Factitial panniculitis as a manifestation of self-imposed factitious disorder
Factitious disorder imposed on self is characterized by self-induction. Dermatitis artefacta, the cutaneous subtype of factitious disorder imposed on self, can have a variety of atypical presentations. A 36-year-old woman with an extensive past medical history presented with painful nodules on her abdomen, thighs, and arms. Histologic evaluation identified panniculitis with foreign body material seen under polarization. Chart review from previous hospital visits established a history of factitious disorder imposed on self and upon subsequent search of the hospital room, syringes with an unknown substance were found. Factit...
Source: Dermatology Online Journal - June 13, 2019 Category: Dermatology Source Type: research

Novel PTEN mutation in Cowden syndrome: case report with late diagnosis and non-malignant course
We present a case of Cowden syndrome with late diagnosis presenting with a florid dermatological expression and multiple benign tumors, but no malignancies. A novel PTEN mutation was identified. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - June 11, 2019 Category: Dermatology Source Type: research

Multiple eruptive dermatofibromas associated with pregnancy- a case and literature review
Dermatofibromas are common and asymptomatic benign histiocytic tumors. The occurrence in a small number (up to 5 lesions) is frequent. However, the expression "multiple eruptive dermatofibromas" is reserved for the appearance of more than 5 lesions in less than four months. Multiple eruptive dermatofibromas are rare and usually associated with an underlying systemic condition, the most common being autoimmune diseases or HIV infection. Herein we report multiple eruptive dermatofibromas developing in an otherwise healthy pregnant woman. Although the pathogenesis of this condition remains unknown, it is believed to...
Source: Dermatology Online Journal - June 11, 2019 Category: Dermatology Source Type: research

Prurigo pigmentosa following laparoscopic gastric sleeve
Prurigo pigmentosa is an uncommon inflammatory skin disease predominately affecting young women. Clinically the disease presents with erythematous and urticarial papules arranged in a reticular pattern. Lesions heal with reticulated hyperpigmentation. Strict ketogenic diet is one of many factors that might trigger the disease. In this article, we present a case of prurigo pigmentosa following a complicated laparoscopic gastric sleeve with the resolution of the rash after improvement of the patient's diet. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - June 11, 2019 Category: Dermatology Source Type: research

Apocrine adenocarcinoma of the eyelid: case report and literature review on management
We report the case of a 58-year-old woman with apocrine adenocarcinoma located on her left upper eyelid. Excisional biopsy demonstrated focal apocrine secretion in a basaloid nest proliferation. The patient had no recurrence at four months. Our case provides insight into the workup and management of eyelid apocrine adenocarcinoma. Furthermore, we discuss key management recommendations according to previous authors' experiences with eyelid apocrine adenocarcinoma. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - June 11, 2019 Category: Dermatology Source Type: research

Wound healing elective: an opportunity to improve medical education curriculum to better manage the increasing burden of chronic wounds
Chronic wounds are highly prevalent and have become a public health crisis. Successful treatment of chronic wounds requires that healthcare providers study both the pathophysiology of wound healing and maintain knowledge of the most current wound care guidelines set forth by the Agency for Healthcare Research and Quality. Unfortunately, medical students currently receive limited wound care training. A focused and well-organized course integrating a diverse group of medical and surgical faculty, residents, and medical students in the clinical years has been created to address this growing medical issue. The goal of such cur...
Source: Dermatology Online Journal - June 11, 2019 Category: Dermatology Source Type: research

A fleshy papule on the eyelid
We report an instance of angiolymphoid hyperplasia with eosinophilia involving the eyelid in a 19-year-old woman with review of literature. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - June 11, 2019 Category: Dermatology Source Type: research

Keratosis lichenoides chronica: First case reported in Chile
We present a woman with a history of years of evolution of confluent hyperkeratotic papules and plaques with a generalized linear and reticulate pattern. Histopathological characteristics concordant with keratosis lichenoides chronica were finally evidenced after several non-specific biopsies. The cutaneous manifestations, chronicity. histopathology findings, and refractoriness to therapies are typical of this rare dermatosis. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - June 11, 2019 Category: Dermatology Source Type: research

Late-onset pseudoepitheliomatous hyperplasia developing within a red ink tattoo
The popularity of tattoos has increased dramatically worldwide particularly in the last three decades, giving rise to the frequent occurrence of a wide spectrum of secondary cutaneous and systemic complications. Pseudoepitheliomatous hyperplasia (PEH) is a benign irregular hyperplasia of the epidermis occurring in response to various stimuli, that clinically and histopathologically resembles cutaneous neoplasms such as squamous cell carcinoma and keratoacanthoma. In an attempt to improve the awareness of the possible occurrence of PEH in tattoos and of its diagnostic and therapeutic aspects, we present herein the case of a...
Source: Dermatology Online Journal - June 11, 2019 Category: Dermatology Source Type: research

Indurated purple plaques on the scalp
We describe a 75-year-old man who presented with three tender, indurated violaceous plaques on his scalp. Biopsy revealed a poorly circumscribed infiltrate extending into the subcutaneous fat, composed of atypical epithelioid cells lining vascular spaces. We provide a brief review of the clinical presentation, histopathologic features, differential diagnosis, and management of this rare tumor. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - June 11, 2019 Category: Dermatology Source Type: research

Topical probiotics: the unknowns behind their rising popularity
Objective: Topical probiotics have been used for skin care and treatment since the early 20th century. Over the past decade, there has been a dramatic surge of commercially-available topical probiotic products. We conducted a systematic search of clinical data relating to the use of topical probiotics and identified relevant clinical and regulatory gaps. Methods: PubMed and Google Scholar searches were conducted for trials and reviews of probiotics. FDA definitions of cosmetics, drugs, and regulation of topical probiotics were reviewed. Results: Topical probiotics have shown efficacy in a number of limited trials, particul...
Source: Dermatology Online Journal - June 10, 2019 Category: Dermatology Source Type: research

Comparison of quality of life and illness perception among patients with acne, eczema, and psoriasis
Dermatologic diseases have a similar influence on quality of life (QoL) and disability as other chronic medical conditions. Although QoL has been studied in relation to acne, eczema, and psoriasis, there is little information on how patients conceptualize their diseases - the illness experience. More information about illness perception (IP) and the impact of these perceptions on QoL, will help clinicians identify and address patients' conceptions, with the potential to positively impact patients' wellbeing. We sought to examine the effect of IP on QoL and make comparisons across acne, psoriasis, and eczema among a diverse...
Source: Dermatology Online Journal - June 10, 2019 Category: Dermatology Source Type: research

Ashy dermatosis: a review
Ashy dermatosis is characterized by asymptomatic, symmetrically-distributed, gray-colored macules located on the trunk, neck, face, and upper extremities. The condition occurs most commonly in patients with Fitzpatrick phototype III-V skin. The etiology is unknown, but drug ingestion, infection, and genetic factors have been suggested to elicit ashy dermatosis. No gold standard treatments have been established yet. The most successful treatment to date has been clofazimine, although topical tacrolimus, oral dapsone, narrowband ultraviolet light B phototherapy, and isotretinoin have shown treatment success. Ashy dermatosis ...
Source: Dermatology Online Journal - June 10, 2019 Category: Dermatology Source Type: research

Interview date trends for dermatology residency from 2012-2017
Data regarding dermatology residency interview patterns can better inform applicants regarding the application process as well as encourage further coordination among programs. Our objective was to describe dermatology residency interview date patterns over the past five applications cycles from 2012 to 2017. A retrospective review of dermatology online forums (the Dermatology Interest Group Association and Student Doctor Network) was performed from 2012 to 2017; these web-based public databases were reviewed for interview dates and interview offer dates. Data from 117 programs per year were obtained. The majority of inter...
Source: Dermatology Online Journal - June 10, 2019 Category: Dermatology Source Type: research

Treatment of warts with topical cidofovir in a pediatric patient
Cidofovir is an antiviral nucleotide analogue with relatively new treatment capacities for dermatological conditions, specifically verruca vulgaris caused by human papilloma virus infection. In a 10-year old boy with severe verruca vulgaris recalcitrant to multiple therapies, topical 1% cidofovir applied daily for eight weeks proved to be an effective treatment with no adverse side effects. This case report, in conjunction with multiple published reports, suggests that topical 1% cidofovir is a safe and effective treatment for viral warts in pediatric patients. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - June 10, 2019 Category: Dermatology Source Type: research

Impact on clinical practice of a non-invasive gene expression melanoma rule-out test: 12-month follow-up of negative test results and utility data from a large US registry study
The Pigmented Lesion Assay (PLA, sensitivity 91-95%, specificity 69-91%, negative predictive value ?99%) is a commercially available, non-invasive gene expression test that helps dermatologists guide pigmented lesion management decisions and rule out melanoma. Earlier studies have demonstrated high clinical utility and no missed melanomas in a 3-6-month follow-up period. We undertook the current investigations to provide 12-month follow-up data on PLA(-) tests, and to further confirm utility. A 12-month chart review follow-up of 734 pigmented lesions that had negative PLA results from 5 US dermatology centers was performed...
Source: Dermatology Online Journal - June 10, 2019 Category: Dermatology Source Type: research

Extramammary Paget disease
In 1874, Sir James Paget first described Paget disease of the nipple, also known as mammary Paget disease. In 1889, extramammary Paget disease (EMPD) of the scrotum and penis was identified. Although mammary and extramammary Paget disease are both characterized by epidermal Paget cells and share a similar clinical presentation, their uniqueness lies in anatomical location and histogenesis. EMPD presents as an erythematous plaque on apocrine gland bearing areas (i.e. vulva, perineum, perianal region, scrotum, and penis) in older men and women. It can be a focal, multifocal, or an ectopic process. Immunohistochemical stainin...
Source: Dermatology Online Journal - May 3, 2019 Category: Dermatology Source Type: research

Corrigendum: A novel ultraviolet B home phototherapy system: Efficacy, tolerability, adherence, and satisfaction
The original article was published on February 15, 2019 and corrected on April 15, 2019.The third pair of panes of Figure 2 were reversed, such that the pane previously depicted on the left was after phototherapy. The corrected sequence is now before phototherapy, on the left, and after, on the right. This change appears in the revised online PDF copy of this article. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 29, 2019 Category: Dermatology Source Type: research

Melanoma patient notification and treatment timelines
Melanoma is an extremely aggressive cancer for which the American Academy of Dermatology currently does not have formal recommendations outlining a timeline from biopsy to definitive treatment. Our dermatology department investigated our treatment timeline for melanoma. Using the database from our electronic medical record, Epic, we evaluated patients over a one-year period; in total we identified 109 melanomas. We evaluated patient demographics, tumor characteristics, and timelines regarding diagnosis and treatments. There was a statistically significant difference in patient notification of diagnosis and treatment times ...
Source: Dermatology Online Journal - April 29, 2019 Category: Dermatology Source Type: research

Metastatic squamous cell carcinoma arising in the setting of folliculitis decalvans
We present a patient with severe, chronic FD who developed metastatic squamous cell carcinoma of the scalp. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 29, 2019 Category: Dermatology Source Type: research

Paradoxical reversed plantar involvement during ixekizumab therapy for psoriasis
We present a patient with palmoplantar psoriasis treated with ixekizumab who achieved a favorable response that was coupled with a rare paradoxical reaction, reversed plantar involvement. The reason for this phenomenon and its clinical course are uncertain, but these new lesions are proving recalcitrant to complementary therapies. Provided the increasingly widespread use of biologic therapies, the incidence and diversity of paradoxical reactions are expected to increase. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 29, 2019 Category: Dermatology Source Type: research

Late-onset amyloidosis cutis dyschromica: an unusual case
Amyloidosis cutis dyschromica (ACD) is a rare form of primary cutaneous amyloidosis. ACD, first described by Morishima in 1970 is characterized by (i) macular, speckled, reticular hyperpigmentation with hypopigmented spots distributed extensively over the body; (ii) little or no pruritus; (iii) prepubertal onset; and (iv) focal subepidermal amyloid deposition. A 49-year-old woman presented with a 20-year history of progressive, asymptomatic, generalized mottled hyper- and hypopigmented macules all over the body. Histopathological examination of a punch biopsy specimen showed deposition of homogeneous, eosinophilic material...
Source: Dermatology Online Journal - April 28, 2019 Category: Dermatology Source Type: research

Molluscum contagiosum with dermoscopic features in an unusual areola and nipple location
Molluscum contagiosum is a common, contagious viral skin disease that often affects children and adolescents. Involvement of the areola and nipple are rarely reported. Herein we report two young women with molluscum contagiosum on the areola-nipple complex and we discuss the dermoscopic features of the lesions at this unusual site. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 28, 2019 Category: Dermatology Source Type: research

Multiple acantholytic dyskeratotic acanthomas in a liver-transplant recipient
We present here a new case of this rare lesion that developed in a liver-transplant patient and review the salient features of this uncommon condition. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 28, 2019 Category: Dermatology Source Type: research

Morphea secondary to interferon beta1b injection: a case and review of the literature
Interferon beta (IFN β) is a drug used successfully in the treatment of multiple sclerosis (MS). Although IFNβ is a safe and well-tolerated drug, dermatological side effects are common. The most common dermatological adverse effect is a local reaction at the injection site. It may also cause inflammatory and immune-me diated dermatological side effects. However, morphea induced by IFNβ1b injection is very rare (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 28, 2019 Category: Dermatology Source Type: research

Darier disease with disseminated herpes simplex virus type 2 infection
Darier disease (DD), also known as keratosis follicularis or Darier-White disease, is a rare autosomal dominant genodermatosis that presents as hyperkeratotic, warty papules affecting the seborrheic and intertriginous areas. Patients with DD are at risk of secondary infections including the rare complication of Kaposi varicelliform eruption (KVE), a widespread viral infection most commonly caused by herpes simplex virus (HSV). Darier disease with secondary KVE can lead to widespread systemic infection and death. This case report discusses an individual with DD who subsequently developed KVE due to disseminated HSV type 2 i...
Source: Dermatology Online Journal - April 28, 2019 Category: Dermatology Source Type: research

Endogenous ochronosis: when clinical suspicion prevails over histopathology
We report a new case of EO with cutaneous and joint involvement, in which a high clinical suspicion, confirmed by elevated AHG in urine was the key in the diagnosis. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 28, 2019 Category: Dermatology Source Type: research

Exogenous ochronosis: the failure of depigmenting creams
We present a woman who developed EO on the face, upper chest, and back after prolonged use of a depigmenting cream containing hydroquinone. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 28, 2019 Category: Dermatology Source Type: research

Incisional biopsy critical in obtaining definitive diagnosis in a clinically challenging case
We present a case of a 70-year-old man with hidradenocarcinoma of the left chin, a diagnosis that was delayed owing to repeated superficial biopsies that were negative for disease. Diagnosis was ultimately obtained via an incisional biopsy. We discuss the clinical features of hidradenocarcinoma and why this diagnosis can be easily missed with superficial biopsies. It is important that dermatologists consider incisional biopsies in the workup of clinically challenging lesions for which malignancy is considered. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 28, 2019 Category: Dermatology Source Type: research

Allergic contact dermatitis related to homemade slime: a case and review of the literature
We present a case of a child with hand dermatitis, history of exposure to slime, and positive allergen patch testing to two ingredients found in slime. The case underscores the need for clinicians to be aware of slime as a possible cause of allergic contact dermatitis in children. Given the trend of newly-reported cases, we briefly review the current literature to date. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 28, 2019 Category: Dermatology Source Type: research

Healthcare and dermatology on WeChat
WeChat is a closed social networking platform that allows users to connect privately, providing instant text, photo sharing, voice, and video calls. It is now the most popular mobile chat app in China. The widespread use and ease of establishing technology made WeChat an ideal platform for healthcare, in which it has many uses that include scheduling, follow up, and post-procedure monitoring. In addition, one may make payments and handle prescriptions via e-pharmacy. Dermatologists are often looking for a secure and easy way to use mobile applications to share clinical images and to obtain photographs from patients. We aim...
Source: Dermatology Online Journal - April 26, 2019 Category: Dermatology Source Type: research

Oral lichen sclerosus: a rare case and update
Lichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease that often affects the anogenital area; oral mucosal lesions are extremely rare. A 52-year-old woman presented for evaluation of an 8-year history of a persistent whitish plaque in the buccal mucosa. Intraoral examination revealed multiple elevated whitish plaques diffusely distributed in the buccal mucosa associated with an area of tissue atrophy. Although both leukoplakia and lichen planus were considered, incisional biopsy and later, full excision confirmed the histopathological diagnosis of oral LS. After 6 months of follow-up, there are no clinical ...
Source: Dermatology Online Journal - April 26, 2019 Category: Dermatology Source Type: research

The nail flag sign in heart transplant recipients: case reports and review of the patients with the flag sign of the nail
The nail plate flag sign is a distinctive nail plate change that appears as white, red, white, and red sequential transverse bands beginning at the proximal nail fold. This distinctive nail change was initially described in patients with diabetes mellitus and leprosy; indeed, it was considered to be characteristic, but not diagnostic of leprosy. Subsequently, the flag sign was observed in patients with vitiligo. The flag sign has recently been noted in two men following heart transplantation. In summary, the flag sign is a unique nail change that has occurred in patients with autoimmune disorders, infection, and post trans...
Source: Dermatology Online Journal - April 14, 2019 Category: Dermatology Source Type: research

A diagnostic challenge: inflamed and pigmented seborrheic keratosis. Clinical, dermoscopic, and histopathological correlation
In conclusion, pigmented and inflamed SK does not... (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 8, 2019 Category: Dermatology Source Type: research

Sexual dimorphism and transgender medicine: appealing to a viewer's sense of beauty
Sexual dimorphism  — the phenotypic structural differences between male and female faces — has been shown to be an important universal component of beauty. This concept plays a key role in facial feminization surgery (FFS), which consists of contouring and reshaping features of the skull itself to alter the foun dation of the face. FFS has been shown to improve quality of life among transgender women and therefore an understanding of the procedure and the concept of sexual dimorphism is key for plastic surgeons, dermatologists, and other healthcare providers. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 5, 2019 Category: Dermatology Source Type: research

Multiple flat-topped scaly violaceous papules
Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis characterized by susceptibility to beta-genus human papillomavirus (HPV) infection. Owing to TMC6/EVER1 and TMC8/EVER2 mutations that lead to abnormal transmembrane channels in the endoplasmic reticulum involved in immunological pathways, keratinocytes cannot combat infection from non-pathogenic HPV strains. Mutations involving RHOH, MST-1, CORO1A, and IL-7 have also been associated with EV in patients without TMC6 or TMC8 mutations. We highlight a 27-year-old man with multiple violaceous flat-topped papules with scale and irregular borders distr...
Source: Dermatology Online Journal - April 5, 2019 Category: Dermatology Source Type: research

Persistent generalized Grover disease: complete remission after treatment with oral acitretin
We report a 56-year-old woman with recalcitrant, persistent, and generalized GD who showed complete remission after 6 weeks of treatment with oral acitretin (0.8mg/kg/day). The treatment was well-tolerated and laboratory parameters remained unchanged. The patient remains free of any recurrence at 26 months. To the best of our knowledge, this is the first report of a complete remission of the persistent form of GD as a result of oral acitretin monotherapy. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 5, 2019 Category: Dermatology Source Type: research

A case of cutaneous nodules in a sporotrichoid pattern
We present a patient with a sporotrichoid cutaneous infection byMycobacterium marinum, highlighting that even with the availability of novel microbiological detection techniques, tissue culture remains an essential tool for diagnostic confirmation. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 5, 2019 Category: Dermatology Source Type: research

Ulcerated tophaceous gout
We report the case of a 38-year-old man, undiagnosed with gout, who presented to clinic for evaluation of ulcers with chalky white granules. The wounds were determined to be ulcerated tophaceous gout. Risk factors for ulceration over tophi and reported treatments are discussed. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 5, 2019 Category: Dermatology Source Type: research

A novel case of TIF1 gamma autoantibody positive dermatomyositis associated with a non-functional pancreatic neuroendocrine tumor
Dermatomyositis (DM) is an idiopathic inflammatory myopathy characterized by proximal muscle weakness associated with a distinct cutaneous eruption. The association of DM with malignancy has been extensively described in the literature. Patients with DM that also have transcriptional intermediary factor 1 (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 5, 2019 Category: Dermatology Source Type: research

Medical school ranking and dermatology match results: an analysis of the 2018 match data
This study sought to explore whether there is a difference in the percentage of graduates matching into dermatology residencies based on the rank of the medical school. Publicly available match lists from highly ranked medical schools were compared to match lists from other allopathic schools to determine the proportion of graduates matching into dermatology. The data was analyzed using a chi square test and a significant difference was found between the percentage of students matching into dermatology from top schools (5.19%) compared to control schools (1.92%), (P
Source: Dermatology Online Journal - April 5, 2019 Category: Dermatology Source Type: research

Elastosis perforans serpiginosa related to vascular Ehlers-Danlos syndrome
We present a 26-year-old woman with EPS known to have vascular Ehlers-Danlos syndrome. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 5, 2019 Category: Dermatology Source Type: research

Unilateral granuloma annulare in association with pyoderma gangrenosum and chronic lymphocytic leukemia
We describe an unusual case of unilateral GA confined to the thigh on a previously amputated limb. A man in his 80s with a past medical history of below-knee amputation of the left leg owing to severe leg ulcers from pyoderma gangrenosum, chronic lymphocytic leukemia, and dyslipidemia developed a slowly spreading eruption on the distal stump spreading proximally. On physical examination, he had numerous non-scaly violaceous papules and annular plaques from the stump to the lateral, medial, and anterior thigh. Histology confirmed a diagnosis of GA. The extensive, chronic lesions make this presentation of GA very unusual in ...
Source: Dermatology Online Journal - April 5, 2019 Category: Dermatology Source Type: research

Late onset nevus comedonicus of scalp: a rare site for an uncommon condition
We report a case of a 19-year old woman with nevus comedonicus of the scalp that appeared in adolescence. This case has been presented for its sheer rarity, atypical site, and classic appearance. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 5, 2019 Category: Dermatology Source Type: research

The cotton tipped applicator – a scratch for the itch and more during dermatologic surgery
An itch during surgery can be distracting. Sterile cotton tipped applicators are inexpensive and multipurpose tools that may be used for a variety of simple surgical tasks such as scratching an itch on the surgeon or patient ’s face. They may also be used to adjust glasses and turn on surgical lights or the electrocautery machine. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 5, 2019 Category: Dermatology Source Type: research

Identification of a novel mutation in the ST14 gene in an Iranian family with ichthyosis and hypotrichosis
Inherited ichthyosis is a heterogeneous group of rare cutaneous disorders characterized by hyperkeratosis and scaly skin. So far, only a few genetic studies on ichthyosis have been performed in Iran. Herein, we reported a family with two cases of ichthyosis and hypotrichosis that were investigated by whole exome sequencing. Targeted data analysis identified a novel nonsense variant c.1243C>T (p.Gln415Ter) located at exon 11 of theST14 gene in the proband. Sanger sequencing showed co-segregation of this mutation with the disease in this family. Further studies are needed to develop knowledge about the spectrum of changes...
Source: Dermatology Online Journal - April 5, 2019 Category: Dermatology Source Type: research

Adherence to a novel home phototherapy system with integrated features
Objective: To measure adherence using a novel home UVB phototherapy system designed to promote adherence.Study Design: A retrospective, observational study conducted to evaluate patients' adherence to a prescribed three-times-per-week treatment protocol using a novel home phototherapy system with integrated features designed to improve adherence.Methods: Data was collected from 18 psoriasis patients, 27 vitiligo patients, and three atopic dermatitis patients using a novel home phototherapy system under normal use conditions. Adherence was also calculated using two alternative methods to allow for comparison between publish...
Source: Dermatology Online Journal - April 4, 2019 Category: Dermatology Source Type: research

Animated video consultation for reducing pre-operative anxiety in dermatologic surgery
Pre-operative anxiety is common in patients undergoing dermatologic surgery. This pilot study aimed to evaluate whether the addition of an animated educational video to conventional in-person surgery consultation helps to reduce pre-operative anxiety related to anesthesia, surgery, wound care, and post-operative pain in patients undergoing outpatient dermatologic surgery. Patients awaiting dermatologic surgery were randomized into groups with conventional consultation, or video with consultation prior to undergoing their procedure. The conventional consultation group received conventional consultation with the surgeon, whe...
Source: Dermatology Online Journal - April 4, 2019 Category: Dermatology Source Type: research

Revised Mohs surgery care guidelines for squamous cell carcinoma in-situ are overdue
The treatment of cutaneous squamous cell carcinoma in situ by Mohs micrographic surgery is currently deemed as appropriate by the Mohs Appropriate Use Criteria. However, squamous cell carcinoma in situ is a very superficial, indolent, low-risk tumor amenable to destructive and non-surgical treatments. It is uncommon for squamous cell carcinoma in situ to have progressed to invasive malignancy subsequent to definitive management. The suggestion that squamous cell carcinoma in situ on certain anatomic locations has a poorer prognosis is widely assumed but lacks an evidence base. We recommend that most primary squamous cell c...
Source: Dermatology Online Journal - April 4, 2019 Category: Dermatology Source Type: research

Umbilical condyloma lata
We describe a patient with an unusual presentation of condyloma lata on the umbilicus. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 9, 2019 Category: Dermatology Source Type: research