GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection
In this study, we investigated the role of the G protein-coupled receptors (GPR)41 and GPR43 that can bind microbiota-derived short chain fatty acids (SCFAs) in CD8+ T cell priming following epicutaneous herpes simplex virus type 1 (HSV-1) infection. We found that HSV-specific CD8+ T cells in GPR41/43-deficient mice were impaired in the antigen-elicited production of interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α), granzyme B and perforin, and failed to differentiate effectively into memory precursors. The defect in controlling HSV-1 at the site of infection could be restored when GPR41 and GPR43 were expr...
Source: Frontiers in Immunology - March 8, 2024 Category: Allergy & Immunology Source Type: research
Four new resin glycosides from Ipomoea muricata seeds: muricatins XIV –XVII
AbstractIpomoea muricata (L.) Jacq. seeds (Convolvulaceae) are used as a traditional laxative and carminative medicine. Muricatins XIV (1), XV (2), XVI (3), and XVII (4), were isolated from I. muricata seeds as four new resin glycosides, along with seven known compounds, three of which were isolated for the first time as natural products; their structures were determined using MS and NMR spectroscopy. Compounds1–4 are macrolactones (jalapins); the sugar moieties of1,2, and4 are partially acylated with 2S-methylbutyric acid, while that of3 is esterified with 2S-methylbutyric and 2S-methyl-3S-hydroxybutyric acids. In addit...
Source: Journal of Natural Medicines - March 8, 2024 Category: Drugs & Pharmacology Source Type: research
Viruses, Vol. 16, Pages 419: Herpes Simplex Virus Bronchopneumonitis in Critically Ill Patients with Acute on Chronic Liver Failure: A Retrospective Analysis
Conclusions: Mortality of critically ill patients with ACLF with HSV bronchopneumonitis was not increased in spite of the cirrhosis-associated immune dysfunction. Their clinical course, however, was more complicated with significantly longer mechanical ventilation. (Source: Viruses)
Source: Viruses - March 8, 2024 Category: Virology Authors: Miriam Dibos Julian Triebelhorn Jochen Schneider Sebastian Rasch Roland M. Schmid Tobias Lahmer Ulrich Mayr Tags: Article Source Type: research
ASFV pA151R negatively regulates type I IFN production via degrading E3 ligase TRAF6
In this study, we demonstrated that ASFV pA151R negatively regulated type I IFN production. Ectopic expression of pA151R dramatically inhibited K63-linked polyubiquitination and Ser172 phosphorylation of TANK-binding kinase 1 (TBK1). Mechanically, we demonstrated that E3 ligase TNF receptor-associated factor 6 (TRAF6) participated in the ubiquitination of TBK1 in cGAS-STING signaling pathway. We showed that pA151R interacted with TRAF6 and degraded it through apoptosis pathway, leading to the disruption of TBK1 and TRAF6 interaction. Moreover, we clarified that the amino acids H102, C109, C132, and C135 in pA151R were cruc...
Source: Herpes - March 7, 2024 Category: Infectious Diseases Authors: You Li Li Huang Hui Li Yingqi Zhu Zilong Yu Xiaojie Zheng Changjiang Weng Wen-Hai Feng Source Type: research
Histone H2A variant H2A.B is enriched in transcriptionally active and replicating HSV-1 lytic chromatin
J Virol. 2024 Mar 7:e0201523. doi: 10.1128/jvi.02015-23. Online ahead of print.ABSTRACTHerpes simplex virus 1 (HSV-1) transcription is restricted in latently infected neurons and the genomes are in mostly silenced chromatin, whereas all viral genes are transcribed in lytically infected cells, in which the genomes are dynamically chromatinized. Epigenetic regulation modulates HSV-1 transcription during lytic, latent, and reactivating infections but the precise mechanisms are not fully defined. Nucleosomes are dynamic: they slide, breathe, assemble, and disassemble. We and others have proposed that the most dynamic HSV-1 chr...
Source: Herpes - March 7, 2024 Category: Infectious Diseases Authors: Esteban Flores Cortes Sarah M Saddoris Arryn K Owens Rebecca Gibeault Daniel P Depledge Luis M Schang Source Type: research
