Secondary syphilis presenting as leukocytoclastic vasculitis in a 61-year-old man
We report a case of secondary syphilis presenting with an acute, rapidly progressive purpuric eruption mimicking leukocytoclastic vasculitis. A 61-year-old man presented with a 6-day history of nonpruritic rash on his chest and lower extremities associated with fatigue, sore throat, and night sweats. Examination revealed purpuric papules, extending from the dorsal feet to the hips; mucosal surfaces were not involved. A diagnosis of cutaneous small-vessel... (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Mohamed, Nada Source Type: research
We hardly knew ye... goodbye, #dermtwitter?
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Kennedy, Jake Source Type: research
Two congenital cases of pigmented epithelioid melanocytoma with unique clinical and genetic features
We report two unique cases of congenital PEM with PRKCA fusion transcripts: a multifocal PEM with an aggressive incompletely resectable scalp tumor and a solitary palmar PEM with newly reported ITGB5-PRKCA fusion. Through these case reports and a summary of previously reported cases, we outline the spectrum of disease of PEM and highlight the key clinical and histopathologic features associated with PEM with PRKCA fusion transcripts. We also discuss the treatment options and suggest that surgical excision without further adjuvant systemic treatment is reasonable first-line therapy given the favorable prognosis. (Source: De...
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Zaaroura, Hiba Source Type: research
Generalized perforating granuloma annulare associated with latent tuberculosis successfully treated with isoniazid: case report and review
We report a 66-year-old woman who presented with a 7-month history of mostly asymptomatic generalized infiltrated, flesh-colored to red-brown umbilicated or crusted papules. Histopathological findings were compatible with perforating granuloma annulare. Diagnostic workup revealed latent tuberculosis. To the best of our knowledge, this is the second published case of GPGA associated with latent tuberculosis and the first one that was successfully treated by isoniazid... (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Kapetanovic, Igor Source Type: research
Prescription trends of antidepressant, anxiolytic, and anticonvulsant medications among dermatologists from 2013 to 2020
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Roster, Katie Source Type: research
Erythema elevatum diutinum in a patient with rheumatoid arthritis
We report a 65-year-old woman with painful and itchy lesions on her elbows, hands, knees, and foot for a year. Histopathologic examination confirmed the diagnosis of erythema elevatum diutinum and treatment with dapsone produced significant clinical improvement within few weeks. Erythema elevatum diutinum is a rare disease that should be considered in patients with violaceous nodular plaques located over the extensor regions of the limbs. Knowledge of this unusual pathology and its association helps to avoid misdiagnosis and late treatment. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Bittencourt, Maraya Semblano Source Type: research
Assessment and quality improvement of the Community Care Network: Veterans Administration (VA) patient access to community Mohs micrographic surgery
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Chattopadhyay, Aheli Source Type: research
A case series of hydroxychloroquine exacerbating the dermatomyositis rash
Hydroxychloroquine (HCQ) is an antimalarial agent that is commonly used in the management of rheumatic skin disease. Few reports exist documenting exacerbation of dermatomyositis (DM) related to HCQ. Herein, we describe three adult patients with worsening DM cutaneous disease after starting HCQ and resolution or improvement with cessation. The time to exacerbation ranged from two weeks to nine months after the initiation of HCQ 400mg/day. Two of the three patients had antibodies to transcription intermediary factor 1 γ (TIF1γ) and the other had antibodies to anti-nuclear matrix protein 2 (NXP2). After discontinuation of ...
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Rypka, Katelyn Source Type: research
Cutaneous metastasis as a first sign of adenocarcinoma of the cervix
We present a patient whose cutaneous signs led to the diagnosis of metastatic adenocarcinoma of the cervix. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Gociman, Shadai Source Type: research
Anti-laminin 332 antibodies in graft-versus-host disease-associated bullous pemphigoid after allogeneic peripheral blood stem cell transplantation
We report a 48-year-old woman with bullous pemphigoid (BP) with antibodies against the B3 subunit of laminin 332 after the development of graft-versus-host disease (GVHD). She was diagnosed with recurrent acute lymphoblastic leukemia at 40 years of age and underwent two rounds of allogeneic peripheral blood stem cell transplantations (PBST). Two and a half years after the second PBST, multiple tense blisters appeared on her face, hands, and lower legs. The diagnosis of BP was based on hematoxylin eosin and immunofluorescence staining and immunoblotting analyses. A combination regimen of topical corticosteroids (clobetasol ...
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Hida, Yasutoshi Source Type: research
A case of monkeypox and cytomegalovirus coinfection manifesting with crusted lesions mimicking rupiod syphilis
We present a 41-year-old man patient with untreated HIV with generalized rupioid crusted ulcerated plaques with perineal ulceration that were found to represent monkeypox and cytomegalovirus infections. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Zevallos, Jean Source Type: research
Ficus carica L photodermatitis: a report of five cases with histopathologic study and review of the literature.
We present five cases of photodermatitis caused by contact with Ficus carica L and subsequent exposure to sunlight. A histopathologic study and review of the literature are included. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Veraldi, Stefano Source Type: research
Exacerbation of Darier disease with lithium therapy
Darier disease is an autosomal dominant blistering disorder linked to mutation of the endoplasmic reticulum calcium pump, SERCA2, which compromises keratinocyte adhesion and differentiation. Beyond the typical keratotic and eroded skin lesions, patients with Darier disease often present with psychiatric co-morbidities. Herein, we present a biopsy-confirmed case of Darier disease in a patient with bipolar disorder, whose cutaneous disease dramatically worsened upon initiation of lithium therapy. In consultation with the patient's psychiatrist, lithium was tapered, leading to rapid improvement in her skin. This case highligh...
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Tamazian, Shant Source Type: research
Red crusty plaques in a young man
Pemphigus foliaceus is a superficial blistering disorder characterized by erosions and scaling in a seborrheic distribution. The condition typically occurs in healthy individuals but issues arise from delayed diagnosis. Many cases remain undiagnosed or misdiagnosed due to the lack of awareness of the condition. With use of common diagnostic tools, pemphigus foliaceus can be easily identified and monitored. Histological analysis exhibits "chicken wire" patterning along keratinocytes in the upper epidermis, whereas immunofluorescence study displays subcorneal acantholysis. Pemphigus foliaceus is confirmed via ELISA studies r...
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: Farsi, Mishma Source Type: research
An unusual presentation of pigmented purpuric lichenoid dermatitis
Pigmented purpuric lichenoid dermatitis (PPLD) is a rare subtype of pigmented purpuric dermatosis, which classically presents with a mixture of lichenoid papules and patches on the bilateral lower extremities. Herein, we describe an unusual case of a 47-year-old man with PPLD who presented with 1-3mm discrete papules without the presence of larger patches. The diagnosis of PPLD should be considered for patients presenting with bilateral symmetric discrete papules on the legs. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - October 26, 2023 Category: Dermatology Authors: De Antonis, Christine Source Type: research
