Oncolytic herpes simplex virus expressing IL-2 controls glioblastoma growth and improves survival

CONCLUSIONS: Our findings illustrate that G47Δ-mIL2 is efficacious, stimulates antitumor immunity against orthotopic GBM, and may also target GSC. OHSV expressing IL-2 may represent an agent that merits further exploration in patients with GBM.PMID:38599661 | DOI:10.1136/jitc-2024-008880

Source: Herpes - April 10, 2024 Category: Infectious Diseases Authors: Praveen K Bommareddy Hiroaki Wakimoto Robert L Martuza Howard L Kaufman Samuel D Rabkin Dipongkor Saha Source Type: research