Antiviral and synergistic effects of photo-energy with acyclovir on herpes simplex virus type 1 infection
Virology. 2024 Mar 31;595:110063. doi: 10.1016/j.virol.2024.110063. Online ahead of print.ABSTRACTThis experimental study aimed to evaluate the antiviral and synergistic effects of photoenergy irradiation on human herpes simplex virus type I (HSV-1) infection. We assessed viral replication, plaque formation, and relevant viral gene expression to examine the antiviral and synergistic effects of blue light (BL) with acyclovir treatment. Our results showed that daily BL (10 J/cm2) irradiation inhibited plaque-forming ability and decreased viral copy numbers in HSV-1-infected monkey kidney epithelial Vero cells and primary hum...
Source: Virology - April 2, 2024 Category: Virology Authors: Phil-Sun Oh Yeon-Hee Han SeokTae Lim Berwin Singh Swami Vetha Hwan-Jeong Jeong Source Type: research
Trajectories of intimate partner violence and their relationship to stress among young women in South Africa: An HPTN 068 study
CONCLUSIONS: Sustained IPV risk during adolescence was associated with elevated CRP in young adulthood. The relationship between IPV and elevated CMV was attenuated among those receiving a CT, suggesting that CTs could possibly reduce biological stress due to IPV.PMID:38563376 | DOI:10.1177/00207640241239535 (Source: The International Journal of Social Psychiatry)
Source: The International Journal of Social Psychiatry - April 2, 2024 Category: Psychiatry Authors: Nicole K Kelly Nivedita L Bhushan Nisha Gottfredson O'Shea F Xavier G ómez-Olivé Allison E Aiello Laura Danielle Wagner Sumaya Mall Kathleen Kahn Audrey E Pettifor Marie Cd Stoner Source Type: research
Acute-Onset Lower Extremity Weakness and Urinary Retention in a Chronically Immunosuppressed Patient: Diagnosis and Management of Herpes Simplex Virus Type 2 Myelitis
Cureus. 2024 Feb 29;16(2):e55248. doi: 10.7759/cureus.55248. eCollection 2024 Feb.ABSTRACTA 34-year-old immunosuppressed male presented with worsening bilateral lower extremity weakness and urinary retention accompanied by a painless clean-based chancre on his glans penis. Physical examination revealed symmetrically diminished lower extremity weakness most pronounced with hip flexion and knee extension and absent Achilles reflexes. Full MRI spine without contrast was noncontributory. Lumbar puncture showed elevated protein and total nucleated cells with lymphocytic predominance. Both CSF and serum polymerase chain reaction...
Source: Herpes - April 1, 2024 Category: Infectious Diseases Authors: Jaya Chandra Hamid R Khatibi Source Type: research
Successful treatment with tofacitinib for anti-melanoma differentiation-associated gene 5 antibody-positive juvenile dermatomyositis: case reports and review of the literature
We describe two female Japanese patients with anti-MDA5 Ab + JDM and rapidly progressive interstitial lung disease who achieved remission by adding tofacitinib to existing immunosuppressive drugs and present a literature review. While both patients received various immunosuppressive or anti-inflammatory treatments for induction therapy, remission could not be achieved. Subsequently, tofacitinib was administered to reduce the Krebs von den Lungen-6 level 5 months after diagnosis in one patient; the other patient received tofacitinib 4 months after diagnosis to reduce ferritin levels and skin manifestations. Subsequently, bo...
Source: Herpes - April 1, 2024 Category: Infectious Diseases Authors: Susumu Yamazaki Masaki Shimizu Ayane Yakabe Eisuke Inage Keisuke Jimbo Mitsuyoshi Suzuki Futaba Miyaoka Shuya Kaneko Hitoshi Irabu Asami Shimbo Yoshiyuki Ohtomo Masaaki Mori Tomohiro Morio Toshiaki Shimizu Source Type: research
Eczema Herpeticum Complicating Atopic Dermatitis: A Rare Presentation
Cureus. 2024 Feb 28;16(2):e55171. doi: 10.7759/cureus.55171. eCollection 2024 Feb.ABSTRACTAtopic dermatitis (AD) has become a global health concern due to an increase in its frequency over the past few decades. This illness not only reduces the quality of life but also imposes a considerable financial burden due to the increased risk of skin infections. This case report explores the presentation of a four-month-old male infant with a personal history of atopic dermatitis that developed yellow scaly lesions on the scalp, which were assumed to be cradle cap. However, there was a clinical worsening of the cutaneous lesions, w...
Source: Herpes - April 1, 2024 Category: Infectious Diseases Authors: Mariana Pedro Marta Caldas Fernanda Neves Sara Diogo Fabiana Fortunato Source Type: research
AEDV Expert Document on the management of ulcerative venereal infections
Actas Dermosifiliogr. 2024 Mar 29:S0001-7310(24)00267-9. doi: 10.1016/j.ad.2024.03.021. Online ahead of print.ABSTRACTCurrently, ulcerative sexually transmitted infections, including syphilis, herpes simplex virus (HSV), lymphogranuloma venereum (LGV), chancroid, donovanosis and, more recently, monkeypox (MPOX), represent a growing challenge for health care professionals. The incidence of syphilis and LGV has increased in recent years in Spain. Additionally, HSV, syphilis and chancroid can also increase the risk of HIV acquisition and transmission. The population groups most vulnerable to these infections are young people,...
Source: Herpes - March 31, 2024 Category: Infectious Diseases Authors: Caridad E Morales Francisco Montoya Nicol ás de Loredo Elena Sendagorta Source Type: research
AEDV Expert Document on the management of ulcerative venereal infections
Actas Dermosifiliogr. 2024 Mar 29:S0001-7310(24)00267-9. doi: 10.1016/j.ad.2024.03.021. Online ahead of print.ABSTRACTCurrently, ulcerative sexually transmitted infections, including syphilis, herpes simplex virus (HSV), lymphogranuloma venereum (LGV), chancroid, donovanosis and, more recently, monkeypox (MPOX), represent a growing challenge for health care professionals. The incidence of syphilis and LGV has increased in recent years in Spain. Additionally, HSV, syphilis and chancroid can also increase the risk of HIV acquisition and transmission. The population groups most vulnerable to these infections are young people,...
Source: Actas Dermo-Sifiliograficas - March 31, 2024 Category: Dermatology Authors: Caridad E Morales Francisco Montoya Nicol ás de Loredo Elena Sendagorta Source Type: research
AEDV Expert Document on the management of ulcerative venereal infections
Actas Dermosifiliogr. 2024 Mar 29:S0001-7310(24)00267-9. doi: 10.1016/j.ad.2024.03.021. Online ahead of print.ABSTRACTCurrently, ulcerative sexually transmitted infections, including syphilis, herpes simplex virus (HSV), lymphogranuloma venereum (LGV), chancroid, donovanosis and, more recently, monkeypox (MPOX), represent a growing challenge for health care professionals. The incidence of syphilis and LGV has increased in recent years in Spain. Additionally, HSV, syphilis and chancroid can also increase the risk of HIV acquisition and transmission. The population groups most vulnerable to these infections are young people,...
Source: Herpes - March 31, 2024 Category: Infectious Diseases Authors: Caridad E Morales Francisco Montoya Nicol ás de Loredo Elena Sendagorta Source Type: research
AEDV Expert Document on the management of ulcerative venereal infections
Actas Dermosifiliogr. 2024 Mar 29:S0001-7310(24)00267-9. doi: 10.1016/j.ad.2024.03.021. Online ahead of print.ABSTRACTCurrently, ulcerative sexually transmitted infections, including syphilis, herpes simplex virus (HSV), lymphogranuloma venereum (LGV), chancroid, donovanosis and, more recently, monkeypox (MPOX), represent a growing challenge for health care professionals. The incidence of syphilis and LGV has increased in recent years in Spain. Additionally, HSV, syphilis and chancroid can also increase the risk of HIV acquisition and transmission. The population groups most vulnerable to these infections are young people,...
Source: Actas Dermo-Sifiliograficas - March 31, 2024 Category: Dermatology Authors: Caridad E Morales Francisco Montoya Nicol ás de Loredo Elena Sendagorta Source Type: research
AEDV Expert Document on the management of ulcerative venereal infections
Actas Dermosifiliogr. 2024 Mar 29:S0001-7310(24)00267-9. doi: 10.1016/j.ad.2024.03.021. Online ahead of print.ABSTRACTCurrently, ulcerative sexually transmitted infections, including syphilis, herpes simplex virus (HSV), lymphogranuloma venereum (LGV), chancroid, donovanosis and, more recently, monkeypox (MPOX), represent a growing challenge for health care professionals. The incidence of syphilis and LGV has increased in recent years in Spain. Additionally, HSV, syphilis and chancroid can also increase the risk of HIV acquisition and transmission. The population groups most vulnerable to these infections are young people,...
Source: Actas Dermo-Sifiliograficas - March 31, 2024 Category: Dermatology Authors: Caridad E Morales Francisco Montoya Nicol ás de Loredo Elena Sendagorta Source Type: research
GSE247024 m1A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating PD-L1 expression
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA N1-methyladenosine methylation (m1A) modification is critical in regulating mRNA translation and thus protein synthesis, but the role of m1A modification in the occurrence, progression, and immunotherapy of head and neck squamous cell cancer (HNSCC) remains largely unknown. In Tgfbr1/Pten 2cKO mice, we found that the spontaneous neoplastic transformation of oral mucosa is accompanied by elevated levels of m1A modification. Analysis of m1A-associated genes identified TRMT61A as the key m1A writer associated with cancer progression, an...
Source: GEO: Gene Expression Omnibus - March 31, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
The conserved RNP motif of the herpes simplex virus 1 family B DNA polymerase is crucial for viral DNA synthesis but not polymerase activity
Virology. 2024 Mar 3;594:110035. doi: 10.1016/j.virol.2024.110035. Online ahead of print.ABSTRACTThe herpes simplex virus 1 DNA polymerase contains a highly conserved structural motif found in most family B polymerases and certain RNA-binding proteins. To investigate its importance within cells, we constructed a mutant virus with substitutions in two residues of the motif and a rescued derivative. The substitutions resulted in severe impairment of plaque formation, yields of infectious virus, and viral DNA synthesis while not meaningfully affecting expression of the mutant enzyme, its co-localization with the viral single-...
Source: Virology - March 30, 2024 Category: Virology Authors: Jessica L Lawler Shariya Terrell Donald M Coen Source Type: research
Function of autophagy genes in innate immune defense against mucosal pathogens
Curr Opin Microbiol. 2024 Mar 29;79:102456. doi: 10.1016/j.mib.2024.102456. Online ahead of print.ABSTRACTMucosal immunity is posed to constantly interact with commensal microbes and invading pathogens. As a fundamental cell biological pathway affecting immune response, autophagy regulates the interaction between mucosal immunity and microbes through multiple mechanisms, including direct elimination of microbes, control of inflammation, antigen presentation and lymphocyte homeostasis, and secretion of immune mediators. Some of these physiologically important functions do not involve canonical degradative autophagy but rely...
Source: Current Opinion in Microbiology - March 30, 2024 Category: Microbiology Authors: Xiaoyan Cui Ya-Ting Wang Source Type: research
Function of autophagy genes in innate immune defense against mucosal pathogens
Curr Opin Microbiol. 2024 Mar 29;79:102456. doi: 10.1016/j.mib.2024.102456. Online ahead of print.ABSTRACTMucosal immunity is posed to constantly interact with commensal microbes and invading pathogens. As a fundamental cell biological pathway affecting immune response, autophagy regulates the interaction between mucosal immunity and microbes through multiple mechanisms, including direct elimination of microbes, control of inflammation, antigen presentation and lymphocyte homeostasis, and secretion of immune mediators. Some of these physiologically important functions do not involve canonical degradative autophagy but rely...
Source: Herpes - March 30, 2024 Category: Infectious Diseases Authors: Xiaoyan Cui Ya-Ting Wang Source Type: research
The conserved RNP motif of the herpes simplex virus 1 family B DNA polymerase is crucial for viral DNA synthesis but not polymerase activity
Virology. 2024 Mar 3;594:110035. doi: 10.1016/j.virol.2024.110035. Online ahead of print.ABSTRACTThe herpes simplex virus 1 DNA polymerase contains a highly conserved structural motif found in most family B polymerases and certain RNA-binding proteins. To investigate its importance within cells, we constructed a mutant virus with substitutions in two residues of the motif and a rescued derivative. The substitutions resulted in severe impairment of plaque formation, yields of infectious virus, and viral DNA synthesis while not meaningfully affecting expression of the mutant enzyme, its co-localization with the viral single-...
Source: Herpes - March 30, 2024 Category: Infectious Diseases Authors: Jessica L Lawler Shariya Terrell Donald M Coen Source Type: research
