICALTRIALS: gov/ct2/show/NCT05603559 .PMID:38658392 | DOI:10.1007/s00259-024-06721-x ...
Source: Molecular Medicine - April 24, 2024 Category: Molecular Biology Authors: Linlin Li Jiarou Wang Guochang Wang Rongxi Wang Wenbin Jin Jie Zang Huimin Sui Chenhao Jia Yuanyuan Jiang Haiyan Hong Lin Zhu David Alexoff Karl Ploessl Hank F Kung Zhaohui Zhu Source Type: research
Probabilistic U-Net model observer for the DDC method in CT scan protocol optimization
Phys Med Biol. 2024 Apr 24. doi: 10.1088/1361-6560/ad4302. Online ahead of print.ABSTRACTOptimizing complex imaging procedures within Computed Tomography,
considering both dose and image quality, presents significant challenges amidst rapid
technological advancements and the adoption of Machine Learning (ML) methods.
A crucial metric in this context is the Difference-Detailed Curve, which relies on
human observer studies. However, these studies are labor-intensive and prone to
both inter- and intra-observer variability. To tackle these issues, a ML-based model
observer utiliz...
Source: Physics in Medicine and Biology - April 24, 2024 Category: Physics Authors: David Stocker Christian Sommer Sarah Gueng Jason St äuble Ismail Özden Jennifer Griessinger Mathias Weyland Gerd Lutters Stephan Scheidegger Source Type: research
