Correlation of Early-Phase F-18 Florapronal PET with F-18 FDG PET in Alzheimer ’s Disease and Normal Brain
ConclusionsEarly F-18 FPN study can be used as a proxy marker for the F-18 FDG PET. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - September 11, 2019 Category: Nuclear Medicine Source Type: research

Postoperative Radioiodine Treatment within 9  Months from Diagnosis Significantly Reduces the Risk of Relapse in Low-Risk Differentiated Thyroid Carcinoma
ConclusionIf postoperative RAI treatment is considered in low-risk DTC, any delay in RAI administration above 9  months since diagnosis may be related to poorer long-term outcomes. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - September 5, 2019 Category: Nuclear Medicine Source Type: research

Debates over NICE Guideline Update: What Are the Roles of Nuclear Cardiology in the Initial Evaluation of Stable Chest Pain?
AbstractRecent clinical trials have demonstrated the values of cardiac computed tomography (CT) in the initial evaluation of stable chest pain which led to drastic changes in the National Institute for Health and Care Excellence (NICE) guidelines in 2016. According to the updated NICE guidelines, cardiac CT should be performed as the initial cardiac testing in stable chest pain regardless of pre-test probability (PTP) of coronary artery disease (CAD). As a result, cardiac CT is now considered as a validated gatekeeper for assessing stable chest pain, which precedes all the functional studies including nuclear myocardial pe...
Source: Nuclear Medicine and Molecular Imaging - August 28, 2019 Category: Nuclear Medicine Source Type: research

Cerebral Amyloid Quantification in Cognitively Normal Korean Adults Using F-18 Florbetaben PET
ConclusionsWe provide reference values of normative data obtained from healthy elderly Koreans and suggest its use for accurate diagnosis of patients with Alzheimer ’s disease. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - August 28, 2019 Category: Nuclear Medicine Source Type: research

False-negative Hepatobiliary Scintigraphy for Biliary Atresia
We present the case of a patient with biliary and duodenal atresia who showed false-negative hepatobiliary scintigraphy results. The patient was born at 37  weeks and 2 days of gestation. Her mother had undergone amnioreduction after detection of a double-bubble ultrasound sign in the fetal abdomen. At 2 days of age, total serum bilirubin level was elevated. On hepatobiliary scintigraphy 4 days later, the gallbladder was visualized from 30 min and it showed duodeno-gastric reflux at 240 min. After 24 h, the radiotracer was almost washed out in the hepatic parenchyma, but there was retenti...
Source: Nuclear Medicine and Molecular Imaging - August 21, 2019 Category: Nuclear Medicine Source Type: research

Calf “Arch Sign” Seen on a Tc-99m-MDP Bone Scan Is Indicative of Synovial Fluid Leak in Ruptured Baker’s Cysts: Case Reports and Analysis of Literature
AbstractThe authors present two cases in which the ruptured popliteal (Baker ’s) cysts remained undetected and were diagnosed only during an isotope investigation. The aim was to describe a specific imaging sign, the “arch sign”, that is indicative of ruptured Baker’s cysts. In both cases, the whole-body imaging was performed 2 hours after injection of 706.7 MBq of Tc-99m-MDP. Single-photon emission computed tomography (SPECT) imaging was performed to localize an accumulation of the radiopharmaceutical. An analysis of literature was performed to connect these cases with previously reported data...
Source: Nuclear Medicine and Molecular Imaging - August 19, 2019 Category: Nuclear Medicine Source Type: research

Pleuropericardial Cyst Mimicking a Metastasis of Differentiated Thyroid Carcinoma on Whole-Body Iodine-131 Scan: a Case Report
AbstractPost-therapeutic whole-body scan (WBS) with I-131 has been widely used for the follow-up of patients with well-differentiated thyroid cancer (DTC). Although the sensitivity of WBS with I-131 in detection of functioning thyroid tissues is high, its specificity is low. So, a further evaluation is required in cases of unexpected findings. The purpose of the study was to demonstrate that awareness of the potential pitfalls of WBS in DTC, knowledge of physiology and characteristics of radioiodine uptake, and correlation with other imaging modalities are needed to avoid incorrect management of patients with DTC. This is ...
Source: Nuclear Medicine and Molecular Imaging - July 30, 2019 Category: Nuclear Medicine Source Type: research

Theranostics Based on Liposome: Looking Back and Forward
AbstractLiposome is one of the oldest yet most successful nanomedicine platforms. Doxil ®, PEGylated liposome loaded with doxorubicin (DOX), was approved by the FDA in 1995 for the treatment of AIDS-related Kaposi’s sarcoma, and it was the first approval for nanomedicine. Since then, liposome-based therapeutics were approved for the treatment of various diseases and many clinical tr ials are underway. The success of the liposome-based therapeutics was due to following factors: (1) ease of synthesis, (2) biocompatibility, (3) the ability to load both hydrophilic and hydrophobic agents, and (4) long circulation pro...
Source: Nuclear Medicine and Molecular Imaging - July 22, 2019 Category: Nuclear Medicine Source Type: research

Predictive Value of Interim and End-of-Therapy 18F-FDG PET/CT in Patients with Follicular Lymphoma
This study investigated the prognostic value of Deauville 5-point scale (D5PS) from paired interim PET/CT (PETInterim) and end-of-induction therapy PET/CT (PETEOI) in patients with FL.MethodsFL staging and response assessment PET/CT images from 2013 to 2015 were retrospectively reviewed. PETInterim was performed 3 or 4  cycles after chemotherapy and PETEOI after 6 or 8  cycles. D5PS scores of 1, 2, and 3 were considered as negative (−), and scores 4 and 5 were considered as positive (+). Statistical analysis was done using Cox regression analysis, Kaplan–Meier survival analysis, and the log-rank test....
Source: Nuclear Medicine and Molecular Imaging - June 29, 2019 Category: Nuclear Medicine Source Type: research

Treatment Response Assessment of Skeletal Metastases in Prostate Cancer with 18 F-NaF PET/CT
Conclusion18F-NaF PET/CT is complementary to biochemical monitoring in patients with bone-only metastases from prostate cancer which can be helpful in subsequent treatment management decisions. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - June 24, 2019 Category: Nuclear Medicine Source Type: research

Minimum Standardized Uptake Value from Quantitative Bone Single-Photon Emission Computed Tomography/Computed Tomography for Evaluation of Femoral Head Viability in Patients with Femoral Neck Fracture
ConclusionsThe non-viable femoral heads from the femoral neck fracture showed significantly reduced SUVmin. Quantitative bone SPECT/CT holds promise for objective evaluation of femoral head viability. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - June 22, 2019 Category: Nuclear Medicine Source Type: research

Utility of FDG-PET/CT for the Detection and Characterization of Sternal Wound Infection Following Sternotomy
ConclusionsResults suggest that FDG-PET/CT may be useful for the diagnosis of SWI with optimal diagnostic accuracy achieved by identifying specific patterns of uptake. SUVmax can be helpful in assessing subjects with remote surgery, but its use is limited in the context of recent surgery. Further studies are required to confirm these results. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - June 14, 2019 Category: Nuclear Medicine Source Type: research

Measurement of Tumor Pressure and Strategies of Imaging Tumor Pressure for Radioimmunotherapy
AbstractTumor interstitial pressure is a fundamental feature of cancer biology. Elevation in tumor pressure affects the efficacy of cancer treatment and results in the heterogenous intratumoral distribution of drugs and macromolecules. Monoclonal antibodies (mAb) play a prominent role in cancer therapy and molecular nuclear imaging. Therapy using mAb labeled with radionuclides —also known as radioimmunotherapy (RIT)—is an effective form of cancer treatment. RIT is clinically effective for the treatment of lymphoma and other blood cancers; however, its clinical use for solid tumor was limited because their high ...
Source: Nuclear Medicine and Molecular Imaging - June 13, 2019 Category: Nuclear Medicine Source Type: research

18 F-FDG PET/MR Refines Evaluation in Newly Diagnosed Metastatic Urethral Adenocarcinoma
We described the clinical impact of18F-FDG PET/MR in refining the evaluation of a 39-year-old female with newly diagnosed metastatic urethral adenocarcinoma. We detailed the diagnostic imaging workup focusing our attention on the CT, MR, and18F-FDG PET/MR different findings. In this case,18F-FDG PET/MR imaging evaluation resulted not only effective but also altered staging and spared additional invasive procedures in the assessment of a metastatic urethral adenocarcinoma. Combining a highly sensitive PET with the increase tissue resolution of MR (PET/MR) may improve abdominal and pelvic lesion detection outperforming PET/C...
Source: Nuclear Medicine and Molecular Imaging - June 12, 2019 Category: Nuclear Medicine Source Type: research

The Correlation Between Tenosynovitis Pattern on Two-Phase Bone Scintigraphy and Clinical Manifestation in Patients with Suspected Rheumatoid Arthritis
ConclusionTenosynovitis pattern on 2P-BS was more commonly detected in the RA group and was more frequently associated with early arthritis pattern. Therefore, 2P-BS could give additional information for the detection of subclinical tenosynovitis in early or preclinical RA patients. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - June 3, 2019 Category: Nuclear Medicine Source Type: research

Value of the Filtration Fraction Assessed by Dynamic 99m Tc-Diethylenetriaminepentaacetic Acid Renal Scintigraphy After Angiotensin-Converting Enzyme Inhibition for the Diagnosis of Renovascular Hypertension
This study aimed to determine the diagnostic value of the relative filtration fraction (RFF) assessed by dynamic99mTc-diethylenetriaminepentaacetic acid (99mTc-DTPA) renal scintigraphy after angiotensin-converting enzyme (ACE) inhibition for renovascular hypertension (RVHT) diagnosis.Methods99mTc-DTPA captopril renal scintigraphy performed in adolescents or adults ( ≥ 10 years) with suspected RVHT was retrospectively reviewed. The RFF of the affected kidney was qualitatively assessed as the relative glomerular filtration rate during the 2 to 3-min period compared with the relative perfusion during the first ...
Source: Nuclear Medicine and Molecular Imaging - May 27, 2019 Category: Nuclear Medicine Source Type: research

How Do the More Recent Reconstruction Algorithms Affect the Interpretation Criteria of PET/CT Images?
AbstractPurposeRecently, a new Bayesian Penalized Likelihood (BPL) Reconstruction Algorithm was introduced by GE Healthcare, Q.Clear; it promises to provide better PET image resolution compared to the widely used Ordered Subset Expectation Maximization (OSEM). The aim of this study is to compare the performance of these two algorithms on several types of findings, in terms of image quality, lesion detectability, sensitivity, and specificity.MethodsBetween September 6th 2017 and July 31st 2018, 663 whole body 18F-FDG PET/CT scans were performed at the Nuclear Medicine Department of S. Martino Hospital (Belluno, Italy). Base...
Source: Nuclear Medicine and Molecular Imaging - May 1, 2019 Category: Nuclear Medicine Source Type: research

Lesion-Wise Comparison of Pre-Therapy and Post-Therapy Effective Half-Life of Iodine-131 in Pediatric and Young Adult Patients with Differentiated Thyroid Cancer Undergoing Radioiodine Therapy
AbstractPurposeThe effective half-life of radioiodine is an important parameter for dosimetry in differentiated thyroid cancer patients, particularly in children. We determined the pre-therapy and post-therapy effective half-life in different types of lesions, i.e., remnant, node, or lung metastases.MethodsOf 84 patients recruited, 27 were
Source: Nuclear Medicine and Molecular Imaging - April 23, 2019 Category: Nuclear Medicine Source Type: research

Use of Molecular Imaging in Clinical Drug Development: a Systematic Review
ConclusionsThe present study confirmed the trend that molecular imaging has been more actively employed in recent clinical drug development studies although its adoption was rather slow and rare in phase 0 studies. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - April 16, 2019 Category: Nuclear Medicine Source Type: research

Promotion of Nuclear Medicine-Related Sciences in Developing Countries
(Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - April 8, 2019 Category: Nuclear Medicine Source Type: research

Theranostics in Bangladesh: Current Status, Challenges, and Future Perspective
AbstractBackground and Current Status of TheranosticsTherapeutic nuclear medicine (NM) in Bangladesh began in the early 1980s with the application of radioactive iodine for treatment of thyroid cancer and primary hyperthyroidism. Since then, NM practice has remarkably developed in the country with the advancement of instrumentation, radiopharmacy, and information technology. The government took the initiative to establish four PET-CT centers at different NM centers, including one at the National Institute of Nuclear Medicine and Allied Sciences (NINMAS). A further development is the installation of a cyclotron center (18-M...
Source: Nuclear Medicine and Molecular Imaging - April 2, 2019 Category: Nuclear Medicine Source Type: research

Perspective in Nuclear Theranostics Using Exosome for the Brain
AbstractOwing to its highly biocompatible property as naturally produced nanoscale particle and drug carrying ability, exosome has attracted much interest in the biomedical area. Versatile functions of exosome in biological system play an important role in elucidating mysterious and unknown biological processes and pathological disease progression. For usage of exosome as brain disease therapeutics, even though the ability of exosomes crossing blood brain barrier (BBB) is not well clearly proven, the small size and their own characteristics possessing cell-derived molecular contents may provide great and beneficial tools f...
Source: Nuclear Medicine and Molecular Imaging - March 31, 2019 Category: Nuclear Medicine Source Type: research

Ipsilateral Hyperhidrosis: Atypical Symptom of Small Lung Adenocarcinoma Evaluated by 18 F-FDG PET-CT
AbstractA 45-year-old male visited our clinic due to right palmar anhidrosis and contralateral hyperhidrosis. Chest computed tomography (CT) showed a solitary pulmonary nodule with mediastinal lymph node enlargement, but a cause for atypical palmar anhidrosis was not identified. Subsequent fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed (PET/CT) revealed a localized pleural metastasis at the right apex with direct invasion of the paravertebral sympathetic chain. The pleural metastasis, which was not seen on chest CT, evoked ipsilateral anhidrosis independent of a mass effect or direct invasio...
Source: Nuclear Medicine and Molecular Imaging - March 26, 2019 Category: Nuclear Medicine Source Type: research

Clinical Applications of Technetium-99m Quantitative Single-Photon Emission Computed Tomography/Computed Tomography
AbstractSingle-photon emission computed tomography/computed tomography (SPECT/CT) is an already established nuclear imaging modality. Co-registration of functional information (SPECT) with anatomical images (CT) paved the way to the wider application of SPECT. Recent advancements in quantitative SPECT/CT have made it possible to incorporate quantitative parameters, such as standardized uptake value (SUV) or %injected dose (%ID), in gamma camera imaging. This is indeed a paradigm shift in gamma camera imaging from qualitative to quantitative evaluation. In fact, such quantitative approaches of nuclear imaging have only been...
Source: Nuclear Medicine and Molecular Imaging - March 15, 2019 Category: Nuclear Medicine Source Type: research

Eruption of Metastatic Paraganglioma After Successful Therapy with 177 Lu/ 90 Y-DOTATOC and 177 Lu-DOTATATE
We present two cases of marked progression of metastatic paraganglioma following initial partial response to PRRT. Given their positivity on68Ga-DOTATATE PET/CT and111In-octreotide SPECT, they underwent PRRT. Imaging following treatment revealed significant improvement in size and intensity, with some foci nearly completely resolved in one patient, and disease regression with a decrease in the number and size of bone and liver lesions in the second patient. Within months, repeat imaging in both patients revealed extensive metastatic disease with new lesions, which eventually lead to their deaths. The mechanism for rapid di...
Source: Nuclear Medicine and Molecular Imaging - February 22, 2019 Category: Nuclear Medicine Source Type: research

Development of a Novel Imaging Agent for Determining Albumin Uptake in Solid Tumors
Conclusion111In-C4-DTPA bound rapidly to circulating albumin upon injection and showed time-dependent uptake in the tumors demonstrating a potential for clinical application as a companion imaging diagnostic for albumin-binding anticancer drugs. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 20, 2019 Category: Nuclear Medicine Source Type: research

Gallbladder Paraganglioma Associated with SDHD Mutation: a Potential Pitfall on 18 F-FDOPA PET Imaging
We report an unusual location of PGL in the gallbladder associated withSDHD mutation which could present as a potential pitfall on18F-FDOPA PET/CT as its normal excretion occurs through biliary system and gallbladder. This case highlights the superiority of68Ga-DOTATATE in comparison to18F-FDOPA and18F-FDG in the detection ofSDHD-related parasympathetic PGL.ClinicalTrials.gov Identifier:NCT00004847. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 19, 2019 Category: Nuclear Medicine Source Type: research

Quantitative Imaging of Alpha-Emitting Therapeutic Radiopharmaceuticals
AbstractTargeted alpha therapy (TAT) is an active area of drug development as a highly specific and highly potent therapeutic modality that can be applied to many types of late-stage cancers. In order to properly evaluate its safety and efficacy, understanding biokinetics of alpha-emitting radiopharmaceuticals is essential. Quantitative imaging of alpha-emitting radiopharmaceuticals is often possible via imaging of gammas and positrons produced during complex decay chains of these radionuclides. Analysis of the complex decay chains for alpha-emitting radionuclides (Tb-149, At-211, Bi-212 (decayed from Pb-212), Bi-213, Ra-2...
Source: Nuclear Medicine and Molecular Imaging - February 18, 2019 Category: Nuclear Medicine Source Type: research

Efforts in the Formation and Development of Nuclear Medicine in Vietnam
AbstractThe foundations of nuclear medicine in Vietnam were established from 1970. Until now, after 48  years of development, in Vietnam, we have some basic equipment including 31 SPECT, 4 SPECT/CT machines, 11 PET/CT scanners, five cyclotrons, and one nuclear reactor. Many nuclear medicine techniques in diagnosis and treatment have been routinely performed at provincial and central level health fac ilities such as tumor scintigraphy, thyroid scintigraphy, bone scintigraphy, kidney scintigraphy, cardiac scintigraphy, and radio-isotope therapy with I-131 and P-32. Selective internal radiation therapy with Y-90 microsph...
Source: Nuclear Medicine and Molecular Imaging - February 13, 2019 Category: Nuclear Medicine Source Type: research

Development of Predictive Models in Patients with Epiphora Using Lacrimal Scintigraphy and Machine Learning
ConclusionsML-based predictive models using different programming languages and different computing platforms were useful for classifying clinical diagnoses in patients with epiphora and were similar to a clinician ’s diagnostic ability. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 7, 2019 Category: Nuclear Medicine Source Type: research

Nuclear Theranostics in Taiwan
AbstractBoron neutron capture therapy and Y-90 radioembolization are emerging therapeutic methods for uncontrolled brain cancers and hepatic cancers, respectively. These advanced radiation therapies are heavily relied on theranostic nuclear medicine imaging before the therapy for the eligibility of patients and the prescribed-dose simulation, as well as the post-therapy scanning for assessing the treatment efficacy. In Taiwan, the Taipei Veterans General Hospital is the only institute performing the BNCT and also the leading institute performing Y-90 radioembolization. In this article, we present our single institute exper...
Source: Nuclear Medicine and Molecular Imaging - February 1, 2019 Category: Nuclear Medicine Source Type: research

Diagnostic Reference Levels for Adult Nuclear Medicine Imaging Established from the National Survey in Korea
ConclusionThe first DRLs for nuclear medicine imaging in Korean adults were confirmed. The DRLs will enable optimized radiation protection in the field of nuclear medicine imaging in Korea. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 1, 2019 Category: Nuclear Medicine Source Type: research

Perspectives for Concepts of Individualized Radionuclide Therapy, Molecular Radiotherapy, and Theranostic Approaches
AbstractRadionuclide therapy (RNT) stands on the delivery of radiation to tumors or non-tumor target organs using radiopharmaceuticals that are designed to have specific affinity to targets. RNT is recently called molecular radiotherapy (MRT) by some advocators in order to emphasize its characteristics as radiotherapy and the relevance of dosimetry-guided optimization of treatment. Moreover, RNT requires relevant radiation protection standards because it employs unsealed radionuclides and gives therapeutic radiation doses in humans. On the basis of these radiation protection standards, the development and use of radiopharm...
Source: Nuclear Medicine and Molecular Imaging - January 29, 2019 Category: Nuclear Medicine Source Type: research

Progress of Coordination and Utilization of Zirconium-89 for Positron Emission Tomography (PET) Studies
AbstractRadiometals have been commonly used in medical applications, and utilization of such metals continues to be an attractive research area. In particular, a variety of radiometals have been developed and implemented for molecular imaging. For such applications,89Zr has been one of the most interesting radiometals currently used for tumor targeting. Several chemical ligands were developed as89Zr chelators, and new coordinating methods have also been developed more recently. In addition, immuno-positron emission tomography (PET) studies using89Zr-labeled monoclonal antibodies have been performed by several scientists. I...
Source: Nuclear Medicine and Molecular Imaging - January 29, 2019 Category: Nuclear Medicine Source Type: research

Current Status and Growth of Nuclear Theranostics in Singapore
AbstractThe concept of theranostics, where individual patient-level biological information is used to choose the optimal therapy for that individual, has become more popular in the modern era of ‘personalised’ medicine. With the growth of theranostics, nuclear medicine as a specialty is uniquely poised to grow along with the ever-increasing number of concepts combining imaging and therapy. This special report summarises the status and growth of Theranostic Nuclear Medicine in Singapore. We will cover our experience with the use of radioiodine, radioiodinated metaiodobenzylguanidine, peptide receptor radionuclid...
Source: Nuclear Medicine and Molecular Imaging - January 25, 2019 Category: Nuclear Medicine Source Type: research

Theranostics in India: a Particularly Exquisite Concept or an Experimental Tool
AbstractThe term theranostics is a combination of a diagnostic tool that helps to define a right therapeutic tool for specific disease and paves the approach towards personalized or precision medicine. In Nuclear Medicine, a diagnostic radionuclide is labeled with the target and once expression is documented, the same target is labeled with a therapeutic radionuclide and treatment is executed. The theranostic concept was applied first time in 1964 in the treatment of thyroid cancer with I-131 (RAI). Over the years, other theranostic radiotracers became available indigenously from the Bhabha Atomic Research Centre (BARC) in...
Source: Nuclear Medicine and Molecular Imaging - January 23, 2019 Category: Nuclear Medicine Source Type: research

Tracer Accumulation in Relation to Venous Thrombus on 18 F-DOPA PET/CT in a Case of Persistent Hyperinsulinemic Hypoglycemia of Infancy
We present the findings in a 20-day-old neonate with PHHI who underwent18F-DOPA PET/CT. The scan showed diffuse uptake in the pancreas with no focal lesion, physiologic excretion into the genito-urinary system, and interestingly tracer accumulation was seen in the inferior vena cava and ilio-femoral veins which is a non-physiological site for tracer accumulation. The uptake corresponded to a large venous thrombus which was confirmed by a venous Doppler. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 23, 2019 Category: Nuclear Medicine Source Type: research

Perspectives in Radiomics for Personalized Medicine and Theranostics
AbstractRadiomics handles imaging biomarker from high-throughput feature extraction through complex pattern recognition that is difficult for human to process. Recent medical paradigms are rapidly changing to personalized medicine, including molecular targeted therapy, immunotherapy, and theranostics, and the importance of biomarkers for these is growing day by day. Even though biopsy continues to gold standard for tumor assessment in personalized medicine, imaging is expected to complement biopsy because it allows whole tumor evaluation, whole body evaluation, and non-invasive and repetitive evaluation. Radiomics is known...
Source: Nuclear Medicine and Molecular Imaging - January 23, 2019 Category: Nuclear Medicine Source Type: research

Assessment of Left Ventricular Ejection Fraction by Thallium-201 Myocardial SPECT-CT in Patients with Angina Pectoris: Comparison with 2D Echocardiography
AbstractPurposeLeft ventricular (LV) ejection fraction (EF) is an important parameter for assessing cardiac systolic function and predicting prognosis in patients with cardiovascular disease. The aim of this study was to evaluate the feasibility of assessing LVEF by Tl-201 hybrid myocardial single-photon emission computed tomography (SPECT)/CT using two attenuation correction methods in patients with angina pectoris.MethodsA total of 339 patients with angina pectoris (62.8  ± 12.9 years, male:female = 206:133) were analyzed. All patients underwent Tl-201 myocardial SPECT/CT and trans...
Source: Nuclear Medicine and Molecular Imaging - January 16, 2019 Category: Nuclear Medicine Source Type: research

Nuclear Theranostics in Asia: In vivo Companion Diagnostics
(Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 15, 2019 Category: Nuclear Medicine Source Type: research

Clinical Personal Connectomics Using Hybrid PET/MRI
AbstractBrain connectivity can now be studied with topological analysis using persistent homology. It overcame the arbitrariness of thresholding to make binary graphs for comparison between disease and normal control groups. Resting-state fMRI can yield personal interregional brain connectivity based on perfusion signal on MRI on individual subject bases and FDG PET produces the topography of glucose metabolism. Assuming metabolism perfusion coupling and disregarding the slight difference of representing time of metabolism (before image acquisition) and representing time of perfusion (during image acquisition), topography ...
Source: Nuclear Medicine and Molecular Imaging - January 15, 2019 Category: Nuclear Medicine Source Type: research

Radiomics in Oncological PET/CT: a Methodological Overview
AbstractRadiomics is a medical imaging analysis approach  based on computer-vision. Metabolic radiomics in particular analyses the spatial distribution patterns of molecular metabolism on PET images. Measuring intratumoral heterogeneity via image is one of the main targets of radiomics research, and it aims to build a image-based model for better patient management. The workflow of radiomics using texture analysis follows these steps: 1) imaging (image acquisition and reconstruction); 2) preprocessing (segmentation& quantization); 3) quantification (texture matrix design& texture feature extraction); and 4) an...
Source: Nuclear Medicine and Molecular Imaging - January 15, 2019 Category: Nuclear Medicine Source Type: research

Dawn of Theranostics in Myanmar (Dream, Reality, and Constraint)
AbstractProstate cancer is third common malignancy in men of old age (average 65  years) in Myanmar. Currently, serum PSA and bone scan are the markers of choice. Because of the evidence-based, promising success of68Ga-PSMA PET-CT and177Lu-PSMA theranostics in prostate cancer worldwide,99mTc-PSMA SPECT-CT imaging and177Lu-PSMA therapy has launched as a stepping-stone of theranostics in Myanmar with the available facilities. Twelve cases of prostate cancer patients were imaged with 600  MBq of99mTc-PSMA I+S SPECT-CT. Four metastatic castration resistant prostate cancer (MCRPC) patients with abnormal result were tr...
Source: Nuclear Medicine and Molecular Imaging - January 11, 2019 Category: Nuclear Medicine Source Type: research

Procedural Recommendations for Lymphoscintigraphy in the Diagnosis of Peripheral Lymphedema: the Genoa Protocol
DiscussionIt is past time that lymphoscintigraphy in the diagnosis of lymphatic disorders becomes standardized. This represents our first attempt to outline a clear protocol and delineate the relevant points for lymphoscintigraphy in this patient population. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 7, 2019 Category: Nuclear Medicine Source Type: research

Nuclear Medicine Theranostics: Perspective from Pakistan
AbstractNuclear medicine has been offering diagnostic and therapeutic solution since the introduction of radioactive iodine for thyroid diseases since decades. However, the concept of theranostics has given a new found impetus to the use of pairs of radiopharmaceuticals for diagnosis and treatment. Presented here is a perspective on theranostics from Pakistan. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 4, 2019 Category: Nuclear Medicine Source Type: research

The Emergence of Theranostics in the Philippines: Overcoming Challenges and Bringing Hope
AbstractMedical managements are becoming personalized while diseases are being understood at the molecular level. Nuclear medicine is one of the fields actively contributing to this development. In particular, theranostics, a combinatorial term for therapy and diagnostics, enables accurate imaging and subsequent targeted radionuclide treatment. Due to its high impact in healthcare, many countries have begun to offer Ga-68 PET/CT scans and Lu-177 therapies. The Philippines has followed suit through the initiative of this author and able support of the administration and staff of St. Luke ’s Medical Center. The Ga-68 D...
Source: Nuclear Medicine and Molecular Imaging - December 18, 2018 Category: Nuclear Medicine Source Type: research

Activities for the Development of Targeted Radionuclide Therapy in Japan
AbstractTargeted radionuclide therapy (TRT) is unique because of its efficacy and its theranostic feature in the era of precision medicine. So far, introduction of new TRT has not been going well in Japan due to several reasons including strict regulations, shortage of facilities for TRT, and insufficient reimbursement for TRT in clinic. Japanese community had several strategies to develop TRT in these 10  years, including the establishment of the National Conference for Nuclear Medicine Theranostics in which physicians, scientists, patients, people supporting patients, and industrial people gather. To promote TRT wit...
Source: Nuclear Medicine and Molecular Imaging - December 15, 2018 Category: Nuclear Medicine Source Type: research

Nuclear Theranostics in Turkey
AbstractNuclear theranostics functions as a bridge which connects targeted diagnosis to targeted therapy, just like Turkey functions as a geographical bridge which connects Asia to Europe. This unique geographical site of the country plays an important role with regard to introduction of novel scientific and technologic improvements, which originate from one continent to another, in the era of accelerated information. The first nuclear medicine practice in Turkey started in the beginning of 1950s with the first radioiodine treatment, which actually was a debut for nuclear theranostics in Turkey, years before many other cou...
Source: Nuclear Medicine and Molecular Imaging - December 15, 2018 Category: Nuclear Medicine Source Type: research

Nuclear Theranostics in Indonesia: Past, Present, and Future
AbstractNuclear medicine in Indonesia has a quite long history since the late 1960s. There are some problems and obstacles that have to be solved and overcome in order to develop nuclear medicine services, spread the services to reach every target area, and implement new novel therapeutic nuclear medicine as well. The right strategy and strong effort should be performed for a successful result. Theranostics nuclear medicine will play a more prominent role in the management of cancer patients. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - December 14, 2018 Category: Nuclear Medicine Source Type: research

Comparative Cardiac Phantom Study Using Tc-99m/I-123 and Tl-201/I-123 Tracers with Cadmium-Zinc-Telluride Detector-Based Single-Photon Emission Computed Tomography
AbstractObjectiveA recently introduced single-photon emission computed tomography (SPECT), based on cadmium-zinc-telluride (CZT) detectors (D-SPECT), supports high energy resolution for cardiac imaging. Importantly, the high energy resolution may allow simultaneous dual-isotope (SDI) imaging (e.g., using Tc-99m and I-123). We quantitatively evaluated Tc-99m/I-123 SDI imaging by D-SPECT in comparison with conventional T1-201/I-123.Materials and MethodsEnergy resolution was measured as a percentage of the full width at half maximum (FWHM) for Tc-99m, I-123, and Tl-201. The impact of cross-talk and reconstructed image contras...
Source: Nuclear Medicine and Molecular Imaging - December 12, 2018 Category: Nuclear Medicine Source Type: research