CNS Aspergillosis and Cryptococcosis with Cytomegalovirus Pneumonia in a Patient with Chronic Lymphocytic Leukemia Treated with Acalabrutinib

We describe a 68-year-old male who developed multiple bacterial, fungal and viral infections while on treatment with acalabrutinib. To our knowledge, this is the first reported case of concomitant CNS infections with Cryptococcus neoformans and Aspergillus fumigatus, along with cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1) pneumonia while on acalabrutinib. This case adds to the scarce literature of fungal and bacterial infections associated with acalabrutinib, raising the suspicion that infection risk is a medication class effect for BTKis.PMID:38621678 | DOI:10.1177/08971900241247660

Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Taylor Fallin Erica Thacker Syeda Sahra Emily A Siegrist Bryan P White Katherine Summers Dena Shibib Joseph Sassine Source Type: research