Movement disorders associated with pediatric encephalitis
Handb Clin Neurol. 2024;200:229-238. doi: 10.1016/B978-0-12-823912-4.00018-9.ABSTRACTNew onset movement disorders are a common clinical problem in pediatric neurology and can be infectious, inflammatory, metabolic, or functional in origin. Encephalitis is one of the more important causes of new onset movement disorders, and movement disorders are a common feature (~25%) of all encephalitis. However, all encephalitides are not the same, and movement disorders are a key diagnostic feature that can help the clinician identify the etiology of the encephalitis, and therefore appropriate treatment is required. Movement disorders...
Source: Herpes - March 17, 2024 Category: Infectious Diseases Authors: Russell C Dale Shekeeb S Mohammad Source Type: research
Characteristics of reproductive tract infections caused by common pathogens among the outpatients of reproductive medicine center in Putian: retrospective study
CONCLUSIONS: This study showed that UU was the most frequently identified pathogen in infertile men in Putian, Fujian Province. The CT infection rate was the highest in people under 20 years old, and the infection showed a tendency toward young individuals. Therefore, the publicity of sexual health knowledge must be strengthened, and the prevention and treatment of venereal diseases among young and middle-aged people must be improved. Moreover, the pathogen infection is related to infertility to a certain extent, which is conducive to clinical diagnosis and treatment.PMID:38486167 | DOI:10.1186/s12879-024-09180-9 (Source: Herpes)
Source: Herpes - March 15, 2024 Category: Infectious Diseases Authors: Jiancheng Zeng Tingli Wu Laiping Wang Liumin Yu Hua Lin Zhanfei Chen Source Type: research
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo
Acta Pharm Sin B. 2024 Mar;14(3):1362-1379. doi: 10.1016/j.apsb.2023.10.004. Epub 2023 Oct 13.ABSTRACTExtracellular vesicles (EVs) have recently emerged as a promising delivery platform for CRISPR/Cas9 ribonucleoproteins (RNPs), owing to their ability to minimize off-target effects and immune responses. However, enhancements are required to boost the efficiency and safety of Cas9 RNP enrichment within EVs. In response, we employed the Fc/Spa interaction system, in which the human Fc domain was fused to the intracellular domain of PTGFRN-Δ687 and anchored to the EV membrane. Simultaneously, the B domain of the Spa protein ...
Source: Herpes - March 15, 2024 Category: Infectious Diseases Authors: Yuanda Wan Liren Li Ruilin Chen Jiajia Han Qiyun Lei Zhipeng Chen Xiaodong Tang Wenyu Wu Shuwen Liu Xingang Yao Source Type: research
Trigeminal Neuralgia Secondary to Herpes Simplex Virus Type 1 Infection Treated With Oral Acyclovir
We report the case of a 30-year-old woman who developed oral HSV-1 lesions followed by right-sided TN pain. MRI of the brain did not reveal neurovascular compression. TN pain completely resolved with oral acyclovir treatment alone, without anticonvulsants. This highlights the importance of considering atypical etiologies such as HSV-1 reactivation in TN evaluation. Early antiviral therapy may treat underlying inflammation and provide sustained symptom relief in HSV-associated TN.PMID:38487110 | PMC:PMC10939157 | DOI:10.7759/cureus.54128 (Source: Herpes)
Source: Herpes - March 15, 2024 Category: Infectious Diseases Authors: Amal J Alfaifi Ohood S Wasli Thamer M Almalki Ahmad Y Alqassim Source Type: research
Trigeminal Neuralgia Secondary to Herpes Simplex Virus Type 1 Infection Treated With Oral Acyclovir
We report the case of a 30-year-old woman who developed oral HSV-1 lesions followed by right-sided TN pain. MRI of the brain did not reveal neurovascular compression. TN pain completely resolved with oral acyclovir treatment alone, without anticonvulsants. This highlights the importance of considering atypical etiologies such as HSV-1 reactivation in TN evaluation. Early antiviral therapy may treat underlying inflammation and provide sustained symptom relief in HSV-associated TN.PMID:38487110 | PMC:PMC10939157 | DOI:10.7759/cureus.54128 (Source: Herpes)
Source: Herpes - March 15, 2024 Category: Infectious Diseases Authors: Amal J Alfaifi Ohood S Wasli Thamer M Almalki Ahmad Y Alqassim Source Type: research
Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo
Acta Pharm Sin B. 2024 Mar;14(3):1362-1379. doi: 10.1016/j.apsb.2023.10.004. Epub 2023 Oct 13.ABSTRACTExtracellular vesicles (EVs) have recently emerged as a promising delivery platform for CRISPR/Cas9 ribonucleoproteins (RNPs), owing to their ability to minimize off-target effects and immune responses. However, enhancements are required to boost the efficiency and safety of Cas9 RNP enrichment within EVs. In response, we employed the Fc/Spa interaction system, in which the human Fc domain was fused to the intracellular domain of PTGFRN-Δ687 and anchored to the EV membrane. Simultaneously, the B domain of the Spa protein ...
Source: Herpes - March 15, 2024 Category: Infectious Diseases Authors: Yuanda Wan Liren Li Ruilin Chen Jiajia Han Qiyun Lei Zhipeng Chen Xiaodong Tang Wenyu Wu Shuwen Liu Xingang Yao Source Type: research
Characteristics of reproductive tract infections caused by common pathogens among the outpatients of reproductive medicine center in Putian: retrospective study
CONCLUSIONS: This study showed that UU was the most frequently identified pathogen in infertile men in Putian, Fujian Province. The CT infection rate was the highest in people under 20 years old, and the infection showed a tendency toward young individuals. Therefore, the publicity of sexual health knowledge must be strengthened, and the prevention and treatment of venereal diseases among young and middle-aged people must be improved. Moreover, the pathogen infection is related to infertility to a certain extent, which is conducive to clinical diagnosis and treatment.PMID:38486167 | PMC:PMC10941379 | DOI:10.1186/s12879-024...
Source: Herpes - March 15, 2024 Category: Infectious Diseases Authors: Jiancheng Zeng Tingli Wu Laiping Wang Liumin Yu Hua Lin Zhanfei Chen Source Type: research
GSE261599 Therapeutic Prime/Pull Vaccination of HSV-2 Infected Guinea Pigs with the Ribonucleotide Reductase 2 (RR2) and CXCL11 boosts TRM and TEM CD4+/CD8+ T cells to protect from recurrent genital herpes
Contributors : Afshana Quadiri ; Swayam Prakash ; Lbachir BenMohamedSeries Type : Expression profiling by high throughput sequencingOrganism : Cavia porcellusFollowing acute herpes simplex virus type 2 (HSV-2) infection, the virus undergoes an asymptomatic latent infection of sensory neurons of dorsal root ganglia (DRG). Chemical and physical stress cause intermittent virus reactivation from latently infected DRG and recurrent virus shedding in the genital mucosal epithelium causing genital herpes in symptomatic patients. While T-cells appear to play a role in controlling virus reactivation from DRG and reducing the sev...
Source: GEO: Gene Expression Omnibus - March 14, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Cavia porcellus Source Type: research
Infection risk and antimicrobial prophylaxis in bendamustine-treated patients with indolent non-Hodgkin lymphoma: An Australasian Lymphoma Alliance study
Br J Haematol. 2024 Mar 14. doi: 10.1111/bjh.19407. Online ahead of print.ABSTRACTInfection and lymphopenia are established bendamustine-related complications. The relationship between lymphopenia severity and infection risk, and the role of antimicrobial prophylaxis, is not well described. This multicentre retrospective study analysed infection characteristics and antimicrobial prophylaxis in 302 bendamustine-treated indolent non-Hodgkin lymphoma patients. Lymphopenia (<1 × 109 /L) was near universal and time to lymphocyte recovery correlated with cumulative bendamustine dose. No association between lymphopenia severi...
Source: Herpes - March 14, 2024 Category: Infectious Diseases Authors: Kate Manos Leonid Churilov Andrew Grigg Pietro Di Ciaccio Jonathan Wong Usha Chandra Sekaran Joel Wight Zhong Goh Hayden Jina Llewyn Butler Costas K Yannakou Nada Hamad Gareth P Gregory Shane Gangatharan Tara Cochrane Eliza A Hawkes Masa Lasica Source Type: research
Infection risk and antimicrobial prophylaxis in bendamustine-treated patients with indolent non-Hodgkin lymphoma: An Australasian Lymphoma Alliance study
Br J Haematol. 2024 Mar 14. doi: 10.1111/bjh.19407. Online ahead of print.ABSTRACTInfection and lymphopenia are established bendamustine-related complications. The relationship between lymphopenia severity and infection risk, and the role of antimicrobial prophylaxis, is not well described. This multicentre retrospective study analysed infection characteristics and antimicrobial prophylaxis in 302 bendamustine-treated indolent non-Hodgkin lymphoma patients. Lymphopenia (<1 × 109 /L) was near universal and time to lymphocyte recovery correlated with cumulative bendamustine dose. No association between lymphopenia severi...
Source: Herpes - March 14, 2024 Category: Infectious Diseases Authors: Kate Manos Leonid Churilov Andrew Grigg Pietro Di Ciaccio Jonathan Wong Usha Chandra Sekaran Joel Wight Zhong Goh Hayden Jina Llewyn Butler Costas K Yannakou Nada Hamad Gareth P Gregory Shane Gangatharan Tara Cochrane Eliza A Hawkes Masa Lasica Source Type: research
The associations of herpes simplex virus and varicella zoster virus infection with dementia: a nationwide retrospective cohort study
CONCLUSIONS: Individual HSV and VZV infections were associated with an increased risk of all types of dementia, including AD and VD. Patients co-infected with HSV and VZV, VZV infection in the eye, CNS, or complicated type were more vulnerable to the development of dementia.PMID:38475873 | DOI:10.1186/s13195-024-01418-7 (Source: Herpes)
Source: Herpes - March 13, 2024 Category: Infectious Diseases Authors: Eunhae Shin Sang Ah Chi Tae-Young Chung Hee Jin Kim Kyunga Kim Dong Hui Lim Source Type: research
Vaginal Lactobacilli Supernatants Protect from Herpes Simplex Virus Type 1 Infection in Cell Culture Models
In this report, we analyze the activity of supernatants of vaginal lactobacilli against HSV-1 infection, which is becoming increasingly relevant as a STI. We show that the supernatants of two vaginal Lactobacillus species (i.e., L. crispatus and L. gasseri) were active at neutralizing HSV-1 infection in two different cell lines of human and simian origin. Specifically, we demonstrate that L. crispatus strains are the most effective in antiviral activity, as evidenced by the comparison with a vaginal pathogen taken as reference. The effect was specific and not attributable to the generic toxicity of the supernatants to the ...
Source: Herpes - March 13, 2024 Category: Infectious Diseases Authors: Elisa Avitabile Laura Menotti Barbara Giordani Vanessa Croatti Carola Parolin Beatrice Vitali Source Type: research
Production and characterization of rhamnolipids by Pseudomonas aeruginosa isolated in the Amazon region, and potential antiviral, antitumor, and antimicrobial activity
Sci Rep. 2024 Mar 12;14(1):4629. doi: 10.1038/s41598-024-54828-w.ABSTRACTBiosurfactants encompass structurally and chemically diverse molecules with surface active properties, and a broad industrial deployment, including pharmaceuticals. The interest is growing mainly for the low toxicity, biodegradability, and production from renewable sources. In this work, the optimized biosurfactant production by Pseudomonas aeruginosa BM02, isolated from the soil of a mining area in the Brazilian Amazon region was assessed, in addition to its antiviral, antitumor, and antimicrobial activities. The optimal conditions for biosurfactant ...
Source: Herpes - March 13, 2024 Category: Infectious Diseases Authors: Sidnei Cerqueira Dos Santos Chayenna Ara újo Torquato Darlisson de Alexandria Santos Alexandre Orsato Karoline Leite Juliana Mara Serpeloni Roberta Losi-Guembarovski Erica Rom ão Pereira Andr é Luiz Dyna Mario Gabriel Lopes Barboza Matheus Hideki Ferna Source Type: research
Production and characterization of rhamnolipids by Pseudomonas aeruginosa isolated in the Amazon region, and potential antiviral, antitumor, and antimicrobial activity
Sci Rep. 2024 Mar 12;14(1):4629. doi: 10.1038/s41598-024-54828-w.ABSTRACTBiosurfactants encompass structurally and chemically diverse molecules with surface active properties, and a broad industrial deployment, including pharmaceuticals. The interest is growing mainly for the low toxicity, biodegradability, and production from renewable sources. In this work, the optimized biosurfactant production by Pseudomonas aeruginosa BM02, isolated from the soil of a mining area in the Brazilian Amazon region was assessed, in addition to its antiviral, antitumor, and antimicrobial activities. The optimal conditions for biosurfactant ...
Source: Herpes - March 13, 2024 Category: Infectious Diseases Authors: Sidnei Cerqueira Dos Santos Chayenna Ara újo Torquato Darlisson de Alexandria Santos Alexandre Orsato Karoline Leite Juliana Mara Serpeloni Roberta Losi-Guembarovski Erica Rom ão Pereira Andr é Luiz Dyna Mario Gabriel Lopes Barboza Matheus Hideki Ferna Source Type: research
Vaginal Lactobacilli Supernatants Protect from Herpes Simplex Virus Type 1 Infection in Cell Culture Models
In this report, we analyze the activity of supernatants of vaginal lactobacilli against HSV-1 infection, which is becoming increasingly relevant as a STI. We show that the supernatants of two vaginal Lactobacillus species (i.e., L. crispatus and L. gasseri) were active at neutralizing HSV-1 infection in two different cell lines of human and simian origin. Specifically, we demonstrate that L. crispatus strains are the most effective in antiviral activity, as evidenced by the comparison with a vaginal pathogen taken as reference. The effect was specific and not attributable to the generic toxicity of the supernatants to the ...
Source: Herpes - March 13, 2024 Category: Infectious Diseases Authors: Elisa Avitabile Laura Menotti Barbara Giordani Vanessa Croatti Carola Parolin Beatrice Vitali Source Type: research
