Enhanced therapeutic efficacy for glioblastoma immunotherapy with an oncolytic herpes simplex virus armed with anti-PD-1 antibody and IL-12
In this study, we developed a new generation of oncolytic herpes simplex virus C5252 by deletion of a 15-kb internal repeat region and both copies of γ34.5 genes. Additionally, C5252 was armed with anti-programmed cell death protein 1 antibody and interleukin-12 to enhance its therapeutic efficacy for glioblastoma immune-virotherapy. In vitro and in vivo experiments demonstrate that C5252 has a remarkable safety profile and potent anti-tumor activity against glioblastoma. Mechanistic studies demonstrated that C5252 specifically induces cell apoptosis by caspase-3/7 activation via downregulating ciliary neurotrophic factor...
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Lei Wang Xusha Zhou Xiaoqing Chen Yuanyuan Liu Yue Huang Yuan Cheng Peigen Ren Jing Zhao Grace Guoying Zhou Source Type: research
In vitro evaluation of inhibitory effect of Lactobacillus reuteri supernatant on the replication of herpes simplex virus type 1 and expression of UL54, UL52 and UL27 genes
CONCLUSION: The study findings indicated that the supernatant of L. reuteri has a potent anti-HSV-1 effect especially if it is incubated with the virus before inoculation into the cell. Its possible antiviral mechanism is to inhibit the virus by binding to it or changing the surface structure of the virus. Metabolites of L. reuteri can be considered as a novel inhibitor of HSV-1 infection.PMID:38682053 | PMC:PMC11055432 | DOI:10.18502/ijm.v16i1.14877 (Source: Herpes)
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Faezeh Ebneali Mohammad Shayestehpour Ahmad Piroozmand Hossein Sedaghat Shaghayegh Yazdani Zahrasadat Fateminasab Source Type: research
Ligand-based drug design against Herpes Simplex Virus-1 capsid protein by modification of limonene through in silico approaches
Sci Rep. 2024 Apr 29;14(1):9828. doi: 10.1038/s41598-024-59577-4.ABSTRACTThe pharmacological effects of limonene, especially their derivatives, are currently at the forefront of research for drug development and discovery as well and structure-based drug design using huge chemical libraries are already widespread in the early stages of therapeutic and drug development. Here, various limonene derivatives are studied computationally for their potential utilization against the capsid protein of Herpes Simplex Virus-1. Firstly, limonene derivatives were designed by structural modification followed by conducting a molecular doc...
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Md Rezaul Islam Md Shafiqul Islam Sovon Ummy Amena Miadur Rahman Md Eram Hosen Ajoy Kumer Mohammed Bourhia Yousef A Bin Jardan Samir Ibenmoussa Gezahign Fentahun Wondmie Source Type: research
< em > In vitro < /em > evaluation of inhibitory effect of < em > Lactobacillus reuteri < /em > supernatant on the replication of herpes simplex virus type 1 and expression of < em > UL54, UL52 < /em > and < em > UL27 < /em > genes
CONCLUSION: The study findings indicated that the supernatant of L. reuteri has a potent anti-HSV-1 effect especially if it is incubated with the virus before inoculation into the cell. Its possible antiviral mechanism is to inhibit the virus by binding to it or changing the surface structure of the virus. Metabolites of L. reuteri can be considered as a novel inhibitor of HSV-1 infection.PMID:38682053 | PMC:PMC11055432 | DOI:10.18502/ijm.v16i1.14877 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Faezeh Ebneali Mohammad Shayestehpour Ahmad Piroozmand Hossein Sedaghat Shaghayegh Yazdani Zahrasadat Fateminasab Source Type: research
Molecules, Vol. 29, Pages 2052: External Guide Sequence Effectively Suppresses the Gene Expression and Replication of Herpes Simplex Virus 2
This study shows the effective and specific anti-HSV-2 activity of the RNase P-EGS approach and demonstrates the potential of EGS RNAs for anti-HSV-2 applications. (Source: Molecules)
Source: Molecules - April 29, 2024 Category: Chemistry Authors: Bin Yan Yujun Liu Yuan-Chuan Chen Fenyong Liu Tags: Article Source Type: research
A case of guttate psoriasis after primary herpetic gingivostomatitis
We describe the case of a 23-year-old man with an acute episode of guttate psoriasis related to primary herpetic gingivostomatitis. The diagnosis of guttate psoriasis was pathologically confirmed and the condition fully regressed after proper antiviral therapy. This case adds herpes simplex virus to the growing list of pathogens capable of acting as triggers for guttate psoriasis and highlights the need for better insight of the relationship between psoriasis and viral infections.PMID:38679796 | DOI:10.1177/09564624241248873 (Source: Herpes)
Source: Herpes - April 28, 2024 Category: Infectious Diseases Authors: Valeria Gaspari Gionathan Orioni Isabella Peron Cosimo Misciali Federico Bardazzi Source Type: research
Herpes simplex encephalitis in France: incidence, 6-month rehospitalizations and mortality
ConclusionIn France, the incidence of hospitalizations for HSE was 2.3 per 1,000,000 inhabitants with more than half of the patients admitted in ICU and a 6-month in-hospital mortality about 16.5%. This real-life update on the characteristics and severe outcomes of the disease raises awareness among care practitioners, of the serious nature of the disease, and thus can lead to higher vigilance. (Source: Infection)
Source: Infection - April 28, 2024 Category: Infectious Diseases Source Type: research
Neonatal herpes: case series in two obstetric centres over a 10-year period (2013-2023), France
Conclusion: This case series confirms that neonates at risk for HSV disease and poor outcome are those born to HSV-seronegative mothers, preterm infants, and those who received acyclovir after onset of symptoms (mainly because mothers did not present evidence of acute HSV infection). Our study confirms the major role of HSV-1 and the frequency of its early post-natal acquisition. What is known: • Neonatal herpes simplex virus infection is rare but motality and morbidity rates are high after disseminted disease and encephalitis. National recommendations exist worldwide but mangement of this disease is not always easy. Wha...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Elise Bouthry Vincent Portet-Sulla Melek Manai Bouokazi Claire P érillaud-Dubois Fran çois-Charles Javaugue Laure Jule Claire Boithias Nolwenn Le Sach é Mostafa Mokhtari Diane Carri ère Louise Sonnier Rafik Benammar Alexandra Letourneau Alexandre J Vi Source Type: research
Herpes simplex encephalitis in France: incidence, 6-month rehospitalizations and mortality
CONCLUSION: In France, the incidence of hospitalizations for HSE was 2.3 per 1,000,000 inhabitants with more than half of the patients admitted in ICU and a 6-month in-hospital mortality about 16.5%. This real-life update on the characteristics and severe outcomes of the disease raises awareness among care practitioners, of the serious nature of the disease, and thus can lead to higher vigilance.PMID:38678152 | DOI:10.1007/s15010-024-02272-3 (Source: Herpes)
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Ambre Sauvage Emeline Laurent Christophe Gaborit Antoine Guillon Leslie Grammatico-Guillon Source Type: research
Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
Cell Rep Med. 2024 Apr 23:101528. doi: 10.1016/j.xcrm.2024.101528. Online ahead of print.ABSTRACTStimulator of interferon genes (STING)-dependent signaling is requisite for effective anti-microbial and anti-tumor activity. STING signaling is commonly defective in cancer cells, which enables tumor cells to evade the immunosurveillance system. We evaluate here whether intrinsic STING signaling in such tumor cells could be reconstituted by creating recombinant herpes simplex viruses (rHSVs) that express components of the STING signaling pathway. We observe that rHSVs expressing STING and/or cGAS replicate inefficiently yet re...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Tiphaine Delaunay Sehee Son Seongji Park Balveen Kaur Jeonghyun Ahn Glen N Barber Source Type: research
A Review of the Association between Infections, Seizures, and Drugs
CONCLUSION: Due to changes in drug metabolism, co-administration of antiseizure drugs and antibiotics may lead to an enhanced risk of seizures. In patients with neurocysticercosis, cerebral malaria, viral encephalitis, bacterial meningitis, tuberculosis, and human immunodeficiency virus, the evidence-based study recommended different mechanisms mediating epileptogenic properties of toxins and drugs.PMID:38676494 | DOI:10.2174/0118715249288932240416071636 (Source: Herpes)
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Zahra Tolou-Ghamari Source Type: research
