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The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis
Only one new class of antifungal drugs has been introduced into clinical practice in the last 30 years, and thus the identification of small molecules with novel mechanisms of action is an important goal of current anti-infective research. Here, we describe the characterization of the spectrum of in vitro activity and in vivo activity ofAR-12, a celecoxib derivative which has been tested in a phase I clinical trial as an anticancer agent. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 10, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis.
Only one new class of antifungal drugs has been introduced into clinical practice in the last 30 years, and thus the identification of small molecules with novel mechanisms of action is an important goal of current anti-infective research. Here, we describe the characterization of the spectrum of in vitro activity and in vivo activity of AR-12, a celecoxib derivative which has been tested in a phase I clinical trial as an anticancer agent. AR-12 inhibits fungal acetyl coenzyme A (acetyl-CoA) synthetase in vitro and is fungicidal at concentrations similar to those achieved in human plasma. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 20, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Alexis Arquette Reportedly Died From AIDS. Here’s What That Really Means
Actress Alexis Arquette has died from complications related to AIDS, according to news reports, but how exactly, does someone die from the disease? Arquette, who was an activist in the transgender community, died on Sunday at age 47, according to People magazine. Members of Arquette’s family, including her sister Patricia Arquette and brother David Arquette, who are both actors, also released statements about their loss on social media. “Alexis was a brilliant artist and painter, a singer, an entertainer and an actor,” the family said in a Facebook post. “Despite the fact that there are few parts fo...
Source: Healthy Living - The Huffington Post - September 15, 2016 Category: Consumer Health News Source Type: news

Angina drug could inform a new strategy to fight cryptococcosis
A drug, more commonly used in the treatment of angina, could be the focus of a new strategy in fighting the fatal fungal infection cryptococcosis, report scientists. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 7, 2016 Category: Science Source Type: news

Angina drug could inform a new strategy to fight cryptococcosis
(University of Birmingham) A drug, more commonly used in the treatment of angina, could be the focus of a new strategy in fighting the fatal fungal infection cryptococcosis. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 7, 2016 Category: Infectious Diseases Source Type: news

An Unusual Cause of Laryngotracheobronchitis
We present a case of pseudomembranous cryptococcal laryngotracheobronchitis in an 80-year-old woman with a history of intractable cough with production of long sputum strings and severe dysphonia. Her main risk factor was considered to be the use of high-dose inhaled fluticasone, given for severe mixed asthma/chronic obstructive pulmonary disease (COPD). This is an unusual presentation of pulmonary cryptococcal disease, which commonly presents as parenchymal disease. We also present a review of the published case reports of endobronchial and laryngeal cryptococcal disease. (Source: Clinical Microbiology Newsletter)
Source: Clinical Microbiology Newsletter - May 5, 2016 Category: Microbiology Authors: Vidthiya Menon, H.E. Jo, P. Corte, A.S. Lee, A.C. Wignall, H.K. Reddel Source Type: news

Guideline Updates: Adult & Adolescent OI Guideline
Authors of the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents have recently released updates to the following sections: HPV - This update provides new recommendations regarding the cervical cancer screening interval for HIV-positive women after 3 consecutive normal Pap tests, and the use of HPV co-testing among HIV-positive  women>30 years of age. It additionally includes recommendations regarding the use of 9-valent HPV vaccine among HIV-positive females and males ages 9-26 to prevent HPV infection. HSV - This update provides new information rega...
Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS) - September 25, 2015 Category: Infectious Diseases Source Type: news

JCI online ahead of print table of contents for April 17, 2014
(Journal of Clinical Investigation) This release contains summaries, links to PDFs, and contact information for the following newsworthy papers published online, April 17, 2014 in the JCI: 'Double-stapled peptide inhibits RSV infection,' 'Fibroblast-derived exosomes mediate caridiomyocyte hypertrophy via microRNA delivery,' 'Patient response to cryptococcosis is dependent on fungal-specific factors,' 'The coinhibitory receptor PD-1H suppresses T cell responses,' 'Type-1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis,' and more. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 17, 2014 Category: Biology Source Type: news

Some HIV-infected patients with certain gene at increased risk for fungal disease
HIV-infected people who carry a gene for a specific protein face a 20-fold greater risk of contracting cryptococcal disease, according to a study published in mBio®, the online open-access journal of the American Society for Microbiology. Cryptococcus neoformans is the most common cause of fungal meningitis among HIV-infected individuals. While the disease is a risk for everyone with HIV who has a very low level of CD4+ T cells, researchers have discovered that those with the gene for the protein FCGR3A 158V have an immune cell receptor that binds tightly to antibody-bound C... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 29, 2013 Category: Consumer Health News Tags: HIV / AIDS Source Type: news

Gene makes some HIV-infected patients more at risk for fungal disease
(American Society for Microbiology) HIV-infected people who carry a gene for a specific protein face a 20-fold greater risk of contracting cryptococcal disease, according to a study published in mBio®, the online open-access journal of the American Society for Microbiology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 27, 2013 Category: Global & Universal Source Type: news

Meth Use Linked to Deadly Fungal InfectionMeth Use Linked to Deadly Fungal Infection
Methamphetamine use has been linked to cryptococcosis, a deadly lung infection, new research suggests. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 2, 2013 Category: Consumer Health News Tags: Psychiatry News Source Type: news

Susceptibility to deadly fungal infection increased by methamphetamine
Methamphetamine use can make a person more susceptible to the lung infection cryptococcosis, according to a study published in mBio®, the online open-access journal of the American Society for Microbiology. Researchers found that injected methamphetamine (METH) significantly enhanced colonization of the lungs by Cryptococcus neoformans and accelerated progression of the disease and the time to death in mouse models. C... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 31, 2013 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Methamphetamine increases susceptibility to deadly fungal infection
(American Society for Microbiology) Methamphetamine use can make a person more susceptible to the lung infection cryptococcosis, according to a study published in mBio®, the online open-access journal of the American Society for Microbiology. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - July 30, 2013 Category: Global & Universal Source Type: news

Cryptococcosis and Meningitis
"Cryptococcosis," is an infection that is caused when a person inhales the fungus, "Cryptococcus Neoformans." The disease most often affects people with AIDS. While it might be limited to a person's lungs, it frequently spreads throughout a person's body. Although nearly any organ in the body can become infected, the fungus is often times fatal if it infects a person's nervous system where it causes an inflammation of the membranes covering the spinal cord and brain - referred to as, "meningitis." (Source: Disabled World)
Source: Disabled World - May 9, 2013 Category: Disability Tags: HIV and Aids Information Source Type: news

Updated Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents Released
The National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the HIV Medicine Association (HIVMA) of the Infectious Diseases Society of America (IDSA) announce the release of the updated Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents.   Selected key updates to the guidelines include the following: New information on the diagnosis and management of immune reconstitution inflammatory syndrome (IRIS), particularly as it relates to tuberculosis and cryptococcosis. New guidance for managing IRIS related to each opport...
Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS) - May 7, 2013 Category: Infectious Diseases Source Type: news