Herpes simplex virus reactivation among hematopoietic stem cell transplant recipients: re-evaluating acyclovir dosage
Bone Marrow Transplant. 2024 Apr 16. doi: 10.1038/s41409-024-02273-8. Online ahead of print.NO ABSTRACTPMID:38627451 | DOI:10.1038/s41409-024-02273-8 (Source: Herpes)
Source: Herpes - April 16, 2024 Category: Infectious Diseases Authors: Nada Alsuhebany Bashayer Alshehri Atheer Aldairem Muneerah M Aleissa Hajar AlQahtani Khalid Albarqi Basil Almotairi Mohammed AlAmri Walid Alanazi Saeed Alay Bader Alahmari Mohsen Alzahrani Source Type: research
A lentivirus-vectored feline erythropoietin gene therapy strategy in tissue culture and rodent models for the potential treatment of chronic renal disease-associated anemia
Am J Vet Res. 2024 Apr 20:1-12. doi: 10.2460/ajvr.23.12.0280. Online ahead of print.ABSTRACTOBJECTIVE: The aim of this study was to assess the efficacy and safety of a third-generation lentivirus-based vector encoding the feline erythropoietin (EPO) (feEPO) gene in vitro and in rodent models in vivo. This vector incorporates a genetic mechanism to facilitate the termination of the therapeutic effect in the event of supraphysiologic polycythemia, the herpes simplex virus thymidine kinase (HSV-TK) "suicide gene."ANIMALS: CFRK cells and replication-defective lentiviral vectors encoding feEPO were used for in vitro experiments...
Source: Herpes - April 16, 2024 Category: Infectious Diseases Authors: Sarah E Cook Diego Castillo Tatiana Wolf Chadwick Hillman Katherine Bauer Sonyia Williams Brian G Murphy Source Type: research
Severe Herpes Simplex Encephalitis: an Unusual Presentation of IPEX
J Clin Immunol. 2024 Apr 16;44(4):100. doi: 10.1007/s10875-024-01702-z.NO ABSTRACTPMID:38625673 | DOI:10.1007/s10875-024-01702-z (Source: Herpes)
Source: Herpes - April 16, 2024 Category: Infectious Diseases Authors: Linda Rossini Claudia Maria Bonardi Silvia Bresolin Eva Trevisson Antonio Marzollo Source Type: research
A lentivirus-vectored feline erythropoietin gene therapy strategy in tissue culture and rodent models for the potential treatment of chronic renal disease-associated anemia
Am J Vet Res. 2024 Apr 20:1-12. doi: 10.2460/ajvr.23.12.0280. Online ahead of print.ABSTRACTOBJECTIVE: The aim of this study was to assess the efficacy and safety of a third-generation lentivirus-based vector encoding the feline erythropoietin (EPO) (feEPO) gene in vitro and in rodent models in vivo. This vector incorporates a genetic mechanism to facilitate the termination of the therapeutic effect in the event of supraphysiologic polycythemia, the herpes simplex virus thymidine kinase (HSV-TK) "suicide gene."ANIMALS: CFRK cells and replication-defective lentiviral vectors encoding feEPO were used for in vitro experiments...
Source: American Journal of Veterinary Research - April 16, 2024 Category: Veterinary Research Authors: Sarah E Cook Diego Castillo Tatiana Wolf Chadwick Hillman Katherine Bauer Sonyia Williams Brian G Murphy Source Type: research
A lentivirus-vectored feline erythropoietin gene therapy strategy in tissue culture and rodent models for the potential treatment of chronic renal disease-associated anemia
Am J Vet Res. 2024 Apr 20:1-12. doi: 10.2460/ajvr.23.12.0280. Online ahead of print.ABSTRACTOBJECTIVE: The aim of this study was to assess the efficacy and safety of a third-generation lentivirus-based vector encoding the feline erythropoietin (EPO) (feEPO) gene in vitro and in rodent models in vivo. This vector incorporates a genetic mechanism to facilitate the termination of the therapeutic effect in the event of supraphysiologic polycythemia, the herpes simplex virus thymidine kinase (HSV-TK) "suicide gene."ANIMALS: CFRK cells and replication-defective lentiviral vectors encoding feEPO were used for in vitro experiments...
Source: American Journal of Veterinary Research - April 16, 2024 Category: Veterinary Research Authors: Sarah E Cook Diego Castillo Tatiana Wolf Chadwick Hillman Katherine Bauer Sonyia Williams Brian G Murphy Source Type: research
Severe Herpes Simplex Encephalitis: an Unusual Presentation of IPEX
(Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - April 16, 2024 Category: Allergy & Immunology Source Type: research
Herpes simplex virus reactivation among hematopoietic stem cell transplant recipients: re-evaluating acyclovir dosage
Bone Marrow Transplantation, Published online: 16 April 2024; doi:10.1038/s41409-024-02273-8Herpes simplex virus reactivation among hematopoietic stem cell transplant recipients: re-evaluating acyclovir dosage (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 16, 2024 Category: Hematology Authors: Nada Alsuhebany Bashayer Alshehri Atheer Aldairem Muneerah M. Aleissa Hajar AlQahtani Khalid Albarqi Basil Almotairi Mohammed AlAmri Walid Alanazi Saeed Alay Bader Alahmari Mohsen Alzahrani Source Type: research
Combination of ganciclovir and trifluridine prevents drug-resistance emergence in HSV-1
Antimicrob Agents Chemother. 2024 Apr 15:e0011024. doi: 10.1128/aac.00110-24. Online ahead of print.ABSTRACTOcular herpes simplex virus 1 (HSV-1) infections can lead to visual impairment. Long-term acyclovir (ACV) prophylaxis reduces the frequency of recurrences but is associated with drug resistance. Novel therapies are needed to treat drug-resistant HSV-1 infections. Here, we describe the effects of trifluridine (TFT) in combination with ACV or ganciclovir (GCV) on HSV-1 replication and drug-resistance emergence. Wild-type HSV-1 was grown under increasing doses of one antiviral (ACV, GCV, or TFT) or combinations thereof ...
Source: Antimicrobial Agents and Chemotherapy - April 15, 2024 Category: Microbiology Authors: Hanna Helena Schalkwijk Neesha Rajesh Shewakramani Kalyan Das Graciela Andrei Robert Snoeck Source Type: research
Herpes simplex keratitis: A brief clinical overview
World J Virol. 2024 Mar 25;13(1):89934. doi: 10.5501/wjv.v13.i1.89934.ABSTRACTThe aim of our minireview is to provide a brief overview of the diagnosis, clinical aspects, treatment options, management, and current literature available regarding herpes simplex keratitis (HSK). This type of corneal viral infection is caused by the herpes simplex virus (HSV), which can affect several tissues, including the cornea. One significant aspect of HSK is its potential to cause recurrent episodes of inflammation and damage to the cornea. After the initial infection, the HSV can establish a latent infection in the trigeminal ganglion, ...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Mutali Musa Ehimare Enaholo Gladness Aluyi-Osa George Nnamdi Atuanya Leopoldo Spadea Carlo Salati Marco Zeppieri Source Type: research
Investigating the Effects of HMGB1 Overexpression on Colorectal Cancer Cell Migration via Oncolytic Herpes simplex Virus Type 1 (oHSV-1)
CONCLUSION: Our findings emphasize the complex regulation of CRC cell migration, and provides valuable insights into potential molecular mechanisms and pathways. These findings have implications for further research into cancer progression and the development of therapeutic strategies.PMID:38618508 | PMC:PMC11007377 | DOI:10.18502/ajmb.v16i2.14863 (Source: Herpes)
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Sara Shayan Arash Arashkia Golnaz Bahramali Kayhan Azadmanesh Source Type: research
Combination of ganciclovir and trifluridine prevents drug-resistance emergence in HSV-1
Antimicrob Agents Chemother. 2024 Apr 15:e0011024. doi: 10.1128/aac.00110-24. Online ahead of print.ABSTRACTOcular herpes simplex virus 1 (HSV-1) infections can lead to visual impairment. Long-term acyclovir (ACV) prophylaxis reduces the frequency of recurrences but is associated with drug resistance. Novel therapies are needed to treat drug-resistant HSV-1 infections. Here, we describe the effects of trifluridine (TFT) in combination with ACV or ganciclovir (GCV) on HSV-1 replication and drug-resistance emergence. Wild-type HSV-1 was grown under increasing doses of one antiviral (ACV, GCV, or TFT) or combinations thereof ...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Hanna Helena Schalkwijk Neesha Rajesh Shewakramani Kalyan Das Graciela Andrei Robert Snoeck Source Type: research
Progression of herpesvirus infection remodels mitochondrial organization and metabolism
PLoS Pathog. 2024 Apr 15;20(4):e1011829. doi: 10.1371/journal.ppat.1011829. Online ahead of print.ABSTRACTViruses target mitochondria to promote their replication, and infection-induced stress during the progression of infection leads to the regulation of antiviral defenses and mitochondrial metabolism which are opposed by counteracting viral factors. The precise structural and functional changes that underlie how mitochondria react to the infection remain largely unclear. Here we show extensive transcriptional remodeling of protein-encoding host genes involved in the respiratory chain, apoptosis, and structural organizati...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Simon Leclerc Alka Gupta Visa Ruokolainen Jian-Hua Chen Kari Kunnas Axel A Ekman Henri Niskanen Ilya Belevich Helena Vihinen Paula Turkki Ana J Perez-Berna Sergey Kapishnikov Elina M äntylä Maria Harkiolaki Eric Dufour Vesa Hyt önen Eva Pereiro Tony Mc Source Type: research
CNS Aspergillosis and Cryptococcosis with Cytomegalovirus Pneumonia in a Patient with Chronic Lymphocytic Leukemia Treated with Acalabrutinib
We describe a 68-year-old male who developed multiple bacterial, fungal and viral infections while on treatment with acalabrutinib. To our knowledge, this is the first reported case of concomitant CNS infections with Cryptococcus neoformans and Aspergillus fumigatus, along with cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1) pneumonia while on acalabrutinib. This case adds to the scarce literature of fungal and bacterial infections associated with acalabrutinib, raising the suspicion that infection risk is a medication class effect for BTKis.PMID:38621678 | DOI:10.1177/08971900241247660 (Source: Herpes)
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Taylor Fallin Erica Thacker Syeda Sahra Emily A Siegrist Bryan P White Katherine Summers Dena Shibib Joseph Sassine Source Type: research
Management of Oral Manifestations of Herpes Simplex Virus, Varicella Zoster Virus, and Human Papillomavirus
Compend Contin Educ Dent. 2024 Apr;45(4):192-197; quiz 198.ABSTRACTHuman herpes virus is a family of DNA viruses that includes herpes simplex virus (HSV) and varicella zoster virus (VZV). HSV-1 and HSV-2 are fairly common and result in oral and genital lesions. Recurrent infections of herpes include lesions on the lips resulting in pain and possibly societal stigma, making adequate treatment of these conditions crucial. VZV is the cause of chicken pox and shingles. Acyclovir and other nucleoside analogues have been the gold standard of treatment for HSV and VZV, but newer, more effective treatments are being developed, whi...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Lauren Elkada Aviv Ouanounou Source Type: research
Combination of ganciclovir and trifluridine prevents drug-resistance emergence in HSV-1
Antimicrob Agents Chemother. 2024 Apr 15:e0011024. doi: 10.1128/aac.00110-24. Online ahead of print.ABSTRACTOcular herpes simplex virus 1 (HSV-1) infections can lead to visual impairment. Long-term acyclovir (ACV) prophylaxis reduces the frequency of recurrences but is associated with drug resistance. Novel therapies are needed to treat drug-resistant HSV-1 infections. Here, we describe the effects of trifluridine (TFT) in combination with ACV or ganciclovir (GCV) on HSV-1 replication and drug-resistance emergence. Wild-type HSV-1 was grown under increasing doses of one antiviral (ACV, GCV, or TFT) or combinations thereof ...
Source: Antimicrobial Agents and Chemotherapy - April 15, 2024 Category: Microbiology Authors: Hanna Helena Schalkwijk Neesha Rajesh Shewakramani Kalyan Das Graciela Andrei Robert Snoeck Source Type: research
