A case series of hydroxychloroquine exacerbating the dermatomyositis rash
Hydroxychloroquine (HCQ) is an antimalarial agent that is commonly used in the management of rheumatic skin disease. Few reports exist documenting exacerbation of dermatomyositis (DM) related to HCQ. Herein, we describe three adult patients with worsening DM cutaneous disease after starting HCQ and resolution or improvement with cessation. The time to exacerbation ranged from two weeks to nine months after the initiation of HCQ 400mg/day. Two of the three patients had antibodies to transcription intermediary factor 1 γ (TIF1γ) and the other had antibodies to anti-nuclear matrix protein 2 (NXP2). After discontinuation of ...
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Rypka, Katelyn Source Type: research

Cutaneous metastasis as a first sign of adenocarcinoma of the cervix
We present a patient whose cutaneous signs led to the diagnosis of metastatic adenocarcinoma of the cervix. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Gociman, Shadai Source Type: research

Anti-laminin 332 antibodies in graft-versus-host disease-associated bullous pemphigoid after allogeneic peripheral blood stem cell transplantation
We report a 48-year-old woman with bullous pemphigoid (BP) with antibodies against the B3 subunit of laminin 332 after the development of graft-versus-host disease (GVHD). She was diagnosed with recurrent acute lymphoblastic leukemia at 40 years of age and underwent two rounds of allogeneic peripheral blood stem cell transplantations (PBST). Two and a half years after the second PBST, multiple tense blisters appeared on her face, hands, and lower legs. The diagnosis of BP was based on hematoxylin eosin and immunofluorescence staining and immunoblotting analyses. A combination regimen of topical corticosteroids (clobetasol ...
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Hida, Yasutoshi Source Type: research

A case of monkeypox and cytomegalovirus coinfection manifesting with crusted lesions mimicking rupiod syphilis
We present a 41-year-old man patient with untreated HIV with generalized rupioid crusted ulcerated plaques with perineal ulceration that were found to represent monkeypox and cytomegalovirus infections. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Zevallos, Jean Source Type: research

Ficus carica L photodermatitis: a report of five cases with histopathologic study and review of the literature.
We present five cases of photodermatitis caused by contact with Ficus carica L and subsequent exposure to sunlight. A histopathologic study and review of the literature are included. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Veraldi, Stefano Source Type: research

Exacerbation of Darier disease with lithium therapy
Darier disease is an autosomal dominant blistering disorder linked to mutation of the endoplasmic reticulum calcium pump, SERCA2, which compromises keratinocyte adhesion and differentiation. Beyond the typical keratotic and eroded skin lesions, patients with Darier disease often present with psychiatric co-morbidities. Herein, we present a biopsy-confirmed case of Darier disease in a patient with bipolar disorder, whose cutaneous disease dramatically worsened upon initiation of lithium therapy. In consultation with the patient's psychiatrist, lithium was tapered, leading to rapid improvement in her skin. This case highligh...
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Tamazian, Shant Source Type: research

Red crusty plaques in a young man
Pemphigus foliaceus is a superficial blistering disorder characterized by erosions and scaling in a seborrheic distribution. The condition typically occurs in healthy individuals but issues arise from delayed diagnosis. Many cases remain undiagnosed or misdiagnosed due to the lack of awareness of the condition. With use of common diagnostic tools, pemphigus foliaceus can be easily identified and monitored. Histological analysis exhibits "chicken wire" patterning along keratinocytes in the upper epidermis, whereas immunofluorescence study displays subcorneal acantholysis. Pemphigus foliaceus is confirmed via ELISA studies r...
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Farsi, Mishma Source Type: research

An unusual presentation of pigmented purpuric lichenoid dermatitis
Pigmented purpuric lichenoid dermatitis (PPLD) is a rare subtype of pigmented purpuric dermatosis, which classically presents with a mixture of lichenoid papules and patches on the bilateral lower extremities. Herein, we describe an unusual case of a 47-year-old man with PPLD who presented with 1-3mm discrete papules without the presence of larger patches. The diagnosis of PPLD should be considered for patients presenting with bilateral symmetric discrete papules on the legs. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: De Antonis, Christine Source Type: research

The effect of perceived health status on satisfaction with care among acne patients: A population-based study
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Kingston, Paige Source Type: research

COVID-19 vaccine-induced cutaneous lupus erythematosus
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Famularo, Giuseppe Source Type: research

Associations between different mask wearing patterns and rosacea severity
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Shah, Pooja M Source Type: research

Update on patterns of use of a genetic expression profiling adhesive test to detect melanoma: a cross-sectional survey of academic pigmented lesion experts and private practice clinicians
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - September 8, 2023 Category: Dermatology Authors: Trepanowski, Nicole Source Type: research

Sickle cell crisis presenting as livedo racemosa
We report a case highlighting an unusual presentation of livedo racemosa as the presenting sign in a patient with sickle cell disease in vaso-occlusive crisis. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - September 5, 2023 Category: Dermatology Authors: Nguyen, Tue F Source Type: research

Bullous pemphigoid after the second SARS-CoV-2 infection
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - September 5, 2023 Category: Dermatology Authors: Correia, Catarina Source Type: research

Tache and talon noir in patient with mycosis fungoides on acitretin
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - September 5, 2023 Category: Dermatology Authors: Obijiofor, Chinemelum Source Type: research