Tau Imaging: New Era of Neuroimaging for Alzheimer ’s Disease
(Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - July 27, 2020 Category: Nuclear Medicine Source Type: research

The Role of 18 F-FDG PET/CT for Evaluation of Cervical Metastatic Lymph Nodes in a Patient with Metallic Artifacts from Dental Prosthesis: a Case Report
AbstractCervical metastasis of squamous cell carcinoma from an unknown primary site occurs in approximately 2 –4% of head and neck tumor cases. Without identification of the primary site, proper management cannot be achieved, resulting in significant morbidity and a lower cure rate. For the primary site assessment, positron emission tomography/computed tomography (PET/CT) using the radiotracer18F-fluorodeoxyglucose (FDG) is the imaging modality of choice and has been shown to be superior to CT alone. Here, we report a case of cervical metastasis of squamous cell carcinoma in an 82-year-old man.18F-FDG PET/CT revealed...
Source: Nuclear Medicine and Molecular Imaging - July 25, 2020 Category: Nuclear Medicine Source Type: research

18 F-FDG PET/CT Imaging of Peritoneal Fibrosis Mimicking Persistent Metastatic Ovarian Carcinoma
AbstractA 65-year-old woman was addressed for clinical and biological suspicion of ovarian cancer relapse.18F-FDG PET/CT revealed massive peritoneal carcinomatosis. Post-chemotherapy PET/CT showed complete metabolic response in initial localizations albeit three new18F-FDG uptakes appeared in the mesentery and in the retro-hepatic space. Close follow-up (including PET/CT scan) and surgical examination of the abdominal cavity confirmed the absence of malignancy and the benign nature of these lesions, which appeared to be peritoneal fibrosis mimicking persistent carcinomatosis. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - July 25, 2020 Category: Nuclear Medicine Source Type: research

Recent Survey of Effective Doses of F-18 FDG Torso PET/CT in Korea and the Current Recommendations for CT Protocols of PET/CT
This study aimed to construct a database of the effective doses (ED) from F-18 fluorodeoxyglucose (FDG) torso positron emission tomography/computed tomography (PET/CT) in Korea to provide data that supports the reduction of the CT dose of PET/CT and optimization of PET/CT protocols in Korea.MethodsWe investigated data of ED and CT parameters of FDG PET/CT. The data were analyzed by body weight groups.ResultsA total of 31 hospitals participated in the survey (99 adults). The mean total EDs ( ± SD) were 8.77 ± 2.76, 10.93 ± 3.14, and 12.57 ± 3.79 mSv ...
Source: Nuclear Medicine and Molecular Imaging - July 20, 2020 Category: Nuclear Medicine Source Type: research

Real Time F-18 FDG PET-CT-Guided Metabolic Biopsy Targeting Differential FDG Avidity in a Pulmonary Blastoma
AbstractPulmonary blastoma (PB) is a rare thoracic malignancy and preoperative diagnosis is challenging. A young man presented with dyspnea and chest pain for 3 –4 months and chest-computed tomography (CT) revealed large mass in the left lung upper lobe and pleural effusion. Repeated CT-guided fine-needle aspiration cytology from the lesion and pleural fluid aspiration was negative for malignancy. F-18-fluorodeoxyglucose positron emission tomography-comp uted tomography (FDG PET-CT) revealed heterogeneous tracer avidity in left lung mass with areas of necrosis. Real-time PET-CT-guided biopsy from metabolically a...
Source: Nuclear Medicine and Molecular Imaging - July 20, 2020 Category: Nuclear Medicine Source Type: research

Message from the Editor-in-Chief
(Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - July 14, 2020 Category: Nuclear Medicine Source Type: research

Acute Promyelocytic Leukemia After Radium-223 Exposure for Prostate Cancer in a Chemotherapy-Na ïve Patient
Abstract223Ra-dichloride is a bone-seeking targeted alpha ( α)-emitting approved for bone metastases in prostate cancer. Here, we report a case of therapy-related acute promyelocytic leukemia (t-APL) following administration of223Ra, showing some evidence of a causative relationship. A patient with metastatic prostate cancer received therapy with223Ra, with 6 injections of the radiopharmaceutical at a standard dose of 55  kBq/kg at 4-week intervals for a cumulative administered activity of 26.3 MBq. PET/CT with18F-methylcholine repeated 1  month after the conclusion of223Ra was negative. After 8  ...
Source: Nuclear Medicine and Molecular Imaging - July 9, 2020 Category: Nuclear Medicine Source Type: research

Clinical Impact of F-18 FDG PET-CT on Biopsy Site Selection in Patients with Suspected Bone Metastasis of Unknown Primary Site
AbstractPurposeWe investigated the clinical role of F-18 fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) in the identification of the primary site and the selection of the optimal biopsy site in patients with suspected bone metastasis of unknown primary site.MethodsThe patients with suspected bone metastasis who underwent PET-CT for evaluation of primary site were enrolled in this study. The primary sites were identified by the histopathologic or imaging studies and were classified according to the FDG uptake positivity of the primary site. To evaluate the guiding capability of PET-CT in ...
Source: Nuclear Medicine and Molecular Imaging - July 6, 2020 Category: Nuclear Medicine Source Type: research

68 Ga DOTA-TOC Uptake in Non-ossifying Fibroma: a Case Report
AbstractNon-ossifying fibroma (NOF) is a common benign bone tumor with a high probability of occurrence in children and adolescents. It is commonly seen in the metaphysis of long bones, eccentrically located, and can coexist with other malignant tumors such as neuroendocrine tumors (NET). To date, plain radiographs play a major role in the diagnosis of these benign bone tumors. Herein, we report the case of a 13-year-old male patient who was diagnosed with pulmonary NET and underwent right lung lobectomy for a hilar mass which later revealed a well-differentiated NET. The follow-up68Ga DOTA-TOC PET/CT showed a focal somato...
Source: Nuclear Medicine and Molecular Imaging - July 6, 2020 Category: Nuclear Medicine Source Type: research

Physiological Uptake of Radioactive Iodine Around an Artificial Eyeball Observed with Single-Photon Emission Computed Tomography/Computed Tomography After Radioactive Iodine Treatment
In this study, scintigraphy and single-photon emission computed tomography/computed tomography images after radioactive iodine treatment revealed a physiological uptake of radioactive iodine due to lacrimal secretion around an artificial eyeball; such findings have not been reported previously. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - July 6, 2020 Category: Nuclear Medicine Source Type: research

Assessment of Suspected Malignancy or Infection in Immunocompromised Patients After Solid Organ Transplantation by [ 18 F]FDG PET/CT and [ 18 F]FDG PET/MRI
AbstractPurposeTo study the value of 2-deoxy-2-[18F]fluoro-D-glucose([18F]FDG) positron emission tomography/computed tomography (PET/CT) and [18F]FDG positron emission tomography/magnetic resonance imaging (PET/MRI) in assessing immunocompromised patients with suspected malignancy or infection.Methods[18F]FDG-PET/CT and [18F]FDG-PET/MRI examinations of patients who were immunocompromised after receiving lung, heart, pancreas, kidney, liver, or combined kidney-liver transplants were analyzed in this retrospective study. Patients underwent whole-body hybrid-imaging because of clinical signs of malignancy and/or infection. Fi...
Source: Nuclear Medicine and Molecular Imaging - July 2, 2020 Category: Nuclear Medicine Source Type: research

Association Between Colonic 18 F-FDG Uptake and Glycemic Control in Patients with Diabetes Mellitus
ConclusionsPatients with DM who did not show increased colonic FDG uptake after taking OHA were associated with higher fasting blood glucose and HbA1c levels on the day of FDG PET/CT. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - June 17, 2020 Category: Nuclear Medicine Source Type: research

Relationship of EGFR Mutation to Glucose Metabolic Activity and Asphericity of Metabolic Tumor Volume in Lung Adenocarcinoma
AbstractPurposeEGFR-mutation (EGFR-mt) is a major oncogenic driver mutation in lung adenocarcinoma (ADC) and is more often observed in Asian population. In lung ADC, some radiomics parameters of FDG PET have been reported to be associated with EGFR-mt. Here, the associations between EGFR-mt and PET parameters, particularly asphericity (ASP), were evaluated in Asian population.MethodsLung ADC patients who underwent curative surgical resection as the first treatment were retrospectively enrolled. EGFR mutation was defined as exon 19 deletion and exon 21 point mutation and was evaluated using surgical specimens. On FDG PET, i...
Source: Nuclear Medicine and Molecular Imaging - June 14, 2020 Category: Nuclear Medicine Source Type: research

Computed Tomography (CT) Protocols Associated with Cardiac and Bone Single-Photon Emission Computed Tomography/CT (SPECT/CT) in Korea
ConclusionsThe results and current recommendations will be helpful for optimizing CT protocols for SPECT/CT. Optimization of SPECT/CT protocols will be required for generating the proper strategy for the specific lesions and clinical purpose. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - June 1, 2020 Category: Nuclear Medicine Source Type: research

Rodent Leukocyte Isolation and Radiolabeling for Inflammation Imaging Study
ConclusionInflamed lesions of rats were well visualized using autologous radiolabeled leukocytes. This method might provide good information for understanding inflammatory diseases. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - May 29, 2020 Category: Nuclear Medicine Source Type: research

How to Publish Good Nuclear Medicine and Molecular Imaging Scientific Papers?
(Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - May 16, 2020 Category: Nuclear Medicine Source Type: research

Reduction of Salivary Gland Damage During Radioiodine Therapy for Differentiated Thyroid Cancers
(Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - May 12, 2020 Category: Nuclear Medicine Source Type: research

Radiogenomics Based on PET Imaging
AbstractRadiogenomics or imaging genomics is a novel omics strategy of associating imaging data with genetic information, which has the potential to advance personalized medicine. Imaging features extracted from PET or PET/CT enable assessment of in vivo functional and physiological activity and provide comprehensive tumor information non-invasively. However, PET features are considered secondary to features on conventional imaging, and there has not yet been a review of the radiogenomic approach using PET features. This review article summarizes the current state of PET-based radiogenomic research for cancer, which discus...
Source: Nuclear Medicine and Molecular Imaging - May 9, 2020 Category: Nuclear Medicine Source Type: research

First In-Human Medical Imaging with a PASylated 89 Zr-Labeled Anti-HER2 Fab-Fragment in a Patient with Metastatic Breast Cancer
ConclusionThis study demonstrates that a PASylated Fab tracer shows appropriate blood clearance to allow sensitive visualization of small tumor lesions in a clinical setting. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - April 20, 2020 Category: Nuclear Medicine Source Type: research

Preclinical Voxel-Based Dosimetry in Theranostics: a Review
AbstractDue to the increasing use of preclinical targeted radionuclide therapy (TRT) studies for the development of novel theranostic agents, several studies have been performed to accurately estimate absorbed doses to mice at the voxel level using reference mouse phantoms and Monte Carlo (MC) simulations. Accurate dosimetry is important in preclinical theranostics to interpret radiobiological dose-response relationships and to translate results for clinical use. Direct MC (DMC) simulation is believed to produce more realistic voxel-level dose distribution with high precision because tissue heterogeneities and nonuniform s...
Source: Nuclear Medicine and Molecular Imaging - April 19, 2020 Category: Nuclear Medicine Source Type: research

Sleep and Neuroimaging
AbstractWe spend about one-third of our lives either sleeping or attempting to sleep. Therefore, the socioeconomic implications of sleep disorders may be higher than expected. However, the fundamental mechanisms and functions of sleep are not yet fully understood. Neuroimaging has been utilized to reveal the connectivity between sleep and the brain, which is associated with the physiology of sleep. Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging studies have become increasingly common in sleep research. Recently, significant progress has been made in understanding the physi...
Source: Nuclear Medicine and Molecular Imaging - April 15, 2020 Category: Nuclear Medicine Source Type: research

Renal Potassium Excretion Visualized on 82 Rubidium PET/CT
AbstractThe positron emission tomography (PET) flow tracer82Rubidium is a known potassium analogue. During our studies of tumor blood flow in prostate cancer, we found that approximately 10% of the patients had high urinary82Rubidium activity. In roughly half of these patients, the increased renal rubidium/potassium excretion was either causing hypokalemia or explained by Thiazide treatment. In the other half, there was no obvious explanation or clinical consequence of the renal rubidium/potassium excretion. This is the first time enhanced renal potassium excretion is visualized on82Rubidium PET/CT. (Source: Nuclear Medici...
Source: Nuclear Medicine and Molecular Imaging - April 15, 2020 Category: Nuclear Medicine Source Type: research

From Theranostics to Immunotheranostics: the Concept
AbstractImmunotheranostics will be an important development in the future of nuclear medicine and medical oncology. It describes the synergy of theranostic procedures in nuclear medicine and immune oncology (IO) treatment. In brief, it takes advantage of molecular imaging and subsequent targeted modulation of the —in most cases immunosuppressive—tumor microenvironment (TME) by diagnostic and therapeutic radioisotopes. This is of high importance since only a fraction of patients receiving IO is currently being cured by this exciting therapy option. We therefore envision the concept of immunotheranostics a s a po...
Source: Nuclear Medicine and Molecular Imaging - April 8, 2020 Category: Nuclear Medicine Source Type: research

Radioactivity Reduction of 2-Deoxy-2-[18F] Fluoro-D-Glucose by Milk and Ursodeoxycholic Acid in Preclinical Study
ConclusionThe present study demonstrated that administration of milk and UDCA increased G6Pase expression levels and18F-FDG release from the tissue. These results suggest milk and UDCA could be used to reduce radiation exposure from18F-FDG after image acquisition. The mechanisms underpinning this phenomenon should be explored in a human study. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 22, 2020 Category: Nuclear Medicine Source Type: research

New Frontiers in Molecular Imaging with Superparamagnetic Iron Oxide Nanoparticles (SPIONs): Efficacy, Toxicity, and Future Applications
AbstractSupermagnetic Iron Oxide Nanoparticles (SPIONs) are nanoparticles that have an iron oxide core and a functionalized shell. SPIONs have recently raised much interest in the scientific community, given their exciting potential diagnostic and theragnostic applications. The possibility to modify their surface and the characteristics of their core make SPIONs a specific contrast agent for magnetic resonance imaging but also an intriguing family of tracer for nuclear medicine. An example is 68Ga-radiolabeled bombesin-conjugated to superparamagnetic nanoparticles coated with trimethyl chitosan that is selective for the ga...
Source: Nuclear Medicine and Molecular Imaging - February 8, 2020 Category: Nuclear Medicine Source Type: research

Role of 68 Ga-DOTATATE PET/CT in a Case of SDHB -Related Pterygopalatine Fossa Paraganglioma Successfully Controlled with Octreotide
We describe an unusual case of a 42-year-old female with an unresectable succinate dehydrogenase subunit B (SDHB)-related pterygopalatine fossa paraganglioma. She underwent somatostatin receptor imaging with68Ga-DOTA(0)-Tyr(3)-octreotate (68Ga-DOTATATE) positron emission tomography/computed tomography (PET/CT), which showed uptake in the above mentioned tumor. Hence, the patient was started on octreotide, a cold somatostatin analog, and responded with tumor stabilization and improvement of clinical symptoms for 36  months since initiation of octreotide therapy. This case demonstrates the role of68Ga-DOTATATE PET/CT in...
Source: Nuclear Medicine and Molecular Imaging - January 22, 2020 Category: Nuclear Medicine Source Type: research

Basal and Acetazolamide Brain Perfusion SPECT in Internal Carotid Artery Stenosis
AbstractInternal carotid artery (ICA) stenosis including Moyamoya disease needs revascularization when hemodynamic insufficiency is validated. Vascular reserve impairment was the key to find the indication for endarterectomy/bypass surgery in the atherosclerotic ICA stenosis and to determine the indication, treatment effect, and prognosis in Moyamoya diseases. Vascular reserve was quantitatively assessed by 1-day split-dose I-123 IMP basal/acetazolamide SPECT in Japan or by Tc-99m HMPAO SPECT in other countries using qualitative or semi-quantitative method. We summarized the development of 1-day basal/ acetazolamide brain ...
Source: Nuclear Medicine and Molecular Imaging - January 8, 2020 Category: Nuclear Medicine Source Type: research

Analysis Natrium Iodide Symporter Expression in Breast Cancer Subtypes for Radioiodine Therapy Response
ConclusionNIS protein expression is detectable in breast cancer cells to varying degrees. HER2+ is the most likely to express NIS in the cell membrane followed by TN subtypes. This indicates that radioiodine could be used as a novel adjuvant treatment in breast cancer. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 3, 2020 Category: Nuclear Medicine Source Type: research

Malignant Transformation of an Epidermoid Cyst in an Intrapancreatic Accessory Spleen: A Case Report
AbstractA 33-year-old man was evaluated because of an incidentally found cyst in the pancreatic tail, which was first seen 6  years ago. The cyst was a unilocular cystic mass, 13.0 cm in diameter, and had increased in size in last 2 months. On F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT), the cystic wall showed increased FDG uptake. The patient underwent distal pancreatectomy wi th suspicion of mucinous cystic neoplasm of the pancreas. The mass turned out to be a squamous carcinoma arising from an epidermoid cyst in an intrapancreatic accessory spleen (ECIPAS). FDG PE...
Source: Nuclear Medicine and Molecular Imaging - December 21, 2019 Category: Nuclear Medicine Source Type: research

Clinical Applications of 68 Ga-PSMA PET/CT on Residual Disease Assessment of Juvenile Nasopharyngeal Angiofibroma (JNA)
We present a case of a 16-year-old boy who underwent68Ga-PSMA PET/CT for residual disease assessment of juvenile nasal angiofibroma. Positive uptake was noted in residual tumor on PET/CT imaging. However, there was no abnormal uptake in surrounding scar tissues as compared with contrast-enhanced magnetic resonance imaging. These findings were confirmed by biopsy from the scar tissue on posterior ethmoids.68Ga-PSMA PET/CT may be a potentially valuable tool especially in distinguishing recurrences from surgical site reparative tissue and in planning and delivering stereotactic radiotherapy. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - December 18, 2019 Category: Nuclear Medicine Source Type: research

An Unusual Case of Simultaneous Cricoid and Thyroid Cartilage Metastases from Prostatic Adenocarcinoma on 68 Ga-PSMA PET/CT
AbstractAlthough prostate cancer can metastasize to any part of the body, laryngeal cartilage metastasis is extremely rare and few cases have been published so far. Here we present the case of a 65-year-old male patient, recently diagnosed with prostate adenocarcinoma, referred for staging with68Ga-PSMA PET/CT. He was found to have extensive skeletal metastasis along with cartilage metastasis involving both thyroid and cricoid cartilages. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - December 18, 2019 Category: Nuclear Medicine Source Type: research

Prognostic Value of Bone Marrow F-18 FDG Uptake in Patients with Advanced-Stage Diffuse Large B-Cell Lymphoma
ConclusionWe showed that BM FDG-positive predicted a poorer survival in patients with advanced stage DBLCL. We also found that BMB-negative and BM FDG-positive patients had similar PFS or OS to BMB-positive and BM FDG-negative patients. Further study in a larger population is needed to clarify clinical significance of BM FDG in these patients. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - December 13, 2019 Category: Nuclear Medicine Source Type: research

Spleen Scan for 68 Ga-DOTATOC PET-Positive Pancreatic Tail Lesion: Differential Diagnosis of Neuroendocrine Tumor from Accessory Spleen
Abstract68Ga-DOTATOC PET/CT is widely used as a functional imaging technique in the detection and characterization of neuroendocrine tumors (NETs). Pancreatic NET and intrapancreatic accessory spleen (IPAS) have similar radiologic characteristics in anatomical imaging and usually show high uptake of68Ga-DOTATOC. Thus, it is challenging to make a differential diagnosis between NET and IPAS when the tumor-like lesion is located in the pancreatic tail. Here, we present a case of68Ga-DOTATOC PET-positive pancreatic tail lesion with high arterial enhancement on CT and MRI. Since99mTc-labeled damaged red blood cell does not accu...
Source: Nuclear Medicine and Molecular Imaging - December 9, 2019 Category: Nuclear Medicine Source Type: research

Bone SPECT/CT of the Foot and Ankle: Potential Clinical Application for Chronic Foot Pain
AbstractDiseases of the foot and ankle are common but relatively difficult to diagnose because of the complexity of the anatomy and the frequent occurrence of multiple diseases at the same time. For these reasons, management of chronic foot pain is often clinically challenging. MRI is the imaging modality of choice in many types of diseases causing chronic foot pain, due to high resolution and excellent soft tissue contrast. However, in the postoperative state, the use of MRI can be limited by artifact from metallic devices, and it may be difficult to confirm whether the pathology detected on the MRI is the actual cause of...
Source: Nuclear Medicine and Molecular Imaging - December 9, 2019 Category: Nuclear Medicine Source Type: research

Isolated Hepatic Metastasis of Prostate Cancer with Variable 18 F-fluociclovine Uptake by PET/CT Imaging
AbstractA 74-year-old man presented with rapid rising prostate-specific antigen (PSA) 2 years after treatment of prostate cancer with prostatectomy and salvage radiation therapy. PSA increased from 923 to 4349 ng/mL within 2 months. No osseous metastatic lesions of prostate cancer were detected by18F-sodium fluoride PET/CT imaging at an outside facility.18F-fluciclovine PET/CT imaging was performed to evaluate local recurrence of prostate cancer at surgical bed of prostatectomy and distant metastasis. One small focus of low-level18F-fluciclovine radiotracer uptake was noted in the surgical bed of prostatectomy without corr...
Source: Nuclear Medicine and Molecular Imaging - November 22, 2019 Category: Nuclear Medicine Source Type: research

Prognostic Value of Metabolic Information in Advanced Gastric Cancer Using Preoperative 18 F-FDG PET/CT
ConclusionHigh SUVmax and high MTV of the primary tumor suggest a high risk of recurrence for AGC patients. Even if SUVmax is similar, the prognosis may vary depending on MTV. Combining PET parameters results in a better prediction for prognosis. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 18, 2019 Category: Nuclear Medicine Source Type: research

Safety Profile and Therapeutic Efficacy of One Cycle of Lu177-PSMA in End-Stage Metastatic Castration-Resistant Prostate Cancer Patients with Low Performance Status
AbstractPurposeThe aim of this study was to evaluate safety and therapeutic efficacy of lutetium 177 prostate-specific membrane antigen (Lu-177-PSMA) in metastatic castration-resistant prostate cancer (mCRPC) patients with low performance status.MethodsTwenty-two patients already treated with anti-androgens and docetaxel were enrolled for one cycle of Lu-177-PSMA therapy. Haemoglobin, total leukocyte counts, platelets and serum creatinine for toxicity profile while prostate specific antigen (PSA), Eastern Cooperative Oncology Group (ECOG) performance status, visual analogue scale (VAS) and analgesic quantification scale (A...
Source: Nuclear Medicine and Molecular Imaging - November 18, 2019 Category: Nuclear Medicine Source Type: research

Perspectives in TSPO PET Imaging for Neurologic Diseases
AbstractThe translocator protein (18 kDa) (TSPO) is a mitochondrial transmembrane protein, which has brought attention as a neuroinflammatory biomarker. Positron emission tomography (PET) imaging studies have been done for several decades, since neuroinflammation has been implicated as an important pathophysiology of several common neurologic disorders. However, despite numerous previous studies with positive findings, its clinical significance is not yet clear. Various attempts to overcome the limitations are ongoing, in order to bring acceptance for use in clinics. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 16, 2019 Category: Nuclear Medicine Source Type: research

Intramastoid Phosphaturic Mesenchymal Tumor Causing Hypophosphatemic Osteomalacia Detected on 68 Ga-DOTATATE PET/CT But Not on 99m Tc-Sestamibi and 18 F-FDG Scans
Abstract68Ga-DOTATATE uptake in mesenchymal tumors causing hypophosphatemic osteomalacia has been recently described. Herein, we present a case of68Ga-DOTATATE uptake in an intramastoid phosphaturic mesenchymal tumor that had not been depicted in previous99mTc-Sestamibi and18F-FDG scans. The lesion was surgically removed and the phosphorus level increased to the normal range. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 14, 2019 Category: Nuclear Medicine Source Type: research

Effect of ME Collimator Characteristic, Energy Window Width, and Reconstruction Algorithm Selection on Imaging Performance of Yttrium-90: Simulation Study
ConclusionsThe acquired optimal ME collimator and energy window along with using a suitable reconstruction algorithm lead to improved contrast and SNR of90Y bremsstrahlung images of hot spheres of the digital Jaszczak phantom. This can improve the accuracy and precision of the90Y activity distribution estimation after radioembolization in targeted radionuclide therapy. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 13, 2019 Category: Nuclear Medicine Source Type: research

Radioimmunotherapy (RIT) in Brain Tumors
AbstractAnnually, the incidence of brain tumors has slightly increased and also the patient prognosis is still disappointing, especially for high-grade neoplasms. So, researchers seek methods to improve therapeutic index as a critical aim of treatment. One of these new challenging methods is radioimmunotherapy (RIT) that involves recruiting a coupling of radionuclide component with monoclonal antibody (mAb) which are targeted against cell surface tumor –related antigens or antigens of cells within the tumor microenvironment. In the context of cancer care, precision medicine is exemplified by RIT; precision medicine c...
Source: Nuclear Medicine and Molecular Imaging - November 12, 2019 Category: Nuclear Medicine Source Type: research

Comparative Analysis of Lung Perfusion Scan and SPECT/CT for the Evaluation of Functional Lung Capacity
ConclusionsWe suggest SPECT/CT as the primary modality of choice for the assessment of the ratio of diseased lung area. Both perfusion scan and SPECT/CT can be used for the prediction of postoperative lung function. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 11, 2019 Category: Nuclear Medicine Source Type: research

68Ga-PSMA: a One-stop Shop in Radioactive Iodine Refractory Thyroid Cancer?
We report a case of a 47-year-old female known with metastatic papillary thyroid cancer. Her treatment history included total thyroidectomy and 3 previous radio ablations with a cumulative dose of 950 mCi of131I. On follow-up, her thyroglobulin levels had demonstrated a rising trend (from 3789.0 to 4240.0 ug/L) despite a123I whole-body scan demonstrating a reduction in tracer avid lesions. She was suspected of having radio-resistant disease. The patient underwent both18F-FDG and68Ga-PSMA PET/CT imaging with both scans demonstrating congruent lesions however with far greater intensity on the68Ga-PSMA study. (Source: Nuclear...
Source: Nuclear Medicine and Molecular Imaging - November 11, 2019 Category: Nuclear Medicine Source Type: research

Radioembolization for the Treatment of Primary and Metastatic Liver Cancers
AbstractRadioembolization using90Y microspheres (glass or resin) has been introduced as an effective intraarterial therapy for unresectable primary and metastatic liver cancers. Although the basic therapeutic effect of chemoembolization results from ischemia, the therapeutic efficacy of radioembolization comes from radiation. Furthermore, compared with surgical resection and local ablation therapy, radioembolization is available with less limitation on the sites or number of liver cancers. The radioisotope90Y is a β-radiation emitter without γ-radiation, with the emission of secondary bremsstrahlung photons and ...
Source: Nuclear Medicine and Molecular Imaging - November 8, 2019 Category: Nuclear Medicine Source Type: research

Reverse Warburg Effect-Related Mitochondrial Activity and 18 F-FDG Uptake in Invasive Ductal Carcinoma
ConclusionsThe assessment of preoperative18F-FDG uptake and post-surgical mitochondrial activity may be used for the prediction of DFS in patients with IDCB. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 28, 2019 Category: Nuclear Medicine Source Type: research

Orbital IgG4 Disease: Imaging Findings on 68Ga-DOTANOC PET/CT
AbstractImmunoglobulin G4 (IgG4) –related diseases are a spectrum of systemic inflammatory conditions of unknown etiology, which are characterized by infiltration of tissues by IgG4 plasma cells and sclerosing inflammation (Cheuk and Chan Adv Anat Pathol 17:303–32,2010). Although this condition was initially described in relation to autoimmune pancreatitis, now it has been reported in almost every organ system of body (Zen and Nakanuma Am J Surg Pathol 34:1812 –9,2010, Masaki et al. Ann Rheuma Dis 68:1310 –5,2009). Orbital involvement by IgG4 disease can involve extraocular muscles (EOM), lacrimal g...
Source: Nuclear Medicine and Molecular Imaging - October 25, 2019 Category: Nuclear Medicine Source Type: research

Molecular Imaging in Breast Cancer
AbstractBreast cancer (BC) is the most common cancer among females with more than 2 million new cases diagnosed worldwide in 2018. Although the prognosis in the majority of cases in the early stages combined with appropriate treatment is positive, there are still about 30% of patients who will develop locoregional diseases and distant metastases. Molecular imaging is very important in the diagnosis, staging, follow-up, and radiotherapy planning. Additionally, it is useful in characterizing lesions, prognosis, and therapy response in BC patients. Nuclear medicine imaging modalities (SPECT and PET) are of indispensable impor...
Source: Nuclear Medicine and Molecular Imaging - October 16, 2019 Category: Nuclear Medicine Source Type: research

Amyloid PET Quantification Via End-to-End Training of a Deep Learning
ConclusionWe suggest a one-step quantification method for amyloid PET via a deep learning model. The model is highly reliable to quantify the amyloid PET regardless of multicenter images and various radiotracers. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 14, 2019 Category: Nuclear Medicine Source Type: research

Correlation of Early-Phase F-18 Florapronal PET with F-18 FDG PET in Alzheimer ’s Disease and Normal Brain
ConclusionsEarly F-18 FPN study can be used as a proxy marker for the F-18 FDG PET. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - September 11, 2019 Category: Nuclear Medicine Source Type: research

Postoperative Radioiodine Treatment within 9  Months from Diagnosis Significantly Reduces the Risk of Relapse in Low-Risk Differentiated Thyroid Carcinoma
ConclusionIf postoperative RAI treatment is considered in low-risk DTC, any delay in RAI administration above 9  months since diagnosis may be related to poorer long-term outcomes. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - September 5, 2019 Category: Nuclear Medicine Source Type: research