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Global Aspergillosis Statistics
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 20, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

LIFE Worldwide Newsletter published
Welcome to LIFE's (Leading International Fungal Education) July newsletter. Please  follow this link.Leading feature: Randomised trial establishes amphotericin B as best therapy forTalaromyces marneffei in HIVOther featured news items include:Updates (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 20, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

ISMA Early Bird Registration and Abstract Deadline
Date: Wednesday, July 19, 2017Year: 2017Location: Luxembourg (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 19, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

International Symposium on Molecular Allergology
Date: Wednesday, July 19, 2017Year: 2017Location: Luxembourg (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 19, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

14th International Workshops on Opportunistic Protists
Date: Tuesday, July 18, 2017Year: 2017Location: Cincinnati, USA (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 18, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Fungal Disease expert urges Government to review house building regulations
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 18, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Clinical Fellow - Infectious Disease
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 13, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

EXTENDED ABSTRACT DEADLINE 31 JULY 2017: 14th Congress of the BADV / 2nd Vilnius Summit on Communicable Diseases
Date: Wednesday, July 12, 2017Year: 2017 (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 12, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

2nd Vilnius Summit on Communicable Diseases and 14th Congress of the Baltic Association for Dermatovenerologists
Date: Wednesday, July 12, 2017Year: 2017Location: Academy of Sciences of Lithuania (Gedimino Avenue, 3, Vilnius) (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 12, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Asthma Breakthrough: Azithromycin Improves Quality of Life for Asthma Patients
News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 11, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Consultant - Infectious Diseases
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 11, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

General training in mycology can be offered
Agro-food& Environmental Fungal Collection  (BCCM/MUCL)General training in mycology can be offered under different objectives:Courses& Workshops (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 5, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Laboratory practice in mycology
This training proposes to acquire basic practical knowledge in the mycology laboratory.Courses& Workshops (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 5, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Identification of fungi using MALDI-TOF MS
This training shows how to identify yeasts and filamentous fungi using MALDI-TOF mass spectrometry.Courses& Workshops (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 5, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Fungi from veterinary practice
Fungi from the veterinary practiceThe workshop focusses on recognizing pathogenic species based on macroscopic and microscopic characters. We also take a look at often isolated, but non-pathogenic contaminants.Courses& Workshops (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 5, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Fungi of the indoor and outdoor environment
Training: Moulds in the indoor environment and outdoor air This 5-day course introduces you to the mycology of the human environment. Each day starts with a theoretical session, followed by practical sessions in the lab. There is a strong focus on recognizing the main genera and identifying the most important species. Each participant will observe over 80 different species, covering the largest part of the commonly encountered fungal diversity. The following topics will be handled: basic fungal biology, classification, nomenclature and morphologyCourses& Workshops (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 5, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

14th meeting of the Nordic Society of Medical Mycology
Date: Wednesday, July 5, 2017Year: 2017Location: Copenhagen, Denmark (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 5, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

2nd CPAnet
Date: Wednesday, July 5, 2017Year: 2018Location: Amsterdam (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 5, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

2nd International Conference on Mycology, Mushrooms & Mycotechnology
Date: Wednesday, July 5, 2017Year: 2017Location: Chicago, Illinois, USA (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 5, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

NW Mycology conference 2017
Date: Tuesday, July 4, 2017Year: 2017Location: ERC, UHSM Wythenshawe Hospital, Manchester, UK (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 4, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

eCourse in fungal microscopy
Direct microscopy is a rapid method for distinguishing many fungal infections using microscopic methods with specific stains. This is the first online microscopy course for fungal infections.Courses& Workshops (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 3, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

1st International Collaborative Mycology Conference: Impact of Fungi on Health and Environment
Date: Monday, July 3, 2017Year: 2017Location: Aga Khan University, Karachi, Pakistan (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 3, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

59th Annual Meeting of the Japanese Respiratory Society
Date: Monday, July 3, 2017Year: 2019Location: Tokyo International Forum, Japan (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 3, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

58th Annual Meeting of the Japanese Respiratory Society
Date: Monday, July 3, 2017Year: 2018Location: Osaka International Convention Center, Japan (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 3, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

12th NATIONAL CONFERENCE OF SOCIETY OF INDIAN HUMAN AND ANIMAL MYCOLOGISTS
Date: Monday, July 3, 2017Year: 2018Location: DEPARTMENT OF MICROBIOLOGY, SJNAHS, BENGALURU (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 3, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Tulips from amsterdam: roses from columbia - how these beautiful bulbs and flowers are spreading a deadly legacy
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 29, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Skin lesions in patient with acute myeloid leukemia
Images and abstract taken from  Mert D et.al.,  HemMedical images: Other sites of aspergillosis›Skin and nailsImages (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 29, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Aspergillus flavus
Images (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 28, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Mouldy Wallpaper and Mycotoxins
News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 23, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Pfizer Will Manufacture and Commercialise Isavuconazole in Europe, Russia, Turkey and Israel.
News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 21, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Ar-12
For further details go to thenew antifungal drugs sectionMedical images: Antifungal drug structures›AR-12Images (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 20, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase.
ACS Infect Dis. 2016 Apr 8;2(4):268-280. Epub 2016 Feb 23.Koselny K1, Green J1, Favazzo L1, Glazier VE1, DiDone L1, Ransford S1, Krysan DJ1.AbstractAR-12/OSU-03012 is an antitumor celecoxib-derivative that has progressed to Phase I clinical trial as an anticancer agent and has activity against a number of infectious agents including fungi, bacteria and viruses. However, the mechanism of these activities has remained unclear. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 20, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

AR-12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication.
We have recently demonstrated that AR-12 (OSU-03012) reduces the function and ATPase activities of multiple HSP90 and HSP70 family chaperones. Combined knock down of chaperones or AR-12 treatment acted to reduce the expression of virus receptors and essential glucosidase proteins. Combined knock down of chaperones or AR-12 treatment inactivated mTOR and elevated ATG13 S318 phosphorylation concomitant with inducing an endoplasmic reticulum stress response that in an eIF2 α-dependent fashion increased Beclin1 and LC3 expression and autophagosome formation. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 20, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis.
Only one new class of antifungal drugs has been introduced into clinical practice in the last 30 years, and thus the identification of small molecules with novel mechanisms of action is an important goal of current anti-infective research. Here, we describe the characterization of the spectrum of in vitro activity and in vivo activity of AR-12, a celecoxib derivative which has been tested in a phase I clinical trial as an anticancer agent. AR-12 inhibits fungal acetyl coenzyme A (acetyl-CoA) synthetase in vitro and is fungicidal at concentrations similar to those achieved in human plasma. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 20, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Trans-ungual Delivery of AR-12, a Novel Antifungal Drug.
AAPS PharmSciTech. 2017 Mar 13. doi: 10.1208/s12249-017-0752-y.Kushwaha AS, Sharma P, Shivakumar HN, Rappleye C, Zukiwski A, Proniuk S, Murthy SN.AR-12 is a novel small molecule with broad spectrum antifungal activity. Recently, AR-12 was found to be highly active against Trichophyton rubrum, one of the predominantly responsible organisms that cause onychomycosis. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 20, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

ram1 gene, encoding a subunit of farnesyltransferase, contributes to growth, antifungal susceptibility to amphotericin B of Aspergillus fumigatus.
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 20, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Tipifarnib
Farnesyltransferase inhibitor - seenew Antifungal drugs section for more detailsMedical images: Antifungal drug structures›TipifarnibImages (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 20, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

In vitro antifungal activity of farnesyltransferase inhibitors against clinical isolates of Aspergillus and Candida.
Ann Clin Microbiol Antimicrob. 2013 Dec 5;12:37. doi: 10.1186/1476-0711-12-37.In vitro antifungal activity of farnesyltransferase inhibitors against clinical isolates of Aspergillus and Candida.Qiao J, Gao P, Jiang X, Fang H.BACKGROUND:Protein farnesylation is an important tosttranslational modification in fungi. We evaluated the antifungal activity of two farnesyltransferase inhibitors against clinical isolates of Aspergillus and Candida. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 20, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Manumycin A
Farnesyltransferase inhibitor - seeNew Antifungal drugs section for more detailsMedical images: Antifungal drug structuresImages (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 20, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

In vitro antifungal activity of farnesyltransferase inhibitors against clinical isolates of Aspergillus and Candida.
BACKGROUND:Protein farnesylation is an important posttranslational modification in fungi. We evaluated the antifungal activity of two farnesyltransferase inhibitors against clinical isolates of Aspergillus and Candida.METHODS:Disk diffusion assay and broth microdilution assay were used to determine the antifungal susceptibility of two farnesyltransferase inhibitors (manumycin A and tipifarnib) against clinical isolates of Aspergillus and Candida. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 20, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Clinical Educational Fellow in Infectious Diseases
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 15, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Communication and Digital Content Officer, National Aspergillosis Centre
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 15, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Clinical Senior Lecturer/Reader/Chair and Honorary Consultant in Medicine- Infection Diseases
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 9, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Research Fellowships
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 8, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Studentship within the department of Infection, Immunity and Inflammation at the University of Leicester.
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 8, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Penicillenols (A1, A2, B1, B2, C1 and C2)
Metabolites (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 8, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

First Balkan Conference on Medical Mycology and Mycotoxicology - Balkan Fungus 2018
Date: Wednesday, June 7, 2017Year: 2018Location: Timisoara (Romania) (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 7, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

GCCMID Abstracts deadline
Date: Tuesday, June 6, 2017Year: 2017Location: Bahrain (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 6, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

NCPF training course - Identification of Pathogenic Fungi
Each July the Mycology Reference Laboratory, which houses the NCPF, runs a course on the identification of pathogenic fungi. The four day course is designed for beginners and those with some experience in the identification of medically important fungi. The isolates delegates will be given to examine include a wide range of moulds and yeasts, with particular emphasis on dermatophytes and other organisms encountered in hospital microbiology laboratories. It includes a number of species featured in external quality assessment schemes.Courses& Workshops (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - May 25, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

National Collection of Pathogenic Fungi Launches Newsletter
News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - May 25, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news