A rationally designed nuclei-targeting FAPI 04-based molecular probe with enhanced tumor uptake for PET/CT and fluorescence imaging
ConclusionsThe NOTA-FAPI-MB was successfully synthesized, in which FAPI and MB simultaneously contributed to the targeting effect. Notably, the nuclear delivery mechanism of the probes improved intracellular retention time and targeting efficacy, broadening the imaging time window for fluorescence imaging. In vivo PET/CT demonstrated favorable performance of NOTA-FAPI-MB compared to [18F]F-FDG. This study highlights the significance of fluorescence imaging as an adjunct technique to PET/CT. Furthermore, the encouraging results obtained from the imaging of human HCC tissues hold promise for the potential application of NOTA...
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 24, 2024 Category: Nuclear Medicine Source Type: research
The accuracy and intra- and interobserver variability of PSMA PET/CT for the local staging of primary prostate cancer
ConclusionIn a large, multicentre study evaluating 600 patients with newly diagnosed intermediate and high-risk PCa, we showed that PSMA PET/CT may have a value in local tumour staging when pathological tumour stage in the radical prostatectomy specimen was used as the reference standard. The intra-observer and interobserver variability of assessment of tumour extent on PSMA PET/CT was moderate to substantial. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 24, 2024 Category: Nuclear Medicine Source Type: research
Thrombus or tumor? A case report of a rare sarcoma entity: intimal sarcoma of the pulmonary arteries
CONCLUSION: In case of atypical presentation of a pulmonary embolism, a tumor originating from the great vessels should be considered. Molecular pathology techniques support in establishing a reliable diagnosis.PMID:38656400 | DOI:10.1007/s11033-024-09467-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: A D örr A Fl örcken L Bullinger D Capper A Von Deimling D Kaul S M ärdian C Starck D Horst M P Dragomir F M Sch äfer A Jarosch Source Type: research
[18F]fluorodeoxyglucose positron emission tomography/computed tomography in combination with clinical data in predicting overall survival in non-small-cell lung cancer patients: A retrospective study
Positron emission tomography/computed tomography (PET/CT) has an established role in evaluating patients with lung cancer. The aim of this work was to assess the predictive capability of [18F]Fluorodeoxyglucose ([18F]FDG) PET/CT parameters on overall survival (OS) in lung cancer patients using an artificial neural network (ANN) in parallel with conventional statistical analysis. (Source: Radiography)
Source: Radiography - April 24, 2024 Category: Radiology Authors: P. Cegla, G.M. Currie, W. Cholewinski, M. Bryl, M. Trojanowski, K. Matuszewski, T. Piotrowski, R. Czepczy ński Source Type: research
Ultra-High-Resolution CT vs. Invasive Angiography for Detecting Hemodynamically Significant Coronary Artery Disease: Rationale and Methods of The CORE-PRECISION Multicenter Study
Direct coronary arterial evaluation via computed tomography (CT) angiography is the most accurate noninvasive test for the diagnosis of coronary artery disease (CAD). However, diagnostic accuracy is limited in the setting of severe coronary calcification or stents. Ultra-high-resolution CT (UHR-CT) may overcome this limitation, but no rigorous study has tested this hypothesis. (Source: Journal of Cardiovascular Computed Tomography)
Source: Journal of Cardiovascular Computed Tomography - April 24, 2024 Category: Radiology Authors: Bruna R. Scarpa Matuck, Naruomi Akino, Hooman Bakhshi, Christopher Cox, Elnaz Ebrahimihoor, Masaru Ishida, Pedro A. Lemos, Joao A.C. Lima, Matthew B. Matheson, Makoto Orii, Aysa Ostovaneh, Mohammad R. Ostovaneh, Joanne D. Schuijf, Gilberto Szarf, Jeffrey Source Type: research
Dialysis Duration, Time Interaction, and Visceral Fat Accumulation: A 6-Year Posttransplantation Study
ConclusionsThe study revealed that KT promoted significant alterations in body composition characterized by increase in the VAT and SAT and a decline in SMR. Notably, dialysis duration and its interaction with posttransplantation duration emerged as significant factors influencing VAT increase. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 24, 2024 Category: Urology & Nephrology Source Type: research
Cell-free DNA assay for malignancy classification of high-risk lung nodules.
Although low-dose computed tomography has been proven effective to reduce lung cancer-specific mortality, a considerable proportion of surgically resected high-risk lung nodules were still confirmed pathologically benign. There is an unmet need of a novel method for malignancy classification in lung nodules. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 24, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Siwei Wang, Fanchen Meng, Peng Chen, Yang Lv, Min Wu, Haimeng Tang, Hua Bao, Xue Wu, Yang Shao, Jie Wang, Juncheng Dai, Lin Xu, Xiaoxiao Wang, Rong Yin Source Type: research
Prophylactic Biosynthetic Retrorectus Mesh Placement During Stoma Reversal Reduces the Rate of Stoma Site Incisional Hernia
The objective of this study was to assess the use of prophylactic biosynthetic mesh at the time of stoma reversal on the overall SSIH rate.METHODS: This is an observational retrospective cohort study. A review of 101 consecutive patients who underwent PMR in the retrorectus plane from 2015 to 2020 was compared to 73 consecutive patients who underwent primary stoma closure without mesh from 2011 to 2014. The primary endpoint was the presence of SSIH on clinical examination or computed tomography after ostomy takedown.RESULTS: In total, 174 cases were analyzed with 101 patients in the treatment group (median follow-up 45.2 m...
Source: The Permanente journal - April 23, 2024 Category: General Medicine Authors: Brandon K Vu Jessica Lam Matthew J Sherman Michael S Tam Source Type: research
Severity of COVID-19 infection in patients with COVID-19 combined with diabetes
CONCLUSION: Blood glucose control is significantly correlated with the CTSS; the higher the blood glucose is, the more severe the lung manifestation. The CTSS can also be used to evaluate and predict the clinical severity of COVID-19.PMID:38654371 | DOI:10.1186/s41043-024-00548-w (Source: Journal of Health, Population, and Nutrition)
Source: Journal of Health, Population, and Nutrition - April 23, 2024 Category: International Medicine & Public Health Authors: Dan Lu Yuhong Liu Pengcheng Ma Rui Hou Jin Wang Source Type: research
Simultaneous Viability Assessment and Invasive Coronary Angiography Using a Therapeutic CT System in Chronic Myocardial Infarction Patients
CONCLUSION: The feasibility of the DE-MDCT viability assessment acquired simultaneously with conventional ICA was proven in patients with chronic MI using DE-CMR as the reference standard.PMID:38653564 | DOI:10.3349/ymj.2023.0208 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 23, 2024 Category: Universities & Medical Training Authors: Seongmin Ha Yeonggul Jang Byoung Kwon Lee Youngtaek Hong Byeong-Keuk Kim Seil Park Sun Kook Yoo Hyuk-Jae Chang Source Type: research
The 1-cm lower calyx calculus: SWT, URS or Mini-PCNL? Guidelines vs. reality.
Aktuelle Urol. 2024 Apr 23. doi: 10.1055/a-2290-7250. Online ahead of print.ABSTRACTUrinary stones of the upper urinary tract can be considered a widespread public health concern due to their high incidence and prevalence and their health policy-related and financial implications. A significant proportion of newly diagnosed kidney stones are lower-pole stones, i.e., stones affecting the lower calyx group of the renal pelvicalyceal system. These are often diagnosed by chance, i.e., as incidental findings during ultrasound or CT scans performed for other reasons, or as "secondary stones" detected during the diagnostic work-u...
Source: Aktuelle Urologie - April 23, 2024 Category: Urology & Nephrology Authors: Peter Jochen Olbert Source Type: research
Impact of body composition on outcomes of immune checkpoint inhibitor combination therapy in patients with previously untreated advanced renal cell carcinoma
CONCLUSION: The SFI can be potentially utilized as an effective predictive and prognostic biomarker for first-line ICI combination therapy for advanced RCC.PMID:38653590 | DOI:10.1016/j.urolonc.2024.04.008 (Source: Urologic Oncology)
Source: Urologic Oncology - April 23, 2024 Category: Urology & Nephrology Authors: Hiroki Ishihara Koichi Nishimura Takashi Ikeda Hironori Fukuda Kazuhiko Yoshida Junpei Iizuka Tsunenori Kondo Toshio Takagi Source Type: research
Association of the multi-biomarker disease activity score with arterial 18-fluorodeoxyglucose uptake in rheumatoid arthritis
CONCLUSIONS: Among treated RA patients, achieved MBDA predicts of changes in arterial inflammation. Achieving low MBDA at 24 weeks was associated with clinically meaningful reductions in arterial inflammation, regardless of treatment.PMID:38652572 | DOI:10.1093/rheumatology/keae242 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Jon T Giles Daniel H Solomon Katherine P Liao Pamela M Rist Zahi A Fayad Ahmed Tawakol Joan M Bathon Source Type: research
Artificial intelligence-powered insights into high-risk, non-obstructive coronary atherosclerosis: a case report
DISCUSSION: The main clinical message of this case report is that advanced plaque analysis by cardiac CT, especially when performed with AI-based software, may provide important prognostic information leading to a personalized preventive approach. Moreover, AI-based software may contribute to promote a routine evaluation of these important data already included in traditional cardiac CT.PMID:38651080 | PMC:PMC11033843 | DOI:10.1093/ehjcr/ytae172 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Andrea Provera Daniele Andreini Kersten Petersen Emanuele Gallinoro Edoardo Conte Source Type: research
Radio-Guided Surgery with a New-Generation β-Probe for Radiolabeled Somatostatin Analog, in Patients with Small Intestinal Neuroendocrine Tumors
CONCLUSION: This study reports optimal accuracy in detecting lesions of SI-NETs using the intraoperative RGS approach with a novel β-probe. The method was found to be safe, feasible, and easily reproducible in daily clinical practice, with minimal radiation exposure for the staff. RGS might potentially improve radical resection rates in SI-NETs.CLINICAL TRIALS REGISTRATION: 68Ga-DOTATOC Radio-Guided Surgery with β-Probe in GEP-NET (RGS GEP-NET) [NCT0544815; https://classic.CLINICALTRIALS: gov/ct2/show/NCT05448157 ].PMID:38652200 | DOI:10.1245/s10434-024-15277-x (Source: Ann Oncol)
Source: Ann Oncol - April 23, 2024 Category: Cancer & Oncology Authors: Emilio Bertani Francesco Mattana Francesco Collamati Mahila E Ferrari Vincenzo Bagnardi Samuele Frassoni Eleonora Pisa Riccardo Mirabelli Silvio Morganti Nicola Fazio Uberto Fumagalli Romario Francesco Ceci Source Type: research
