A Study of the Disruptive Effect of the Acetate Fraction of Punica granatum Extract on Cryptococcus Biofilms
This study aimed to evaluate the activity of the acetate fraction of P. granatum leaf extract against environmental and clinical isolates of Cryptococcus. Three environmental isolates of C. laurentii, PMN, PMA, and PJL II, isolated from soils of different municipalities in the state of Maranhão, a clinical isolate, C. gattii, from a patient with neurocryptococcosis, and a standard strain of C. gattii (ATCC 32068) were used. The minimum and fractional inhibitory concentrations (MIC and FIC, respectively) and time-kill curve of the extract and fluconazole were determined to assess the susceptibility profile of the fun...
Source: Frontiers in Microbiology - January 18, 2021 Category: Microbiology Source Type: research

First report of cryptococcosis due to Cryptococcus gattii sensu stricto VGI in an Ivorian HIV negative patient
Publication date: Available online 16 January 2021Source: Journal of Medical MycologyAuthor(s): V Bellet, FK Kassi, D Krasteva, F Roger, P Drakulovski, C Mossou, GA kouakou, A Doumbia, E Delaporte, H Menan, S Bertout (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - January 17, 2021 Category: Biology Source Type: research

A case of methicillin resistant Staphylococcus aureus necrotizing pneumonia with pulmonary cryptococcosis
Publication date: Available online 13 January 2021Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Jiunn-Sheng Wu, Ming-Yieh Peng, Chan-Yen Kuo, Jiann-Der Wu (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - January 13, 2021 Category: Microbiology Source Type: research

Histoplasma capsulatum Glycans From Distinct Genotypes Share Structural and Serological Similarities to Cryptococcus neoformans Glucuronoxylomannan
The cell wall is a ubiquitous structure in the fungal kingdom, with some features varying depending on the species. Additional external structures can be present, such as the capsule of Cryptococcus neoformans (Cn), its major virulence factor, mainly composed of glucuronoxylomannan (GXM), with anti-phagocytic and anti-inflammatory properties. The literature shows that other cryptococcal species and even more evolutionarily distant species, such as the Trichosporon asahii, T. mucoides, and Paracoccidioides brasiliensis can produce GXM-like polysaccharides displaying serological reactivity to GXM-specific monoclonal antibodi...
Source: Frontiers in cellular and infection microbiology - January 8, 2021 Category: Microbiology Source Type: research

Small-molecule inhibitors for the Prp8 intein as antifungal agents [Microbiology]
Self-splicing proteins, called inteins, are present in many human pathogens, including the emerging fungal threats Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga), the causative agents of cryptococcosis. Inhibition of protein splicing in Cryptococcus sp. interferes with activity of the only intein-containing protein, Prp8, an essential intron splicing factor. Here, we... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 4, 2021 Category: Science Authors: Zhong Li, Anil Mathew Tharappel, Jimin Xu, Yuekun Lang, Cathleen M. Green, Jing Zhang, Qishan Lin, Sudha Chaturvedi, Jia Zhou, Marlene Belfort, Hongmin Li Tags: Biological Sciences Source Type: research

Acute Fluctuant Neurological Symptoms in Stable Chronic Cryptococcus gattii Cryptococcomas: A Novel Disease Complication
Conclusions: Central nervous system cryptococcomas are difficult to treat, chronic infections, that in our patient had lasted over 10 years despite treatment compliance. A true cryptococcal meningitis relapse is indicated by positive cell cultures in previously sterile fluid but cryptococcoma progression is measured by serial magnetic resonance imaging or computed tomography scans. In the case of progression or relapse induction and consolidation therapy should be restarted. Our patient demonstrated neither relapse nor progression but presented with a novel disease complication of acute fluctuating neurology in chronic...
Source: The Neurologist - January 1, 2021 Category: Neurology Tags: Case Report/Case Series Source Type: research

Tongue lesion due to Cryptococcus neoformans as the first finding in an HIV-positive patient.
CONCLUSIONS: The involvement of the oral mucosa is uncommon in this fungal infection, but is important to include it in the differential diagnosis in HIV positive patients. PMID: 33388240 [PubMed - as supplied by publisher] (Source: Revista Iberoamericana de Micologia)
Source: Revista Iberoamericana de Micologia - December 30, 2020 Category: Biology Authors: Santiso GM, Messina F, Gallo A, Marín E, Depardo R, Arechavala A, Walker L, Negroni R, Romero MM Tags: Rev Iberoam Micol Source Type: research

Disseminated cryptococcosis presenting with cutaneous involvement in an immunocompromised patient
Cryptococcosis is a fungal infection that typically affects immunocompromised patients. It most commonly affects the lungs and may then disseminate to the central nervous system, bone, skin, and adrenal glands. Herein, we describe a 69-year-old man who presented with skin lesions as the initial manifestation of disseminated cryptococcosis. Initial workup led to an assumption that the patient was immunocompetent. Later in the clinical course, idiopathic depletion of CD4 T cells was discovered. This case highlights that disseminated cryptococcosis may present with cutaneous symptoms even when there is no evidence of pulmonar...
Source: Dermatology Online Journal - December 29, 2020 Category: Dermatology Source Type: research

Skin Lesions Caused by Disseminated Cryptococcosis.
Authors: Konishi K, Nakagawa H, Asaoka T, Shirano M PMID: 33328399 [PubMed - as supplied by publisher] (Source: Internal Medicine)
Source: Internal Medicine - December 19, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Cryptococcemia According to Immune Status: An Analysis of 65 Critical Cases
ConclusionsOur study indicated that patients with different immune statuses presented different clinical features. Immunosuppressed patients with cryptococcemia presented a higher risk of mortality with poor prognosis, which required intense attention and treatment in time. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - December 16, 2020 Category: Infectious Diseases Source Type: research

Disseminated cryptococcosis presenting with cutaneous involvement in an immunocompromised patient.
Abstract Cryptococcosis is a fungal infection that typically affects immunocompromised patients. It most commonly affects the lungs and may then disseminate to the central nervous system, bone, skin, and adrenal glands. Herein, we describe a 69-year-old man who presented with skin lesions as the initial manifestation of disseminated cryptococcosis. Initial workup led to an assumption that the patient was immunocompetent. Later in the clinical course, idiopathic depletion of CD4 T cells was discovered. This case highlights that disseminated cryptococcosis may present with cutaneous symptoms even when there is no ev...
Source: Dermatol Online J - December 15, 2020 Category: Dermatology Authors: Bardhi R, Lawrence K, Bedford LM, Deirawan H, Moossavi M Tags: Dermatol Online J Source Type: research

Diagnosis of Hyper IgM syndrome in a Previously Healthy Adolescent Boy Presented with Cutaneous and Cerebral Cryptococcosis
This report demonstrates that X-HIGM could have an age of onset in teens and systemic cryptococcosis could be its presenting symptoms. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - December 14, 2020 Category: Infectious Diseases Tags: Immunology and Host Response Source Type: research

Cryptococcoid Sweet Syndrome: A Clinical and Histologic Imitator of Cryptococcosis
Publication date: Available online 13 December 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): M.E. Mazzei, A. Guerra, L. Dufrechou, M. Vola (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - December 14, 2020 Category: Dermatology Source Type: research

Cryptococcosis caused by cryptococcus gattii: 2 case reports and literature review
Cryptococcosis caused by Cryptococcus gattii, is a life threatening fungal infection with recently increasing prevalence. C. gattii is a species complex comprising multiple independent species. However, many biological characteristics and clinical features of cryptococcosis due to C. gattii are relatively less well defined. In this paper, we identify two cases of C. gattii infection, and laboratory findings of genotype VGI and VGII in two groups of apparently immunocompetent Chinese individuals respectively. Upon detailed review of all 35 cases of C. gattii infections, it was observed that C. gattii can cause debilitating ...
Source: Medicine - December 11, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Asymptomatic cryptococcal antigenemia in HIV-infected patients: a review of recent studies.
Abstract The prevalence of asymptomatic cryptococcal antigenemia (ACA) in human immunodeficiency virus (HIV) infected individuals has been observed to be elevated. The prevalence of ACA ranges from 1.3% to 13%, with different rates of prevalence in various regions of the world. We reviewed studies conducted internationally, and also referred to two established expert consensus guideline documents published in China, and we have concluded that Chinese HIV-infected patients should undergo cryptococcal antigen screening when CD4 T-cell counts fall below 200 cells/μL and that the recommended treatment regimen for t...
Source: Chinese Medical Journal - December 5, 2020 Category: General Medicine Authors: Xu XL, Zhao T, Harypursat V, Lu YQ, Li Y, Chen YK Tags: Chin Med J (Engl) Source Type: research

Executive Summary of JSMM Clinical Practice Guidelines for Diagnosis and Treatment of Cryptococcosis 2019.
Authors: Izumikawa K, Kakeya H, Sakai F, Shibuya K, Sugita T, Takazono T, Takata T, Tashiro M, Teruya K, Nakamura S, Noguchi H, Hiruma M, Makimura K, Miyazaki T, Miyazaki Y, Yamagishi Y, Yoshida K, Watanabe A PMID: 33250505 [PubMed - in process] (Source: Medical Mycology Journal)
Source: Medical Mycology Journal - December 2, 2020 Category: Biology Tags: Med Mycol J Source Type: research

15672 A cutaneous crypt for cryptococcosis: The skin as a marker for disseminated disease
Cutaneous cryptococcosis is caused by Cryptococcus neoformans, an opportunistic, encapsulated yeast that can cause significant morbidity and mortality. Cutaneous cryptococcosis can affect both immunocompromised and immunocompetent individuals, and can result from direct inoculation or hematogenous spread to skin. In primary cutaneous cryptococcosis, localized infection is subsequent to direct inoculation. In contrast, the more common, secondary skin involvement is due to hematogenous dissemination, which can be accompanied by spread to other organs such as the lungs and central nervous system. (Source: Journal of the Ameri...
Source: Journal of the American Academy of Dermatology - November 28, 2020 Category: Dermatology Authors: Kayla Babbush, Jamie R. Manning, Bijal Amin, Yevgeniy Balagula Source Type: research

Pleural Cryptococcosis in a Patient with AIDS.
Authors: Lee E, Jang Y, Choi IH PMID: 33200595 [PubMed - in process] (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - November 18, 2020 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

CircRNA-1806 Decreases T Cell Apoptosis and Prolongs Survival of Mice After Cryptococcal Infection by Sponging miRNA-126
In this study, high-throughput microarray was performed to identify the circRNA expression profile in cryptococcal meningitis patients. Circ_0001806 was significantly decreased in cryptococcal meningitis individuals. Then the effects of circ_0001806 and its interaction with miRNAs were explored in vivo and in vitro. The knock-down of circ_0001806 led to higher fungal infection and shorter survival in an experimental murine cryptococcosis model. Transcriptome analysis showed that decreased circ_0001806 regulated pathways related to the host antimicrobe response in T cells. Furthermore, in vitro experiments showed that circ_...
Source: Frontiers in Microbiology - November 13, 2020 Category: Microbiology Source Type: research

Cryptococcal empyema treated with tube thoracostomy and intrapleural fibrinolysis.
Authors: Kohli A, Sachdeva A, Pickering EM Abstract A 55-year old woman with a history of relapsed T-cell ALL presented with right pleuritic chest pain and decreased breath sounds over the right hemithorax. Imaging of the chest showed loculated effusions. Tube thoracostomy was performed with intrapleural application of alteplase and dornase alpha over a 3-day period. Repeat imaging demonstrated a marked decrease in the volume of the effusion. In most prior published cases of pleural cryptococcosis, surgical drainage was required in addition to prolonged antifungal agents. More than 50% of patients with cryptococcal...
Source: Monaldi Archives for Chest Disease - November 12, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

The antifungal and synergistic effect of bisphosphonates in Cryptococcus.
This study demonstrates the utility of targeting squalene synthesis for improving the efficacy of azole-based antifungal drugs, and suggests bisphosphonates are promising lead compounds for further antifungal development. PMID: 33139289 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - November 2, 2020 Category: Microbiology Authors: Kane A, Campbell L, Ky D, Hibbs D, Carter D Tags: Antimicrob Agents Chemother Source Type: research

A study for precision diagnosing and treatment strategies in difficult-to-treat AIDS cases and HIV-infected patients with highly fatal or highly disabling opportunistic infections: Study protocol for the optimal early intervention for cryptococcal antigenemia in HIV-infected patients
This study will be an open-labeled, multi-center, prospective, randomized controlled trial, and 450 eligible participants will be randomized into a control arm and 2 intervention arms at a 1:1:1 ratio, with 150 subjects in each arm. Participants in the control arm will not receive antifungal treatment during the study period. Participants in intervention arm 1 will receive oral fluconazole 800 mg/day for 2 weeks, followed by 400 mg/day for 8 weeks and 200 mg/day for 42 weeks, and participants in intervention arm 2 will receive oral fluconazole 400 mg/day for 52 weeks. The primary outcome is the incidence of CM amon...
Source: Medicine - October 29, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Cerebral cryptococcosis with pseudo ‐meningiomatous revelation?
We report the case of a 28 ‐year‐old woman with history of lupus treated by Mycophenolate Mofetil and admitted for febrile meningeal syndrome associated with diplopia. Both initial and control brain MRI showed pseudo‐meningiomatous lesion while second CSF microscopy revealed characterizing images of Cryptococcus neoform ans. (Source: Clinical Case Reports)
Source: Clinical Case Reports - October 27, 2020 Category: General Medicine Authors: Asmaa Hazim, Omar Amriss Tags: CLINICAL IMAGE Source Type: research

Performance of the Lateral Flow Assay and the Latex Agglutination Serum Cryptococcal Antigen Test in Cryptococcal Disease in Patients with and without HIV [Mycology]
In this study, we evaluate the real-life performance of CrAg testing in patients with cryptococcal disease. We conducted a retrospective review of patients with cryptococcosis from 2002 to 2019 at Barnes-Jewish Hospital. Latex agglutination (LA) was used exclusively until April 2016, at which point LFA was used exclusively. Demographics, presentations, and testing outcomes were evaluated. Serum CrAg testing was completed in 227 patients with cryptococcosis. Of 141 HIV-negative patients, 107 had LA testing and 34 had LFA testing. In patients with disseminated disease, serum CrAg sensitivity by LA was 78.1% compared to 82.6%...
Source: Journal of Clinical Microbiology - October 21, 2020 Category: Microbiology Authors: Hevey, M. A., George, I. A., Rauseo, A. M., Larson, L., Powderly, W., Spec, A. Tags: Mycology Source Type: research

Asymptomatic cryptococcal antigenemia in HIV-infected patients: a review of recent studies.
Abstract The prevalence of asymptomatic cryptococcal antigenemia (ACA) in human immunodeficiency virus (HIV) infected individuals has been observed to be elevated. The prevalence of ACA ranges from 1.3% to 13%, with different rates of prevalence in various regions of the world. We reviewed studies conducted internationally, and also referred to two established expert consensus guideline documents published in China, and we have concluded that Chinese HIV-infected patients should undergo cryptococcal antigen screening when CD4 T-cell counts fall below 200 cells/μL and that the recommended treatment regimen for t...
Source: Chinese Medical Journal - October 20, 2020 Category: General Medicine Authors: Xu XL, Zhao T, Harypursat V, Lu YQ, Li Y, Chen YK Tags: Chin Med J (Engl) Source Type: research

Intracellular PRRs Activation in Targeting the Immune Response Against Fungal Infections
The immune response against fungal infections is complex and exhibits several factors involving innate elements that participate in the interaction with the fungus. The innate immune system developed pattern recognition receptors that recognize different pathogen-associated molecular patterns present both on the surface of the fungi cell wall and on their genetic material. These receptors have the function of activating the innate immune response and regulating a subsequent adaptive immune response. Among pattern recognition receptors, the family of Toll-like receptors and C-type lectin receptors are the best described and...
Source: Frontiers in cellular and infection microbiology - October 20, 2020 Category: Microbiology Source Type: research

Population diversity and virulence characteristics of < i > Cryptococcus neoformans/C < /i > . < i > gattii < /i > species complexes isolated during the pre-HIV-pandemic era
by Sujiraphong Pharkjaksu, Kyung J. Kwon-Chung, John E. Bennett, Popchai Ngamskulrungroj Cryptococcosis has become a major global health problem since the advent of the HIV pandemic in 1980s. Although its molecular epidemiology is well-defined, using isolates recovered since then, no pre-HIV-pandemic era epidemiological data exist. We conducted a molecular epidemiological study using 228 isolates of theC.neoformans/C.gattii species complexes isolated before 1975. Genotypes were determined byURA5 restriction fragment length polymorphism analysis and multi-locus sequence typing. Population genetics were defined by nucleotid...
Source: PLoS Neglected Tropical Diseases - October 4, 2020 Category: Tropical Medicine Authors: Sujiraphong Pharkjaksu Source Type: research

Cryptococcosis in HIV-AIDS Patients from Southern Brazil: still a major problem
Publication date: Available online 24 September 2020Source: Journal de Mycologie MédicaleAuthor(s): Lurdeti Bastos da Silva, Douglas Bock, Gabriel Baracy Klafke, Karine Ortiz Sanchotene, Rossana Patricia Basso, Jéssica Louise Benelli, Vanice Rodrigues Poester, Felipe Almeida da Silva, Luciana Trilles, Cecília Bittencourt Severo, David A. Stevens, Melissa Orzechowski Xavier (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - September 25, 2020 Category: Biology Source Type: research

Cryptococcoid Sweet Syndrome: A Clinical and Histologic Imitator of Cryptococcosis.
PMID: 32986969 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - September 24, 2020 Category: Dermatology Authors: Eugenia Mazzei M, Guerra A, Dufrechou L, Vola M Tags: Actas Dermosifiliogr Source Type: research

Rapid onsite evaluation of pulmonary cryptococcosis: An preliminary assessment.
PMID: 32948385 [PubMed - as supplied by publisher] (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - September 14, 2020 Category: Surgery Authors: Zhang X, Ye L, Hong L Tags: Asian J Surg Source Type: research

Animal Models of Cryptococcus neoformans in Identifying Immune Parameters Associated With Primary Infection and Reactivation of Latent Infection
Cryptococcus species are environmental fungal pathogens and the causative agents of cryptococcosis. Infection occurs upon inhalation of infectious particles, which proliferate in the lung causing a primary infection. From this primary lung infection, fungal cells can eventually disseminate to other organs, particularly the brain, causing lethal meningoencephalitis. However, in most cases, the primary infection resolves with the formation of a lung granuloma. Upon severe immunodeficiency, dormant cryptococcal cells will start proliferating in the lung granuloma and eventually will disseminate to the brain. Many investigator...
Source: Frontiers in Immunology - September 14, 2020 Category: Allergy & Immunology Source Type: research

Evaluation of lateral flow immunochromatographic assay for diagnostic accuracy of cryptococcosis
Cryptococcus is a conditional pathogenic fungus causing cryptococcosis, which is one of the most serious fungal diseases faced by humans. Lateral flow immunochromatographic assay (LFA) is successfully applied to ... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - September 4, 2020 Category: Infectious Diseases Authors: Li-Min Xie, Geng-Ling Lin, Hao-Neng Dong, Ying-Xia Liao, Ye-Ling Liu, Jian-Feng Qin and Xu-Guang Guo Tags: Research article Source Type: research

Completely disappearance of opacity of pulmonary cryptococcosis with salazosulfapyridine for rheumatoid arthritis.
PMID: 33295736 [PubMed - as supplied by publisher] (Source: Tuberkuloz ve Toraks)
Source: Tuberkuloz ve Toraks - September 1, 2020 Category: Respiratory Medicine Authors: Satoh H Tags: Tuberk Toraks Source Type: research

Cryptococcosis in non-human immunodeficiency virus-infected patients: A clinical dilemma and diagnostic enigma
Manisha Paul, Mohit Bhatia, Ranjana Rohilla, Udayakumar Sasirekha, Neelam KaisthaIndian Journal of Medical Microbiology 2020 38(2):229-234 Cryptococcosis is a fungal disease with worldwide distribution and wide array of clinical manifestations, caused by encapsulated basidiomycetous yeasts called Cryptococcus spp. It has traditionally been considered an opportunistic infection known to occur in immunocompromised hosts, particularly those who are infected with human immunodeficiency virus. However, this infection has also been reported in phenotypically 'normal' or otherwise clinically non-immunocompromised patient...
Source: Indian Journal of Medical Microbiology - August 28, 2020 Category: Microbiology Authors: Manisha Paul Mohit Bhatia Ranjana Rohilla Udayakumar Sasirekha Neelam Kaistha Source Type: research

A Plumieridine-Rich Fraction From Allamanda polyantha Inhibits Chitinolytic Activity and Exhibits Antifungal Properties Against Cryptococcus neoformans
Cryptococcosis is a fungal infection caused mainly by the pathogenic yeasts Cryptococcus neoformans and Cryptococcus gattii. The infection initiates with the inhalation of propagules that are then deposited in the lungs. If not properly treated, cryptococci cells can disseminate and reach the central nervous system. The current recommended treatment for cryptococcosis employs a three-stage regimen, with the administration of amphotericin B, flucytosine and fluconazole. Although effective, these drugs are often unavailable worldwide, can lead to resistance development, and may display toxic effects on the patients. Thus, ne...
Source: Frontiers in Microbiology - August 27, 2020 Category: Microbiology Source Type: research

Prevalence of Asymptomatic Cryptococcal Antigenemia and Association with Follow-up risk of Cryptococcal Meningitis and Mortality among HIV Infected Patients in North West India - A Prospective Cohort Study.
CONCLUSION: Serum cryptococcal positivity is correlated with increased risk of Cryptococcal meningitis and mortality in PLHIV. We recommend the screening of asymptomatic PLHIV with CD4 ≤ 100/µL for serum cryptococcal antigen, so that pre-emptive treatment can be initiated to reduce morbidity and mortality. PMID: 32860359 [PubMed - as supplied by publisher] (Source: Current HIV Research)
Source: Current HIV Research - August 26, 2020 Category: Infectious Diseases Authors: Bhati R, Sirohi P, Sejoo B, Kumar D, Bohra GK, Meena DS, Verma D, Midha NK Tags: Curr HIV Res Source Type: research

Retrospective Hospital-based Study of Opportunistic Neuroinfections in HIV/AIDS
Conclusion: Opportunistic neuroinfections are the most commonneurological manifestation in patients with AIDS, with cryptococcal meningitis being the most commonopportunistic neuroinfection occurring as AIDS-defining illness in one-third of the patients with neuro-AIDS. (Source: Neurology India)
Source: Neurology India - August 25, 2020 Category: Neurology Authors: Saroja A Onkarappa Nikhil G Panpalia Karkal R Naik Source Type: research

Emerging < i > Cryptococcus gattii < /i > species complex infections in Guangxi, southern China
In this study, we studied eleven clinical strains of theC.gattii species complex isolated from Guangxi, southern China. The genetic identity and variability of these isolates were analyzed via multi-locus sequence typing (MLST), and the phylogenetic relationships among these isolates and global isolates were evaluated. The mating type, physiological features and antifungal susceptibilities of these isolates were also characterized. Among the eleven isolates, six belonged toC.deuterogattii, while five belonged toC.gattii sensu stricto. TheC.deuterogattii strains from Guangxi, southern China were genetically variable and clu...
Source: PLoS Neglected Tropical Diseases - August 25, 2020 Category: Tropical Medicine Authors: Chunyang Huang Source Type: research

Retrospective Hospital-based Study of Opportunistic Neuroinfections in HIV/AIDS
Conclusion: Opportunistic neuroinfections are the most commonneurological manifestation in patients with AIDS, with cryptococcal meningitis being the most commonopportunistic neuroinfection occurring as AIDS-defining illness in one-third of the patients with neuro-AIDS. (Source: Neurology India)
Source: Neurology India - August 25, 2020 Category: Neurology Authors: Saroja A Onkarappa Nikhil G Panpalia Karkal R Naik Source Type: research

Evaluation of a Novel Semiquantitative Cryptococcal Antigen Lateral Flow Assay in Patients with Advanced HIV Disease [Mycology]
Higher cryptococcal antigen (CrAg) titers are strongly associated with mortality risk in individuals with HIV-associated cryptococcal disease. Rapid tests to quantify CrAg levels may provide important prognostic information and enable treatment stratification. We performed a laboratory-based validation of the IMMY semiquantitative cryptococcal antigen (CrAgSQ) lateral flow assay (LFA) against the current gold standard CrAg tests. We assessed the diagnostic accuracy of the CrAgSQ in HIV-positive individuals undergoing CrAg screening, determined the relationship between CrAgSQ scores and dilutional CrAg titers, assessed inte...
Source: Journal of Clinical Microbiology - August 23, 2020 Category: Microbiology Authors: Jarvis, J. N., Tenforde, M. W., Lechiile, K., Milton, T., Boose, A., Leeme, T. B., Tawe, L., Muthoga, C., Rukasha, I., Mulenga, F., Rulaganyang, I., Molefi, M., Molloy, S. F., Ngidi, J., Harrison, T. S., Govender, N. P., Mine, M. Tags: Mycology Source Type: research

Small-bowel cryptococcosis diagnosed by double-balloon endoscopy in patient without human immunodeficiency virus
Endoscopy DOI: 10.1055/a-1216-1048 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Endoscopy)
Source: Endoscopy - August 19, 2020 Category: Gastroenterology Authors: Prazeres, T úlio Riguetti de Vasconcellos, Marcela Almeida Menezes Sousa, Marcella Salazar Ortiz, Evelin S ánchez Ribeiro Junior, Ulysses Nahas, S érgio Carlos Safatle-Ribeiro, Adriana Vaz Tags: E-Videos Source Type: research

False-Negative Serum Cryptococcal Antigen Lateral Flow Immunoassay Result for a Patient with Disseminated Cryptococcal Disease
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - August 17, 2020 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Ibrutinib, a Bruton's tyrosine kinase inhibitor, a new risk factor for cryptococcosis.
CONCLUSION: Clinicians must be aware of this infection in patients with hematological malignancies on ibrutinib. PMID: 32777360 [PubMed - as supplied by publisher] (Source: Medecine et Maladies Infectieuses)
Source: Medecine et Maladies Infectieuses - August 14, 2020 Category: Infectious Diseases Tags: Med Mal Infect Source Type: research

Primary Cutaneous Cryptococcosis: An Unusual Injection Site Infection
We describe an unusual case of PCC in an injection site of an immunocompromised patient. The specific case demonstrates a challenging treating dilemma with different alternative treatment choices. In the presented clinical setting, each choice concealed its risks and benefits. We highlight the importance of patient education for taking the appropriate measures for the disinfection of subcutaneous injection sites.Case Rep Dermatol 2020;12:138 –143 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - August 14, 2020 Category: Dermatology Source Type: research

Comparative performance of the laboratory assays used by a Diagnostic Laboratory Hub for opportunistic infections in people living with HIV
Conclusion: Validated commercial antigen tests, as used in this program, should be the new gold standard for histoplasmosis and cryptococcosis diagnosis. In their absence, 35% of disseminated histoplasmosis and 32.7% of cryptococcal meningitis cases would have been missed. Patients with multiple opportunistic infections were frequently diagnosed and strategies should be designed to screen patients irrespective of their clinical presentation. In low resource settings, Diagnostic Laboratory Hubs can deliver quality diagnostics services in record time at affordable prices. (Source: AIDS)
Source: AIDS - August 13, 2020 Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research

Central nervous system Cryptococcoma mimicking demyelinating disease: a case report
We present a case of cerebral cryptococcomas whose radiological p... (Source: BMC Neurology)
Source: BMC Neurology - August 12, 2020 Category: Neurology Authors: Jie Wei, Xiang-Yu Li and Yue Zhang Tags: Case report Source Type: research

Safety and tolerability of a novel oral formulation of amphotericin B: Phase I EnACT Trial.
Conclusions. Oral cAMB was well tolerated when given in 4-6 divided daily doses without the toxicities commonly seen with IV AMB. PMID: 32747357 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - August 2, 2020 Category: Microbiology Authors: Skipper C, Atukunda M, Stadelman A, Engen N, Bangdiwala A, Huppler Hullsiek K, Abassi M, Rhein J, Nicol MR, Laker E, Williams DA, Mannino R, Matkovits T, Meya DB, Boulware DR Tags: Antimicrob Agents Chemother Source Type: research

Umbilicated papules on the bilateral upper and lower extremities
Cryptococcosis is a rare opportunistic infection with morphologically diverse cutaneous presentations. Primary infection typically occurs in the lungs with subsequent hematogenous dissemination to other organ systems, especially in immunocompromised patients. Herein, we report a woman in her 70's who presented with pruritic, umbilicated papulonodules of the bilateral upper and lower extremities present for many weeks. She was diagnosed with disseminated Cryptococcus and subsequently evaluated for potential pulmonary and meningeal disease involvement. She died as a result of multiple medical comorbidities. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - July 29, 2020 Category: Dermatology Source Type: research

Microbiological, Epidemiological, and Clinical Characteristics of Patients With Cryptococcal Meningitis at a Tertiary Hospital in China: A 6-Year Retrospective Analysis
In conclusion, our data were characterized by a high prevalence of the Cryptococcal meningitis patients without HIV/AIDS and other underlying health conditions, a relatively high non-wild-type rate of fluconazole and amphotericin B resistance, and low genetic diversity in Cryptococcus strains. The present study will provide evidence for further improvement of the diagnosis and treatment of cryptococcosis in China. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - July 28, 2020 Category: Microbiology Source Type: research