Biosimilars in dermatology: identifying myths and knowledge gaps
Biosimilars are beginning to gain regulatory approval in the United States. Biosimilars are structurally near identical to the innovator and must demonstrate identical pharmacokinetics via the same binding affinity and biological function on assays. However, biologics are so complex that even the innovator company cannot produce exact duplicates; there is batch-to-batch variation. The International Psoriasis Council has outlined a biosimilarity index, which aims to standardize preclinical definitions of biosimilarity. Such an index, paired with post-approval monitoring, could provide a transparent, quantitative definition ...
Source: Dermatology Online Journal - June 23, 2023 Category: Dermatology Authors: Patel, Palak v Source Type: research

Diffuse skin findings secondary to lymph node tularemia in a patient with chronic rheumatoid arthritis on methotrexate
Tularemia has many atypical presentations which can represent a diagnostic challenge. The history is essential in the investigation of this disease. Bite-induced primary skin lesions should be distinguished from the infrequent immune-mediated secondary skin lesions. Herein, we present an atypical pseudovesicular rash secondary to Francisella tularensis. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - June 23, 2023 Category: Dermatology Authors: Kandemir, S Source Type: research

A national survey comparing practice patterns and residency training satisfaction for categorical dermatology versus combined internal medicine and dermatology trained physicians
Combined internal medicine and dermatology (med-derm) training programs were created to advance complex medical dermatology and inpatient dermatology care. A prior study demonstrated that compared to categorical dermatology residents, med-derm residents had less program satisfaction, yet indicated a stronger desire to pursue careers in academia. No follow-up data on practice patterns after training has been reported. We aimed to characterize differences in residency program satisfaction and practice patterns between physicians trained in categorical dermatology compared to med-derm residency programs. We surveyed physician...
Source: Dermatology Online Journal - June 23, 2023 Category: Dermatology Authors: Han, Joohee Source Type: research

Effects of virtual interviews on dermatology match trends: a retrospective cohort analysis
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - June 23, 2023 Category: Dermatology Authors: Diamond, Carrie Source Type: research

Workforce requirements for keratinous cysts: clinicians expend 1200 full-time effort years annually
Keratinous cysts are amongst the 10 most common dermatologic ambulatory diagnoses. Thus, we aimed to estimate the time and cost spent annually on management of keratinous cysts. We conducted a cross-sectional study using the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey between 2007 and 2018 (most recent years available). Conservatively, $2.1 billion per year was spent on healthcare for keratinous cysts. On average, the full-time work of 1200 (840-1800) physicians and non-physician providers are required to manage keratinous cysts yearly in the outpatient and emergency dep...
Source: Dermatology Online Journal - June 23, 2023 Category: Dermatology Authors: Rivin, Gabrielle M Source Type: research

Localized alopecic myxedema of the scalp
This report showcases a rare presentation of localized myxedema of the scalp, highlighting the diverse cutaneous manifestations of autoimmune thyroid diseases. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - June 23, 2023 Category: Dermatology Authors: Doost, Mohammad Saffari Source Type: research

Paclitaxel-induced dorsal hand-foot syndrome
We present an unusual case of paclitaxel-induced HFS localized to the dorsal hands of a 66-year-old man with metastatic angiosarcoma. Early identification and management of HFS is critical to allow for continuation of chemotherapy while improving patient quality of life. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - June 23, 2023 Category: Dermatology Authors: Quan, Eugenie Y Source Type: research

Non-psoriatic uses of calcipotriol: a concise updated review
Calcipotriol (calcipotriene) is a synthetic vitamin D3 derivative that is a standard treatment option for psoriasis. It is generally well tolerated with minimal side effects. Due to its ability to reduce keratinocyte proliferation and induce keratinocyte differentiation as well as its immunomodulatory effects, calcipotriol has been used to treat a variety of skin disorders such as atopic dermatitis, actinic keratoses, lichen planus, seborrheic keratoses, and vitiligo [1]. We surveyed the literature examining the use of calcipotriol for non-psoriatic dermatologic disease. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - June 23, 2023 Category: Dermatology Authors: Patel, Riya T Source Type: research

Skin cancer in patients treated with photobiomodulation for alopecia: a retrospective chart review
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - May 3, 2023 Category: Dermatology Authors: Wipf, Angela Source Type: research

Paraneoplastic or treatment-associated dermatomyositis: a diagnostic challenge
Dermatomyositis (DM) is a systemic autoimmune disorder characterized by proximal myopathy and dermatological findings. Approximately 15-30% of DM cases emerge as a paraneoplastic syndrome caused by a concomitant malignancy. Although more rare, in cancer patients DM has also been reported as a possible result of toxicity of some antineoplastic agents, such as taxanes and monoclonal antibodies. Herein, we report a 35-year-old woman with metastatic breast cancer who presented with skin lesions after initiation of paclitaxel and anti-HER2 agents. Clinical, laboratory, and histological findings were consistent with the diagnosi...
Source: Dermatology Online Journal - April 24, 2023 Category: Dermatology Authors: Esperanca-Martins, Miguel Source Type: research

Out of thin air? Investigating the association between pollution and psoriasis in the United States
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 24, 2023 Category: Dermatology Authors: Mehta, Manan D Source Type: research

Artificial intelligence in medicine - dermatology compared to other medical specialties in FDA-cleared software as medical device
Artificial intelligence (AI) and machine learning (ML) have occupied the center stage in healthcare as research groups and institutions investigate their capabilities and risks. Dermatology is often cited as one of the medical specialties most ripe for disruption with AI technology due to the heavy incorporation of visual information into clinical decisions and treatments. Although the literature on AI in dermatology is rapidly growing, there has been a noticeable absence of mature AI solutions utilized by dermatology departments or patients. This commentary provides insight into the regulatory challenges facing AI solutio...
Source: Dermatology Online Journal - April 24, 2023 Category: Dermatology Authors: Vidal, Nahid Y Source Type: research

An oral lesion masquerading as lichen planus
We report on a patient who presented with a 7-year history of worsening oral lesions. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 24, 2023 Category: Dermatology Authors: Mustin, Danielle E Source Type: research

Mycobacterium marinum infection of the wrist
We report a patient with cutaneous Mycobacterium marinum infection with a non-pruritic erythematous plaque on his right wrist for three months. A history of exposure to contaminated freshwater two years prior was the only exposure that could be determined. Treatment with oral ciprofloxacin combined with clarithromycin produced a good outcome. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 24, 2023 Category: Dermatology Authors: Chumsaengsri, Chumsaeng Source Type: research

A pruritic pedunculated pink nodule on the leg
Herein, we present a patient with a lipidized fibrous histiocytoma, an underrecognized variant of dermatofibroma (cutaneous fibrous histiocytoma). Our patient presented with a nodule on the ankle that showed foamy histiocytes and hyalinized collagen bundles on histology. This case highlights a classic presentation and features of lipidized fibrous histiocytoma, raising further awareness of this distinctive variant of dermatofibroma that should be distinguished from xanthoma and xanthogranuloma. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 24, 2023 Category: Dermatology Authors: Kazmi, Maha Source Type: research