Major Virion Tegument Protein VP22 Targets Nuclear Matrix and Chromatin upon Entry into Cells during Productive Herpes Simplex Virus 1 Infection
Microorganisms. 2024 Mar 5;12(3):521. doi: 10.3390/microorganisms12030521.ABSTRACTHSV-1 major tegument protein VP22 is present in multiple subcellular locations in the late stages of productive viral infection. We initially performed a detailed time course experiment and observed that VP22 was detected in nuclear and nuclear matrix fractions as early as 4 hpi. The goal was to determine the fate of virion-derived incoming VP22, and we report the following: (i) VP22 was detected in nuclear matrix fractions 1 hpi. (ii) In the presence of cycloheximide (CHX), VP22 was present in the nuclear matrix 1-6 hpi, demonstrating the st...
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Isabella Chi John A Blaho Source Type: research
A Specific Pattern of Routine Cerebrospinal Fluid Parameters Might Help to Identify Cases of West Nile Virus Neuroinvasive Disease
CONCLUSIONS: Cases with WNV ME showed a specific pattern of routine CSF parameters and demographic data that allowed for their identification with good accuracy. These findings might help to guide the diagnostic workup in cases with viral ME, in particular allowing the timely identification of cases with ME due to WNV.PMID:38543707 | PMC:PMC10974314 | DOI:10.3390/v16030341 (Source: Herpes)
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Johann Otto Pelz Christoph M ühlberg Isabel Friedrich Lorenz Weidhase Silke Zimmermann Melanie Maier Corinna Pietsch Source Type: research
Herpes Simplex Virus Bronchopneumonitis in Critically Ill Patients with Acute on Chronic Liver Failure: A Retrospective Analysis
Conclusions: Mortality of critically ill patients with ACLF with HSV bronchopneumonitis was not increased in spite of the cirrhosis-associated immune dysfunction. Their clinical course, however, was more complicated with significantly longer mechanical ventilation.PMID:38543784 | PMC:PMC10974938 | DOI:10.3390/v16030419 (Source: Herpes)
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Miriam Dibos Julian Triebelhorn Jochen Schneider Sebastian Rasch Roland M Schmid Tobias Lahmer Ulrich Mayr Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Herpes)
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Function and Mechanism of Antiviral Wasp Venom Peptide Protopolybia-MP III and Its Derivatives against HSV-1
Toxins (Basel). 2024 Mar 4;16(3):132. doi: 10.3390/toxins16030132.ABSTRACTViruses are one of the leading causes of human disease, and many highly pathogenic viruses still have no specific treatment drugs. Therefore, producing new antiviral drugs is an urgent matter. In our study, we first found that the natural wasp venom peptide Protopolybia-MP III had a significant inhibitory effect on herpes simplex virus type 1 (HSV-1) replication in vitro by using quantitative real-time PCR (qPCR), Western blotting, and plaque-forming assays. Immunofluorescence analysis showed Protopolybia-MP III could enter cells, and it inhibited mu...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Fang Sun Xiangdong Ye Tanran Han Jingwen Xia Lili Wu Wen Zhu Li Ding Xudong Luo Chenhu Qin Zongyun Chen Source Type: research
Viral Infections, Are They a Trigger and Risk Factor of Alzheimer's Disease?
Pathogens. 2024 Mar 8;13(3):240. doi: 10.3390/pathogens13030240.ABSTRACTAlzheimer's Disease (AD), a progressive and debilitating condition, is reported to be the most common type of dementia, with at least 55 million people believed to be currently affected. Many causation hypotheses of AD exist, yet the intriguing link between viral infection and its possible contribution to the known etiology of AD has become an attractive focal point of research for the field and a challenging study task. In this review, we will explore the historical perspective and milestones that led the field to investigate the viral connection to A...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Meagan D Rippee-Brooks Wenzhe Wu Jianli Dong Miguel Pappolla Xiang Fang Xiaoyong Bao Source Type: research
OH2 oncolytic virus: A novel approach to glioblastoma intervention through direct targeting of tumor cells and augmentation of anti-tumor immune responses
This study marks the first demonstration of an HSV-2 derived OV's effectiveness against GBM. Significantly, these discoveries have driven the initiation of a phase I/II clinical trial (ClinicalTrials.gov: NCT05235074). This trial is designed to explore the potential of OH2 as a therapeutic option for patients with recurrent central nervous system tumors following surgical intervention.PMID:38537773 | DOI:10.1016/j.canlet.2024.216834 (Source: Herpes)
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Yi Zheng Xiaomin Wang Qiang Ji Aizhong Fang Lairong Song Xiaoying Xu Yi Lin Yichen Peng Jianyu Yu Lei Xie Feng Chen Xiaojie Li Sipeng Zhu Botao Zhang Lili Zhou Chunna Yu YaLi Wang Liang Wang Han Hu Ziyi Zhang Binlei Liu Zhen Wu Wenbin Li Source Type: research
Function and Mechanism of Antiviral Wasp Venom Peptide Protopolybia-MP III and Its Derivatives against HSV-1
Toxins (Basel). 2024 Mar 4;16(3):132. doi: 10.3390/toxins16030132.ABSTRACTViruses are one of the leading causes of human disease, and many highly pathogenic viruses still have no specific treatment drugs. Therefore, producing new antiviral drugs is an urgent matter. In our study, we first found that the natural wasp venom peptide Protopolybia-MP III had a significant inhibitory effect on herpes simplex virus type 1 (HSV-1) replication in vitro by using quantitative real-time PCR (qPCR), Western blotting, and plaque-forming assays. Immunofluorescence analysis showed Protopolybia-MP III could enter cells, and it inhibited mu...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Fang Sun Xiangdong Ye Tanran Han Jingwen Xia Lili Wu Wen Zhu Li Ding Xudong Luo Chenhu Qin Zongyun Chen Source Type: research
Viral Infections, Are They a Trigger and Risk Factor of Alzheimer's Disease?
Pathogens. 2024 Mar 8;13(3):240. doi: 10.3390/pathogens13030240.ABSTRACTAlzheimer's Disease (AD), a progressive and debilitating condition, is reported to be the most common type of dementia, with at least 55 million people believed to be currently affected. Many causation hypotheses of AD exist, yet the intriguing link between viral infection and its possible contribution to the known etiology of AD has become an attractive focal point of research for the field and a challenging study task. In this review, we will explore the historical perspective and milestones that led the field to investigate the viral connection to A...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Meagan D Rippee-Brooks Wenzhe Wu Jianli Dong Miguel Pappolla Xiang Fang Xiaoyong Bao Source Type: research
Impact of Toll-Like Receptors (TLRs) and TLR Signaling Proteins in Trigeminal Ganglia Impairing Herpes Simplex Virus 1 (HSV-1) Progression to Encephalitis: Insights from Mouse Models
Front Biosci (Landmark Ed). 2024 Mar 14;29(3):102. doi: 10.31083/j.fbl2903102.ABSTRACTHerpes simplex virus 1 (HSV-1) or simplexvirus humanalpha 1 is a neurotropic virus that is responsible for orofacial infections in humans. More than 70% of the world's population may have seropositivity for HSV-1, and this virus is a leading cause of sporadic lethal encephalitis in humans. The role of toll-like receptors (TLRs) in defending against HSV-1 infection has been explored, including the consequences of lacking these receptors or other proteins in the TLR pathway. Cell and mouse models have been used to study the importance of th...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Marco Ant ônio Campos Guilherme de P ádua Zolini Erna Geessien Kroon Source Type: research
Systemic lupus erythematosus associated with erythema multiforme: A rare case report of Rowell's syndrome
Key Clinical MessageAlthough it is very uncommon, SLE may initially present with recurrent episodes of EM-like rash. Despite the various possibilities underlying their association, prompt identification, and treatment of SLE in patients presenting with EM is important to prevent death or serious organ damage.AbstractRowell's syndrome (RS) is an uncommon presentation of systemic lupus erythematosus (SLE) with erythema multiforme (EM)-like lesions associated with specific serological changes, including positive rheumatoid factor (RF), speckled antinuclear antibody (ANA), positive rheumatoid factor, or anti-La antibodies in t...
Source: Clinical Case Reports - March 27, 2024 Category: General Medicine Authors: Madhur Bhattarai,
Niraj Kumar Sharma,
Shreeram Paudel,
Sujata Bhandari,
Amrit Bhusal,
Kiran Dhonju,
Sandip Kuikel,
Shivendra Kumar Jha,
Egesh Aryal,
Deepak Subedi Tags: CASE REPORT Source Type: research
