Development of a novel, high-efficacy oncolytic herpes simplex virus type 1 platform equipped with two distinct retargeting modalities
Mol Ther Oncol. 2024 Feb 20;32(1):200778. doi: 10.1016/j.omton.2024.200778. eCollection 2024 Mar 21.ABSTRACTTo retarget oncolytic herpes simplex virus (oHSV) to cancer-specific antigens, we designed a novel, double-retargeted oHSV platform that uses single-chain antibodies (scFvs) incorporated into both glycoprotein H and a bispecific adapter expressed from the viral genome to mediate infection predominantly via tumor-associated antigens. Successful retargeting was achieved using a nectin-1-detargeted HSV that remains capable of interacting with herpesvirus entry mediator (HVEM), the second canonical HSV entry receptor, an...
Source: Herpes - April 10, 2024 Category: Infectious Diseases Authors: Hyun-Yoo Joo Hyunjung Baek Chun-Seob Ahn Eun-Ran Park Youngju Lee Sujung Lee Mihee Han Bora Kim Yong-Hoon Jang Heechung Kwon Source Type: research
Oncolytic herpes simplex virus expressing IL-2 controls glioblastoma growth and improves survival
CONCLUSIONS: Our findings illustrate that G47Δ-mIL2 is efficacious, stimulates antitumor immunity against orthotopic GBM, and may also target GSC. OHSV expressing IL-2 may represent an agent that merits further exploration in patients with GBM.PMID:38599661 | DOI:10.1136/jitc-2024-008880 (Source: Herpes)
Source: Herpes - April 10, 2024 Category: Infectious Diseases Authors: Praveen K Bommareddy Hiroaki Wakimoto Robert L Martuza Howard L Kaufman Samuel D Rabkin Dipongkor Saha Source Type: research
Herpes simplex virus infection with a marginal Nikolsky sign in an immunocompromised patient
J Dermatol. 2024 Apr 8. doi: 10.1111/1346-8138.17224. Online ahead of print.NO ABSTRACTPMID:38587235 | DOI:10.1111/1346-8138.17224 (Source: Herpes)
Source: Herpes - April 8, 2024 Category: Infectious Diseases Authors: Eriko Takayama Akiko Yoshioka Source Type: research
Therapeutic prime/pull vaccination of HSV-2-infected guinea pigs with the ribonucleotide reductase 2 (RR2) protein and CXCL11 chemokine boosts antiviral local tissue-resident and effector memory CD4(+) and CD8(+) T cells and protects against recurrent genital herpes
In this study, we used the strategy that involves immunization of herpes simplex virus type 2-infected guinea pigs using a recombinantly expressed herpes tegument protein-ribonucleotide reductase 2 (RR2; prime), followed by intravaginal treatment with the neurotropic adeno-associated virus type 8 expressing CXCL9, CXCL10, or CXCL11 T-cell-attracting chemokines to recruit T cells into the infected dorsal root ganglia (DRG) and vaginal mucosa (VM) (pull). We show that the RR2/CXCL11 prime-pull therapeutic vaccine strategy elicited a significant reduction in virus shedding in the vaginal mucosa and decreased the severity and ...
Source: Herpes - April 8, 2024 Category: Infectious Diseases Authors: Afshana Quadiri Swayam Prakash Nisha Rajeswari Dhanushkodi Mahmoud Singer Latifa Zayou Amin Mohammed Shaik Miyo Sun Berfin Suzer Lauren Su Lin Lau Amruth Chilukurri Hawa Vahed Hubert Schaefer Lbachir BenMohamed Source Type: research
New hopes for the breast cancer treatment: perspectives on the oncolytic virus therapy
Front Immunol. 2024 Mar 21;15:1375433. doi: 10.3389/fimmu.2024.1375433. eCollection 2024.ABSTRACTOncolytic virus (OV) therapy has emerged as a promising frontier in cancer treatment, especially for solid tumours. While immunotherapies like immune checkpoint inhibitors and CAR-T cells have demonstrated impressive results, their limitations in inducing complete tumour regression have spurred researchers to explore new approaches targeting tumours resistant to current immunotherapies. OVs, both natural and genetically engineered, selectively replicate within cancer cells, inducing their lysis while sparing normal tissues. Rec...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Hanna Chowaniec Antonina Ślubowska Magdalena Mroczek Martyna Borowczyk Ma łgorzata Braszka Grzegorz Dworacki Paula Dobosz Mateusz Wichtowski Source Type: research
Management strategies for common viral infections in pediatric renal transplant recipients
World J Transplant. 2024 Mar 18;14(1):89978. doi: 10.5500/wjt.v14.i1.89978.ABSTRACTViral infections have been considered as a major cause of morbidity and mortality after kidney transplantation in pediatric cohort. Children are at high risk of acquiring virus-related complications due to immunological immaturity and the enhanced alloreactivity risk that led to maintenance of high immunosuppressive regimes. Hence, prevention, early detection, and prompt treatment of such infe ctions are of paramount importance. Among all viral infections, herpes viruses (herpes simplex virus, varicella zoster virus, Epstein-Barr virus, cyto...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Randula Ranawaka Kavinda Dayasiri Erandima Sandamali Manoji Gamage Source Type: research
New hopes for the breast cancer treatment: perspectives on the oncolytic virus therapy
Front Immunol. 2024 Mar 21;15:1375433. doi: 10.3389/fimmu.2024.1375433. eCollection 2024.ABSTRACTOncolytic virus (OV) therapy has emerged as a promising frontier in cancer treatment, especially for solid tumours. While immunotherapies like immune checkpoint inhibitors and CAR-T cells have demonstrated impressive results, their limitations in inducing complete tumour regression have spurred researchers to explore new approaches targeting tumours resistant to current immunotherapies. OVs, both natural and genetically engineered, selectively replicate within cancer cells, inducing their lysis while sparing normal tissues. Rec...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Hanna Chowaniec Antonina Ślubowska Magdalena Mroczek Martyna Borowczyk Ma łgorzata Braszka Grzegorz Dworacki Paula Dobosz Mateusz Wichtowski Source Type: research
Management strategies for common viral infections in pediatric renal transplant recipients
World J Transplant. 2024 Mar 18;14(1):89978. doi: 10.5500/wjt.v14.i1.89978.ABSTRACTViral infections have been considered as a major cause of morbidity and mortality after kidney transplantation in pediatric cohort. Children are at high risk of acquiring virus-related complications due to immunological immaturity and the enhanced alloreactivity risk that led to maintenance of high immunosuppressive regimes. Hence, prevention, early detection, and prompt treatment of such infe ctions are of paramount importance. Among all viral infections, herpes viruses (herpes simplex virus, varicella zoster virus, Epstein-Barr virus, cyto...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Randula Ranawaka Kavinda Dayasiri Erandima Sandamali Manoji Gamage Source Type: research
Radiological features of herpetic encephalitis in children
Nonspecific clinical manifestations and unclear radiological features may delay treatment initiation in pediatric Herpes simplex encephalitis (HSE). Aim of this study is to analyze the clinical and radiologic features of the disease. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 5, 2024 Category: Neurology Authors: Thai Son Pham, Federico Montini, Hoang Nhat Pham, Minh-Thu Nguyen Tran, Tien Huy Nguyen, Laura Cacciaguerra, Massimo Filippi Tags: Research Paper Source Type: research
Promising Potential of Curcumin and Related Compounds for Antiviral Drug Discovery
Med Chem. 2024 Apr 2. doi: 10.2174/0115734064277371240325105016. Online ahead of print.ABSTRACTViruses are acellular, microscopic, and mobile particles containing genetic particles, either DNA/RNA strands as nucleoproteins, responsible for 69,53,743 deaths till the year 2023. Curcumin and related compounds are among the areas of pivotal interest for researchers because of their versatile pharmacological profile. Chemically known as diferuloylmethane, which is a main constituent of turmeric along with demethoxycurcumin and bisdemethoxycurcumin, they have a broad spectrum of antiviral activity against viruses such as human i...
Source: Medicinal Chemistry - April 4, 2024 Category: Chemistry Authors: Archana Sharma Twinkle Sharma Rajveer Bhaskar Monika Ola Alok Sharma Vijay Kumar Thakur Prabodh Chander Sharma Source Type: research
Promising Potential of Curcumin and Related Compounds for Antiviral Drug Discovery
Med Chem. 2024 Apr 2. doi: 10.2174/0115734064277371240325105016. Online ahead of print.ABSTRACTViruses are acellular, microscopic, and mobile particles containing genetic particles, either DNA/RNA strands as nucleoproteins, responsible for 69,53,743 deaths till the year 2023. Curcumin and related compounds are among the areas of pivotal interest for researchers because of their versatile pharmacological profile. Chemically known as diferuloylmethane, which is a main constituent of turmeric along with demethoxycurcumin and bisdemethoxycurcumin, they have a broad spectrum of antiviral activity against viruses such as human i...
Source: Herpes - April 4, 2024 Category: Infectious Diseases Authors: Archana Sharma Twinkle Sharma Rajveer Bhaskar Monika Ola Alok Sharma Vijay Kumar Thakur Prabodh Chander Sharma Source Type: research
An epidemiological examination of neonatal opioid withdrawal syndrome and maternal and infant characteristics
CONCLUSIONS: This study emphasizes the complexity of challenges facing families impacted by NOWS, the importance of multifaceted prevention, and the need to conduct HCV testing in NOWS infants.PMID:38573341 | DOI:10.1007/s00737-024-01460-2 (Source: Herpes)
Source: Herpes - April 4, 2024 Category: Infectious Diseases Authors: Ashlyn N Schwartz Laurie L Meschke Source Type: research
Translational arrest and mRNA decay are independent activities of alphaherpesvirus virion host shutoff proteins
J Gen Virol. 2024 Apr;105(4). doi: 10.1099/jgv.0.001976.ABSTRACTThe herpes simplex virus 1 (HSV1) virion host shutoff (vhs) protein is an endoribonuclease that regulates the translational environment of the infected cell, by inducing the degradation of host mRNA via cellular exonuclease activity. To further understand the relationship between translational shutoff and mRNA decay, we have used ectopic expression to compare HSV1 vhs (vhsH) to its homologues from four other alphaherpesviruses - varicella zoster virus (vhsV), bovine herpesvirus 1 (vhsB), equine herpesvirus 1 (vhsE) and Marek's disease virus (vhsM). Only vhsH, ...
Source: Herpes - April 4, 2024 Category: Infectious Diseases Authors: Lucy Eke Alistair Tweedie Sophie Cutts Emma L Wise Gillian Elliott Source Type: research
Comparative analysis of microbial composition and functional characteristics in dental plaque and saliva of oral cancer patients
CONCLUSIONS: Significant differences in the microbial and genetic composition of saliva and dental plaque samples were observed in OC patients. Furthermore, pathogenic bacteria associated with oral diseases were predominantly enriched in saliva. The identification of inter-group differential biomarkers and pathways provide insights into the relationship between oral microbiota and the occurrence and development of OC.PMID:38575895 | DOI:10.1186/s12903-024-04181-1 (Source: Herpes)
Source: Herpes - April 4, 2024 Category: Infectious Diseases Authors: Man Zhang Yiming Zhao Abdulrahim Umar Hailin Zhang Lirong Yang Jing Huang Ying Long Zheng Yu Source Type: research
Promising Potential of Curcumin and Related Compounds for Antiviral Drug Discovery
Med Chem. 2024 Apr 2. doi: 10.2174/0115734064277371240325105016. Online ahead of print.ABSTRACTViruses are acellular, microscopic, and mobile particles containing genetic particles, either DNA/RNA strands as nucleoproteins, responsible for 69,53,743 deaths till the year 2023. Curcumin and related compounds are among the areas of pivotal interest for researchers because of their versatile pharmacological profile. Chemically known as diferuloylmethane, which is a main constituent of turmeric along with demethoxycurcumin and bisdemethoxycurcumin, they have a broad spectrum of antiviral activity against viruses such as human i...
Source: Medicinal Chemistry - April 4, 2024 Category: Chemistry Authors: Archana Sharma Twinkle Sharma Rajveer Bhaskar Monika Ola Alok Sharma Vijay Kumar Thakur Prabodh Chander Sharma Source Type: research
