Invasive Aspergillosis in Coronavirus Disease 2019 Invasive Aspergillosis in Coronavirus Disease 2019
This review examines the potential link between invasive pulmonary aspergillosis and COVID-19 and discusses diagnostic and treatment approaches.Current Opinion in Infectious Diseases (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - March 23, 2022 Category: Pathology Tags: Infectious Diseases Journal Article Source Type: news

Invasive Mold in Patients With COVID-19 Invasive Mold in Patients With COVID-19
COVID-19 is likely to increase the risk for pulmonary aspergillosis and mucormycosis, life-threatening infections caused by environmental molds.CDC Expert Commentary (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - March 3, 2022 Category: Infectious Diseases Tags: Infectious Diseases Article Source Type: news

COVID-19 rapid guideline: managing COVID-19 [NG191], NICE (updated 16th December 2021)
This guideline covers the management of COVID-19 for children, young people and adults in all care settings. It brings together our existing recommendations on managing COVID-19, and new recommendations on therapeutics, so that healthcare staff and those planning and delivering services can find and use them more easily. We are continually monitoring the evidence and updating the guideline as new information emerges. On 16 December, we added new recommendations on COVID-19-associated pulmonary aspergillosis. We revised our statement about the Omicron variant in the recommendation on casirivimab and imdevimab. (Source: Cu...
Source: Current Awareness Service for Health (CASH) - December 17, 2021 Category: Consumer Health News Source Type: news

Cohort Study of COVID-19-Associated Pulmonary Aspergillosis Cohort Study of COVID-19-Associated Pulmonary Aspergillosis
Learn more about the incidence, risk factors and outcomes associated with pulmonary aspergillosis occurring in COVID-19 patients.Emerging Infectious Diseases (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - November 30, 2021 Category: Infectious Diseases Tags: Infectious Diseases Journal Article Source Type: news

Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study
Cohort study (n=565) found 15% of mechanically ventilated patients with COVID-19 had proven or probable COVID-19-associated pulmonary aspergillosis (CAPA). Age>62yrs, treatment with dexamethasone and>14 days mechanical ventilation were associated with increased risk. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 30, 2021 Category: Consumer Health News Source Type: news

European CHMP recommend license extension of posaconazole (Noxafil) for fungal infections
The licence extension recommended for approval is for use in invasive aspergillosis in adults and children above 2 years age and 40kg weight with disease that is refractory to amphotericin B or itraconazole or in patients who are intolerant of these medicines. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 16, 2021 Category: Consumer Health News Source Type: news

Invasive pulmonary aspergillosis caused by Aspergillus terreus diagnosed using virtual bronchoscopic navigation and endobronchial ultrasonography with guide sheath and successfully treated with liposomal amphotericin B
Invasive aspergillosis is a significant cause of mortality in patients with hematological malignancy. Early diagnosis of invasive pulmonary aspergillosis (IPA) by bronchoscopy is recommended but is often difficult to perform because of small lesion size and bleeding risk due to thrombocytopenia. A 71-year-old woman had received initial induction therapy for acute myeloid leukemia. On day 22 of chemotherapy, she had a high fever, and the chest computed tomography scan revealed a 20-mm-sized nodule with a halo sign. Bronchoscopy assisted by virtual bronchoscopic navigation (VBN) and endobronchial ultrasonography with a guide...
Source: Current Awareness Service for Health (CASH) - November 12, 2021 Category: Consumer Health News Source Type: news

Antifungal Prophylaxis for Preventing COVID-19 Aspergillosis Antifungal Prophylaxis for Preventing COVID-19 Aspergillosis
The prophylactic administration of antifungal drugs may help prevent the development of pulmonary aspergillosis among critically ill COVID-19 patients.Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 10, 2021 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news

Rates of Aspergillus Co-Infection in COVID Patients in ICU Not as High as Previously Reported...White PL, Dhillon R, Cordey A, et al. A national strategy to diagnose coronavirus disease 2019-associated invasive fungal disease in the intensive care un
The article presents the rates of Aspergillus Co-Infection in COVID Patients in ICU Not as High as Previously Reported. Topics discussed include aimed to establish the rates of aspergillus co-infection in COVID19 patients in our ICU; and reviewed both BAL (bronchoalveolar lavage) and Galactomannan Index; and this is indicative of a requirement for a larger multicenter study, with a view to provide stronger evidence on invasive aspergillosis, and guidance on commencement of antifungals. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 15, 2021 Category: Consumer Health News Source Type: news

Invasive aspergillosis in critically ill patients: Review of definitions and diagnostic approaches
Invasive aspergillosis (IA) is an increasingly recognised phenomenon in critically ill patients in the intensive care unit, including in patients with severe influenza and severe coronavirus disease 2019 (COVID-19) infection. To date, there are no consensus criteria on how to define IA in the ICU population, although several criteria are used, including the AspICU criteria and new consensus criteria to categorise COVID-19-associated pulmonary aspergillosis (CAPA). In this review, we describe the epidemiology of IA in critically ill patients, most common definitions used to define IA in this population, and most common clin...
Source: Current Awareness Service for Health (CASH) - September 10, 2021 Category: Consumer Health News Source Type: news

Evaluation of a Prototype of a Novel Galactomannan Sandwich Assay Using the VIDAS ® Technology for the Diagnosis of Invasive Aspergillosis
Conclusions: This new VIDAS ® GM prototype assay showed adequate analytical and clinical performance and a good correlation with that of Platelia ™ Aspergillus Ag with 126 sera, although these results need to be confirmed in a larger prospective and multicentric study. As for the other VIDAS ® assays, VIDAS ® GM is a single-sample automated test using a solid reagent strip and receptacle. It is easy to use and suitable for rapid on-demand test results. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - August 12, 2021 Category: Consumer Health News Source Type: news

Green fungus now a major threat after Covid recovery
While mucormycosis affects sinuses, aspergillosis affects the lungs of a patient. It is not as severe a disease as mucormycosis, which requires debulking surgeries (surgical removal of affected tissue including in eye). (Source: The Economic Times)
Source: The Economic Times - June 30, 2021 Category: Consumer Health News Source Type: news

Invasive Aspergillosis Due to Aspergillus Section Usti: A Multicenter Retrospective Study, Clinical Infectious Diseases
Conclusions Aspergillus ustus IA mainly occurred in nonneutropenic transplant patients and was frequently associated with extrapulmonary sites of infection. Mortality rate was high and optimal antifungal therapy remains to be defined. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 13, 2021 Category: Consumer Health News Source Type: news

Digestive enzymes of fungal origin as a relevant cause of false positive Aspergillus antigen testing in intensive care unit patients, Infection
Background: Galactomannan antigen (GM) testing is widely used in the diagnosis of invasive aspergillosis (IA). Digestive enzymes play an important role in enzyme substitution therapy in exocrine pancreatic insufficiency. As digestive enzymes of fungal origin like Nortase contain enzymes from Aspergillus, a false-positive result of the test might be possible because of cross-reacting antigens of the cell wall of the producing fungi. We, therefore, asked whether the administration of fungal enzymes is a relevant cause of false-positive GM antigen test results. Methods: Patients with a positive GM antigen test between January...
Source: Current Awareness Service for Health (CASH) - May 13, 2021 Category: Consumer Health News Source Type: news

Aspergillus Polymerase Chain ReactionAn Update on Technical Recommendations, Clinical Applications, and Justification for Inclusion in the Second Revision of the EORTC/MSGERC Definitions of Invasive Fungal Disease, Clinical Infectious Diseases
Aspergillus polymerase chain reaction testing of blood and respiratory samples has recently been included in the second revision of the EORTC/MSGERC definitions for classifying invasive fungal disease. This is a result of considerable efforts to standardize methodology, the availability of commercial assays and external quality control programs, and additional clinical validation. This supporting article provides both clinical and technical justifications for its inclusion while also summarizing recent advances and likely future developments in the molecular diagnosis of invasive aspergillosis. (Source: Current Awareness S...
Source: Current Awareness Service for Health (CASH) - April 15, 2021 Category: Consumer Health News Source Type: news