Function of autophagy genes in innate immune defense against mucosal pathogens
Curr Opin Microbiol. 2024 Mar 29;79:102456. doi: 10.1016/j.mib.2024.102456. Online ahead of print.ABSTRACTMucosal immunity is posed to constantly interact with commensal microbes and invading pathogens. As a fundamental cell biological pathway affecting immune response, autophagy regulates the interaction between mucosal immunity and microbes through multiple mechanisms, including direct elimination of microbes, control of inflammation, antigen presentation and lymphocyte homeostasis, and secretion of immune mediators. Some of these physiologically important functions do not involve canonical degradative autophagy but rely...
Source: Current Opinion in Microbiology - March 30, 2024 Category: Microbiology Authors: Xiaoyan Cui Ya-Ting Wang Source Type: research
The conserved RNP motif of the herpes simplex virus 1 family B DNA polymerase is crucial for viral DNA synthesis but not polymerase activity
Virology. 2024 Mar 3;594:110035. doi: 10.1016/j.virol.2024.110035. Online ahead of print.ABSTRACTThe herpes simplex virus 1 DNA polymerase contains a highly conserved structural motif found in most family B polymerases and certain RNA-binding proteins. To investigate its importance within cells, we constructed a mutant virus with substitutions in two residues of the motif and a rescued derivative. The substitutions resulted in severe impairment of plaque formation, yields of infectious virus, and viral DNA synthesis while not meaningfully affecting expression of the mutant enzyme, its co-localization with the viral single-...
Source: Virology - March 30, 2024 Category: Virology Authors: Jessica L Lawler Shariya Terrell Donald M Coen Source Type: research
Systemic lupus erythematosus associated with erythema multiforme: A rare case report of Rowell's syndrome
Clin Case Rep. 2024 Mar 26;12(4):e8677. doi: 10.1002/ccr3.8677. eCollection 2024 Apr.ABSTRACTKEY CLINICAL MESSAGE: Although it is very uncommon, SLE may initially present with recurrent episodes of EM-like rash. Despite the various possibilities underlying their association, prompt identification, and treatment of SLE in patients presenting with EM is important to prevent death or serious organ damage.ABSTRACT: Rowell's syndrome (RS) is an uncommon presentation of systemic lupus erythematosus (SLE) with erythema multiforme (EM)-like lesions associated with specific serological changes, including positive rheumatoid factor ...
Source: Herpes - March 29, 2024 Category: Infectious Diseases Authors: Madhur Bhattarai Niraj Kumar Sharma Shreeram Paudel Sujata Bhandari Amrit Bhusal Kiran Dhonju Sandip Kuikel Shivendra Kumar Jha Egesh Aryal Deepak Subedi Source Type: research
Human Enterovirus B Is a Significant Cause of Aseptic Meningitis and Sepsis-Like Illness in Young Infants in Thailand
This study tested clinical samples from hospitalized young infants with suspected aseptic meningitis or sepsis-like illness between 2013 and 2022 for EV, PeV, and Herpes simplex virus (HSV). Of 95 specimens, 10 were positive for EV, representing 10.5%. These positive samples included eight CSF and two stool samples. No samples were positive for PeV and HSV. Of these positive cases, EV-B was detected in eight, and EV-A was detected in two cases. The species of EV-B detected include echovirus-18 (E18) (n=2), E21 (n=2), E4(n=1), E5 (n=1), E9 (n=1), and E11 (n=1). Our report demonstrates the significant role of EV-B, and less ...
Source: Herpes - March 29, 2024 Category: Infectious Diseases Authors: Jira Chansaenroj Preeyaporn Vichaiwattana Jiratchaya Puenpa Thaksaporn Thatsanathorn Natthinee Sudhinaraset Nasamon Wanlapakorn Yong Poovorawan Source Type: research
Systemic lupus erythematosus associated with erythema multiforme: A rare case report of Rowell's syndrome
Clin Case Rep. 2024 Mar 26;12(4):e8677. doi: 10.1002/ccr3.8677. eCollection 2024 Apr.ABSTRACTKEY CLINICAL MESSAGE: Although it is very uncommon, SLE may initially present with recurrent episodes of EM-like rash. Despite the various possibilities underlying their association, prompt identification, and treatment of SLE in patients presenting with EM is important to prevent death or serious organ damage.ABSTRACT: Rowell's syndrome (RS) is an uncommon presentation of systemic lupus erythematosus (SLE) with erythema multiforme (EM)-like lesions associated with specific serological changes, including positive rheumatoid factor ...
Source: Herpes - March 29, 2024 Category: Infectious Diseases Authors: Madhur Bhattarai Niraj Kumar Sharma Shreeram Paudel Sujata Bhandari Amrit Bhusal Kiran Dhonju Sandip Kuikel Shivendra Kumar Jha Egesh Aryal Deepak Subedi Source Type: research
Human Enterovirus B Is a Significant Cause of Aseptic Meningitis and Sepsis-Like Illness in Young Infants in Thailand
This study tested clinical samples from hospitalized young infants with suspected aseptic meningitis or sepsis-like illness between 2013 and 2022 for EV, PeV, and Herpes simplex virus (HSV). Of 95 specimens, 10 were positive for EV, representing 10.5%. These positive samples included eight CSF and two stool samples. No samples were positive for PeV and HSV. Of these positive cases, EV-B was detected in eight, and EV-A was detected in two cases. The species of EV-B detected include echovirus-18 (E18) (n=2), E21 (n=2), E4(n=1), E5 (n=1), E9 (n=1), and E11 (n=1). Our report demonstrates the significant role of EV-B, and less ...
Source: Herpes - March 29, 2024 Category: Infectious Diseases Authors: Jira Chansaenroj Preeyaporn Vichaiwattana Jiratchaya Puenpa Thaksaporn Thatsanathorn Natthinee Sudhinaraset Nasamon Wanlapakorn Yong Poovorawan Source Type: research
DDX20 positively regulates the interferon pathway to inhibit viral infection
This study provides new evidence that DDX20 positively modulates the interferon pathway and restricts viral infection.PMID:38552910 | DOI:10.1016/j.antiviral.2024.105875 (Source: Herpes)
Source: Herpes - March 29, 2024 Category: Infectious Diseases Authors: Zhiqiang Chen Jinyu Zhang Tingting Feng Xiujuan Wang Shimeng Zhou Wen Pan Zhengrong Chen Yongdong Yan Jianfeng Dai Source Type: research
DDX20 positively regulates the interferon pathway to inhibit viral infection
This study provides new evidence that DDX20 positively modulates the interferon pathway and restricts viral infection.PMID:38552910 | DOI:10.1016/j.antiviral.2024.105875 (Source: Antiviral Research)
Source: Antiviral Research - March 29, 2024 Category: Virology Authors: Zhiqiang Chen Jinyu Zhang Tingting Feng Xiujuan Wang Shimeng Zhou Wen Pan Zhengrong Chen Yongdong Yan Jianfeng Dai Source Type: research
Human Enterovirus B Is a Significant Cause of Aseptic Meningitis and Sepsis-Like Illness in Young Infants in Thailand
This study tested clinical samples from hospitalized young infants with suspected aseptic meningitis or sepsis-like illness between 2013 and 2022 for EV, PeV, and Herpes simplex virus (HSV). Of 95 specimens, 10 were positive for EV, representing 10.5%. These positive samples included eight CSF and two stool samples. No samples were positive for PeV and HSV. Of these positive cases, EV-B was detected in eight, and EV-A was detected in two cases. The species of EV-B detected include echovirus-18 (E18) (n=2), E21 (n=2), E4(n=1), E5 (n=1), E9 (n=1), and E11 (n=1). Our report demonstrates the significant role of EV-B, and less ...
Source: Herpes - March 29, 2024 Category: Infectious Diseases Authors: Jira Chansaenroj Preeyaporn Vichaiwattana Jiratchaya Puenpa Thaksaporn Thatsanathorn Natthinee Sudhinaraset Nasamon Wanlapakorn Yong Poovorawan Source Type: research
Systemic lupus erythematosus associated with erythema multiforme: A rare case report of Rowell's syndrome
Clin Case Rep. 2024 Mar 26;12(4):e8677. doi: 10.1002/ccr3.8677. eCollection 2024 Apr.ABSTRACTKEY CLINICAL MESSAGE: Although it is very uncommon, SLE may initially present with recurrent episodes of EM-like rash. Despite the various possibilities underlying their association, prompt identification, and treatment of SLE in patients presenting with EM is important to prevent death or serious organ damage.ABSTRACT: Rowell's syndrome (RS) is an uncommon presentation of systemic lupus erythematosus (SLE) with erythema multiforme (EM)-like lesions associated with specific serological changes, including positive rheumatoid factor ...
Source: Herpes - March 29, 2024 Category: Infectious Diseases Authors: Madhur Bhattarai Niraj Kumar Sharma Shreeram Paudel Sujata Bhandari Amrit Bhusal Kiran Dhonju Sandip Kuikel Shivendra Kumar Jha Egesh Aryal Deepak Subedi Source Type: research
DDX20 positively regulates the interferon pathway to inhibit viral infection
This study provides new evidence that DDX20 positively modulates the interferon pathway and restricts viral infection.PMID:38552910 | DOI:10.1016/j.antiviral.2024.105875 (Source: Herpes)
Source: Herpes - March 29, 2024 Category: Infectious Diseases Authors: Zhiqiang Chen Jinyu Zhang Tingting Feng Xiujuan Wang Shimeng Zhou Wen Pan Zhengrong Chen Yongdong Yan Jianfeng Dai Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Two Waves of Specific B Cell Memory Immunoreconstruction Observed in Anti-HHV1-3 IgG Kinetics after Hematopoietic Stem Cell Transplantation
CONCLUSIONS: As is typical for infancy, the kinetics of the IgG level is unique after HSCT (the decline phase is first). Host microbiome factors (e.g., HHV1-3-serostatus) should be taken into account to predict risk of non-relapse mortality and survival after HSCT. The levels of specific antibodies help in predicting prognoses and improve disease management. A lack of differentiation and the confusing bias of the assessor (i.e., observer selection bias) are the main obstacles in statistical HHV1-3 research. Such time-lapse case studies may be the first to build evidence of a pathway and an association between immune parame...
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Przemyslaw Zdziarski Andrzej Gamian Source Type: research
Decrease in Heparan Sulphate Binding in Tropism-Retargeted Oncolytic Herpes Simplex Virus (ReHV) Delays Blood Clearance and Improves Systemic Anticancer Efficacy
Cancers (Basel). 2024 Mar 13;16(6):1143. doi: 10.3390/cancers16061143.ABSTRACTThe role of the interaction with cell-surface glycosaminoglycans (GAGs) during in vivo HSV infection is currently unknown. The rationale of the current investigation was to improve the anticancer efficacy of systemically administered retargeted oHSVs (ReHVs) by decreasing their binding to GAGs, including those of endothelial cells, blood cells, and off-tumor tissues. As a proof-of-principle approach, we deleted seven amino acids critical for interacting with GAGs from the glycoprotein C (gC) of R-337 ReHV. The modification in the resulting R-399 ...
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Andrea Vannini Federico Parenti Cristina Forghieri Gaia Vannini Catia Barboni Anna Zaghini Tatiana Gianni Gabriella Campadelli-Fiume Source Type: research
Urinary Viral Spectrum in Patients with Interstitial Cystitis/Bladder Pain Syndrome and the Clinical Efficacy of Valacyclovir Treatment
Biomedicines. 2024 Feb 26;12(3):522. doi: 10.3390/biomedicines12030522.ABSTRACTOur previous study showed that the Epstein-Barr virus (EBV) may be the etiology for some patients with interstitial cystitis/bladder pain syndrome (IC/BPS); hence, the current study aimed to investigate the urinary viral spectrum in patients with IC/BPS and the clinical efficacy of valacyclovir. Twenty-eight patients were prospectively enrolled for valacyclovir 500 mg twice a day for 4 weeks. Urine samples were collected from IC/BPS patients and 30 controls. The primary outcome was the difference in the visual analog scale (VAS) pain score, and ...
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Hann-Chorng Kuo Chih-Wen Peng Yuan-Hong Jiang Jia-Fong Jhang Source Type: research
