Patients with a new-onset cutaneous sebaceous neoplasm following immunosuppression should be evaluated for Muir-Torre syndrome with germline mismatch repair gene mutation analysis: case reports
Patients with Muir-Torre syndrome may have a systemic malignancy and a sebaceous neoplasm such as an adenoma, epithelioma, and/or carcinoma. The syndrome usually results from a germline mutation in one or more mismatch repair genes. Iatrogenic or acquired immunosuppression can promote the appearance of sebaceous tumors, either as an isolated event or as a feature of Muir-Torre syndrome and may unmask individuals genetically predisposed to the syndrome. Two iatrogenically immunosuppressed men with Muir-Torre syndrome features are described. Similar to these immunocompromised men, Muir-Torre syndrome-associated sebaceous neo...
Source: Dermatology Online Journal - March 15, 2024 Category: Dermatology Authors: Cohen, Philip R Source Type: research
Congenital liquified subcutaneous fat necrosis in a newborn: an unusual case
We report a case of a full-term newborn with a liquidated area of subcutaneous fat necrosis. A surgical incision was performed because of the discomfort and the lack of regression. Hypercalcemia and nephrocalcinosis appeared afterward. A set of clinical, biological, and histological arguments allows the diagnosis of subcutaneous fat necrosis. Follow-up to early detection and to manage such complications is necessary. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Regaieg, Chiraz Source Type: research
Clinical features of atypical presentations of mucocutaneous herpes simplex virus infection observed in immunosuppressed individuals. Part I: herpetic geometric glossitis
Herpetic geometric glossitis is a unique morphologic variant of HSV (herpes simplex virus) type 1 infection on the dorsum of the tongue that presents as an extremely painful linear central lingual fissure with a branched pattern. in the center of the tongue; there is a branched pattern of fissures that extend bilaterally from the central linear fissure. Herpetic geometric glossitis has been reported in 11 patients; 8 of these individuals were immunocompromised. Medical conditions and immunosuppressive medication treatment (7 patients) or only medical disorders (3 patients) or neither (1 patient) were present. HSV type 1 in...
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Cohen, Philip R Source Type: research
A confounding clinically aggressive case of necrotizing granulomatous and suppurative dermatitis
Superficial granulomatous pyoderma gangrenosum is a rare, superficial, vegetating form of pyoderma gangrenosum that tends to occur as a single lesion, most commonly on the trunk. Herein, we report a clinically confounding case of disseminated superficial granulomatous pyoderma gangrenosum in a patient with a 5-year history of painful and chronic ulcerations of the bilateral upper extremities and face in a sun exposed distribution. This was a diagnostically challenging case due to the treatment-refractory nature of our patient's skin lesions and the atypical clinical and histologic presentations encountered. We review our c...
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Bormann, Jordan L Source Type: research
Erythema gyratum repens-like presentation of folliculotropic mycosis fungoides
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Hida, Yasutoshi Source Type: research
Advancing dermatology education with AI-generated images.
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Breslavets, Maksym Source Type: research
Multiple juvenile xanthogranulomata
We report a 2-month-old girl with 22 cutaneous papules, clinically and histologically compatible with juvenile xanthogranulomas. Screening of visceral involvement was performed with no evidence of systemic disease. Identifying high-risk factors of systemic disease in patients with multiple juvenile xanthogranuloma is essential to perform an appropriate management of this entity. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Garcia-Sirvent, Lucia Source Type: research
Clinical features of atypical presentations of mucocutaneous herpes simplex virus infection observed in immunosuppressed individuals. Part II: the knife-cut sign
The knife-cut sign is a distinctive manifestation of herpes simplex virus (HSV) type 1 or HSV type 2 infection that has been described in at least 10 immunocompromised patients. It appears as an extremely painful linear erosion or fissure in an intertriginous area such as the body folds beneath the breast, or within the abdomen, or in the inguinal region. Also, concurrent HSV infection at other mucocutaneous sites, or viscera, or both have been observed. The patients had medical conditions (at least 9 patients) and/or immunosuppressive drug therapy (6 patients). The diagnosis of HSV infection was confirmed by viral culture...
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Cohen, Philip R Source Type: research
Three cases of Anti-MDA5 positive dermatomyositis with interstitial lung disease and pneumomediastium
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Figueiredo, Carolina Source Type: research
Artificial intelligence in dermatology: GPT-3.5-Turbo demonstrates strengths and limitations in residency exams
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Haynes, Dylan Source Type: research
Infliximab-induced amicrobial pustulosis of the folds in a patient with Crohn disease
Tumor necrosis factor (TNF) inhibitors may paradoxically induce pustular eruptions, most of which are classified as pustular psoriasis. Amicrobial pustulosis of the folds (APF) is a much rarer entity that was recently recognized to occur in the setting of chronic anti-TNF therapy and inflammatory bowel disease, with 12 existing cases in the literature. Amicrobial pustulosis of the folds is a neutrophilic dermatosis characterized by aseptic pustules involving the major and minor skin folds, genital regions, and scalp. Herein, we report an additional case of paradoxical APF induced by chronic infliximab therapy in a patient ...
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Meyer, Summer N Source Type: research
Retronychia: the importance of proper footwear
Retronychia is commonly underdiagnosed and exhibits classic features of proximal nail fold elevation and nail plate layering. Herein we summarize the literature and discuss cause, diagnosis, and treatment of this condition. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Riopelle, Alexandria M Source Type: research
Verrucous carcinoma presenting as recalcitrant verruca plantaris
We describe a patient with a 20-year history of a slowly growing, ulcerated, verrucous plaque on the sole of the left foot that was erroneously treated for years as verruca plantaris and was eventually diagnosed as invasive verrucous carcinoma. Verrucous carcinomas are a diagnostic challenge due to clinical and histopathologic mimicry of benign lesions. Mohs micrographic surgery should be employed to allow the ability to intraoperatively assess tumor margins while excising the minimal amount of necessary tissue. It is important for clinicians to recognize the characteristics and accurately diagnose verrucous carcinomas. De...
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Hornback, Cheyenne J Source Type: research
Successful secukinumab treatment of generalized pustular psoriasis
This report aims to evaluate the use of secukinumab in two patients with generalized pustular psoriasis. The standard treatment regimen for secukinumab was as follows: 300mg subcutaneously once weekly in weeks 0-4, followed by 300mg every four weeks. The efficacy was evaluated by analyzing the psoriasis area and severity index (PASI) and dermatology life quality index (DLQI). One patient had generalized pustular psoriasis, which had developed from palmoplantar pustulosis over 12 years. The second patient was an adolescent with recurrent generalized pustular psoriasis. The first patient achieved PASI-75 response by week 3 a...
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Guo, Heng-Shan Source Type: research
Electronic consultation in supportive oncodermatology: a single center retrospective cohort
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Betancourt, Nicolas J Source Type: research
