Stevens-Johnson syndrome/toxic epidermal necrolysis associated with natural thyroid medication
In this report, we present a 52-year-old woman who arrived at the emergency department with a complaint of rash, malaise, and pruritus. She subsequently developed diffuse cutaneous and mucosal detachment. Work-up supported a diagnosis of SJS/TEN secondary to her thyroid replacement therapy, derived from desiccated pig thyroid glands. The patient's natural thyroid medication was discontinued and she responded well to appropriate treatment. This case is unique in that thyroid replacement therapy is not a commonly reported trigger of SJS/TEN. Providers should be aware of the potential for natural thyroid and other animal-deri...
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Obagi, Sabine Source Type: research
Basal cell carcinoma in situ of the skin revisited: case reports of the superficial type and fibroepithelioma type of this in situ cutaneous neoplasm
In conclusion, similar to other cutaneous malignant neoplasms-such as squamous cell carcinoma, malignant melanoma,... (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Cohen, Philip R Source Type: research
Fast and safe clinical response to sonidegib in a 98-year old woman affected by locally advanced basal cell carcinoma
A 98-year-old woman presented with histologically confirmed locally advanced basal cell carcinoma of the face. A multidisciplinary approach excluded surgery because of the site near sensitive organs, extension, age, and comorbidities. Patient and caregivers declined radiotherapy considering the necessity of multiple hospital appointments. The patient was then placed on therapy with sonidegib, an oral inhibitor of the Hedgehog signaling pathway. There was a very rapid clinical response after only 28 days of treatment. The basal cell carcinoma improved progressively, with no adverse events reported. This case illustrates the...
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Mason, Elena Source Type: research
Spindle cell lipoma: a rare case report on the hallux
We report a 24-year-old man with spindle cell lipomas on the hallux of his left foot. He experienced an uneventful recovery after excision of the mass. We discuss clinical, radiologic, and histopathologic features of spindle cell lipomas and we review the differential diagnosis at this anatomic site. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Liu, Caroline C Source Type: research
Osteonecrosis of the jaw after radiation followed by bevacizumab
Osteonecrosis of the jaw is a recognized complication associated with bevacizumab. Here, we present a patient with squamous cell carcinoma of the tonsil who experienced minimal skin fibrosis following intensity-modulated radiation therapy. Subsequently, the patient developed rectal adenocarcinoma and encountered osteonecrosis of the jaw after receiving two cycles of bevacizumab. Close monitoring, accompanied by thorough examination to detect early signs of osteonecrosis of the jaw, should be considered for patients who have undergone radiation therapy in the head and neck region and are receiving bevacizumab or other medic...
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Park, Lily Source Type: research
Milia en plaque on the shoulder as an early manifestations of mycosis fungoides
Milia en plaque (MEP) is an uncommon skin condition identified as retroauricular confluent milium by Boulzer and Fouqet in 1903 [1]. It can be mistaken for other dermatoses like Favre-Racouchot nodular elastosis, steatocystoma multiplex, and nevus comedonicus. Milia en plaque can either be primary or secondary and is typically benign, often triggered by dermatological procedures like cryotherapy, as reported in this journal. In some cases, MEP can arise as a secondary manifestation of other diseases, including folliculotropic mycosis fungoides (FMF). Despite this association, there are few documented cases in the literatur...
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Rodrigues, Felipe Tavares Source Type: research
Jellyfish envenomation with delayed hypersensitivity and concurrent SARS-CoV-2 infection
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Cheema, Karan S Source Type: research
Painful subcutaneous nodules in an alcoholic: a case of pancreatic panniculitis
Pancreatic panniculitis is an uncommon manifestation of pancreatic disease, affecting approximately 2-3% of patients with acute or chronic pancreatitis [1]. Its accurate diagnosis is crucial for effective treatment as skin manifestations usually precede systemic symptoms of pancreatitis. The diagnosis of pancreatic panniculitis requires identifying and confirming pancreatic disease in addition to the typical histopathological findings of lobular panniculitis without vasculitis. Herein, we present a patient with pancreatic panniculitis, underlying acute pancreatic failure, and kidney injury. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - January 25, 2024 Category: Dermatology Authors: Cortes, Marianne Source Type: research
Lupus erythematosus-specific bullous lesions
Lupus erythematosus (LE)-specific bullous lesions are often difficult to distinguish from other bullous diseases presenting in patients with systemic lupus erythematosus. Herein, we describe a 49-year-old woman with systemic lupus erythematosus with recurrent tense bullae on the forearms. Clinical, histopathologic, and serologic findings led to the diagnosis of LE-specific bullous lesions. We also summarize the diagnostic clues for distinguishing LE-specific bullous lesions, bullous systemic lupus erythematosus, and erythema multiforme-like lesions in LE (Rowell syndrome). (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Smith, Kristin N Source Type: research
Spontaneous, long-lasting re-pigmentation of grey hair: an association with psychoemotional stress relief
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Sevilla, Alec Source Type: research
ChatGPT offers an editorial on the opportunities for chatbots in dermatologic research and patient care
ChatGPT is a chatbot developed by OpenAI, an artificial intelligence research laboratory, that is trained on massive-scale internet text data to understand a broad range of language styles and topics. As a mature, conversational chatbot, ChatGPT can respond to follow-up questions and produce coherent primary texts based on the user's request. We explore the opportunities and risks of integrating chatbots into dermatologic patient care and research while presenting ChatGPT's response to the same question. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Kim, Yong-Hun Source Type: research
A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Neutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colony stimulating factors (e.g., filgrastim) can be utilized to rescue th...
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Joshi, Tejas P Source Type: research
A widespread blistering eruption: diffuse cutaneous mastocytosis
We report a 5-month-old male who presented with a 3-week history of cutaneous bullae and pruritus. On examination, he had erythema of the cheeks bilaterally and diffuse slightly hyperpigmented, indurated skin on his trunk and abdomen. There were tense vesicles, bullae, and erosions linearly arranged on his trunk and extremities. Both the laboratory and imaging workup were normal. Subsequently, a punch biopsy of a vesicle on the abdomen was obtained and findings confirmed a diagnosis of diffuse cutaneous mastocytosis. An EpiPen(r) was prescribed due to the slightly increased anaphylaxis risk compared to other forms of masto...
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Ewulu, Adaora Source Type: research
Cutaneous type IV hypersensitivity reaction following tebentafusp treatment for uveal melanoma
Tebentafusp is a bispecific protein that recently underwent FDA approval for the treatment of metastatic uveal melanoma that functions by redirecting cytotoxic T cells to glycoprotein-100, a protein highly expressed in melanoma. Although clinical trials have demonstrated that rashes are common in the first few days of treatment, little is known about skin reactions that develop later in the treatment course. Herein, we describe a type IV hypersensitivity reaction and vitiligo-like depigmentation that developed six weeks into treatment and discuss the possible mechanisms underlying these reactions. The type IV hypersensitiv...
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Fahmy, Lauren M Source Type: research
Disseminated blastomycosis with cutaneous involvement in a 57-year-old woman: a case report and review of management
We present a 57-year-old woman with pulmonary blastomycosis and secondary cutaneous involvement. Her diagnosis was facilitated by dermatology consultation after approximately one year of delay. In endemic areas including Canada and the USA, individuals are at risk for blastomycosis when non-motile fungal spores are inhaled, thus producing pulmonary disease. The organism may disseminate over time, affecting a variety of extrapulmonary organ systems including the skin. In endemic regions of blastomycosis, this important cutaneous manifestation of disease should be considered with a high index of suspicion as to avoid delayed...
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Strain, Jeremy Source Type: research
