Pityriasis rubra pilaris heralding diagnosis of urothelial carcinoma: a case report
Pityriasis rubra pilaris is a papulosquamous inflammatory dermatosis that can be associated with HIV, autoimmunity, infections, certain medications, and neoplasms. Paraneoplastic pityriasis rubra pilaris has previously been reported in association with solid organ malignancies and once with leukemia. Herein, we present an elderly man with paraneoplastic pityriasis rubra pilaris, heralding the diagnosis of low-grade papillary urothelial carcinoma. Our patient's pityriasis rubra pilaris resolved after surgical resection of the tumor. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - August 23, 2022 Category: Dermatology Source Type: research
Werner syndrome associated with acroosteolysis
Werner syndrome (WS) is an autosomal recessive syndrome characterized by genomic instability that affects multiple body systems. The characteristic features of the disease include growth retardation, short stature, alopecia, scleroderma, atrophic skin with ulcerations, infertility, cataracts, premature arteriolosclerosis, diabetes, osteoporosis, and increased risk of malignancies. Werner syndrome protein (WRN) protein deficiency in this disease causes changes in gene expression, similar to those observed in normal aging. As the median age of death in WS is the fourth or fifth decade of life, early diagnosis leads to a bett...
Source: Dermatology Online Journal - August 23, 2022 Category: Dermatology Source Type: research
Annular elastolytic giant cell granuloma in a woman with metabolic syndrome
Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin condition. It belongs to a group of skin and elastic fiber disorders. When it affects sun-exposed skin, it is also called actinic granuloma. The etiology and pathogenesis are still debated. However, sun-induced actinic damage to elastic fibers is acknowledged as the primary triggering factor, though the pathogenesis of instances in sun-covered areas is unknown. The most commonly linked systemic illness is diabetes mellitus. Different case reports show an association of this disease with hematological conditions, infections, sarcoidosis, and proto...
Source: Dermatology Online Journal - August 23, 2022 Category: Dermatology Source Type: research
Noninflammatory presentation of cutaneous breast cancer: a retrospective case series at a single academic institution with review of the literature
Breast cancer with skin involvement is an uncommon clinical presentation of this malignancy. Breast cancer overall has a relatively high mortality rate and wide variety of presentations, making skin involvement by breast cancer a necessary consideration in the differential diagnosis for many types of breast lesions. A retrospective review of our own small academic dermatology outpatient clinic, between August 2006 and January 2020, found four cases of noninflammatory breast cancer with skin involvement diagnosed through biopsy by our dermatologists. This review was approved by the local Institutional Review Board. Of the f...
Source: Dermatology Online Journal - August 23, 2022 Category: Dermatology Source Type: research
Imiquimod-induced hypertrophic lupus erythematosus-like reaction.
We report a case of local induction of a plaque that resembled HLE clinically and histologically in an 82-year old woman following topical treatment with imiquimod. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - August 23, 2022 Category: Dermatology Source Type: research
Blastic plasmacytoid dendritic cell neoplasm presenting as violaceous forehead plaque
A 72-year-old man with a history of squamous cell carcinoma presented to the Portland VA with forehead discoloration. He was initially diagnosed with actinic damage and prescribed topical treatment. However, he returned to clinic months later with a large, violaceous forehead plaque. Upon biopsy, he was diagnosed with blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare hematological malignancy. This case report illustrates the importance of keeping BPDCN in the differential diagnosis for ecchymotic plaques that fail to respond to first line therapy. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - August 23, 2022 Category: Dermatology Source Type: research
Characteristics of non-melanoma skin cancers in Native American patients treated with Mohs micrographic surgery
Despite the lower incidence of non-melanoma skin cancers in skin of color populations, greater morbidity and mortality have been reported. Literature describing non-melanoma skin cancers in Native Americans is scarce. We designed a retrospective review study aimed to evaluate the characteristics of non-melanoma skin cancers (basal cell carcinoma and squamous cell carcinoma) in Native American patients treated with Mohs micrographic surgery between January 2015 and August 2020, at a single academic center. Twenty-six patients with 28 tumors were identified; 12 squamous cell carcinomas (92% well-differentiated) and 16 basal ...
Source: Dermatology Online Journal - August 23, 2022 Category: Dermatology Source Type: research
Drug eruption-like scabies surrepticius: an uncommonly described variant of scabies appearing in a non-classic clinical presentation
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - August 23, 2022 Category: Dermatology Source Type: research
Treatment of longstanding alopecia areata universalis of the eyebrows/facial hair with oral and topical tofacitinib
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - August 23, 2022 Category: Dermatology Source Type: research
Herpes zoster after COVID-19 vaccination in an adolescent
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - August 23, 2022 Category: Dermatology Source Type: research
A new eruption of bullous pemphigoid following mRNA COVID-19 vaccination
The rapid development and implementation of COVID-19 vaccines throughout the global population has given rise to unique, rare, adverse skin reactions. This case report describes an elderly man with new-onset bullous pemphigoid following the second dose of the Pfizer-BioNTech (mRNA) COVID-19 vaccine. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - August 23, 2022 Category: Dermatology Source Type: research
A unique case of subcutaneous panniculitis-like T-cell lymphoma presenting as an abscess following an arthropod bite
We present an exceptional case of SPTCL masquerading as a solitary abscess which developed following an antecedent arthropod bite. Unique histological features encountered include foci of neutrophilic aggregation and admixed eosinophils within the neoplastic lymphomatous subcuticular infiltrate. As SPTCL rarely presents as an abscess, the authors wish to highlight this diagnostic pitfall and suggest excluding SPTCL as a cause of pseudo-pyoderma in patients who are afebrile with a discordant inflammatory marker profile. In addition, this condition should be suspected in non-diabetic patients who experience a rapid clinical ...
Source: Dermatology Online Journal - August 23, 2022 Category: Dermatology Source Type: research
Anti-laminin 332 mucous membrane pemphigoid in a young woman treated with rituximab
We describe a 32-year-old woman who was diagnosed with anti-laminin 332 mucous membrane pemphigoid through indirect immunofluorescence for laminin 332 following nonspecific histologic and direct immunofluorescence findings. At 16 weeks following completion of her first cycle of with rituximab 375mg/m2 weekly for four weeks, her mucosal erosions had resolved. Although not widely available, this case highlights the utility of anti-laminin 332 immunofluorescence for diagnostic confirmation of this entity and the efficacy of rituximab in obtaining disease control. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - August 23, 2022 Category: Dermatology Source Type: research
"Knife-cut" intertriginous ulcers related to herpes simplex virus in three patients
Linear intertriginous erosions and ulcerations related to herpes simplex virus (HSV) infection have been reported in patients with underlying immunosuppression. This rare presentation of HSV seems to occur predominantly in patients undergoing treatment of hematologic malignancies and rheumatologic conditions. Herein, we report three cases of linear "knife-cut" ulcerations in patients who were not undergoing active pharmacologic immunosuppressive therapy and lacked coexisting malignancy or autoimmune disease. Close examination of the skin folds for HSV infection is warranted to rule out disseminated infection as early inter...
Source: Dermatology Online Journal - August 23, 2022 Category: Dermatology Source Type: research
Modified keystone flap used to repair nose defect after Mohs micrographic surgery
We present a case where a modified keystone flap technique was used to close a large defect after Mohs micrographic surgery in a patient with a basal cell carcinoma on the nose. An excellent functional and aesthetic result was obtained with no complications during or after the procedure. We offer a novel indication for this technique for surgical defects in this area. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - August 23, 2022 Category: Dermatology Source Type: research
