The associations of herpes simplex virus and varicella zoster virus infection with dementia: a nationwide retrospective cohort study
CONCLUSIONS: Individual HSV and VZV infections were associated with an increased risk of all types of dementia, including AD and VD. Patients co-infected with HSV and VZV, VZV infection in the eye, CNS, or complicated type were more vulnerable to the development of dementia.PMID:38475873 | PMC:PMC10935826 | DOI:10.1186/s13195-024-01418-7 (Source: Herpes)
Source: Herpes - March 13, 2024 Category: Infectious Diseases Authors: Eunhae Shin Sang Ah Chi Tae-Young Chung Hee Jin Kim Kyunga Kim Dong Hui Lim Source Type: research
RNA-Seq time-course analysis of neural precursor cell transcriptome in response to herpes simplex Virus-1 infection
J Neurovirol. 2024 Mar 13. doi: 10.1007/s13365-024-01198-8. Online ahead of print.ABSTRACTThe neurogenic niches within the central nervous system serve as essential reservoirs for neural precursor cells (NPCs), playing a crucial role in neurogenesis. However, these NPCs are particularly vulnerable to infection by the herpes simplex virus 1 (HSV-1). In the present study, we investigated the changes in the transcriptome of NPCs in response to HSV-1 infection using bulk RNA-Seq, compared to those of uninfected samples, at different time points post infection and in the presence or absence of antivirals. The results showed tha...
Source: Herpes - March 13, 2024 Category: Infectious Diseases Authors: Joel A Wood Srilakshmi Chaparala Cecilia Bantang Ansuman Chattopadhyay Maribeth A Wesesky Paul R Kinchington Vishwajit L Nimgaonkar David C Bloom Leonardo D'Aiuto Source Type: research
Cancers, Vol. 16, Pages 1143: Decrease in Heparan Sulphate Binding in Tropism-Retargeted Oncolytic Herpes Simplex Virus (ReHV) Delays Blood Clearance and Improves Systemic Anticancer Efficacy
ampadelli-Fiume
The role of the interaction with cell-surface glycosaminoglycans (GAGs) during in vivo HSV infection is currently unknown. The rationale of the current investigation was to improve the anticancer efficacy of systemically administered retargeted oHSVs (ReHVs) by decreasing their binding to GAGs, including those of endothelial cells, blood cells, and off-tumor tissues. As a proof-of-principle approach, we deleted seven amino acids critical for interacting with GAGs from the glycoprotein C (gC) of R-337 ReHV. The modification in the resulting R-399 recombinant prolonged the half-life in the blood of system...
Source: Cancers - March 13, 2024 Category: Cancer & Oncology Authors: Andrea Vannini Federico Parenti Cristina Forghieri Gaia Vannini Catia Barboni Anna Zaghini Tatiana Gianni Gabriella Campadelli-Fiume Tags: Article Source Type: research
RNA-Seq time-course analysis of neural precursor cell transcriptome in response to herpes simplex Virus-1 infection
AbstractThe neurogenic niches within the central nervous system serve as essential reservoirs for neural precursor cells (NPCs), playing a crucial role in neurogenesis. However, these NPCs are particularly vulnerable to infection by the herpes simplex virus 1 (HSV-1). In the present study, we investigated the changes in the transcriptome of NPCs in response to HSV-1 infection using bulk RNA-Seq, compared to those of uninfected samples, at different time points post infection and in the presence or absence of antivirals. The results showed that NPCs upon HSV-1 infection undergo a significant dysregulation of genes playing a...
Source: Journal of NeuroVirology - March 13, 2024 Category: Neurology Source Type: research
Downregulation of endogenous nectin1 in human keratinocytes by herpes simplex virus 1 glycoprotein D excludes superinfection but does not affect NK cell function
J Gen Virol. 2024 Mar;105(3). doi: 10.1099/jgv.0.001969.ABSTRACTMany viruses downregulate their cognate receptors, facilitating virus replication and pathogenesis via processes that are not yet fully understood. In the case of herpes simplex virus 1 (HSV1), the receptor binding protein glycoprotein D (gD) has been implicated in downregulation of its receptor nectin1, but current understanding of the process is limited. Some studies suggest that gD on the incoming virion is sufficient to achieve nectin1 downregulation, but the virus-encoded E3 ubiquitin ligase ICP0 has also been implicated. Here we have used the physiologic...
Source: Herpes - March 12, 2024 Category: Infectious Diseases Authors: Joanne Kite Monica Hill Natasha Preston Anzelika Rubina Simon Kollnberger Eddie Chung Yern Wang Gillian Elliott Source Type: research
Clinical features of atypical presentations of mucocutaneous herpes simplex virus infection observed in immunosuppressed individuals. Part I: herpetic geometric glossitis
Herpetic geometric glossitis is a unique morphologic variant of HSV (herpes simplex virus) type 1 infection on the dorsum of the tongue that presents as an extremely painful linear central lingual fissure with a branched pattern. in the center of the tongue; there is a branched pattern of fissures that extend bilaterally from the central linear fissure. Herpetic geometric glossitis has been reported in 11 patients; 8 of these individuals were immunocompromised. Medical conditions and immunosuppressive medication treatment (7 patients) or only medical disorders (3 patients) or neither (1 patient) were present. HSV type 1 in...
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Cohen, Philip R Source Type: research
Clinical features of atypical presentations of mucocutaneous herpes simplex virus infection observed in immunosuppressed individuals. Part II: the knife-cut sign
The knife-cut sign is a distinctive manifestation of herpes simplex virus (HSV) type 1 or HSV type 2 infection that has been described in at least 10 immunocompromised patients. It appears as an extremely painful linear erosion or fissure in an intertriginous area such as the body folds beneath the breast, or within the abdomen, or in the inguinal region. Also, concurrent HSV infection at other mucocutaneous sites, or viscera, or both have been observed. The patients had medical conditions (at least 9 patients) and/or immunosuppressive drug therapy (6 patients). The diagnosis of HSV infection was confirmed by viral culture...
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Cohen, Philip R Source Type: research
Trabectedin Enhances Oncolytic Virotherapy by Reducing Barriers to Virus Spread and Cytotoxic Immunity in Preclinical Pediatric Bone Sarcoma
bioRxiv [Preprint]. 2024 Mar 3:2024.03.02.582994. doi: 10.1101/2024.03.02.582994.ABSTRACTWe previously reported that the DNA alkylator and transcriptional-blocking chemotherapeutic agent trabectedin enhances oncolytic herpes simplex viroimmunotherapy in human sarcoma xenograft models, though the mechanism remained to be elucidated. Here we report trabectedin disrupts the intrinsic cellular anti-viral response which increases viral transcript spread throughout the human tumor cells. We also extended our synergy findings to syngeneic murine sarcoma models, which are poorly susceptible to virus infection. In the absence of ro...
Source: Herpes - March 11, 2024 Category: Infectious Diseases Authors: Emily M Ringwalt Mark A Currier Andrea M Glaspell Chun-Yu Chen Matthew V Cannon Maren Cam Amy C Gross Matthew Gust Pin-Yi Wang Louis Boon Laura E Biederman Emily Schwarz Prajwal Rajappa Dean A Lee Elaine R Mardis William E Carson Ryan D Roberts Timothy P Source Type: research
Resorbable nanofibrous membranes for local and sustained co-delivery of acyclovir and ketorolac in herpes therapy
This study used electrospinning to develop biodegradable nanofibrous poly(lactic-co-glycolic acid) (PLGA) membranes for delivery of both acyclovir and ketorolac. The structure of the spun nanofibers was assessed via scanning electron microscopy (SEM), and the appearance of loaded acyclovir and ketorolac in the nanofibers was confirmed with Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Release profiles of these drugs from the nanofibrous membranes were assessed using in vitro elution studies, high-performance liquid chromatography (HPLC) assays, and in vivo drug release patterns...
Source: Herpes - March 11, 2024 Category: Infectious Diseases Authors: Shih-Jyun Shen Pin-Chao Feng Ren-Chin Wu Yi-Hua Kuo Shih-Jung Liu Hiroshi Ito Source Type: research
Exploring Heparanase Levels in Tears: Insights From Herpes Simplex Virus-1 Keratitis Patients and Animal Studies
CONCLUSIONS: To the best of our knowledge, this study is the first to report elevated HPSE levels in the tears of patients with different forms of HSV-1 keratitis, and it confirms similar findings in a murine model, providing a valuable basis for future in vivo and clinical research on HSV-1 ocular infection.PMID:38466284 | DOI:10.1167/iovs.65.3.7 (Source: Herpes)
Source: Herpes - March 11, 2024 Category: Infectious Diseases Authors: Satyashree Gagan Agimanailiu Khapuinamai Divya Kapoor Pankaj Sharma Tejabhiram Yadavalli Joveeta Joseph Deepak Shukla Bhupesh Bagga Source Type: research
HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
Cell Rep. 2024 Mar 9;43(3):113788. doi: 10.1016/j.celrep.2024.113788. Online ahead of print.ABSTRACTHistone deacetylases (HDACs) regulate gene expression and innate immunity. Previously, we showed that HDAC5 is degraded during Vaccinia virus (VACV) infection and is a restriction factor for VACV and herpes simplex virus type 1. Here, we report that HDAC5 promotes interferon regulatory factor 3 (IRF3) activation downstream of Toll-IL-1 receptor (TIR) domain-containing adaptor molecule-1 or Sendai virus-mediated stimulation without requiring HDAC activity. Loss of HDAC5-mediated IRF3 activation is restored by re-introduction ...
Source: Herpes - March 10, 2024 Category: Infectious Diseases Authors: Yongxu Lu Yiqi Zhao Chen Gao Shreehari Suresh Jinghao Men Amelia Sawyers Geoffrey L Smith Source Type: research
HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
Cell Rep. 2024 Mar 9;43(3):113788. doi: 10.1016/j.celrep.2024.113788. Online ahead of print.ABSTRACTHistone deacetylases (HDACs) regulate gene expression and innate immunity. Previously, we showed that HDAC5 is degraded during Vaccinia virus (VACV) infection and is a restriction factor for VACV and herpes simplex virus type 1. Here, we report that HDAC5 promotes interferon regulatory factor 3 (IRF3) activation downstream of Toll-IL-1 receptor (TIR) domain-containing adaptor molecule-1 or Sendai virus-mediated stimulation without requiring HDAC activity. Loss of HDAC5-mediated IRF3 activation is restored by re-introduction ...
Source: Herpes - March 10, 2024 Category: Infectious Diseases Authors: Yongxu Lu Yiqi Zhao Chen Gao Shreehari Suresh Jinghao Men Amelia Sawyers Geoffrey L Smith Source Type: research
Organotypic model of the gingiva for studying bacterial and viral pathogens implicated in periodontitis
CONCLUSIONS: Presented OTG model constitutes a simple and convenient tool to study the interaction between bacterial and viral pathogens within the gingival tissue, including penetration, persistence and biofilm formation. It is also suitable to examine the efficiency of antimicrobial drugs.PMID:38456121 | PMC:PMC10919308 | DOI:10.1080/20002297.2023.2292382 (Source: Journal of Oral Microbiology)
Source: Journal of Oral Microbiology - March 8, 2024 Category: Microbiology Authors: Anna Golda Anna Gasiorek Ewelina Dobosz Zuzanna Oruba Richard J Lamont Jan Potempa Joanna Koziel Source Type: research
Neonatal herpes simplex virus encephalitis with intracranial bleeding in a newborn baby with concurrent rhesus incompatibility
We report a baby with neonatal herpes simplex virus (HSV) encephalitis concurrent with Rrhesus (Rh) incompatibility. He was delivered by a Ggravida 2 mother with a history of miscarriage in her previous pregnancy at a gestation age of 4 months. She had Bblood group 0 and Rrhesus negative. The baby was noticed to have jaundice on day one1 of life accompanied by generalised petechiae on the face and upper chest. A full blood picture revealed severe anaemia and severe thrombocytopaenia and HSV 1/2 IgM was positive. MRI of the brain showed multiple extensive haemorrhagic lesions on the frontal-temporal regions.PMID:38458763 | ...
Source: Herpes - March 8, 2024 Category: Infectious Diseases Authors: Pascal Clemence Haika Mariki Martha Mkony Karim Premji Manji Source Type: research
Four new resin glycosides from Ipomoea muricata seeds: muricatins XIV-XVII
J Nat Med. 2024 Mar 8. doi: 10.1007/s11418-024-01787-1. Online ahead of print.ABSTRACTIpomoea muricata (L.) Jacq. seeds (Convolvulaceae) are used as a traditional laxative and carminative medicine. Muricatins XIV (1), XV (2), XVI (3), and XVII (4), were isolated from I. muricata seeds as four new resin glycosides, along with seven known compounds, three of which were isolated for the first time as natural products; their structures were determined using MS and NMR spectroscopy. Compounds 1-4 are macrolactones (jalapins); the sugar moieties of 1, 2, and 4 are partially acylated with 2S-methylbutyric acid, while that of 3 is...
Source: Herpes - March 8, 2024 Category: Infectious Diseases Authors: Masateru Ono Daiki Tenmaya Maki Tarumi Syouri Satou Kotone Tsuji Hirotaka Nishikawa Shin Yasuda Hiroyuki Miyashita Jian-Rong Zhou Kazumi Yokomizo Hitoshi Yoshimitsu Ryota Tsuchihashi Masafumi Okawa Junei Kinjo Source Type: research
