Antimicrobial Efficacy of a Vegetable Oil Plasticizer in PVC Matrices
Polymers (Basel). 2024 Apr 10;16(8):1046. doi: 10.3390/polym16081046.ABSTRACTThe growing prevalence of bacterial and viral infections, highlighted by the recent COVID-19 pandemic, urgently calls for new antimicrobial strategies. To this end, we have synthesized and characterized a novel fatty acid epoxy-ester plasticizer for polymers, named GDE. GDE is not only sustainable and user-friendly but also demonstrates superior plasticizing properties, while its epoxy components improve the heat stability of PVC-based matrices. A key feature of GDE is its ability to confer antimicrobial properties to surfaces. Indeed, upon contac...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Greta Bajetto Sara Scutera Francesca Menotti Giuliana Banche Giuseppe Chiaradia Caterina Turesso Marco De Andrea Marta Vallino Daan S Van Es Matteo Biolatti Valentina Dell'Oste Tiziana Musso Source Type: research
Ligand-Free Silver Nanoparticles: An Innovative Strategy against Viruses and Bacteria
Microorganisms. 2024 Apr 18;12(4):820. doi: 10.3390/microorganisms12040820.ABSTRACTThe spread of antibiotic-resistant bacteria and the rise of emerging and re-emerging viruses in recent years constitute significant public health problems. Therefore, it is necessary to develop new antimicrobial strategies to overcome these challenges. Herein, we describe an innovative method to synthesize ligand-free silver nanoparticles by Pulsed Laser Ablation in Liquid (PLAL-AgNPs). Thus produced, nanoparticles were characterized by total X-ray fluorescence, zeta potential analysis, transmission electron microscopy (TEM), and nanoparticl...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Maria Vittoria Morone Annalisa Chianese Federica Dell'Annunziata Veronica Folliero Erwin Pavel Lamparelli Giovanna Della Porta Carla Zannella Anna De Filippis Gianluigi Franci Massimiliano Galdiero Antonio Morone Source Type: research
Herpesviridae and Atypical Bacteria Co-Detections in Lower Respiratory Tract Samples of SARS-CoV-2-Positive Patients Admitted to an Intensive Care Unit
Microorganisms. 2024 Mar 31;12(4):714. doi: 10.3390/microorganisms12040714.ABSTRACTShortly after the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), cases of viral, bacterial, and fungal coinfections in hospitalized patients became evident. This retrospective study investigates the prevalence of multiple pathogen co-detections in 1472 lower respiratory tract (LRT) samples from 229 SARS-CoV-2-positive patients treated in the largest intensive care unit (ICU) in Slovenia. In addition to SARS-CoV-2, (rt)RT-PCR tests were used to detect cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex ...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Ga šper Grubelnik Mi ša Korva Rok Kogoj Tina Polanc Matej Mavri č Monika Jev šnik Virant Tina Ur šič Darja Ke še Katja Seme Miroslav Petrovec Matja ž Jereb Tatjana Av šič-Županc Source Type: research
Clinical and Demographic Characteristics of Herpetic Keratitis Patients-Tertiary Centre Experience
Conclusions: To the best of our knowledge, this is the first prospective study in Croatia, and one of the few in Europe, to describe the demographic and clinical features of HSK patients. We found that HSK is most common in the elderly population, with its dendritic form as a clinical presentation. We have shown that HSK is prone to recurrence and secondary complications, with a worryingly long time between symptom and treatment, indicating the need for diagnostic testing in routine practice.PMID:38674223 | DOI:10.3390/medicina60040577 (Source: Herpes)
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Petra Grube šić Igor Jurak Tea Čaljkušić-Mance Andrej Belan čić Aron Grube šić Source Type: research
Herpesviridae and Atypical Bacteria Co-Detections in Lower Respiratory Tract Samples of SARS-CoV-2-Positive Patients Admitted to an Intensive Care Unit
Microorganisms. 2024 Mar 31;12(4):714. doi: 10.3390/microorganisms12040714.ABSTRACTShortly after the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), cases of viral, bacterial, and fungal coinfections in hospitalized patients became evident. This retrospective study investigates the prevalence of multiple pathogen co-detections in 1472 lower respiratory tract (LRT) samples from 229 SARS-CoV-2-positive patients treated in the largest intensive care unit (ICU) in Slovenia. In addition to SARS-CoV-2, (rt)RT-PCR tests were used to detect cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex ...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Ga šper Grubelnik Mi ša Korva Rok Kogoj Tina Polanc Matej Mavri č Monika Jev šnik Virant Tina Ur šič Darja Ke še Katja Seme Miroslav Petrovec Matja ž Jereb Tatjana Av šič-Županc Source Type: research
Clinical and Demographic Characteristics of Herpetic Keratitis Patients-Tertiary Centre Experience
Conclusions: To the best of our knowledge, this is the first prospective study in Croatia, and one of the few in Europe, to describe the demographic and clinical features of HSK patients. We found that HSK is most common in the elderly population, with its dendritic form as a clinical presentation. We have shown that HSK is prone to recurrence and secondary complications, with a worryingly long time between symptom and treatment, indicating the need for diagnostic testing in routine practice.PMID:38674223 | PMC:PMC11052461 | DOI:10.3390/medicina60040577 (Source: Herpes)
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Petra Grube šić Igor Jurak Tea Čaljkušić-Mance Andrej Belan čić Aron Grube šić Source Type: research
Antimicrobial Efficacy of a Vegetable Oil Plasticizer in PVC Matrices
Polymers (Basel). 2024 Apr 10;16(8):1046. doi: 10.3390/polym16081046.ABSTRACTThe growing prevalence of bacterial and viral infections, highlighted by the recent COVID-19 pandemic, urgently calls for new antimicrobial strategies. To this end, we have synthesized and characterized a novel fatty acid epoxy-ester plasticizer for polymers, named GDE. GDE is not only sustainable and user-friendly but also demonstrates superior plasticizing properties, while its epoxy components improve the heat stability of PVC-based matrices. A key feature of GDE is its ability to confer antimicrobial properties to surfaces. Indeed, upon contac...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Greta Bajetto Sara Scutera Francesca Menotti Giuliana Banche Giuseppe Chiaradia Caterina Turesso Marco De Andrea Marta Vallino Daan S Van Es Matteo Biolatti Valentina Dell'Oste Tiziana Musso Source Type: research
Ligand-Free Silver Nanoparticles: An Innovative Strategy against Viruses and Bacteria
Microorganisms. 2024 Apr 18;12(4):820. doi: 10.3390/microorganisms12040820.ABSTRACTThe spread of antibiotic-resistant bacteria and the rise of emerging and re-emerging viruses in recent years constitute significant public health problems. Therefore, it is necessary to develop new antimicrobial strategies to overcome these challenges. Herein, we describe an innovative method to synthesize ligand-free silver nanoparticles by Pulsed Laser Ablation in Liquid (PLAL-AgNPs). Thus produced, nanoparticles were characterized by total X-ray fluorescence, zeta potential analysis, transmission electron microscopy (TEM), and nanoparticl...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Maria Vittoria Morone Annalisa Chianese Federica Dell'Annunziata Veronica Folliero Erwin Pavel Lamparelli Giovanna Della Porta Carla Zannella Anna De Filippis Gianluigi Franci Massimiliano Galdiero Antonio Morone Source Type: research
Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
Cell Rep Med. 2024 Apr 23:101528. doi: 10.1016/j.xcrm.2024.101528. Online ahead of print.ABSTRACTStimulator of interferon genes (STING)-dependent signaling is requisite for effective anti-microbial and anti-tumor activity. STING signaling is commonly defective in cancer cells, which enables tumor cells to evade the immunosurveillance system. We evaluate here whether intrinsic STING signaling in such tumor cells could be reconstituted by creating recombinant herpes simplex viruses (rHSVs) that express components of the STING signaling pathway. We observe that rHSVs expressing STING and/or cGAS replicate inefficiently yet re...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Tiphaine Delaunay Sehee Son Seongji Park Balveen Kaur Jeonghyun Ahn Glen N Barber Source Type: research
A Review of the Association between Infections, Seizures, and Drugs
CONCLUSION: Due to changes in drug metabolism, co-administration of antiseizure drugs and antibiotics may lead to an enhanced risk of seizures. In patients with neurocysticercosis, cerebral malaria, viral encephalitis, bacterial meningitis, tuberculosis, and human immunodeficiency virus, the evidence-based study recommended different mechanisms mediating epileptogenic properties of toxins and drugs.PMID:38676494 | DOI:10.2174/0118715249288932240416071636 (Source: Herpes)
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Zahra Tolou-Ghamari Source Type: research
Herpes simplex encephalitis in France: incidence, 6-month rehospitalizations and mortality
CONCLUSION: In France, the incidence of hospitalizations for HSE was 2.3 per 1,000,000 inhabitants with more than half of the patients admitted in ICU and a 6-month in-hospital mortality about 16.5%. This real-life update on the characteristics and severe outcomes of the disease raises awareness among care practitioners, of the serious nature of the disease, and thus can lead to higher vigilance.PMID:38678152 | DOI:10.1007/s15010-024-02272-3 (Source: Herpes)
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Ambre Sauvage Emeline Laurent Christophe Gaborit Antoine Guillon Leslie Grammatico-Guillon Source Type: research
Neonatal herpes: case series in two obstetric centres over a 10-year period (2013-2023), France
Conclusion: This case series confirms that neonates at risk for HSV disease and poor outcome are those born to HSV-seronegative mothers, preterm infants, and those who received acyclovir after onset of symptoms (mainly because mothers did not present evidence of acute HSV infection). Our study confirms the major role of HSV-1 and the frequency of its early post-natal acquisition. What is known: • Neonatal herpes simplex virus infection is rare but motality and morbidity rates are high after disseminted disease and encephalitis. National recommendations exist worldwide but mangement of this disease is not always easy. Wha...
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Elise Bouthry Vincent Portet-Sulla Melek Manai Bouokazi Claire P érillaud-Dubois Fran çois-Charles Javaugue Laure Jule Claire Boithias Nolwenn Le Sach é Mostafa Mokhtari Diane Carri ère Louise Sonnier Rafik Benammar Alexandra Letourneau Alexandre J Vi Source Type: research
Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity
PLoS Pathog. 2024 Apr 26;20(4):e1012146. doi: 10.1371/journal.ppat.1012146. eCollection 2024 Apr.ABSTRACTApoptosis is a critical host antiviral defense mechanism. But many viruses have evolved multiple strategies to manipulate apoptosis and escape host antiviral immune responses. Herpesvirus infection regulated apoptosis; however, the underlying molecular mechanisms have not yet been fully elucidated. Hence, the present study aimed to study the relationship between herpesvirus infection and apoptosis in vitro and in vivo using the pseudorabies virus (PRV) as the model virus. We found that mitochondria-dependent apoptosis w...
Source: Herpes - April 26, 2024 Category: Infectious Diseases Authors: Qiongqiong Zhou Deshi Shi Yan-Dong Tang Longfeng Zhang Boli Hu Chunfu Zheng Li Huang Changjiang Weng Source Type: research
An Assessment of a New Rapid Multiplex PCR Assay for the Diagnosis of Meningoencephalitis
Conclusions: A high correlation of the QIAstat-Dx ME panel with reference methods was shown. QIAstat-Dx ME is a rapid-PCR technique to be applied in patients with suspected ME with a high accuracy.PMID:38667448 | DOI:10.3390/diagnostics14080802 (Source: Herpes)
Source: Herpes - April 26, 2024 Category: Infectious Diseases Authors: Genoveva Cuesta Pedro Puerta-Alcalde Andrea Vergara Enric Roses Jordi Bosch Climent Casals-Pascual Alex Soriano M ª Ángeles Marcos Sergi Sanz Jordi Vila Source Type: research
An Assessment of a New Rapid Multiplex PCR Assay for the Diagnosis of Meningoencephalitis
Conclusions: A high correlation of the QIAstat-Dx ME panel with reference methods was shown. QIAstat-Dx ME is a rapid-PCR technique to be applied in patients with suspected ME with a high accuracy.PMID:38667448 | PMC:PMC11048994 | DOI:10.3390/diagnostics14080802 (Source: Herpes)
Source: Herpes - April 26, 2024 Category: Infectious Diseases Authors: Genoveva Cuesta Pedro Puerta-Alcalde Andrea Vergara Enric Roses Jordi Bosch Climent Casals-Pascual Alex Soriano M ª Ángeles Marcos Sergi Sanz Jordi Vila Source Type: research
