Reflectance confocal microscopy for the diagnosis of skin infections and infestations
This article provides an overview of the current available applications of RCM use in cutaneous infections and infestations. PubMed was used to search the following terms in various combinations: reflectance confocal microscopy, skin, hair, nail, infection, parasitosis, mycosis, virus, bacteria. All papers were accordingly reviewed. In most cutaneous infections or infestations, the main alterations are found in the epidermis and upper dermis, where the accuracy of confocal microscopy is nearly similar to that of histopathology. The high resolution of this technique allows the visualization of most skin parasites, fungi, an...
Source: Dermatology Online Journal - May 6, 2020 Category: Dermatology Source Type: research

Unusual case of Paget disease of the nipple diagnosed by nipple scraping cytology
We present a rare case of Paget disease of the nipple without the typical characteristics, detected by simple nipple scraping technique. A 62-year-old woman presented with a small fissure on the left nipple with scant clear nippledischarge. There were no other changes to the nipple-areola complex. The mammography and ultrasound were unremarkable. However, nipplescraping provided the immediate cytological diagnosis of Paget disease. Breast MRI with core biopsy showed high grade ductal carcinoma in situwith suggestion of microinvasion, confirmed histologically after mastectomy. Nipple scraping is a simple and inexpensive tec...
Source: Dermatology Online Journal - May 4, 2020 Category: Dermatology Source Type: research

Corrigendum: Thiotepa hyperpigmentation preceding epidermal necrosis: malignant intertrigo misdiagnosed as Stevens-Johnson syndrome-toxic epidermal necrolysis overlap
The original article was published on February 15, 2020 and corrected on March 15, 2020.The revised version of the article corrects the contact information of the Corresponding Author. The changes appear in the revised online PDF copy of this article. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - May 4, 2020 Category: Dermatology Source Type: research

Sweet syndrome with pulmonary involvement in a patient with myelodysplastic syndrome
We report a patient with Sweet syndrome involving the pulmonary system in the context of myelodysplastic syndrome. Although Sweet syndrome may involve a variety of organ systems, the pulmonary system is rarely affected and can result in poor clinical outcomes, including acute respiratory distress syndrome. Both cutaneous and pulmonary symptoms respond well to systemic corticosteroid therapy and early diagnosis and treatment can improve the prognosis. Our case highlights the importance of collaboration between hematologists, dermatologists, and pulmonologists to facilitate effective diagnosis, triage, and treatment of these...
Source: Dermatology Online Journal - May 4, 2020 Category: Dermatology Source Type: research

A review of intralesional wart therapy
Background: New treatment options for warts include intralesional wart injection with agents such as vitamin D, measles, mumps, and rubella (MMR) vaccine antigen, Bacillus Calmette-Guerin (BCG) antigen, and candida antigen but there have been limited studies to compare their efficacies. Background: New treatment options for warts include intralesional wart injection with agents such as vitamin D, measles, mumps, and rubella (MMR) vaccine antigen, Bacillus Calmette-Guerin (BCG) antigen, and candida antigen but there have been limited studies to compare their efficacies. Objective: The purpose of this systematic review is to...
Source: Dermatology Online Journal - May 4, 2020 Category: Dermatology Source Type: research

Eosinophilic dermatosis of hematologic malignancy: a case report
We report a case of eosinophilic dermatosis of hematologic malignancy in a patient with a hematoproliferative disorder. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - May 4, 2020 Category: Dermatology Source Type: research

A review of non-pharmacologic approaches to enhance the patient experience in dermatologic surgery
Efforts to increase patient comfort by minimizing pain and anxiety have been shown to improve clinical outcomes, reduce pain thresholds, decrease analgesic requirements and complication risk, strengthen the physician-patient relationship, and increase overall patient satisfaction. Patients also have a strong preference for patient-centered communication and educational discussion with physicians. In recent years, the increasing emphasis on patient experience scores as a metric for quality care has had significant implications for physician practice and has reinforced attempts to provide more patient-centered care. Though d...
Source: Dermatology Online Journal - May 4, 2020 Category: Dermatology Source Type: research

Publication rates on the topic of racial and ethnic diversity in dermatology versus other specialties
Background: The population of the U.S. is becoming more diverse every year. The field of dermatology is not following the same trend. Objective: To assess the promotion of diversity in the field of dermatology by analyzing publications focused on diversity, compared to other specialties. Methods: The PubMed database was systematically searched to identify publications focused on diversity from January 2008 to July 2019. The search criteria were as follows: dermatology/radiology/ophthalmology/ anesthesiology/orthopedic surgery/family medicine/ internal medicine/general surgery AND diversity/ diverse/racial/race/ethnic/ethni...
Source: Dermatology Online Journal - May 1, 2020 Category: Dermatology Source Type: research

Successful non-operative treatment of eruptive keratoacanthomas refractory to excision
We present a 68-year-old man who developed multiple eruptive keratoacanthomas around the wound edge of a previous keratoacanthoma excision. Considering previous excisional failure, intralesional 5-fluorouracil was used as a treatment modality. Injections every 3-4 weeks over a course of 12 weeks induced clinical keratoacanthoma clearance with excellent cosmetic results. This case showcases that weekly intralesional 5-fluorouracil injections, as was the standard mode of treatment in previous case reports, may not be necessary. This less frequent injection strategy is more convenient for the patient and may lead to fewer... ...
Source: Dermatology Online Journal - May 1, 2020 Category: Dermatology Source Type: research

A lumpy back: extensive cutaneous collagenomas
A widespread form of eruptive collagenomas in a 12-year-old man is presented for the impressive iconography, challenging differential diagnosis, and histopathological considerations associated with such rare connective tissue disorders. Syndromic forms should be carefully investigated for the different course and prognosis. Treatment is a major unsolved issue as aesthetic concerns are significant, especially in young adults. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - May 1, 2020 Category: Dermatology Source Type: research

A case of resistant pityriasis ribra pilaris responsive to combination acitrentin and ustekinumab
We report a patient with resistant pityriasis rubra pilaris who dramatically improved with acitretin and ustekinumab, a combination not well documented in the literature. The purpose of this letter is to emphasize the potential benefit of dual therapy in patients who fail traditional pityriasis rubra pilaris treatment regimens. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - May 1, 2020 Category: Dermatology Source Type: research

A case of new-onset vitiligo in a patient on tofacitinib and brief review of paradoxical presentations with other novel targeted therapies
We report a 36-year-old woman with a history of rheumatoid arthritis, refractory to multiple pharmacotherapies, who was initiated on tofacitinib and subsequently developed progressive depigmented patches consistent with new-onset vitiligo. Although definitive causation cannot be established in this case without additional studies, it is important to note that many targeted therapies have the potential to induce paradoxical effects, that is, the occurrence or exacerbation of pathologic conditions that have been shown to... (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - May 1, 2020 Category: Dermatology Source Type: research

Women ’s representation at an academic dermatology conference: trending upwards, but not equal yet
This study investigates the number of male and female symposium speakers at the American Academy of Dermatology annual meetings over a three-year period and compares research productivity and academic rank between the men and women invited to speak. The results demonstrate a steady increase in the representation of female symposium speakers at the conference from 2016 to 2018, although a higher proportion of invited male speakers hold professorships and leadership positions. This upward trend in women's representation may translate to more opportunities for female engagement in academic dermatology. Although women make up ...
Source: Dermatology Online Journal - May 1, 2020 Category: Dermatology Source Type: research

Squamous cell carcinoma of the dorsal hands and feet after repeated exposure to ultraviolet nail lamps
Gel nails are a common artificial nail option. Ultraviolet (UV) nail lamps are commonly used to cure gel nails. Ultraviolet A radiation is a known mutagen that penetrates into the nail bed. Although previously reported, the role of UV nail lamps in the carcinogenesis of both keratinocyte carcinoma and melanoma remains controversial. Herein, we report a patient taking the photosensitizing agent hydrochlorothiazide who developed numerous squamous cell carcinomas on the dorsal hands and feet with a 10-year history of UV nail light exposure every 2-3 weeks. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - May 1, 2020 Category: Dermatology Source Type: research

Utilization of Facebook for support and education by patients with skin cancer
The expanding role of social media in medical care has resulted in dermatology patients seeking support online regarding personal experience with diagnosis and treatment of skin cancer. Owing to increased privacy settings in closed Facebook groups, the current study analyzed themes of keratinocyte carcinoma patients ’ posts within a relatively private social media network. Although the majority of messages included sharing personal experience and provided psychosocial support (50%), there were a significant number of posts offering medical advice (35%), with the majority of such replies being unsupported by e vidence...
Source: Dermatology Online Journal - May 1, 2020 Category: Dermatology Source Type: research

Public social media consultations for dermatologic conditions: an online survey
This study examines the role of public social media consultations for dermatologic conditions. A large portion of patients utilize social media for dermatologic consultations and many do not seek care from a dermatologist afterward. Future studies should trend this phenomenon, especially as the use of social media continues to expand. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - May 1, 2020 Category: Dermatology Source Type: research

Lichenoid inflammation of DSAP lesions following treatment with durvalumab, olaparib and paclitaxel: A potential diagnostic pitfall mimicking lichenoid drug eruptions associated with PDL-1 inhibitors
We present a novel case of chemotherapy-associated DSAP inflammation in a 66-year-old woman after triple therapy with durvalumab (PD-L1 inhibitor), olaparib (PARP inhibitor) and paclitaxel, showing similarities to primary lichen planus-like eruption from immune checkpoint inhibitors. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - May 1, 2020 Category: Dermatology Source Type: research

Analyzing China ’s contributions to major dermatologic journals from the past 20 years
Background: Over the past 20 years, China has experienced an increased popularity of Western medicine. The impact of Western medicine in China on the field of dermatology is not well characterized. Objective: To assess the impact China has had on the field of dermatology by analyzing the total publications to six dermatological journals, compared to two other Asian countries: Japan and Korea. Methods: PubMed was utilized to search for publications from China, Japan, and Korea within the past 20 years. Descriptive statistics were used to determine the average percentage change in publications during this 20-year period, and...
Source: Dermatology Online Journal - May 1, 2020 Category: Dermatology Source Type: research

Nuclear matrix protein 2 antibody-positive adult dermatomyositis: a case report and review of the literature
Dermatomyositis is a clinically heterogenous inflammatory myopathy with unique cutaneous features. Myositis-specific antibodies can aid in diagnosis and anticipation of patient prognosis. Herein, we report a 22-year-old man who presented with multifocal erythematous plaques with violaceous papules on his bilateral elbows, neck, and face. He was diagnosed with biopsy-proven dermatomyositis and determined to be seropositive for nuclear matrix protein 2 antibody (NXP-2). He was treated with systemic corticosteroids, then intravenous methylprednisolone and azathioprine, and ultimately achieved greatest treatment response with ...
Source: Dermatology Online Journal - May 1, 2020 Category: Dermatology Source Type: research

A case of eosinophilic fasciitis and generalized morphea overlap
A 60-year old man developed skin hardening and edema on his extremities. Although he had been treated with oral prednisolone at another hospital, skin stiffness relapsed during tapering of prednisolone. At the initial visit to our department, physical examination showed skin hardening of the extremities and also symmetric erythematous macules on the back. Histological examination revealed fasciitis on the forearm and morphea on the back. Eosinophilic fasciitis is occasionally associated with morphea. However, cases of concurrent eosinophilic fasciitis and generalized morphea are rare. In the present case, CD34 was differen...
Source: Dermatology Online Journal - March 27, 2020 Category: Dermatology Source Type: research

Transient acantholytic dermatosis in a patient with prostate cancer
Transient acantholytic dermatosis (TAD) is a relatively common entity that has been also noted to occur in patients with cancer. Herein, we describe a case of transient acantholytic dermatosis occurring in a patient with a history of prostate cancer status post radiation, now being treated with combination therapy with pembrolizumab and carboplatin-pemetrexed for advanced lung adenocarcinoma. Our case emphasizes the importance of being cognizant of TAD and its associations, particularly in cancer patients. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

A patient with anti-NXP2-positive dermatomyositis and syphilis
We present a patient with active syphilis infection who developed dermatomyositis and discuss the significance of anti-NXP2 autoantibody positivity. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

Follicular occlusion triad: an isotopic response or adverse effect of rituximab?
We present a 26-year-old man with a history of pemphigus foliaceus (PF) who developed large draining nodules with scarring and sinus tracts, compatible with follicular occlusion triad, preferentially at areas previously affected by PF thirteen months after treatment with rituximab. To the authors' knowledge there are no reported cases of follicular occlusion triad or HS manifesting as an isotopic response. However, one member of the triad, HS, has been reported to occur infrequently following the use of biologic agents... (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

Long-term follow-up of 22 psoriatic patients treated with ixekizumab after failure of secukinumab
The original article was published on February 15, 2020 and corrected on March 26, 2020. The revised version of the article amends the table and figure, while leaving the text largely unchanged. The changes appear in the revised online PDF copy of this article. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

The use of drug calendars for the diagnosis of cutaneous drug eruptions in the age of electronic medical records
A morbilliform drug eruption is the most common condition leading to a dermatology consultation for a patient in the hospital. Timing is an important diagnostic tool since the onset of a skin rash usually takes place within days-to-weeks of the start of the implicated drug. A comprehensive, thorough, and reliable drug history by the clinician is essential. Therefore, to assist in the task of determining the causative medication of a new skin rash in a hospitalized patient, the creation of a drug calendar is recommended. The development of an electronic version of the drug calendar offers several benefits over the manual ve...
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

Violaceous nodules in an HIV-positive man
We present an HIV-positive man with PBL that presented as ulcers and violaceous exophytic nodules on the legs. The clinical features, histologic appearance, and differential diagnosis of this malignancy are briefly reviewed. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

Thiotepa hyperpigmentation preceding epidermal necrosis: malignant intertrigo misdiagnosed as Stevens-Johnson syndrome-toxic epidermal necrolysis overlap
Thiotepa is a common alkylating agent known to precipitate cutaneous reactions consistent with toxic erythema of chemotherapy, including erythema and hyperpigmentation. Herein, we describe an atypical case of malignant intertrigo involving preferential erythema and desquamation not only of skin folds but also of occluded areas after thiotepa-based conditioning. The diagnosis was complicated by concurrent stomatitis and oral petechiae in the setting of autologous stem cell transplant 11 days prior for diffuse large B-cell lymphoma. Histopathological examination from two cutaneous sites demonstrated epidermal dysmaturation a...
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

Adult-onset porokeratotic eccrine ostial and dermal duct nevus:dermatoscopic findings and treatment with tazarotene
We report herein a new case of adultonset PEODDN with dermatoscopic images. Our patient responded favorably to topical tazarotene. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

A case of atypical disseminated herpes simplex virus 1 with hepatitis in a liver transplant recipient: the need for dermatologic evaluation
Disseminated herpes simplex virus (HSV) is mainly seen in immunocompromised individuals. Atypical lesions can be present in both primary infection and reactivation disease. Compared with the general population, inmunocompromised hosts are at greater risk of increased persistency and severity of clinical manifestations, including severe systemic involvement such as esophagitis, meningitis, and hepatitis. Herein, we report the case of a liver transplant recipient with atypical disseminated herpes simplex virus-1 complicated by HSV-related hepatitis. Dermatological consultation and histological assessment were crucial for a c...
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

BRAF inhibitor and hairy cell leukemia-related transient acantholytic dermatosis
Grover disease (GD) is an acquired, nonfamilial, nonimmune mediated, transient or persistent acantholytic dermatosis. Herein, we present a 72-year-old man who had clinical and histopathologic findings of GD following two weeks of treatment with vemurafenib without MEK inhibitor. The patient was successfully treated with topical emollients and a high-potency corticosteroid. Meanwhile, vemurafenib was temporarily discontinued. Drug-induced GD has increasingly been reported in patients on BRAF inhibitor monotherapy as an immune-related adverse event. The cutaneous side effects seem to arise secondary to a paradoxical activati...
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

Bullous aplasia cutis congenita: A rare presentation of a rare disease
Aplasia cutis congenita (ACC) is a congenital disorder characterized by localized or generalized absence of skin. Bullous aplasia cutis congenita (BACC) is a rare clinical subtype that has few documented reports in the literature. Herein, we present a new case of BACC in which the bulla was unruptured at birth. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

A case of tinea incognito mimicking subcorneal pustular dermatosis
An 89-year-old woman presented with plaque-like lesions, accompanied with pustules and desquamation on the back and front of the trunk for approximately one year. Long term use of potent topical corticosteroids was ineffective. Because of the chronicity of her condition, the diagnoses of subcorneal dermatosis or subcorneal pustular dermatosis type of IgA pemphigus were considered. However, fungal hyphae were observed in the potassium hydroxide examination. Therefore, we present this case since this clinical appearance of tinea incognito can also mimic various pustular dermatoses. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

Erythema nodosum induced by oral isotretinoin in a patient with condylomata acuminata
We present herein a 20-year-old woman with multiple vulvar condylomata acuminata who developed EN two weeks after onset of oral isotretinoin therapy. To the best of our knowledge, this is the first report of EN occurring during isotretinoin treatment in a patient without acne and strongly indicates that the pathogenesis of EN can be directly related to the biological actions of isotretinoin. Erythema nodosum should be regarded as a rare... (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

A unique case of prurigo pigmentosa related to ketogenic diet
Prurigo pigmentosa is a rare inflammatory dermatosis that primarily affects Japanese patients. Various triggers have been identified, including the ketogenic diet. Given the current popularity of the ketogenic diet, the incidence of prurigo pigmentosa may be on the rise. Herein, to the best of our knowledge, we present the first case of prurigo pigmentosa reported in a Hispanic patient in the United States. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

Gram-negative infections in patients with folliculitis decalvans: a subset of patients requiring alternative treatment
Conclusion We present the largest cohort of folliculitis decalvans patients with gram-negative infections, suggesting the... (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

Nevus sebaceus with syringocystadenoma papilliferum, prurigo nodularis, apocrine cystadenoma, basaloid follicular proliferation, and sebaceoma: case report and review of nevus sebaceus-associated conditions
Nevus sebaceus is a benign skin hamartoma of congenital onset that grows during puberty, and in adulthood can develop secondary benign and malignant neoplasms. The most common benign neoplasms occurring in nevus sebaceus are believed to be syringocystadenoma papilliferum, trichilemmoma, and trichoblastoma. A patient with nevus sebaceus developed not only syringocystadenoma papilliferum but also prurigo nodularis within her hamartomatous lesion; multiple biopsies were necessary to establish the diagnoses. Excision of the residual nevus sebaceus also revealed an apocrine cystadenoma, basaloid follicular proliferation, and se...
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

The role of hypothalamus-pituitary-adrenal (HPA)-like axis in inflammatory pilosebaceous disorders
Skin is the largest peripheral endocrine organ and functions as a hormone target and endocrine gland. A cutaneous hypothalamus-pituitary-adrenal (HPA)-like axis enables the skin to respond to stress and regulates its steroidogenic activity. The pilosebaceous unit is a site for production and metabolism of a number of steroid hormones, including stress and sex hormones. This is an overview of the important role that the cutaneous HPA-like-axis plays in the pathogenesis and treatment of inflammatory pilosebaceous disorders, including acne, rosacea, seborrheic dermatitis, and hidradenitis suppurativa. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

Skin involvement as the presenting sign of a male breast cancer
We report a case of a 50-year-old man with a breast cancer revealed by skin involvement. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

Apparent darkening of scalp hair related to pili multigemini Following dabrafenib and trametinib
The combination of dabrafenib and trametinib is an important immunotherapy option for patients with BRAF V600 mutation-positive melanoma. This regimen has been reported to cause cutaneous eruptions. However, hair dysmorphology is not a reported side effect to these or any other medications to date. Herein, we highlight a case of pili multigemini formation in a patient with stage IV melanoma receiving treatment with dabrafenib and trametinib and the corresponding clinical findings. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 5, 2020 Category: Dermatology Source Type: research

Necrosis grasa subcut ánea múltiple: correlación ecográficohistopatológica. Multiple encapsulated fat necrosis: histopathological relation to ultrasound findings
We present a 14-year-old boy with this condition who exhibited numerous nodules that were detected after an intentional weight loss of 20kg. The ultrasound and histopathological examinations were necessary to confirm the diagnosis. Even though there is not a clear traumatic record in all cases, trauma constitutes the main hypothesis for its development, by decreasing the blood supply to the adipose tissue lobules and causing subsequent ischemic necrosis. Similar lesions have been described in the omentum and in the breast after surgical procedures or invasive diagnostic tests. In the ultrasound study, at least three presen...
Source: Dermatology Online Journal - March 2, 2020 Category: Dermatology Source Type: research

Intralesional corticosteroid-induced hypopigmentation and atrophy
We report a case of this rare adverse event. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 2, 2020 Category: Dermatology Source Type: research

SOX10 commonly stains scar in Mohs sections
In this report, we demonstrate that Sox10-stained Mohs sections commonly show strong, fractional staining of scar. When using Sox10 with frozen section immunohistochemistry, Mohs practitioners should recognize the potential of this marker to stain scar to avoid overdiagnosis of desmoplastic melanoma. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 2, 2020 Category: Dermatology Source Type: research

Long-term follow-up of 22 psoriatic patients treated with ixekizumab after failure of secukinumab
Switching of biologic agents in treatment of plaque psoriasis is a common strategy. Only a few studies are available on switching between IL17A-blockers. In a retrospective study, we identified 22 psoriasis patients who, after failing secukinumab as a first IL17A-blocker received ixekizumab with an observation period of at least 24 weeks. At last observation 10/22 patients had a good response (PASI75 or PASI
Source: Dermatology Online Journal - March 2, 2020 Category: Dermatology Source Type: research

Gentian violet for pyoderma gangrenosum: a retrospective chart review
This study aims to evaluate gentian violet in wound healing for pyoderma gangrenosum. We conducted a retrospective chart review of patients with pyoderma gangrenosum treated with gentian violet at the Wake Forest School of Medicine Department of Dermatology in the last 10 years. The primary outcome was clinical improvement. Of the 34 cases that met inclusion criteria, 70% improved with gentian violet, 24% had no documented change, 3% initially improved then worsened, and 3% had unclear results. Gentian violet is a safe and cheap treatment that may improve resolution of pyoderma gangrenosum lesions in addition to systemic t...
Source: Dermatology Online Journal - March 2, 2020 Category: Dermatology Source Type: research

Linear verrucous epidermal nevus with oral manifestations: report of two cases
We present two new cases of LVEN with oral mucosa involvement and briefly discuss this very rare finding. In both cases, oral biopsies showed hyperkeratosis, acanthosis, and papillomatosis. Although several treatment modalities have been reported for the cutaneous lesions, there is no consensus for the management of oral lesions so far. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 2, 2020 Category: Dermatology Source Type: research

Disseminated cutaneous gout: a rare manifestation of a common disease
We present the case of a 50-year-old Hispanic man with poorly controlled gout who was evaluated for several years of firm papulonodules over the trunk and upper and lower extremities, sparing the joints; histopathology confirmed, the diagnosis of disseminated cutaneous gout. Per our literature review, disseminated cutaneous gout presents with polymorphous papules and nodules that can mimic other, more common cutaneous diseases. There is a preponderance of cases in males, Asians, and patients with longstanding gout. The lower extremities are involved in nearly all reports. Uric acid-lowering therapy with allopurinol has bee...
Source: Dermatology Online Journal - March 2, 2020 Category: Dermatology Source Type: research

Toxic epidermal necrolysis after radiotherapy for pleomorphic liposarcoma
Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are life-threatening, cutaneous reactions often associated with culprit drugs. A growing body of knowledge has deepened our understanding of the pathophysiology and clarified mechanisms such as drug-specific cytotoxicity mediated by T-cells, genetic linkage with HLA and non-HLA genes, TCR restriction, and cytotoxicity mechanisms. Physicians should broadly consider the etiology of SJS/TEN in order to better understand treatment strategies as well as identify which patients may be at risk for developing this condition. Mechanisms for how radiotherapy and rar...
Source: Dermatology Online Journal - March 2, 2020 Category: Dermatology Source Type: research

Acremonium nail bed mycetoma masquerading as subungual squamous cell carcinoma
Acremonium is a large fungal genus that is comprised of approximately 150 species, found ubiquitously in nature. Although the majority are recognized as being saprophytes in soil and pathogens of plants, several species are emerging as causative agents of a variety of human infections, including mycetomas. Herein, we present a young man that was referred to our department with a painful subungual mass that developed following traumatic inoculation of Acremonium spp. In recent years, the role of Acremonium spp. has been increasingly recognized in localized infections, such as mycetoma, in humans. Other locally invasive as w...
Source: Dermatology Online Journal - March 2, 2020 Category: Dermatology Source Type: research

Guttate leukoderma and acrokeratosis verruciformis of Hopf: a rare combination in Darier disease
A distinct Darier phenotype presenting with confetti-like hypopigmented macules was first described in 1965. Designated as "guttate leukoderma," this skin finding is a rarely-reported presentation of Darier disease. It has been theorized that the mutation in ATP2A2 causes defective E-cadherin, which in turn disrupts the adhesion of melanocytes to keratinocytes, thus leading to impaired dendrite formation, hindered melanin transfer, and ultimately to melanocyte apoptosis. Herein, we contribute a case of a 56-year old woman who presented with the rarely-described guttate leukoderma of Darier disease and acrokeratos...
Source: Dermatology Online Journal - March 2, 2020 Category: Dermatology Source Type: research

Woolly hair nevus: case report and review of literature
Woolly hair nevus consists of a patch of curly and hypopigmented hair that is restricted to an area of the scalp. It is usually benign but it can be associated with other systemic findings. Trichoscopy and dermoscopy may be useful when analyzing this entity. The authors describe a case of woolly hair nevus in a 5-year-old boy and present a review of the literature of woolly hair nevus, including classification, histopathology, associated systemic findings, and the recent described genetic mutations. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 2, 2020 Category: Dermatology Source Type: research