PD-L1 Expression in Nonbacterial Chronic Cystitis and Bladder Cancer
CONCLUSIONS: Expression of PD-L1 was detected in a cohort of NCC patients, although the PD-L1 positivity rate was lower than that in BC. Our results demonstrate that the degree of PD-L1 expression in bladder tissue is associated with the presence of viral infections and with the degree of inflammatory infiltration of the bladder wall in both NCC and BC.PMID:38662109 | DOI:10.1007/s00192-024-05782-8 (Source: Herpes)
Source: Herpes - April 25, 2024 Category: Infectious Diseases Authors: Inga Kosova Vagan Barsegian Lyudmila Gundorova Dmitriy Kolbasov Source Type: research
Seroprevalence of sexually transmitted infections over 44 years - A cross-sectional study in Sweden
CONCLUSIONS: There was a decrease over time in Chlamydia trachomatis seroprevalence, probably due to contact tracing, testing and early treatment; this might also have affected Mycoplasma genitalium seroprevalence. Despite the reduction, seroprevalences are still high, so continued and new efforts to reduce STI incidence are essential.PMID:38659325 | DOI:10.1177/09564624241248874 (Source: Herpes)
Source: Herpes - April 25, 2024 Category: Infectious Diseases Authors: Nirina Andersson Tim Waterboer Elisabet Nylander Annika Idahl Source Type: research
PD-L1 Expression in Nonbacterial Chronic Cystitis and Bladder Cancer
ConclusionsExpression of PD-L1 was detected in a cohort of NCC patients, although the PD-L1 positivity rate was lower than that in BC. Our results demonstrate that the degree of PD-L1 expression in bladder tissue is associated with the presence of viral infections and with the degree of inflammatory infiltration of the bladder wall in both NCC and BC. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - April 25, 2024 Category: OBGYN Source Type: research
Effect of acyclovir therapy on the outcome of mechanically ventilated patients with lower respiratory tract infection and detection of herpes simplex virus in bronchoalveolar lavage: protocol for a multicentre, randomised controlled trial (HerpMV)
Introduction
Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients and is associated with a worse outcome. The aim of this study is to determine whether antiviral therapy in HSV-positive patients improves outcome.
Methods and analysis
Prospective, multicentre, open-label, randomised, controlled trial in parallel-group design. Adult, mechanically ventilated patients with pneumonia and HSV type 1 detected in bronchoalveolar lavage (≥105 copies/mL) are eligible for participation and will be randomly allocated (1:1) to receive acyclovir (10 mg/kg body weight every 8 ...
Source: BMJ Open - April 25, 2024 Category: General Medicine Authors: Hagel, S., Brillinger, N., Decker, S., Deja, M., Ertmer, C., Fiedler, S., Franken, P., Heim, M., Weigand, M. A., Zarbock, A., Pletz, M. W., SepNet Critical Care Trials Group, Ehler, Bloos, Bauer, Brenner, Meybohm, Kluge, Vogt, Lahmer, Fortenbach, John, Be Tags: Open access, Intensive care Source Type: research
C-C motif chemokine receptor 2 and 7 synergistically control inflammatory monocyte recruitment but the infecting virus dictates monocyte function in the brain
Commun Biol. 2024 Apr 24;7(1):494. doi: 10.1038/s42003-024-06178-6.ABSTRACTInflammatory monocytes (iMO) are recruited from the bone marrow to the brain during viral encephalitis. C-C motif chemokine receptor (CCR) 2 deficiency substantially reduces iMO recruitment for most, but not all encephalitic viruses. Here we show CCR7 acts synergistically with CCR2 to control this process. Following Herpes simplex virus type-1 (HSV-1), or La Crosse virus (LACV) infection, we find iMO proportions are reduced by approximately half in either Ccr2 or Ccr7 knockout mice compared to control mice. However, Ccr2/Ccr7 double knockouts elimin...
Source: Herpes - April 24, 2024 Category: Infectious Diseases Authors: Clayton W Winkler Alyssa B Evans Aaron B Carmody Justin B Lack Tyson A Woods Karin E Peterson Source Type: research
Serious neurological adverse events in immunocompetent children and adolescents caused by viral reactivation in the years following varicella vaccination
Rev Med Virol. 2024 May;34(3):e2538. doi: 10.1002/rmv.2538.ABSTRACTSerious adverse events following vaccination include medical complications that require hospitalisation. The live varicella vaccine that was approved by the Food and Drug Administration in the United States in 1995 has an excellent safety record. Since the vaccine is a live virus, adverse events are more common in immunocompromised children who are vaccinated inadvertently. This review includes only serious adverse events in children considered to be immunocompetent. The serious adverse event called varicella vaccine meningitis was first reported in a hospi...
Source: Herpes - April 24, 2024 Category: Infectious Diseases Authors: Prashanth Ramachandran Charles Grose Source Type: research
GSE242636 Aberrant RNA polymerase Initiation and Processivity on the Genome of a Herpes Simplex Virus 1 Mutant Lacking ICP27
Contributors : Claire Birkenheuer ; Joel BainesSeries Type : OtherOrganism : Drosophila melanogaster ; Homo sapiens ; Human alphaherpesvirus 1Within the first 15 minutes of infection, herpes simplex virus 1 (HSV-1) immediate early proteins repurpose cellular RNA polymerase (Pol II) for viral transcription. An important role of the viral infected cell protein 27 (ICP27) is to facilitate viral pre-mRNA processing and export of viral mRNA to the cytoplasm. Here, we use precision nuclear run-on followed by deep sequencing (PRO-seq) to characterize transcription of a viral ICP27 null mutant. At 1.5 and 3 hours post infection ...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Other Drosophila melanogaster Homo sapiens Human alphaherpesvirus 1 Source Type: research
Microbial keratitis in Southern Malawi: a microbiological pilot study
CONCLUSIONS: In a resource-poor setting, a CIM can be used to safely sample the cornea in patients presenting with suspected MK, enabling identification of causative microorganisms by culture and PCR. Although the microbiological spectrum found was limited to the dry season, these preliminary results could be used to guide empirical treatment.PMID:38653537 | DOI:10.1136/bmjophth-2024-001682 (Source: Herpes)
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Tobi F Somerville Shaffi Mdala Thokozani Zungu Moira Gandiwa Rose Herbert Dean Everett Caroline E Corless Nicholas A V Beare Timothy Neal Malcolm J Horsburgh Alistair Darby Stephen B Kaye Petros C Kayange Source Type: research
ISGylation by HERCs facilitates STING activation
Cell Rep. 2024 Apr 21;43(5):114135. doi: 10.1016/j.celrep.2024.114135. Online ahead of print.ABSTRACTOptimal activation of stimulator of interferon genes (STING) protein is crucial for host defenses against pathogens and avoiding detrimental effects. Various post-translational modifications control STING activity. However, the function of interferon (IFN)-stimulated gene (ISG) 15 modification (ISGylation) in controlling STING stability and activation is unclear. Here, we show that the E3 ISGylation ligases HECT domain- and RCC1-like domain-containing proteins (HERCs; HERC5 in humans and HERC6 in mice) facilitate STING acti...
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Ying Qin Min Wang Xintong Meng Mengge Wang Haojia Jiang Yanjie Gao Jingxin Li Chunyuan Zhao Chaofeng Han Wei Zhao Xuexing Zheng Source Type: research
HSV-1 employs UL56 to antagonize expression and function of cGAMP channels
We report that infection with multiple human viruses depletes some of these cGAMP conduits. This includes herpes simplex virus 1 (HSV-1) that targets SLC46A2, P2X7, and the VRAC subunits LRRC8A and LRRC8C for degradation. The HSV-1 protein UL56 is necessary and sufficient for these effects that are mediated at least partially by proteasomal turnover. UL56 thereby inhibits cGAMP uptake via VRAC, SLC46A2, and P2X7. Taken together, HSV-1 antagonizes intercellular cGAMP transfer. We propose that this limits innate immunity by reducing cell-to-cell communication via the immunotransmitter cGAMP.PMID:38652659 | DOI:10.1016/j.celr...
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Henry T W Blest Alexander Redmond Jed Avissar Jake Barker Anne Bridgeman Gerissa Fowler Lise Chauveau Jonny Hertzog Iolanda Vendrell Roman Fischer Marie B Iversen Lichen Jing David M Koelle S øren R Paludan Benedikt M Kessler Colin M Crump Jan Rehwinkel Source Type: research
A dual fluorescent herpes simplex virus type 1 recombinant reveals divergent outcomes of neuronal infection
We report that the transcriptional state of neuronal HSV-1 infection is variable in response to changes in the intracellular neuronal environment.IMPORTANCEHerpes simplex virus type 1 (HSV-1) is a prevalent human pathogen that infects approximately 67% of the global human population. HSV-1 invades the peripheral nervous system, where latent HSV-1 infection persists within the host for life. Immunological evasion, viral persistence, and herpetic pathologies are determined by the regulation of HSV-1 gene expression. Studying HSV-1 gene expression during neuronal infection is challenging but essential for the development of a...
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Luke F Domanico Gary P Dunn Oren Kobiler Matthew P Taylor Source Type: research
A dual fluorescent herpes simplex virus type 1 recombinant reveals divergent outcomes of neuronal infection
We report that the transcriptional state of neuronal HSV-1 infection is variable in response to changes in the intracellular neuronal environment.IMPORTANCEHerpes simplex virus type 1 (HSV-1) is a prevalent human pathogen that infects approximately 67% of the global human population. HSV-1 invades the peripheral nervous system, where latent HSV-1 infection persists within the host for life. Immunological evasion, viral persistence, and herpetic pathologies are determined by the regulation of HSV-1 gene expression. Studying HSV-1 gene expression during neuronal infection is challenging but essential for the development of a...
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Luke F Domanico Gary P Dunn Oren Kobiler Matthew P Taylor Source Type: research
ISGylation by HERCs facilitates STING activation
Cell Rep. 2024 Apr 21;43(5):114135. doi: 10.1016/j.celrep.2024.114135. Online ahead of print.ABSTRACTOptimal activation of stimulator of interferon genes (STING) protein is crucial for host defenses against pathogens and avoiding detrimental effects. Various post-translational modifications control STING activity. However, the function of interferon (IFN)-stimulated gene (ISG) 15 modification (ISGylation) in controlling STING stability and activation is unclear. Here, we show that the E3 ISGylation ligases HECT domain- and RCC1-like domain-containing proteins (HERCs; HERC5 in humans and HERC6 in mice) facilitate STING acti...
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Ying Qin Min Wang Xintong Meng Mengge Wang Haojia Jiang Yanjie Gao Jingxin Li Chunyuan Zhao Chaofeng Han Wei Zhao Xuexing Zheng Source Type: research
HSV-1 employs UL56 to antagonize expression and function of cGAMP channels
We report that infection with multiple human viruses depletes some of these cGAMP conduits. This includes herpes simplex virus 1 (HSV-1) that targets SLC46A2, P2X7, and the VRAC subunits LRRC8A and LRRC8C for degradation. The HSV-1 protein UL56 is necessary and sufficient for these effects that are mediated at least partially by proteasomal turnover. UL56 thereby inhibits cGAMP uptake via VRAC, SLC46A2, and P2X7. Taken together, HSV-1 antagonizes intercellular cGAMP transfer. We propose that this limits innate immunity by reducing cell-to-cell communication via the immunotransmitter cGAMP.PMID:38652659 | DOI:10.1016/j.celr...
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Henry T W Blest Alexander Redmond Jed Avissar Jake Barker Anne Bridgeman Gerissa Fowler Lise Chauveau Jonny Hertzog Iolanda Vendrell Roman Fischer Marie B Iversen Lichen Jing David M Koelle S øren R Paludan Benedikt M Kessler Colin M Crump Jan Rehwinkel Source Type: research
Microbial keratitis in Southern Malawi: a microbiological pilot study
CONCLUSIONS: In a resource-poor setting, a CIM can be used to safely sample the cornea in patients presenting with suspected MK, enabling identification of causative microorganisms by culture and PCR. Although the microbiological spectrum found was limited to the dry season, these preliminary results could be used to guide empirical treatment.PMID:38653537 | DOI:10.1136/bmjophth-2024-001682 (Source: Herpes)
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Tobi F Somerville Shaffi Mdala Thokozani Zungu Moira Gandiwa Rose Herbert Dean Everett Caroline E Corless Nicholas A V Beare Timothy Neal Malcolm J Horsburgh Alistair Darby Stephen B Kaye Petros C Kayange Source Type: research
