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Current Status of Cardiac CT for Nuclear Medicine Professionals: Coronary Artery Disease Evaluation
AbstractWith advances in computed tomography (CT) technology over the past two decades, cardiac CT has become a noninvasive diagnostic tool for morphological evaluation of coronary artery disease (CAD) caused by atherosclerotic plaques and stenosis and serves as a “gatekeeper” before invasive coronary angiography. Additionally, cardiac CT stress perfusion and CT-derived fractional flow reserve can be used to assess the hemodynamic significance of coronary artery stenosis. Delayed enhancement CT can detect and localize myocardial infarction and assess myoc ardial viability. Currently, cardiac CT serves as a potential �...
Source: Nuclear Medicine and Molecular Imaging - April 18, 2024 Category: Nuclear Medicine Source Type: research

Semi-Quantitative Analysis of Lung Perfusion SPECT/CT for Evaluation of Response to Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension
ConclusionOur results suggest that semi-quantitative analysis of lung perfusion SPECT/CT can provide a potential imaging biomarker for monitoring the efficacy of BPA. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - March 22, 2024 Category: Nuclear Medicine Source Type: research

Contribution of ChatGPT in Parkinson ’s Disease Detection
(Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - March 15, 2024 Category: Nuclear Medicine Source Type: research

Recent Progress in Myocardial Perfusion Imaging Techniques
AbstractNuclear cardiology, similar to other fields of nuclear medicine, has experience rapid advancements. Myocardial perfusion imaging (MPI), an important component of nuclear cardiology that commenced in the 1970s, plays a crucial role in the non-invasive evaluation and management of coronary artery disease. Over the past decade, MPI has witnessed significant changes and advancements. The introduction of gamma cameras using cadmium zinc telluride (CZT) systems, accompanied by advancements in related software, represents a notable development in this nuclear cardiology. Ongoing research and development effects are active...
Source: Nuclear Medicine and Molecular Imaging - March 5, 2024 Category: Nuclear Medicine Source Type: research

Synthesis and Biologic Evaluation of an Iodine-Labeled Entecavir Derivative for Anti-hepatitis B Virus Activity
ConclusionsThe study outcome establishes125I-ETV as a candidate for anti-HBV. However, it is still in need of further endorsement and optimization by animal model studies before using125I-ETV to treat chronic HBV disease. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 24, 2024 Category: Nuclear Medicine Source Type: research

Recent Updates on Applications of Artificial Intelligence for Nuclear Medicine Professionals: Prostate Cancer and PET/CT
(Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 24, 2024 Category: Nuclear Medicine Source Type: research

68Ga-DOATATOC Brain PET/CT Imaging in a case of Dural Metastasis from Synovial Sarcoma
We present the case of a 70-year-old male patient who underwent a gallium-68 (68Ga)-DOTATOC brain positron emission tomography (PET)/computed tomography (CT) for the assessment of a tumorous lesion on the dura. The patient had previously undergone below-knee amputation due to a mass of synovial sarcoma on the left foot and completed adjuvant chemotherapy approximately 3 months ago. Subsequently, a well-demarcated papillary solid mass located on the dura was surgically excised. Pathological examination confirmed that the dural metastasis originated from synovial sarcoma and post-operative magnetic resonance imaging (MRI) re...
Source: Nuclear Medicine and Molecular Imaging - February 23, 2024 Category: Nuclear Medicine Source Type: research

Uncertainty Analysis of Time-Integrated Activity Coefficient in Single-Time-Point Dosimetry Using Bayesian Fitting Method
ConclusionWe introduce the BF method to calculate the SD of individual TIACs in STP dosimetry. The presented method might be used as an alternative method for uncertainty analysis in STP dosimetry. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 23, 2024 Category: Nuclear Medicine Source Type: research

Precise Localization of Urine Leak After Renal Transplantation on Radionuclide Renography: Added Value of the Unclamped Drainage Tube and SPECT-CT
AbstractIdentifying and localizing the site of post-renal transplantation urine leaks is important for patient management and treatment planning. Renal scintigraphy is a proven modality for confirming urine leaks after complicated post-renal transplantation. Routinely, renogram studies are performed with a clamped extraperitoneal drain. This results in the spread of radioactivity in the abdominal region, which makes localization of the leak site difficult in the planar images. Here we are trying to give an insight into minimalizing the accumulated urine volume by an unclamped extraperitoneal drain in order to precisely loc...
Source: Nuclear Medicine and Molecular Imaging - February 23, 2024 Category: Nuclear Medicine Source Type: research

Recent Update on PET/CT Radiotracers for Imaging Cerebral Glioma
AbstractPositron emission tomography/computed tomography (PET/CT) has dramatically altered the landscape of noninvasive glioma evaluation, offering complementary insights to those gained through magnetic resonance imaging (MRI). PET/CT scans enable a multifaceted analysis of glioma biology, supporting clinical applications from grading and differential diagnosis to mapping the full extent of tumors and planning subsequent treatments and evaluations. With a broad array of specialized radiotracers, researchers and clinicians can now probe various biological characteristics of gliomas, such as glucose utilization, cellular pr...
Source: Nuclear Medicine and Molecular Imaging - February 21, 2024 Category: Nuclear Medicine Source Type: research

Unilateral Increased Brown Fat Activities on 18F-FDG PET/CT in a Patient with Contralateral Anhidrosis After Surgical Treatment of Metastatic Osteosarcoma in the Upper Thoracic Spine
(Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 21, 2024 Category: Nuclear Medicine Source Type: research

Anti-amyloid Antibody Therapies for Alzheimer ’s Disease
AbstractAlzheimer ’s disease (AD) is the most common cause of dementia, which is characterized by a progressive neurodegenerative disorder that is extremely difficult to treat and severely reduces quality of life. Amyloid beta (Aβ) has been the primary target of experimental therapies owing to the neurotoxicity of Aβ and the brain Aβ load detected in humans by amyloid positron emission tomography (PET) imaging. Recently completed phase 2 and 3 trials of third-generation anti-amyloid immunotherapies indicated clinical efficacy in significantly reducing brain Aβ load and inhibiting the progression of cognit ive decline...
Source: Nuclear Medicine and Molecular Imaging - February 20, 2024 Category: Nuclear Medicine Source Type: research

Radionuclide Imaging of the Neuroanatomical and Neurochemical Substrate of Cognitive Decline in Parkinson ’s Disease
AbstractCognitive impairment is a frequent manifestation of Parkinson ’s disease (PD), resulting in decrease in patients’ quality of life and increased societal and economic burden. However, cognitive decline in PD is highly heterogenous and the mechanisms are poorly understood. Radionuclide imaging techniques like positron emission tomography (PET) and single pho ton emission computed tomography (SPECT) have been used to investigate the neurochemical and neuroanatomical substrate of cognitive decline in PD. These techniques allow the assessment of different neurotransmitter systems, changes in brain glucose metabolism...
Source: Nuclear Medicine and Molecular Imaging - February 15, 2024 Category: Nuclear Medicine Source Type: research

Annotating the Role of 18F-FDG PET/CT in Fibromatoses: A Benign Masquerader of Malignancies —Is It Really an Advantageous Tool?
AbstractFibromatoses are a heterogeneous group of benign proliferating fibroblasts and myofibroblasts which have a high predilection for recurrence and local invasion, especially deep fibromatoses or desmoid fibromatosis.18F-FDG PET/CT, the workhorse of oncological imaging in nuclear medicine, can be employed to figure out the nature and aggressiveness of the lesions and various sites of involvement and to monitor treatment response to systemic therapies like tyrosine kinase inhibitors in case of deep or desmoid fibromatoses which is shown in the current research work. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 14, 2024 Category: Nuclear Medicine Source Type: research

Recent Progress of Cardiac MRI for Nuclear Medicine Professionals
In conclusion, CMR is an essential modality in the diagnosis of various cardiovascular diseases, especially myocardial diseases. Recent progress in CMR techniques promotes more widespread use of CMR in clinical practice. This review summarizes recent updates in CMR technologies and clinical research. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 14, 2024 Category: Nuclear Medicine Source Type: research