GPR41 and GPR43 regulate CD8(+) T cell priming during herpes simplex virus type 1 infection
In this study, we investigated the role of the G protein-coupled receptors (GPR)41 and GPR43 that can bind microbiota-derived short chain fatty acids (SCFAs) in CD8+ T cell priming following epicutaneous herpes simplex virus type 1 (HSV-1) infection. We found that HSV-specific CD8+ T cells in GPR41/43-deficient mice were impaired in the antigen-elicited production of interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α), granzyme B and perforin, and failed to differentiate effectively into memory precursors. The defect in controlling HSV-1 at the site of infection could be restored when GPR41 and GPR43 were expr...
Source: Herpes - March 25, 2024 Category: Infectious Diseases Authors: Ariane Renita Lee Kayla Roberta Wilson Michele Clarke Sven Engel David C Tscharke Thomas Gebhardt Sammy Bedoui Annabell Bachem Source Type: research
Characteristics, management and outcome of Herpes Simplex and Varicella-Zoster virus encephalitis: a multicenter prospective cohort study
CONCLUSION: HSVE and VZVE are distinct in clinical presentation, outcome, and prognostic factors. The impact of early ACV initiation was more apparent for HSVE than for VZVE, however, this could be due to VZVE smaller sample size and lower outcome rate leading to low statistical power, or due to potential distinct IE pathophysiology.PMID:38527616 | DOI:10.1016/j.cmi.2024.03.017 (Source: Herpes)
Source: Herpes - March 25, 2024 Category: Infectious Diseases Authors: L éa Poussier Alexandra Mailles Pierre Tattevin Jean Paul Stahl Pierre Fillatre scientific committee and investigators group investigators ’ group are scientific committee are Source Type: research
Error in Conflict of Interest Disclosures
In the Editorial titled “Shedding Patterns of Genital Herpes Simplex Virus Infections,” published online on October 22, 2022, and in the November 1, 2022, issue of JAMA, Dr Whitley omitted potential conflict of interest disclosures. The disclosure statement has been corrected to include “serving on the board of direc tors for Gilead Sciences, Inc, with vested shares in the company at the time of this publication, and as cofounder and investor in Treovir LLC.” The article was corrected online. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 25, 2024 Category: General Medicine Source Type: research
UVB induced reactivation leads to HSV1 in the corneas of virtually all latently infected mice and requires STING to develop corneal disease
Sci Rep. 2024 Mar 21;14(1):6859. doi: 10.1038/s41598-024-52597-0.ABSTRACTReactivation of latent herpes simplex type 1 results in virus returning to the cornea leading to recurrent herpetic stromal keratitis (rHSK). We compare two competing models to reactivate viruses from latency, UV-B irradiation and cyclophosphamide (CP). Results revealed that while both result in corneal recrudescence, only UV-B irradiation results in rHSK. To better understand the dynamics of reactivation, we analyzed corneas for both the presence of infectious viruses and the dynamics of exposure to multiple reactivations using UV-B. We noted that mu...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Xiao-Tang Yin Alexis Hartman Nadia Sirajuddin Deepak Shukla Anthony St Leger Tammie L Keadle Patrick M Stuart Source Type: research
Navigating diagnostic challenges: imaging strategies for herpes simplex encephalitis in resource limited settings: A case report
Radiol Case Rep. 2024 Mar 13;19(6):2183-2187. doi: 10.1016/j.radcr.2024.02.060. eCollection 2024 Jun.ABSTRACTEncephalitis refers to the inflammatory condition affecting the brain parenchyma, leading to various neurological impairments. It can have various causes: infectious, postinfectious, and noninfectious origins. In this case, we present a 76-year-old man who presented to the emergency room with complaints of headache and behavioral changes. Initially, a Computed Tomography (CT) scan raised suspicion of herpes simplex encephalitis and prompted the initiation of treatment. Subsequently, Magnetic Resonance Imaging (MRI) ...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Shimalis Tadasa Fayisa Nishma Pokharel Abisiniya Solomon Lense Negash Lidiya Ayele Biltibo Selamawit Hailu Bedasso Abel Tsehay Abebe Source Type: research
Viral Anterior Uveitis: Differences in Retinal Vessel Area Density between the Affected and Non-Affected Eye Using Optical Coherence Tomography Angiography
CONCLUSION: We observed vascular dysfunction characterized by decreased macular and peripapillary VAD in the superficial plexus on OCTA in eyes with HSV- and VZV-positive VAU compared to non-affected fellow eyes. These changes might be an early sign of glaucomatous damage or may be a direct consequence of the herpes viruses themselves.PMID:38517389 | DOI:10.1080/09273948.2024.2329318 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - March 22, 2024 Category: Allergy & Immunology Authors: Anna-Karina B Maier Daniel Mandrossa Emanuel Reitemeyer Sibylle Winterhalter Anne R übsam Uwe Pleyer Source Type: research
Viral Anterior Uveitis: Differences in Retinal Vessel Area Density between the Affected and Non-Affected Eye Using Optical Coherence Tomography Angiography
CONCLUSION: We observed vascular dysfunction characterized by decreased macular and peripapillary VAD in the superficial plexus on OCTA in eyes with HSV- and VZV-positive VAU compared to non-affected fellow eyes. These changes might be an early sign of glaucomatous damage or may be a direct consequence of the herpes viruses themselves.PMID:38517389 | DOI:10.1080/09273948.2024.2329318 (Source: Herpes)
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Anna-Karina B Maier Daniel Mandrossa Emanuel Reitemeyer Sibylle Winterhalter Anne R übsam Uwe Pleyer Source Type: research
Navigating diagnostic challenges: imaging strategies for herpes simplex encephalitis in resource limited settings: A case report
Radiol Case Rep. 2024 Mar 13;19(6):2183-2187. doi: 10.1016/j.radcr.2024.02.060. eCollection 2024 Jun.ABSTRACTEncephalitis refers to the inflammatory condition affecting the brain parenchyma, leading to various neurological impairments. It can have various causes: infectious, postinfectious, and noninfectious origins. In this case, we present a 76-year-old man who presented to the emergency room with complaints of headache and behavioral changes. Initially, a Computed Tomography (CT) scan raised suspicion of herpes simplex encephalitis and prompted the initiation of treatment. Subsequently, Magnetic Resonance Imaging (MRI) ...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Shimalis Tadasa Fayisa Nishma Pokharel Abisiniya Solomon Lense Negash Lidiya Ayele Biltibo Selamawit Hailu Bedasso Abel Tsehay Abebe Source Type: research
UVB induced reactivation leads to HSV1 in the corneas of virtually all latently infected mice and requires STING to develop corneal disease
Sci Rep. 2024 Mar 21;14(1):6859. doi: 10.1038/s41598-024-52597-0.ABSTRACTReactivation of latent herpes simplex type 1 results in virus returning to the cornea leading to recurrent herpetic stromal keratitis (rHSK). We compare two competing models to reactivate viruses from latency, UV-B irradiation and cyclophosphamide (CP). Results revealed that while both result in corneal recrudescence, only UV-B irradiation results in rHSK. To better understand the dynamics of reactivation, we analyzed corneas for both the presence of infectious viruses and the dynamics of exposure to multiple reactivations using UV-B. We noted that mu...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Xiao-Tang Yin Alexis Hartman Nadia Sirajuddin Deepak Shukla Anthony St Leger Tammie L Keadle Patrick M Stuart Source Type: research
Viral Anterior Uveitis: Differences in Retinal Vessel Area Density between the Affected and Non-Affected Eye Using Optical Coherence Tomography Angiography
CONCLUSION: We observed vascular dysfunction characterized by decreased macular and peripapillary VAD in the superficial plexus on OCTA in eyes with HSV- and VZV-positive VAU compared to non-affected fellow eyes. These changes might be an early sign of glaucomatous damage or may be a direct consequence of the herpes viruses themselves.PMID:38517389 | DOI:10.1080/09273948.2024.2329318 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - March 22, 2024 Category: Allergy & Immunology Authors: Anna-Karina B Maier Daniel Mandrossa Emanuel Reitemeyer Sibylle Winterhalter Anne R übsam Uwe Pleyer Source Type: research
UVB induced reactivation leads to HSV1 in the corneas of virtually all latently infected mice and requires STING to develop corneal disease
Sci Rep. 2024 Mar 21;14(1):6859. doi: 10.1038/s41598-024-52597-0.ABSTRACTReactivation of latent herpes simplex type 1 results in virus returning to the cornea leading to recurrent herpetic stromal keratitis (rHSK). We compare two competing models to reactivate viruses from latency, UV-B irradiation and cyclophosphamide (CP). Results revealed that while both result in corneal recrudescence, only UV-B irradiation results in rHSK. To better understand the dynamics of reactivation, we analyzed corneas for both the presence of infectious viruses and the dynamics of exposure to multiple reactivations using UV-B. We noted that mu...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Xiao-Tang Yin Alexis Hartman Nadia Sirajuddin Deepak Shukla Anthony St Leger Tammie L Keadle Patrick M Stuart Source Type: research
Navigating diagnostic challenges: imaging strategies for herpes simplex encephalitis in resource limited settings: A case report
Radiol Case Rep. 2024 Mar 13;19(6):2183-2187. doi: 10.1016/j.radcr.2024.02.060. eCollection 2024 Jun.ABSTRACTEncephalitis refers to the inflammatory condition affecting the brain parenchyma, leading to various neurological impairments. It can have various causes: infectious, postinfectious, and noninfectious origins. In this case, we present a 76-year-old man who presented to the emergency room with complaints of headache and behavioral changes. Initially, a Computed Tomography (CT) scan raised suspicion of herpes simplex encephalitis and prompted the initiation of treatment. Subsequently, Magnetic Resonance Imaging (MRI) ...
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Shimalis Tadasa Fayisa Nishma Pokharel Abisiniya Solomon Lense Negash Lidiya Ayele Biltibo Selamawit Hailu Bedasso Abel Tsehay Abebe Source Type: research
Viral Anterior Uveitis: Differences in Retinal Vessel Area Density between the Affected and Non-Affected Eye Using Optical Coherence Tomography Angiography
CONCLUSION: We observed vascular dysfunction characterized by decreased macular and peripapillary VAD in the superficial plexus on OCTA in eyes with HSV- and VZV-positive VAU compared to non-affected fellow eyes. These changes might be an early sign of glaucomatous damage or may be a direct consequence of the herpes viruses themselves.PMID:38517389 | DOI:10.1080/09273948.2024.2329318 (Source: Herpes)
Source: Herpes - March 22, 2024 Category: Infectious Diseases Authors: Anna-Karina B Maier Daniel Mandrossa Emanuel Reitemeyer Sibylle Winterhalter Anne R übsam Uwe Pleyer Source Type: research
Viral Anterior Uveitis: Differences in Retinal Vessel Area Density between the Affected and Non-Affected Eye Using Optical Coherence Tomography Angiography
CONCLUSION: We observed vascular dysfunction characterized by decreased macular and peripapillary VAD in the superficial plexus on OCTA in eyes with HSV- and VZV-positive VAU compared to non-affected fellow eyes. These changes might be an early sign of glaucomatous damage or may be a direct consequence of the herpes viruses themselves.PMID:38517389 | DOI:10.1080/09273948.2024.2329318 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - March 22, 2024 Category: Allergy & Immunology Authors: Anna-Karina B Maier Daniel Mandrossa Emanuel Reitemeyer Sibylle Winterhalter Anne R übsam Uwe Pleyer Source Type: research
New hopes for the breast cancer treatment: perspectives on the oncolytic virus therapy
Oncolytic virus (OV) therapy has emerged as a promising frontier in cancer treatment, especially for solid tumours. While immunotherapies like immune checkpoint inhibitors and CAR-T cells have demonstrated impressive results, their limitations in inducing complete tumour regression have spurred researchers to explore new approaches targeting tumours resistant to current immunotherapies. OVs, both natural and genetically engineered, selectively replicate within cancer cells, inducing their lysis while sparing normal tissues. Recent advancements in clinical research and genetic engineering have enabled the development of tar...
Source: Frontiers in Immunology - March 21, 2024 Category: Allergy & Immunology Source Type: research
