Lichenoid eruption in a child receiving growth hormone for dwarfism
A wide variety of medications have been associated with lichenoid drug eruption. They present similarly or even identically to idiopathic lichen planus, both clinically and histologically. Lichenoid eruption has been associated with recombinant human growth hormone intake in two previous patients. Herein, we describe a young boy who developed a lichenoid eruption following growth hormone injection for dwarfism. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 8, 2022 Category: Dermatology Source Type: research
Early onset drug-induced hypersensitivity syndrome with lymphopenia, hepatitis, and normal eosinophils induced by BRAF/MEK inhibitor after immune checkpoint inhibitor therapy
We report a case of atypical DIHS with reduced latency, mucosal involvement, lymphopenia, normal eosinophils, and no lymphadenopathy that occurred secondary to vemurafenib and cobimetinib therapy following melanoma progression while on pembrolizumab. Previous immune checkpoint inhibitor therapy has been associated... (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 8, 2022 Category: Dermatology Source Type: research
Ethnic distribution of populations in the highest and lowest dermatologist-dense areas: is there more to the story?
Several studies in the past decade have highlighted the lack of adequate dermatological care in skin of color (SOC) patients. This inquiry has led to further research to identify the sources of this disparity. Previous studies have highlighted the uneven geographic distribution of dermatologists, with a higher density of dermatologists in urban areas compared to other areas. However, the exact ethnic populations served by these dermatologists has remained largely uncharacterized. The purpose of this study was to compare the ethnic distributions in the ten highest and lowest dermatologist-dense areas across the United State...
Source: Dermatology Online Journal - April 8, 2022 Category: Dermatology Source Type: research
PPE dermatitis in Skin of Color during the COVID-19 pandemic
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 8, 2022 Category: Dermatology Source Type: research
An exuberant case of prototecosis: an emergent disease in tropical dermatology.
We described an exuberant case treated as sporotrichosis with prolonged course which evolved to arm deformation. Itraconazole treatment for 8 months was inefective. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 8, 2022 Category: Dermatology Source Type: research
Conjunctival malignant melanoma treated successfully with BRAF inhibitor: encorafenib plus binimetinib
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 8, 2022 Category: Dermatology Source Type: research
Toxic erythema of chemotherapy induced by liposomal doxorubicin, a clinical case
A 76-year-old woman presented to the medical oncology outpatient clinic with painful, burning, pruritic erythematous plaques involving both palms and axillae that had suddenly appeared five days before. Examination revealed no additional relevant findings and laboratory studies did not show any alteration. The patient had been recently diagnosed with a high-grade angiosarcoma of the breast (probably radiation induced) and after frequent local recurrences, was being treated with liposomal doxorubicin (three cycles were administered, the last of which was seven days before the appearance of the mentioned lesions). Oral corti...
Source: Dermatology Online Journal - April 8, 2022 Category: Dermatology Source Type: research
A case of pleomorphic dermal sarcoma with perineural invasion treated with Mohs micrographic surgery and adjuvant radiation therapy
We report the case of a 71-year-old man with a PDS with perineural invasion on the scalp, with no recurrence one-year post-treatment with MMS and adjuvant radiation therapy. In contrast to wide local excision, MMS offers complete margin control and tissue preservation, which helps minimize scarring and morbidity. The comparative efficacy of MMS versus wide local excision in the treatment of PDS with and without radiation remains unknown and warrants further investigation. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 8, 2022 Category: Dermatology Source Type: research
Undesirable repigmentation in vitiligo patient receiving methotrexate therapy for the treatment of psoriasis: treatment or side effect?
Vitiligo is an acquired skin depigmentation disorder related to the destruction of melanocytes. There are a limited number of case reports and studies in current literature that show methotrexate (MTX) is effective in the treatment. A 44-year-old man presented to our clinic with a one-year history of psoriasis. On dermatological examination, there were erythematous, scaly papules and plaques on knees, elbows, gluteal area, and scalp compatible with psoriasis. In addition there was total depigmentation over the body. He had a 30-year history of vitiligo, beginning localized but progressed gradually and covered the entire bo...
Source: Dermatology Online Journal - April 8, 2022 Category: Dermatology Source Type: research
Basal cell carcinoma invasion of an ear piercing
We present a 55-year-old woman with nodular BCC involving her auricular piercing and extending clinically onto the posteroinferior right ear lobule and right post-auricular crease. Histological analysis revealed spread of the BCC through the piercing onto the anterior lobule, with evidence that the cancer utilized the piercing as a low resistance pathway for this microscopic invasion. This case is, to our knowledge, the first report of microscopic BCC present within an auricular piercing itself. Chronic inflammation related to repeated trauma from the embedded jewelry may have played a role in its formation. A piercing may...
Source: Dermatology Online Journal - April 8, 2022 Category: Dermatology Source Type: research
Melanoma presenting as a Marjolin ulcer on the lower extremity
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 8, 2022 Category: Dermatology Source Type: research
Curettage of skin cancer-the bruised apple analogy
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 8, 2022 Category: Dermatology Source Type: research
Cutaneous perivascular epithelioid cell tumor (PEComa): case report and world literature review of clinical and molecular characteristics
Perivascular epithelioid cell tumor (PEComa) expresses melanocytic and smooth muscle markers. A man with a primary malignant cutaneous (distal left forearm) PEComa is reported. Immunohistochemistry demonstrated MiTF, HMB-45, caldesmon, desmin, and smooth muscle actin, as well as BCL1, CD10, and CD68. Next generation sequencing showed four pathogenic genomic aberrations involving BIRC3, FANCC, TP53, and TSC1 genes. His work-up was negative for metastatic disease; a wide local excision was performed. Including the reported patient, cutaneous PEComa has been described in 65 individuals: primary benign (N=58), primary malignan...
Source: Dermatology Online Journal - April 8, 2022 Category: Dermatology Source Type: research
Complete response of Merkel cell carcinoma with talimogene laherparepvec (TVEC) monotherapy
We describe a 62-year-old woman who presented with multifocal recurrence of MCC and was not a candidate for immunotherapy or surgery. The patient underwent four treatments of intratumoral talimogene laherparepvec (TVEC) and demonstrated a complete response with no histologic evidence of remaining MCC on four scouting biopsies. Although TVEC therapy is currently approved for the treatment of advanced stage melanoma, it is still being investigated in MCC. This case supports the use of TVEC as monotherapy in select patients with locally advanced MCC who are not candidates for surgery or systemic immunotherapy. (Source: Dermat...
Source: Dermatology Online Journal - April 8, 2022 Category: Dermatology Source Type: research
Fixed drug eruption from atezolizumab
We present a 48-year-old woman with FDE being treated for metastatic breast cancer with atezolizumab. We believe this is the first reported case of FDE secondary to atezolizumab. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - April 8, 2022 Category: Dermatology Source Type: research
