Long term outcome of liver resection for colorectal metastases in the presence of extrahepatic disease: a multi ‐institutional Japanese study
ConclusionsPerforming R0 liver resection for colorectal liver metastases with treatable extrahepatic disease may prolong survival. Our proposed scoring system may help select appropriate candidates for liver resection. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - July 26, 2020 Category: Gastroenterology Authors: Yu Sawada, Kota Sahara, Itaru Endo, Katsunori Sakamoto, Goro Honda, Toru Beppu, Kenjiro Kotake, Masakazu Yamamoto, Keiichi Takahashi, Kiyoshi Hasegawa, Michio Itabashi, Yojiro Hashiguchi, Yoshihito Kotera, Shin Kobayashi, Tatsuro Yamaguchi, Tags: ORIGINAL ARTICLE Source Type: research

A Multicenter Prospective Randomized Controlled Trial for Preoperative Biliary Drainage with Uncovered Metal versus Plastic Stents for Resectable Periampullary Cancer
ConclusionFor patients who received surgery within the first two weeks from receiving PBD, there was no superiority of uSEMS to PS. According to the expected waiting time for surgery, selective approach for stent choice should be considered. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - July 26, 2020 Category: Gastroenterology Authors: Jaeae Hee Cho, YooSeok Yoon, EuiJoo Kim, Yeon Suk Kim, Jai Young Cho, Ho ‐Seong Han, Yeon Ho Park, Dong Woo Shin, Jong‐chan Lee, Jin‐Hyeok Hwang, Jaihwan Kim Tags: ORIGINAL ARTICLE Source Type: research

Acute and Subacute Effects of Irreversible Electroporation on Normal Common Bile Ducts in a Rabbit Model
ConclusionsThe normal CBD retains the lumen wall integrity following IRE with immediate periductal placement of the electrode. However, the risk of biliary dilatation and stricture reminds that the parameters of IRE need to be determined more precisely to ensure the treatment efficacy and reduce the risk of collateral damage. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - July 22, 2020 Category: Gastroenterology Authors: Qingshan Li, Fenggang Ren, YuChi Zhang, Pengkang Chang, Yue Wang, Tao Ma, Liangshuo Hu, Rongqian Wu, Bo Wang, Yi Lv Tags: ORIGINAL ARTICLE Source Type: research

Laparoscopic excision of type II choledochal cyst arising from the intrapancreatic common bile duct in an adult
AbstractAmong five types of choledochal cysts (CDC), type II cysts, which present as a bile duct diverticulum , are most rare. [1] They are categorized as upper, middle, or lower cysts according to location relative to the hepatoduodenal ligament. [2] Excision of the lower cyst, which arise from the intrapancreatic common bile duct (CBD), is technically demanding because of its location. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - July 21, 2020 Category: Gastroenterology Authors: Jun Suh Lee, Yoo ‐Seok Yoon, Ho‐Seong Han, Junyub Kim, Boram Lee, Jai Young Cho, YoungRok Choi Tags: HOW I DO IT Source Type: research

How I do it? EUS ‐guided gastrojejunostomy: double‐balloon occlusion theory with experimental study (with video)
AbstractSymptomatic gastric outlet obstruction (GOO) is seen in at the end ‐stage of pancreatobiliary cancers and gastroduodenal cancers. Recently, endoscopic ultrasonography (EUS) guided‐gastrojejunostomy (GJ) using lumen‐apposing metal stent (LAMS) has emerged as alternative to surgical GJ and endoscopic gastroduodenal stenting [1‐3]. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - July 21, 2020 Category: Gastroenterology Authors: Takao Itoi, Takayoshi Tsuchiya, Yukitoshi Matsunami, Ryosuke Tonozuka, Kentaro Ishii, Reina Tanaka, Shuntaro Mukai, Kenjiro Yamamoto, Yuichi Nagakawa, Atsushi Sofuni Tags: HOW I DO IT Source Type: research

Mortality analysis of Aeromonas hydrophila infection in hepato ‐biliary pancreatic surgery: multicenter retrospective observational study
ConclusionsIsolation ofA. hydrophila was low in our cases of HBP surgery, but the condition of some patients deteriorated rapidly by this infection. Although there could be several bacterial infections during management of HBP surgery,A. hydrophila should not be overlooked. Preparation of appropriate prophylactic antibiotics may prevent or reduce mortality. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - July 21, 2020 Category: Gastroenterology Authors: Masaki Ueno, Hiroya Iida, Masaki Kaibori, Koji Komeda, Shigekazu Takemura, Takehiro Noda, Hisashi Ikoma, Takeo Nomi, Shinya Hayami, Fumitoshi Hirokawa, Shogo Tanaka, Kousuke Matsui, Morihiko Ishizaki, Ryo Morimura, Daisuke Hokuto, Hidetoshi Tags: ORIGINAL ARTICLE Source Type: research

Prognostic implication of high grade biliary intraepithelial neoplasia in bile duct resection margins in patients with resected perihilar cholangiocarcinoma
ConclusionsAlthough the HG BilIN group had neoplasia with malignant potential, survival and recurrence outcomes were comparable to those of the R0 group, which suggests that no additional resection is needed when the maximal bile duct margin in PHCC surgery contains HG BilIN. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - July 8, 2020 Category: Gastroenterology Authors: Dakyum Shin, Sojung Lee, Jae Hoon Lee, Seung ‐Mo Hong, Seo Young Park, Changhoon Yoo, Woohyung Lee, Ki Byung Song, Dae Wook Hwang, Song Cheol Kim Tags: ORIGINAL ARTICLE Source Type: research

Issue Information ‐ IFA
Journal of Hepato-Biliary-Pancreatic Sciences, Volume 27, Issue 6, Page 354-358, June 2020. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - July 7, 2020 Category: Gastroenterology Tags: Issue Information ‐ IFA Source Type: research

Surgical treatment for chronic pancreatitis: a single ‐center retrospective study in Japan
ConclusionsSurgical treatment for painful chronic pancreatitis can be safe and effective. An optimal procedure should guarantee pain relief and preserve a maximum of pancreatic function. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 30, 2020 Category: Gastroenterology Authors: Ippei Matsumoto, Keiko Kamei, Takaaki Murase, Yuta Yoshida, Kohei Kawaguchi, Masataka Matsumoto, Shumpei Satoi, Atsushi Takebe, Takuya Nakai, Yoshifumi Takeyama Tags: ORIGINAL ARTICLE Source Type: research

Epidemiological features of immunoglobulin G4 ‐related sclerosing cholangitis in Japan
ConclusionsThe point prevalence of IgG4 ‐SC was 2.18 per 100,000 population. The epidemiological features were similar to those observed in previous studies. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 30, 2020 Category: Gastroenterology Authors: Atsushi Tanaka, Mitsuru Mori, Kensuke Kubota, Itaru Naitoh, Takahiro Nakazawa, Hajime Takikawa, Michiaki Unno, Terumi Kamisawa, Shigeyuki Kawa, Kazuichi Okazaki Tags: ORIGINAL ARTICLE Source Type: research

Prognostic value of expanded liver transplantation criteria − the 5‐5‐500 rule − in patients with hepatic resection for intermediate stage hepatocellular carcinoma
ConclusionsThe 5 ‐5‐500 rule could predict prognosis in BCLC‐B patients with hepatic resection. Hepatic resection might provide survival benefit for selected patients with BCLC‐B HCC within the 5‐5‐500 rule. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 23, 2020 Category: Gastroenterology Authors: Hiroji Shinkawa, Shogo Tanaka, Shigekazu Takemura, Ryosuke Amano, Kenjiro Kimura, Masahiko Kinoshita, Toru Miyazaki, Shoji Kubo Tags: ORIGINAL ARTICLE Source Type: research

Prognostic significance of regional lymph node metastasis according to station in ampullary carcinoma
This study aimed to investigate outcome following radical resection of ampullary carcinoma according to station of lymph node metastasis.MethodsPatients who underwent surgical resection for ampullary carcinoma between January 2007 and December 2017 at two separate Japanese institutions were included. Regional lymph nodes were subclassified as follows: Pancreatoduodenal lymph nodes (PD) and others (OT).ResultsOf the 101 patients analyzed, 34 had regional lymph node metastasis. OT metastasis was found in eight patients. Significant differences were found in relapse ‐free survival (RFS) and overall survival (OS) between the...
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 23, 2020 Category: Gastroenterology Authors: Keita Tashiro, Naomi Kuroki, Takahiro Einama, Toshimitsu Iwasaki, Yoichi Miyata, Suefumi Aosasa, Yosuke Inoue, Yu Takahashi, Sho Ogata, Hideki Ueno, Kazuo Hase, Junji Yamamoto, Yoji Kishi Tags: ORIGINAL ARTICLE Source Type: research

Gram staining of gallbladder bile samples is useful for predicting surgical site infection in acute cholecystitis patients undergoing an early cholecystectomy
ConclusionsGram staining diagnosis of bile infection in an early cholecystectomy for AC is useful for predicting postoperative SSI development, which should benefit postoperative management. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 22, 2020 Category: Gastroenterology Authors: Yasunori Nishida, Noriaki Otagiri, Seijiro Yoshifuku, Kenji Misawa, Kenju Ko, Kotaro Sasahara, Osamu Mishima, Katsunori Tauchi Tags: ORIGINAL ARTICLE Source Type: research

Clinical impact of pancreaticoduodenectomy for pancreatic cancer with resection of the secondary or later branches of the superior mesenteric vein
ConclusionPancreaticoduodenectomy with J2VR for PDAC can be safely performed with a satisfactory overall survival rate. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 20, 2020 Category: Gastroenterology Authors: Masayuki Honda, Yuichi Nagakawa, Masanori Akashi, Yuichi Hosokawa, Hiroaki Osakabe, Chie Takishita, Hitoe Nishino, Akihiko Tsuchida Tags: ORIGINAL ARTICLE Source Type: research

A novel reaction force ‐fluorescence measurement system for evaluating pancreatic juice leakage from an excised swine pancreas during distal pancreatectomy
ConclusionsWe have successfully developed a novel force ‐fluorescence measurement system that can detect and quantify pancreatic juice leakage caused by tissue tearing. This system can determine the optimal compression conditions for preventing pancreatic juice leakage. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 8, 2020 Category: Gastroenterology Authors: Etsuko Kobayashi, Shuto Tsuchiya, Yuki Akagi, Naoki Tomii, Keiichi Nakagawa, Kunihiro Inai, Yoshihiro Muragaki, Takehide Asano, Daeyoung Kim Tags: ORIGINAL ARTICLE Source Type: research

Risk factors and characteristics of young patients with the biliary tract carcinoma: results of a project study for biliary surgery by the Japanese Society of Hepato ‐Biliary‐Pancreatic Surgery
This study aimed to elucidate the characteristics of biliary tract carcinoma (BTC) in young patients.MethodsThis is a nationwide, multicenter, retrospective cohort study supervised by the Japanese Society of Hepato ‐Biliary‐Pancreatic Surgery (JSHBPS). Clinicopathological data of patients aged
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 8, 2020 Category: Gastroenterology Authors: Kyohei Ariake, Michiaki Unno, Hiroshi Yoshida, Shoji Kubo, Akihiko Horiguchi, Hiroki Yamaue, Masakazu Yamamoto Tags: ORIGINAL ARTICLE Source Type: research

How to perform EUS ‐guided hepaticogastrostomy easier and safer
ABSTRACTEndoscopic ultrasound ‐guided hepaticogastrostomy (EUS‐HGS) is a useful method for failed ERCP cases[1,2]. B2 route is technically easier than B3 route for puncture the bile duct, guidewire insertion, dilation the track and antegrade stenting. But, B2 route is commonly trans‐esophagus with the conventional oblique‐ viewing EUS. Trans‐esophagus puncture may cause mediastinitis and severe complications[3]. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 8, 2020 Category: Gastroenterology Authors: Kazuo Hara, Shin Haba, Takamichi Kuwahara, Hiroki Koda, Nobumasa Mizuno, Akira Miyano, Nozomi Okuno Tags: HOW I DO IT Source Type: research

Clinicopathological characteristics of intraductal papillary neoplasm of the bile duct: a Japan ‐Korea collaborative study
AbstractBackgroundThe prevalent location and incidence of intraductal papillary neoplasm of the bile duct (IPNB) and invasive carcinoma associated with them have varied markedly among studies due to differences in diagnostic criteria and tumor location.MethodsIPNBs were classified into two types: Type 1 IPNB, being histologically similar to intraductal papillary ‐mucinous neoplasm of the pancreas, and Type 2 IPNB, having a more complex histological architecture with irregular papillary branching or foci of solid‐tubular components. Medical data were evaluated.ResultsAmong 694 IPNB patients, 520 and 174 had Type 1 and T...
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 8, 2020 Category: Gastroenterology Authors: Keiichi Kubota, Jin ‐Young Jang, Yasuni Nakanuma, Kee‐Taek Jang, Yasuo Haruyama, Noriyoshi Fukushima, Toru Furukawa, Seung‐Mo Hong, Yuhki Sakuraoka, Haeryoung Kim, Takatsugu Matsumoto, Kyung Bun Lee, Yoh Zen, Jaeri Kim, Masaru Miyazaki Tags: ORIGINAL ARTICLE Source Type: research

Safety of a new spray ‐type adhesion barrier (AdSpray®) in liver surgery
ConclusionsAdSpray used was not associated with global incidence of major morbidity after liver surgery, although surgeon ’s experience would be needed for adequate use of AdSpray to minimize the risk of postoperative abscess formation. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 8, 2020 Category: Gastroenterology Authors: Satoshi Okubo, Junichi Shindoh, Yuta Kobayashi, Masaji Hashimoto Tags: ORIGINAL ARTICLE Source Type: research

Risk factors for walled ‐off necrosis associated with severe acute pancreatitis: a multicenter retrospective observational study
This study aimed to identify the risk factors for walled ‐off necrosis (WON) associated with severe acute pancreatitis (SAP).MethodsThis retrospective study was conducted in eight institutions in Japan between 2014 and 2017. We analyzed WON incidence, patient characteristics, and risk factors for WON in patients with SAP who were observed for>28 days.ResultsOf 134 patients with SAP, WON occurred in 40 (29.9%). Male sex (p = 0.045), body mass index (BMI) ≥25 (p
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 7, 2020 Category: Gastroenterology Authors: Satoshi Ikarashi, Hirokazu Kawai, Kazunao Hayashi, Junji Kohisa, Toshifumi Sato, Yujiro Nozawa, Shin ‐ichi Morita, Hiromitsu Oka, Munehiro Sato, Yukio Aruga, Seiichi Yoshikawa, Shuji Terai Tags: ORIGINAL ARTICLE Source Type: research

Standardized laparoscopic right hepatic lobe mobilization
We present here a standardized technique of right hepatic lobe mobilization including technical steps and video. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 7, 2020 Category: Gastroenterology Authors: B. Ielpo, G. Pittau, O. Ciacio, M. Tedeschi, D. Pietrasz, L. Torrent, A. Sa Cunha, D. Cherqui Tags: HOW I DO IT Source Type: research

Duplication of extrahepatic bile duct with lower common bile duct cancer
AbstractA 90 ‐year‐old female who previously underwent a cholecystectomy for a gallbladder stone was admitted to our hospital with jaundice. Magnetic resonance cholangiopancreatography (MRCP) revealed left and right bile ducts parallel with the duodenal papilla, and joined distally to form a single short com mon bile duct with no pancreaticobiliary maljunction (Figure 1). The remnant cystic duct diverged from the right hepatic duct without a common hepatic duct. Endoscopic ultrasound revealed the lower common bile duct as stenotic due to a 6‐mm tumor. Based on results of bile duct brush cytology durin g endoscopic re...
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 7, 2020 Category: Gastroenterology Authors: Nobuhiko Fukuba, Hitomi Ishitobi, Yoshiko Takahashi Tags: IMAGE OF INTEREST Source Type: research

Level of total bilirubin in the bile of the future remnant liver of patients with obstructive jaundice undergoing hepatectomy predicts postoperative liver failure
ConclusionsLTB may be a potential functional assessment in jaundiced patients before right hepatectomy and right/left trisectionectomy. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 7, 2020 Category: Gastroenterology Authors: Shuichiro Uemura, Ryota Higuchi, Takehisa Yazawa, Wataru Izumo, Takehito Otsubo, Masakazu Yamamoto Tags: ORIGINAL ARTICLE Source Type: research

Risk factors for dysfunction of preoperative endoscopic biliary drainage for malignant hilar biliary obstruction
ConclusionsDysfunction of the initial EBD frequently occurs in patients with the BC ‐IV and those with pre‐EBD cholangitis. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 7, 2020 Category: Gastroenterology Authors: Ryo Sugiura, Masaki Kuwatani, Shin Kato, Kazumichi Kawakubo, Hirofumi Kamachi, Akinobu Taketomi, Takehiro Noji, Keisuke Okamura, Satoshi Hirano, Naoya Sakamoto Tags: ORIGINAL ARTICLE Source Type: research

Modification of a new subclassification of Grade B postoperative pancreatic fistula: A bicenter retrospective cohort study
AbstractObjectiveTo propose a modified subclassification of grade B postoperative pancreatic fistula (POPF) based on management approaches in Chinese patients.MethodsData of consecutive pancreatoduodenectomy at 2 hospitals in China from 2013 to 2018 were collected and outcomes were compared across different group of POPF. Subclassification of B ‐POPF was made based on intervention to B1: non‐interventional subclass and B2: interventional subclass.Results142 of 522 patients had Biochemical leaks (BLs) (27.2%), and POPFs developed in 106 of 522 patients (20.3%), with 81 B ‐POPFs (15.5%) and 25 C‐POPFs (4.8%). BL did ...
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 7, 2020 Category: Gastroenterology Authors: Jingyong Xu, Aoran Zhang, Bingjun Tang, Xiaodong Tian, Yongsu Ma, Jinghai Song, Jiangchun Qiao, Junmin Wei, Jian Chen, Yinmo Yang Tags: ORIGINAL ARTICLE Source Type: research

Preoperative Cholangitis is Associated with Increased Surgical Site Infection following Pancreaticoduodenectomy
AbstractPurposeFew reports describe the relationship between preoperative cholangitis and surgical site infections (SSIs) after pancreaticoduodenectomy (PD). We aimed to determine the association between the incidence of preoperative cholangitis and SSI following PD.MethodsThe surgical outcomes of 359 patients who underwent PD were compared between patients with (n=92) and without (n=267) preoperative cholangitis. Bacterial cultures from the postoperative drainage fluid were examined. Risk factors for postoperative infectious complication were evaluated.ResultsThe incidence of postoperative infectious complications includi...
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 7, 2020 Category: Gastroenterology Authors: Masanori Akashi, Yuichi Nagakawa, Yuichi Hosokawa, Chie Takishita, Hiroaki Osakabe, Hitoe Nishino, Kenji Katsumata, Yoshito Akagi, Takao Itoi, Akihiko Tsuchida Tags: ORIGINAL ARTICLE Source Type: research

New insight into the association between bile infection and clinically relevant pancreatic fistula in patients undergoing pancreatoduodenectomy
ABSTRACTBackgroundThe association between bacterial infection and clinically relevant postoperative pancreatic fistula (CR ‐POPF) after pancreatoduodenectomy (PD) has not been fully elucidated.MethodsMicrobiological data for intraoperative bile culture (BC) and drain culture on postoperative day 4 (DC) were collected. The study population was classified into the following 3 groups: P1 (positive BC and DC), P2 (positive BC and negative DC), and N (negative BC). A total of 209 patients (P1: 38, P2: 72, and N: 99) who underwent PD between May 2013 and May 2018 met the inclusion criteria of the study.ResultsThe rate of CR ...
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 7, 2020 Category: Gastroenterology Authors: Kota Nakamura, Masayuki Sho, Shoichi Kinoshita, Takahiro Akahori, Minako Nagai, Kenji Nakagawa, Tadataka Takagi, Naoya Ikeda Tags: ORIGINAL ARTICLE Source Type: research

Immunosuppressive tumor microenvironment in occupational cholangiocarcinoma: Supportive evidence for the efficacy of immune checkpoint inhibitor therapy
ConclusionsThe tumor microenvironment of occupational CCA had features of immunosuppression, and the occurrence of T ‐cell dysfunction or exhaustion was suggested. The results provide supportive evidence for the efficacy of immune checkpoint inhibitor therapy for this disease. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 7, 2020 Category: Gastroenterology Authors: Yasunori Sato, Shogo Tanaka, Masahiko Kinoshita, Shigekazu Takemura, Hiroji Shinkawa, Takashi Kokudo, Kiyoshi Hasegawa, Hiromu Tanaka, Hidero Yoshimoto, Akira Mori, Minako Yamamura, Motoko Sasaki, Kenichi Harada, Shoji Kubo Tags: ORIGINAL ARTICLE Source Type: research

Revisiting the indications for liver transplantation in cirrhotic patients considering the long ‐term outcomes of cirrhotic patients
In this study, we investigated long ‐term survival of cirrhotic patients without hepatocellular carcinoma (HCC) and the proper timing of liver transplantation in the era with recent progress of management.Patients and MethodsWe first classified 217 non ‐transplant cirrhotic patients without HCC according to the long‐term survival based on Child‐Turcotte‐Pugh (CTP) scores and the MELD scores. And then, we compared them with the survival after liver transplantation in 114 patients with liver cirrhosis.ResultsWe classified into 4 groups (class A as CTP score of 5,6, B as 7,8, C as 9 ‐12, D as 13‐15) according to...
Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 5, 2020 Category: Gastroenterology Authors: Masatoshi Ishigami, Takashi Honda, Teiji Kuzuya, Yoji Ishizu, Takanori Ito, Hideya Kamei, Yasuhiro Ogura, Mitsuhiro Fujishiro Tags: ORIGINAL ARTICLE Source Type: research

Optimal timing of laparoscopic cholecystectomy after gallbladder drainage for acute cholecystitis: A multi ‐institutional retrospective study
ConclusionsSurgical outcome of LC after gallbladder drainage for AC was inferior in Group B compared with the other groups. This finding could be useful for determining the optimal timing of LC after gallbladder drainage for AC. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - May 27, 2020 Category: Gastroenterology Authors: Yoshito Tomimaru, Nariaki Fukuchi, Shigekazu Yokoyama, Takuji Mori, Masahiro Tanemura, Kenji Sakai, Yutaka Takaeda, Masanori Tsujie, Terumasa Yamada, Atsushi Miyamoto, Yasuji Hashimoto, Hisanori Hatano, Junzo Shimizu, Keishi Sugimoto, Masaki Tags: ORIGINAL ARTICLE Source Type: research

A direct peroral cholangioscopy ‐assisted therapy for a choledochojejunostomy anastomotic stricture via EUS‐guided hepaticogastrostomy
AbstractA 70 ‐year‐old woman who had undergone a pancreaticoduodenectomy was admitted to our hospital due to obstructive jaundice caused by a benign stricture of choledochojejunostomy anastomosis. Single balloon enteroscopy‐assisted endoscopic retrograde cholangiopancreatography was attempted, but the scop e could not reach the site of choledochojejunostomy anastomosis. Endoscopic ultrasound‐guided hepaticogastrostomy (EUS‐HGS) was then performed using a fully covered metal stent with a diameter of 6 mm. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - May 27, 2020 Category: Gastroenterology Authors: Koichiro Mandai, Koji Uno, Kenjiro Yasuda Tags: HOW I DO IT Source Type: research

Risk factors for cholecystitis after stent placement in patients with distal malignant biliary obstruction
ConclusionsUse of covered SEMS might be a risk factor for cholecystitis onset within 30 days after placement. Clinicians should be aware of the risk for severe cholecystitis after covered SEMS placement, even if the tumor does not invade the cystic duct. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - May 27, 2020 Category: Gastroenterology Authors: Masaki Takinami, Gou Murohisa, Yashiro Yoshizawa, Erina Shimizu, Masamichi Nagasawa Tags: ORIGINAL ARTICLE Source Type: research

Tumor marker recovery rather than major pathological response is a preferable prognostic factor in patients with pancreatic ductal adenocarcinoma with preoperative therapy
AbstractBackground/PurposeA pathological response of the primary tumor by preoperative therapy is a prognostic factor in various malignancies, and several histologic grading systems have been proposed for pancreatic ductal adenocarcinoma (PDAC). However, the prognostic value remains unclear. We explored the clinical implication of a major pathological response following preoperative therapy in patients with PDAC.MethodsOf 415 patients with resected PDAC, 137 who had undergone preoperative therapy were examined. Cox proportional hazards models were used to determine the predictors of a major pathological response, and survi...
Source: Journal of Hepato-Biliary-Pancreatic Sciences - May 14, 2020 Category: Gastroenterology Authors: Suguru Yamada, Yukihiro Yokoyama, Fuminori Sonohara, Junpei Yamaguchi, Hideki Takami, Masamichi Hayashi, Shunsuke Onoe, Tsutomu Fujii, Masato Nagino, Yasuhiro Kodera Tags: ORIGINAL ARTICLE Source Type: research

Bouncing off the Balloon: A New Trick for Selective Cystic Duct Cannulation
AbstractManagement of acute cholecystitis in high ‐risk and non‐surgical candidates includes endoscopic (transpapillary or transmural stenting) or percutaneous drainage of the gallbladder (GB).1 ‐5 Endoscopic cannulation of the cystic duct (CD) for transpapillary GB drainage in such cases can be technically challenging and difficult given narrowing of cystic duct orifice from edema, stones and valves in the cystic duct, and angulation of the cystic duct takeoff.1 ‐5 Here we describe a novel technique, using no special equipment that can be utilized for selective CD cannulation in cases of angulated CD takeoff. (Sou...
Source: Journal of Hepato-Biliary-Pancreatic Sciences - May 6, 2020 Category: Gastroenterology Authors: Rishabh Gulati, Tarun Rustagi Tags: IMAGE OF INTEREST Source Type: research

Hepatocellular carcinoma with a non ‐smooth tumor margin on hepatobiliary‐phase gadoxetic acid disodium‐enhanced magnetic resonance imaging. Is sectionectomy the suitable treatment?
ConclusionsOur preliminary results appear to recommend that HCC with a non ‐smooth margin on HB‐phase images is treated with anatomical sectionectomy or larger hepatectomy. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - May 4, 2020 Category: Gastroenterology Authors: Andrea Romanzi, Shunichi Ariizumi, Yoshihito Kotera, Akiko Omori, Shingo Yamashita, Satoshi Katagiri, Hiroto Egawa, Masakazu Yamamoto Tags: ORIGINAL ARTICLE Source Type: research

Conversion to Complete Resection with mFOLFOX6 with Bevacizumab or Cetuximab Based on K ‐RAS Status for Unresectable Colorectal Liver Metastasis (BECK study): Long‐Term Results of Survival
ConclusionsConversion hepatectomy achieved a similar long ‐term survival to the results of previous studies in initially resectable patients, although many of them experienced several post‐hepatectomy recurrences. Left‐sided primary was found to be the predictor for conversion hepatectomy. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - May 3, 2020 Category: Gastroenterology Authors: Masayuki Okuno, Etsuro Hatano, Rei Toda, Hiroto Nishino, Kojiro Nakamura, Takamichi Ishii, Satoru Seo, Kojiro Taura, Kentaro Yasuchika, Takefumi Yazawa, Masazumi Zaima, Akiyoshi Kanazawa, Hiroaki Terajima, Satoshi Kaihara, Yukihito Adachi, Tags: ORIGINAL ARTICLE Source Type: research

Peroxisome proliferator ‐activated receptor activity correlates with poor survival in patients resected for hepatocellular carcinoma
ConclusionPPAR activity in a subset of tumor samples was associated with reduced overall survival indicating that PPAR may be a valuable prognostic biomarker. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - May 2, 2020 Category: Gastroenterology Authors: Hans ‐Christian Pommergaard, Jane Preuss Hasselby, Gro Linno Willemoe, Adela Ralbovska, Andreas Arendtsen Rostved, Allan Rasmussen, Nicolai Aagaard Schultz, Jens Hillingsø, Peter Nørgaard Larsen, Jan‐Michael Kugler Tags: ORIGINAL ARTICLE Source Type: research

Tumour Marker Recovery rather than Major Pathological Response is a Preferable Prognostic Factor in Patients with Pancreatic Ductal Adenocarcinoma with Preoperative Therapy
ABSTRACTBackgroundA pathological response of the primary tumour by preoperative therapy is a prognostic factor in various malignancies, and several histologic grading systems have been proposed for pancreatic ductal adenocarcinoma (PDAC). However, the prognostic value remains unclear. We explored the clinical implication of a major pathological response following preoperative therapy in patients with PDAC.MethodsOf 415 patients with resected PDAC, 137 who had undergone preoperative therapy were examined. Cox proportional hazards models were employed to determine the predictors of a major pathological response, and survival...
Source: Journal of Hepato-Biliary-Pancreatic Sciences - May 2, 2020 Category: Gastroenterology Authors: Suguru Yamada, Yukihiro Yokoyama, Fuminori Sonohara, Junpei Yamaguchi, Hideki Takami, Masamichi Hayashi, Shunsuke Onoe, Tsutomu Fujii, Masato Nagino, Yasuhiro Kodera Tags: ORIGINAL ARTICLE Source Type: research

Impact of postoperative bile leakage on long ‐term outcome in patients following liver resection for hepatocellular carcinoma
This study aims to evaluate the effects of postoperative bile leakage on recurrence‐free survival (RFS) and overall survival (OS).MethodsA total of 1178 patients who underwent curative liver resection for HCC between 1986 and 2012 were included in the present study. Postoperative bile leakage was defined using the International Study Group of Liver Surgery definition, and the primary end points of the study were OS and RFS at 5 years.ResultsForty ‐three (3.7%) patients had bile leakage following liver resection. The median follow‐up was 5 years. A follow‐up analysis revealed that patients with bile leakage had poor...
Source: Journal of Hepato-Biliary-Pancreatic Sciences - May 2, 2020 Category: Gastroenterology Authors: Masateru Yamamoto, Tsuyoshi Kobayashi, Shintaro Kuroda, Michinori Hamaoka, Naruhiko Honmyo, Megumi Yamaguchi, Daisuke Takei, Hideki Ohdan Tags: ORIGINAL ARTICLE Source Type: research

Prophylactic drain management after pancreaticoduodenectomy without focusing on the drain fluid amylase level: A prospective validation study regarding criteria for early drain removal that do not include the drain fluid amylase level
ConclusionsOur new criteria for EDR, without DFA, enabled ≥90% applicability of EDR and reduced CR‐POPF. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - May 1, 2020 Category: Gastroenterology Authors: Koichi Taniguchi, Ryusei Matsuyama, Yasuhiro Yabushita, Yuki Homma, Yohei Ota, Ryutaro Mori, Daisuke Morioka, Itaru Endo Tags: ORIGINAL ARTICLE Source Type: research

Gastric subtype of intraductal papillary neoplasm of the bile duct: The pathologic spectrum
In conclusion, type 1 lesions shared features of gIPMN, while type 2 lesions differed from gIPMN and were more pathologically malignant. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - May 1, 2020 Category: Gastroenterology Authors: Nakanuma Yasuni, Katsuhiko Uesaka, Takuro Terada, Yukie Fukumura, Takashi Sugino, Yuko Kakuda, Hiroko Ikeda, Kenichi Harada, Yasunori Sato, Shinichiro Shimizu, Susumu Matsukuma, Jang Kee Taek, Young Nyun Park Tags: ORIGINAL ARTICLE Source Type: research

Factors affecting technical success of endoscopic transpapillary gallbladder drainage for acute cholecystitis
ConclusionAlthough ETGBD was an effective and safe procedure for acute cholecystitis, it has a limited success rate. The presence of cystic duct stone, dilation of CBD, and cystic duct direction (proximal and caudal branches) can serve as important predictors of ETGBD difficulties. These findings should be considered before procedures and the necessary adaptation of ETGBD made. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - April 30, 2020 Category: Gastroenterology Authors: Akinori Maruta, Keisuke Iwata, Takuji Iwashita, Kensaku Yoshida, Nobuhiro Ando, Katsuhisa Toda, Tsuyoshi Mukai, Masahito Shimizu Tags: ORIGINAL ARTICLE Source Type: research

Reproducibility and reliability of CT volumetry in estimation of the right ‐lobe graft weight in adult‐to‐adult living donor liver transplantation: Cantlie's line vs. portal vein territorialization
This study aimed to compare reliability and reproducibility between two major methods to define virtual hepatectomy plane, based on Cantlie's line (CTV‐Cantlie) and portal vein territorialization (CTV‐PVT) for right‐lobe graft weight estimation in LDLT.MethodsA total of 188 donors who underwent preoperative CT scans were included. The liver was divided into right and left lobes using CTV ‐Cantlie and CTV‐PTV measurements by two readers. Intraclass correlation coefficient(ICC) was used to determine interreader variability of hepatic weight measured using each CTV method. Intraoperative graft weight (IOW) was used ...
Source: Journal of Hepato-Biliary-Pancreatic Sciences - April 30, 2020 Category: Gastroenterology Authors: Heon ‐Ju Kwon, Kyoung Won Kim, Jin Kyoo Jang, Jeongjin Lee, Gi‐Won Song, Sung‐Gyu Lee Tags: ORIGINAL ARTICLE Source Type: research

Relations between hepatobiliary scintigraphy findings and histopathological factors in patients with recurrent biliary colic
ConclusionsIn patients with recurrent biliary colic, nonvisualization of gallbladder activity on hepatobiliary scintigraphy was related to the degree of inflammation in the gallbladder, while low GBEF was related to muscular hypertrophy of the gallbladder. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - April 30, 2020 Category: Gastroenterology Authors: Hyein Ahn, Si ‐Hyong Jang, Hyun Ju Lee, Ji‐Hye Lee, Hae Il Jung, Mee‐Hye Oh, Sang Mi Lee, Jeong Won Lee Tags: ORIGINAL ARTICLE Source Type: research

Reappraisal of the advantages of laparoscopic liver resection for intermediate hepatocellular carcinoma within a stage migration perspective: Propensity score analysis of the differential benefit
ConclusionsThe favorable biological scenario associated with laparoscopic approach allows to obtain enhanced benefits in the setting of more advanced liver disease. The push towards minimal invasiveness and the incremental benefit associated with it could potentially promote stage migration in suitable patients. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - April 16, 2020 Category: Gastroenterology Authors: Francesca Ratti, Federica Cipriani, Guido Fiorentini, Marco Catena, Michele Paganelli, Luca Aldrighetti Tags: ORIGINAL ARTICLE Source Type: research

Minimally invasive surgery for the management of major bile duct injury due to cholecystectomy
ConclusionsThe absence of high ‐level evidences precludes the possibility to draw definitive conclusions. However, the available data derived from a growing number of centers demonstrate that minimally invasive surgery may offer its well‐known advantages on postoperative outcomes also in the setting of severe iatrogenic injur y to the bile ducts. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - April 14, 2020 Category: Gastroenterology Authors: Francesco Guerra, Diego Coletta, Manuel Gavioli, Danilo Coco, Alberto Patriti Tags: SYSTEMATIC REVIEW Source Type: research

Issue Information ‐ IFA
Journal of Hepato-Biliary-Pancreatic Sciences, Volume 27, Issue 4, Page 219-223, April 2020. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - April 14, 2020 Category: Gastroenterology Tags: Issue Information ‐ IFA Source Type: research

A novel scoring system for evaluating the difficulty of lysis of adhesion and surgical risk at repeat hepatectomy
ConclusionsThe new difficulty scoring system for the lysis of adhesion at ReHx showed good interobserver agreement and reproducibility of the results. Given the strong correlation with postoperative morbidity rate, the present score could be used for evaluating the technical difficulties in ReHx and may offer a reliable measure for estimating the efficacy of anti ‐adhesion materials in future analysis. (Source: Journal of Hepato-Biliary-Pancreatic Sciences)
Source: Journal of Hepato-Biliary-Pancreatic Sciences - April 14, 2020 Category: Gastroenterology Authors: Yuta Kobayashi, Junichi Shindoh, Yu Igata, Satoshi Okubo, Masaji Hashimoto Tags: ORIGINAL ARTICLE Source Type: research

Impact of microbial contamination of the islet product during total pancreatectomy with islet autotransplantation
HighlightKumano and colleagues analyzed data from 108 patients undergoing total pancreatectomy with islet autotransplantation (TPIAT) and reported that preoperative stent treatment and pancreas fibrosis score were independent risk factors for contamination of the islet product. They recommended earlier TPIAT approach rather than endoscopic intervention for better metabolic outcomes. AbstractBackgroundThe combined use of interleukin ‐1β and tumor necrosis factor–α blockers in the peritransplant period has improved outcomes of total pancreatectomy with islet autotransplantation (TPIAT). However, these drug...
Source: Journal of Hepato-Biliary-Pancreatic Sciences - April 14, 2020 Category: Gastroenterology Authors: Kenjiro Kumano, Morihito Takita, Srividya Vasu, Carly Darden, Michael Lawrence, Ernest Beecherl, Amar Gupta, Nicholas Onaca, Bashoo Naziruddin Tags: ORIGINAL ARTICLE Source Type: research