Pediatric cutaneous mucormicosis
A 9-year-old boy diagnosed with acute myeloblastic leukemia and undergoing chemotherapy, was admitted with febrile neutropenia. During his admission, several violaceous plaques appeared on the upper extremities and anterior left hemithorax, which worsened and acquired a necrotic center. We performed a biopsy and histology showed a cutaneous infarction at the dermoepidermal and subcutaneous level. We observed abundant wide hyphae with right-angled branching and a culture isolated Rhizopus oryzae. A plastic surgery consultant performed a surgical debridement of the lesions and treatment was started with intravenous amphoteri...
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Matei, Mariana Claudia Source Type: research
Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone... (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Momin, Bahar Source Type: research
Symptomatic perineural and intraneural invasion of the trigeminal nerve and subsequent abducens Nerve palsy by cutaneous squamous cell carcinoma
A 74-year-old woman who presented initially with trigeminal neuralgia of the left forehead and scalp was later found to have a poorly differentiated squamous cell carcinoma (SCC) with large-nerve perineural and intraneural invasion of the left supraorbital nerve. Negative histopathologic margins were achieved in three stages of permanent fixed tissue en face processing and the final defect was repaired with a large rotation flap. Approximately one month after repair, the patient presented with new-onset diplopia and was found to have a complete left cranial nerve VI palsy suspicious for continued disease spread. MRI confir...
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Winsett, Frank T Source Type: research
Letterer-Siwe disease presenting with gastrointestinal and cutaneous manifestations
Histiocytosis is a set of distinct proliferative illnesses defined by the proliferation and infiltration of varied numbers of dendritic cells, macrophages, and monocytes in the afflicted tissues. The skin and other organs may be impacted by the inflammatory infiltration. It can occur at any age. The severity of the symptoms can range from mild to severe, depending on the degree and type of organ involvement. Although certain forms of histiocytosis can be fatal, others can be treated successfully without sequelae. Langerhans cell histiocytosis manifests itself clinically in both children and adults. A combination of clinica...
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Stadnikova, Antonina Sergeevna Source Type: research
When a travel bug gets you down[SS1]: severe, hypotensive African tick bite fever and response to therapy
We present a United States traveler with African tick bite fever 5 days after she returned from a mission trip to Zimbabwe. The patient exhibited symptomatic hypotension in addition to more typical findings, including fever, fatigue, and a necrotic eschar. The diagnosis was supported by histopathological findings and the patient's symptoms rapidly resolved with oral doxycycline therapy. We believe this case represents the first African tick bite fever diagnosis associated with symptomatic hypotension. This case additionally serves as a reminder of the importance of evaluating patient travel history. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Saxena, Sarthak Singh Source Type: research
Recurrence of non-sexually acquired acute genital ulceration following COVID-19 vaccination
We report a case of non-sexually acquired acute genital ulceration that initially presented in 2008 as Lipschutz labial ulcers associated with acute Epstein-Barr virus infection, with recurrence twelve years later following administration of the second dose of the Pfizer-BioNTech COVID-19 vaccine. This case... (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Waterman, Christy L Source Type: research
Implementation of a dermatology skin of color educational module for medical students
Research in dermatology education highlights the lack of skin of color (SOC) instruction for medical students, leading to concerning healthcare outcomes. Because of the already limited opportunity for students to have dedicated teaching in pathophysiology, management, and treatment of dermatologic diseases in medical school, we developed an educational module that addresses these gaps. We created a one-hour virtual lecture for medical students focused on common skin diseases tested on the United States Medical Licensing Examination with visual images across all skin types. A questionnaire was administered before and after ...
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Han, Joseph Source Type: research
Linear discoid lupus erythematous simulating en coup de sabre morphea in a female chronic granulomatous disease carrier
Discoid lupus erythematosus (DLE), a subtype of chronic cutaneous lupus may be observed in a linear pattern. A 21-year-old woman with history of chronic granulomatous disease state presented to our clinic for a chronic six-year skin eruption on her left eyebrow, left cheek, and left forehead. A punch biopsy of involved left forehead skin was performed and revealed perivascular and periadnexal lymphohistiocytic infiltrate without features of morphea or panniculitis, confirming the histopathologic changes of cutaneous lupus erythematous. The patient was diagnosed with linear DLE, mimicking en coup de sabre, within Blaschko l...
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Dao, Diem-Phuong Source Type: research
Actinic comedonal plaque sine elastosis: a rare presentation or a hitherto unexplored variant of comedonal plaque in skin of color?
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Hilts, Alexis Source Type: research
Provider language proficiency information on dermatology residency program web sites
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Olsen, Eric Source Type: research
Cutaneous erythematous lupus with acneiform presentation
We present a 57-year-old woman with cutaneous lupus erythematosus (CLE), initially treated as acne. She noted blemishes, including nodules and facial swelling for nine months associated with discrete itching of the ears. Examination showed multiple malar nodules, comedones, pustules, atrophic scars, and hyperpigmentation. A biopsy was performed and revealed atrophic epidermis, discrete hyperkeratosis, vacuolar degeneration of basal layer, basal membrane zone with upper dermal lymphohistiocytic inflammatory infiltrate and deep perivascular and peri-adenexal lymphocytes, vascular ectasia, and mucin deposits. The acneiform pr...
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Caputo, Gabriela C Source Type: research
Is orofacial granulomatosis a distinct clinical disorder?
Orofacial granulomatosis is a rare disorder that is heterogeneously defined in the published literature. Herein, we describe a patient with orofacial granulomatosis with clinical and histologic evidence, discuss differential diagnoses, and offer clinical pearls for diagnosing and assessing this disorder. Our case provides support that orofacial granulomatosis is a distinct disorder as opposed to a sequela of other systemic granulomatous diseases. This information will aid dermatologists in decision making and diagnosing the disorder. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Jackson, Tiaranesha K Source Type: research
Erythematous scaly plaques and nodules on scalp
We describe a 45-year-old man who presented with erythematous scaly plaques and nodules on his scalp. In previously reported cases, there were only descriptions of nodules as well as tumors. However, in our case, the patient presented with plaques and nodules on his scalp that quickly resolved with treatment for syphilis. It is important to recognize and treat syphilis at an early stage. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - November 3, 2023 Category: Dermatology Authors: Ho, Peiying Audrey Source Type: research
Underemphasis of histopathology training in the micrographic fellowship application process
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Sarlin, Samantha Source Type: research
Livedoid vasculopathy
is a painful thrombo-occlusive vascular disorder characterized by spontaneous thrombosis in medium-size arterioles, which causes localized hypoxia and skin ulceration. As livedoid vasculopathy is rare, case reports are the primary means of expanding collective knowledge about its presentation and response to various therapies. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Leeolou, Melissa C Source Type: research
