Potential roles of microRNA-1 and microRNA-133 in cardiovascular disease.
Authors: Song Z, Gao R, Yan B Abstract Cardiovascular disease is still the main cause of morbidity and mortality worldwide. Currently, the frontier of research into cardiovascular disease is the field of non-coding RNA. In this review, information was collected on the use of micro-RNAs as non-invasive biomarkers and their role in pathophysiological processes and therapeutic applications. In the case of microRNA-1 and microRNA-133, the roles and regulatory mechanisms of them are reviewed for arrhythmia, myocardial infarction, diabetic cardiomyopathy, myocardial hypertrophy, cardiomyocyte differentiation, and cell re...
Source: Reviews in Cardiovascular Medicine - April 8, 2020 Category: Cardiology Tags: Rev Cardiovasc Med Source Type: research

SPARCL1 as a biomarker of maladaptive right ventricular remodelling in pulmonary hypertension.
This study assessed the utility of SPARC-like protein 1 (SPARCL1) as a biomarker of maladaptive right ventricular (RV) function in patients with pulmonary hypertension (PH).Methods: In this prospective study, we examined SPARCL1 levels in 105 patients with adaptive (n = 34) and maladaptive RV (n = 32) pressure overload caused by PH, dilated cardiomyopathy (DCM, n = 18) with LVEF
Source: Biomarkers - April 8, 2020 Category: Research Tags: Biomarkers Source Type: research

Assessing the cost-effectiveness of home automated external defibrillators for pediatric patients – getting us closer to the truth
Risk matrices categorize risk level based on the probability of an event occurring versus the severity of that event. As a risk assessment tool, they help anticipate future events, understand the tolerability of consequences, and design effective prevention or mitigation strategies. In the case of cardiac conditions that predispose to sudden cardiac death at a young age, such as hypertrophic cardiomyopathy, the severity of the outcome is always catastrophic. Where variability exists is in the probability of that outcome. (Source: Heart Rhythm)
Source: Heart Rhythm - April 8, 2020 Category: Cardiology Authors: Jonathan R. Kaltman Source Type: research

Duchenne Muscular Dystrophy: the Heart of the Matter
This article reviews the diagnosis and treatment of heart disease in Duchenne muscular dystrophy as well as emerging therapies. (Source: Current Heart Failure Reports)
Source: Current Heart Failure Reports - April 8, 2020 Category: Cardiology Source Type: research

Post-transplantation Outcomes in Patients with PA or MMA: A Review of the Literature
ConclusionsLiver transplantation and combined liver –kidney transplantation appears to benefit some patients with PA or MMA, respectively, but this approach does not provide complete correction of the metabolic defect and some patients remain at risk from disease-related and transplantation-related complications, including death. Thus, all treatmen t avenues should be exhausted before consideration of organ transplantation and the benefits of this approach must be weighed against the risk of perioperative complications on an individual basis. (Source: Advances in Therapy)
Source: Advances in Therapy - April 8, 2020 Category: Drugs & Pharmacology Source Type: research

Ventricular arrhythmias in heart failure with reduced ejection fraction
Purpose of review To provide a framework for approaching ventricular arrhythmias in the setting of cardiomyopathy, outline the latest evidence-based recommendations for catheter ablation and device therapy, and discuss novel treatment strategies. Recent findings Risk stratification of ventricular arrhythmias in systolic heart failure has evolved, with an increasing role for cardiac magnetic resonance imaging to identify underlying substrate and scar burden. Medical therapy for heart failure has greatly improved, and the role of primary prevention defibrillators in nonischemic cardiomyopathy has become more ambiguous. ...
Source: Current Opinion in Cardiology - April 7, 2020 Category: Cardiology Tags: CARDIAC FAILURE: Edited by Rebecca Cogswell and Gene Kim Source Type: research

Prevalence of atrial arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy: a systematic review and meta-analysis
Conclusion Atrial arrhythmia is common among patients with ARVC with the pooled prevalence of approximately 18%, which is substantially higher than the reported prevalence of atrial arrhythmia in the general population. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - April 7, 2020 Category: Cardiology Tags: Research articles: Arrhythmias Source Type: research

Sudden cardiac death in a girl with familiar left-dominant arrhythmogenic cardiomyopathy: a multidisciplinary approach
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - April 7, 2020 Category: Cardiology Tags: Case reports Source Type: research

The colours of amphetamine-induced cardiomyopathy
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - April 7, 2020 Category: Cardiology Tags: Images in cardiovascular medicine Source Type: research

Cardiac Resynchronization Therapy for Chemotherapy-Induced Cardiomyopathy —Reply
In Reply We agree with Dr Schwartz and colleagues that it would be worthwhile examining the time from the last anthracycline dose on the extent of CRT benefit. However, for CRT to work, there needed to have been concomitant conduction tissue disease because all the patients in our study had an accompanying LBBB contributing to the mechanical dyssynchrony that was corrected with CRT. The temporal relationship of the LBBB to the development of cardiomyopathy could influence the degree of response. We do not have data to examine the relationship between the last dose of anthracycline, the development of LBBB, and the onset of...
Source: JAMA - April 7, 2020 Category: General Medicine Source Type: research

Cardiac Resynchronization Therapy for Chemotherapy-Induced Cardiomyopathy
To the Editor Dr Singh and colleagues reported that patients with chemotherapy-induced cardiomyopathy (CHIC) who met class I or II indications for cardiac resynchronization therapy (CRT) showed improvement in left ventricular ejection fraction (LVEF) and heart failure symptoms by 6 months following CRT implantation. We would like to raise a few points for consideration. (Source: JAMA)
Source: JAMA - April 7, 2020 Category: General Medicine Source Type: research

Tolerogenic Dendritic Cells Reduce Cardiac Inflammation and Fibrosis in Chronic Chagas Disease
Chronic Chagas disease cardiomyopathy (CCC) is the most frequent and severe form of this parasitic disease. CCC is caused by a progressive inflammation in the heart, resulting in alterations that can culminate in heart failure and death. The use of dendritic cells (DCs) appears as an option for the development of treatments due to their important role in regulating immune responses. Here, we investigated whether tolerogenic cells (tDCs) could interfere with the progression of CCC in an experimental model of Chagas disease. The tDCs were generated and characterized as CD11b+ CD11c+ cells, low expression of MHC-II, CD86, CD8...
Source: Frontiers in Immunology - April 7, 2020 Category: Allergy & Immunology Source Type: research

Diagnosis of Transthyretin Amyloid Cardiomyopathy
AbstractTransthyretin amyloid cardiomyopathy (ATTR-CM) continues to be an easily overlooked, life-threatening, yet treatable cause of heart failure. Furthermore, its elusive diagnosis leads to late or misdiagnosis. As therapeutic advancements such as tafamidis usher in a promising new era in the management of ATTR-CM, the need for disease awareness and efficient diagnostic evaluation is crucial. With newer inexpensive imaging modalities and techniques, such as longitudinal strain imaging, T1 mapping on cardiac magnetic resonance imaging, and cardiac scintigraphy, the diagnosis of ATTR-CM no longer requires invasive evaluat...
Source: Cardiology and Therapy - April 7, 2020 Category: Cardiology Source Type: research

Percutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy through non-left anterior descending septal perforators
AbstractPercutaneous transluminal septal myocardial ablation (PTSMA) has become a significant treatment for symptomatic patients with hypertrophic obstructive cardiomyopathy (HOCM) despite maximal medical therapy. The target septal arteries usually arise from the left anterior descending artery (LAD). However, when septal perforators do not originate from the LAD, non-LAD septal perforators should be included as candidate-target septal branches that feed the hypertrophic septal myocardium, causing left ventricular outflow tract (LVOT) obstruction. Data pertaining to the procedure remain limited. We aimed to investigate PTS...
Source: Heart and Vessels - April 6, 2020 Category: Cardiology Source Type: research

Clinical features differentiating Takotsubo cardiomyopathy in the peripartum period from peripartum cardiomyopathy
AbstractThere are some similarities in clinical features between Takotsubo cardiomyopathy during the peripartum period (PTCM) and peripartum cardiomyopathy (PPCM). Both conditions present as acute heart failure and decreased left ventricular (LV) ejection fraction in the peripartum period in previously heart-healthy women. The present study aimed to evaluate the differences in clinical features and outcomes between PTCM and PPCM. Between January 2004 and December 2016, 37 consecutive patients who demonstrated LV dysfunction during the peripartum period without previous heart disease were recruited retrospectively. The clin...
Source: Heart and Vessels - April 6, 2020 Category: Cardiology Source Type: research

Adding clinical value with coronary flow assessment in hypertrophic obstructive cardiomyopathy
Publication date: Available online 4 April 2020Source: IJC Heart & VasculatureAuthor(s): Thomas H. Schindler, David L. Brown, Justin S. Sadhu (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - April 6, 2020 Category: Cardiology Source Type: research

Letter To The Editor Re: Echocardiographic assessment of right ventricular systolic function in Boxers with arrhythmogenic right ventricular cardiomyopathy
Publication date: Available online 4 April 2020Source: Journal of Veterinary CardiologyAuthor(s): Mark D. Kittleson (Source: Journal of Veterinary Cardiology)
Source: Journal of Veterinary Cardiology - April 6, 2020 Category: Veterinary Research Source Type: research

Precision Cardio-Oncology: a Systems-Based Perspective on Cardiotoxicity of Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors
AbstractCancer therapies have been evolving from conventional chemotherapeutics to targeted agents. This has fulfilled the hope of greater efficacy but unfortunately  not of greater safety. In fact, a broad spectrum of toxicities can be seen with targeted therapies, including cardiovascular toxicities. Among these, cardiomyopathy and heart failure have received greatest attention, given their profound implications for continuation of cancer therapies and card iovascular morbidity and mortality. Prediction of risk has always posed a challenge and even more so with the newer targeted agents. The merits of...
Source: Journal of Cardiovascular Translational Research - April 6, 2020 Category: Cardiology Source Type: research

Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs
AbstractMany crucial cardiovascular adaptations occur in the body during pregnancy to ensure successful gestation. Maladaptation of the cardiovascular system during pregnancy can lead to complications that promote cardiac dysfunction and may lead to heart failure (HF). About 12% of pregnancy-related deaths in the USA have been attributed to HF and the detrimental effects of cardiovascular complications on the heart can be long-lasting, pre-disposing the mother to HF later in life. Indeed, cardiovascular complications such as gestational diabetes mellitus, preeclampsia, gestational hypertension, and peripartum cardiomyopath...
Source: Biology of Sex Differences - April 6, 2020 Category: Biology Source Type: research

Left ventricular endocardial pacing is less arrhythmogenic than conventional epicardial pacing when pacing in proximity to scar
Epicardial pacing increases risk of ventricular tachycardia (VT) in patients with ischemic cardiomyopathy (ICM) when pacing in proximity to scar. Endocardial pacing may be less arrhythmogenic as it preserves the physiological sequence of activation and repolarization. (Source: Heart Rhythm)
Source: Heart Rhythm - April 6, 2020 Category: Cardiology Authors: Caroline Mendonca Costa, Aurel Neic, Karli Gillette, Bradley Porter, Justin Gould, Baldeep Sidhu, Zhong Chen, Mark Elliott, Vishal Mehta, Gernot Plank, Christopher A. Rinaldi, Martin J. Bishop, Steven A. Niederer Source Type: research

Clinical utility of genetic testing in the early diagnosis of Danon disease mimicking hypertrophic cardiomyopathy: a case report
Danon disease (OMIM 300257) is an X-linked lysosomal storage disorder, characterized by hypertrophic cardiomyopathy (HCM), skeletal myopathy, variable intellectual disability, and other minor clinical features. (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - April 5, 2020 Category: Cardiology Authors: Valeria Novelli, Antonio Bisignani, Gemma Pelargonio, Guido Primiano, Maria Lucia Narducci, Vincenzo Palmieri, Francesco Danilo Tiziano, Paolo Zeppilli, Serenella Servidei, Filippo Crea and Maurizio Genuardi Tags: Case report Source Type: research

Sudden cardiac death in hypertrophic cardiomyopathy: Improved risk stratification strategies are needed
Publication date: December 2019Source: Revista Portuguesa de Cardiologia (English Edition), Volume 38, Issue 12Author(s): Inês Cruz (Source: Revista Portuguesa de Cardiologia)
Source: Revista Portuguesa de Cardiologia - April 5, 2020 Category: Cardiology Source Type: research

The SHIFT model combines clinical, electrocardiographic and echocardiographic parameters to predict sudden cardiac death in hypertrophic cardiomyopathy
Publication date: December 2019Source: Revista Portuguesa de Cardiologia (English Edition), Volume 38, Issue 12Author(s): Catarina Ruivo, Fernando Montenegro Sá, Joana Correia, Adriana Belo, Maria Fátima Loureiro, João Morais, on behalf of Portuguese National Registry of Hypertrophic Cardiomyopathy (Source: Revista Portuguesa de Cardiologia)
Source: Revista Portuguesa de Cardiologia - April 5, 2020 Category: Cardiology Source Type: research

Reduction in Filamin C transcript is associated with arrhythmogenic cardiomyopathy in Ashkenazi Jews
Filamin C is a cytoskeletal protein expressed in cardiac cells. Nonsense variations in the filamin C gene (FLNC) were associated with dilated and arrhythmogenic cardiomyopathies. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 5, 2020 Category: Cardiology Authors: Oz Shimrit, Yonath Hagith, Visochyk Leonid, Ofek Efrat, Landa Natalie, Reznik-Wolf Haike, F. Ortiz-Genga Martin, Monserrat Lorenzo, Ben-Gal Tuvia, Goitein Orly, Beinart Roy, Glikson Michael, Freimark Dov, Pras Elon, Arad Michael, Nof Eyal Source Type: research

Author response to Letter to the Editor re: Echocardiographic assessment of right ventricular systolic function in Boxers with arrhythmogenic right ventricular cardiomyopathy
Publication date: Available online 3 April 2020Source: Journal of Veterinary CardiologyAuthor(s): Suzanne M. Cunningham (Source: Journal of Veterinary Cardiology)
Source: Journal of Veterinary Cardiology - April 4, 2020 Category: Veterinary Research Source Type: research

[The Therapeutic Potency of Natural Products against Heart Failure].
This report reviews our basic studies and clinical trials using curcumin therapeutically to prevent heart failure, as well as the possibility of clinical applications of curcumin. PMID: 32238626 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 4, 2020 Category: Drugs & Pharmacology Authors: Sunagawa Y Tags: Yakugaku Zasshi Source Type: research

A 67-Year-Old Man With a Mass Shadow in His Heart Chamber During Coronary Angiography.
Authors: Han Z, Xu X, Lin Y Abstract A 67-year-old man was admitted to our hospital due to chest tightness induced by activity that had started about 2 months earlier. To clarify the causes of chest pain in this patient, cardiac magnetic resonance imaging was performed, resulting in a diagnosis of ventricular apical hypertrophic cardiomyopathy with intramyocardial calcification. PMID: 32240101 [PubMed - in process] (Source: The Journal of Invasive Cardiology)
Source: The Journal of Invasive Cardiology - April 4, 2020 Category: Cardiology Tags: J Invasive Cardiol Source Type: research

Alpha-Loop for Permanent Pacemaker Implantation in Restrictive Cardiomyopathy.
Authors: Sharma YP, Kanabar K, Makode S, Prasad K Abstract High-grade and complete heart block commonly occurs in adult patients with restrictive cardiomyopathy, and requires aggressive monitoring and prophylactic pacemaker/defibrillator. There are limited data on the procedural details of pacemaker implantation in this group of patients, and as reported, special maneuvers may be required for ventricular lead placement. PMID: 32240099 [PubMed - in process] (Source: The Journal of Invasive Cardiology)
Source: The Journal of Invasive Cardiology - April 4, 2020 Category: Cardiology Tags: J Invasive Cardiol Source Type: research

Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) in pregnancy: a case series of nine patients and review of literature
. (Source: Journal of Maternal-Fetal and Neonatal Medicine)
Source: Journal of Maternal-Fetal and Neonatal Medicine - April 3, 2020 Category: Perinatology & Neonatology Authors: Fang Yuan Luo Rati Chadha Christine Osborne Angela Kealey Source Type: research

Could myocardial viability be related to left ventricular dyssynchrony? Simultaneous evaluation by gated SPECT-MPI
AbstractBackground Left ventricular contraction dyssynchrony (LVCD) has been related to induced ischemia and transmural scar but the interplay of myocardial viability and dyssynchrony is unknown. The aim of the present study was to establish the role of dyssynchrony in the context of a viability study performed with nitrate augmentation gated single photon emission computed tomography (GSPECT) myocardial perfusion imaging (MPI).Methods Fifty-four consecutive patients with ischemic dilated cardiomyopathy (IDC) and depressed left ventricular ejection fraction (LVEF) were included. They underwent a two-day rest/nitroglyce...
Source: Journal of Nuclear Cardiology - April 3, 2020 Category: Nuclear Medicine Source Type: research

Fibrosis in Arrhythmogenic Cardiomyopathy: The Phantom Thread in the Fibro-Adipose Tissue
Arrhythmogenic cardiomyopathy (ACM) is an inherited heart disorder, predisposing to malignant ventricular arrhythmias leading to sudden cardiac death, particularly in young and athletic patients. Pathological features include a progressive loss of myocardium with fibrous or fibro-fatty substitution. During the last few decades, different clinical aspects of ACM have been well investigated but still little is known about the molecular mechanisms that underlie ACM pathogenesis, leading to these phenotypes. In about 50% of ACM patients, a genetic mutation, predominantly in genes that encode for desmosomal proteins, has been i...
Source: Frontiers in Physiology - April 3, 2020 Category: Physiology Source Type: research

Unplanned Thirty-Day Readmission After Alcohol Septal Ablation for Hypertrophic Cardiomyopathy (From the Nationwide Readmission Database)
Alcohol septal ablation (ASA) is indicated for symptomatic hypertrophic cardiomyopathy (HC) patients. We sought to analyze the incidence of the 30-day readmission rate, predictors, causes of readmission, and incremental healthcare resource (cost and length of stay) utilization after ASA. Nationwide readmission database from 2010 January to 2015 September was queried to identify 30-day unplanned readmission after ASA for HC by using the International Classification of Disease, 9th Revision, Clinical Modification. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 3, 2020 Category: Cardiology Authors: Tomo Ando, Oluwole Adegbala, Ankita Aggarwal, Luis Afonso, Cindy L. Grines, Hisato Takagi, Alexandros Briasoulis Source Type: research

Exercise Training Attenuates Cirrhotic Cardiomyopathy
AbstractCirrhotic cardiomyopathy is a condition where liver cirrhosis is associated with cardiac dysfunction. Triggers and blockers of cirrhotic cardiomyopathy are poorly understood, which might compromise the prognosis of chronic liver disease patients. We tested whether exercise training would reduce liver damage induced by thioacetamide and prevent liver cirrhosis-associated cardiomyopathy. Wistar rats were divided into three groups: control, thioacetamide (TAA), or TAA plus exercise. Thioacetamide increased liver weight and serum alanine aminotransferase and aspartate aminotransferase levels. Also, TAA treatment was in...
Source: Journal of Cardiovascular Translational Research - April 3, 2020 Category: Cardiology Source Type: research

The electrocardiogram in the diagnosis and management of patients with dilated cardiomyopathy
We describe various clinical settings where the appropriate use and interpretation of the ECG can provide invaluable clues, co ntributing to the important role of this basic tool as cardiovascular medicine evolves. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - April 3, 2020 Category: Cardiology Authors: Gherardo Finocchiaro, Marco Merlo, Nabeel Sheikh, Giulia De Angelis, Michael Papadakis, Iacopo Olivotto, Claudio Rapezzi, Gerald Carr ‐White, Sanjay Sharma, Luisa Mestroni, Gianfranco Sinagra Tags: Review Source Type: research

A network analysis to identify pathophysiological pathways distinguishing ischaemic from non ‐ischaemic heart failure
ConclusionsPathophysiological pathways distinguishing patients with ischaemic HF from those with non ‐ischaemic HF were related to inflammation, endothelial dysfunction superoxide production, coagulation, and atherosclerosis. The five key pathway proteins identified are potential treatment targets specifically for patients with ischaemic HF. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - April 3, 2020 Category: Cardiology Authors: Iziah E. Sama, Rebecca J. Woolley, Jan F. Nauta, Simon P.R. Romaine, Jasper Tromp, Jozine M. Maaten, Peter Meer, Carolyn S.P. Lam, Nilesh J. Samani, Leong L. Ng, Marco Metra, Kenneth Dickstein, Stefan D. Anker, Faiez Zannad, Chim C. Lang, J Tags: Research Article Source Type: research

Hypocalcaemic cardiomyopathy: a description of two cases and a literature review
AbstractHypocalcaemic cardiomyopathy is a rare form of dilated cardiomyopathy. The authors here present two cases in which symptomatic dilated cardiomyopathy was the result of severe hypocalcaemia. First, we report about a 26 ‐year‐old woman with primary hypoparathyroidism and then about a 74‐year‐old man with secondary hypoparathyroidism following a thyroidectomy. In both cases, the left ventricular systolic function improved after calcium supplementation. In the first case, a lack of compliance led to a repeate d decrease of both serum calcium level and left ventricular systolic function. The authors also present...
Source: ESC Heart Failure - April 3, 2020 Category: Cardiology Authors: Martin V álek, Lenka Roblová, Ivan Raška, Dita Schaffelhoferová, Tomáš Paleček Tags: Review Source Type: research

"Upregulation of PKR Pathway Mediates Glucolipotoxicity Induced Diabetic Cardiomyopathy In vivo in Wistar Rats and In vitro in Cultured Cardiomyocytes".
CONCLUSION: Our present study reports for the first time that inhibition of PKR may have great therapeutic potential in the treatment of DCM by attenuating inflammation, oxidative stress, apoptosis and fibrosis. PMID: 32251680 [PubMed - as supplied by publisher] (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - April 3, 2020 Category: Drugs & Pharmacology Authors: Mangali S, Bhat A, Jadhav K, Kalra J, Sriram D, Vamsi Krishna Venuganti V, Dhar A Tags: Biochem Pharmacol Source Type: research

Left Ventricular Noncompaction: Diagnostic Approach, Prognostic Evaluation, and Management Strategies
Left ventricular noncompaction cardiomyopathy is a heart disease with relevant potential complications including heart failure, life-threatening arrhythmias, and embolic events. In order to prevent adverse outcomes, it is crucial to appropriately recognize and manage this cardiomyopathy. In this paper, we report the main clinical presentations and imaging modalities used for diagnosis, including echocardiography and magnetic resonance imaging. We highlight the role of a comprehensive functional cardiac evaluation and the possible prognostic implications of both systolic and diastolic dysfunction. Furthermore, we summarize ...
Source: Cardiology in Review - April 2, 2020 Category: Cardiology Tags: Review Articles Source Type: research

Peripartum Cardiomyopathy Incidence, Risk Factors, Diagnostic Criteria, Pathophysiology, and Treatment Options
This article will provide a comprehensive review and update on this important disease state. (Source: Cardiology in Review)
Source: Cardiology in Review - April 2, 2020 Category: Cardiology Tags: Review Articles Source Type: research

Tafamidis: A Novel Treatment for Transthyretin Amyloid Cardiomyopathy
Transthyretin (TTR) amyloid cardiomyopathy is a life-threatening condition in which amyloid fibrils accumulate in the heart, eventually leading to cardiac symptomatology and death. To date, treatment of this condition has been directed at symptom relief due to a lack of effective treatment options which target the cause of the disease. The discovery that amyloid deposition was a result of dissociation of the TTR protein structure allowed for the development of tafamidis, which acts by stabilizing the TTR tetramer. Due to the rare nature of the disease, there is limited clinical trial data with tafamidis, with the largest c...
Source: Cardiology in Review - April 2, 2020 Category: Cardiology Tags: New Therapy Update Source Type: research

[ASAP] Correction to “Ginsenoside-Rb1 Improved Diabetic Cardiomyopathy through Regulating Calcium Signaling by Alleviating Protein O-GlcNAcylation”
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.0c01904 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - April 2, 2020 Category: Food Science Authors: Linhui Qin, Jianping Wang, RongRong Zhao, Xiao Zhang, and Yingwu Mei* Source Type: research

Protective effects of AS-IV on diabetic cardiomyopathy by improving myocardial lipid metabolism in rat models of T2DM
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Zhongyuan Wang, Yunfeng Zhu, Yanhua Zhang, Jie Zhang, Tianjiao Ji, Weizu Li, Weiping Li (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 2, 2020 Category: Drugs & Pharmacology Source Type: research

Single Coil Implantable Cardioverter Defibrillator Leads in Patients with Hypertrophic Cardiomyopathy
Patients with hypertrophic cardiomyopathy (HC) may require higher energies to terminate ventricular fibrillation (VF); thus, dual coil defibrillation leads are often implanted. However, single coil leads may be preferred in young patients. All patients with HCM implanted with a transvenous ICD from years 2000 to 2014 were included. Of 249 patients, 223 underwent VF testing including 150 with a dual coil lead and 73 a single coil. Patients tested with dual coil compared to single coil had lower successful VF energies (15.7 ± 6.1 joule to 20.2 ± 7.9 joule (p (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 2, 2020 Category: Cardiology Authors: Kartik R. Kumar, Swati N. Mandleywala, Christopher Madias, Jonathan Weinstock, Ethan J. Rowin, Barry J Maron, Martin S. Maron, Mark S. Link Source Type: research

Minimal clinically important difference in quality of life scores for patients with heart failure and reduced ejection fraction
ABSTRACTAimsWhile the associations of health ‐related quality of life scores in heart failure (HF) [e.g. the Kansas City Cardiomyopathy Questionnaire (KCCQ)] with clinical outcomes are well established, their interpretation in the context of what magnitudes of change are clinically important to patients is less clear. The main objective of t his study was to correlate the changes in the KCCQ and Patient Global Assessment (PGA) in patients with HF with reduced ejection fraction (HFrEF) to determine minimal clinically important difference (MCID).Methods and resultsWe analysed data from 459 patients of the FAIR ‐HF trial....
Source: European Journal of Heart Failure - April 2, 2020 Category: Cardiology Authors: Javed Butler, Muhammad Shahzeb Khan, Claudio Mori, Gerasimos S. Filippatos, Piotr Ponikowski, Josep Comin ‐Colet, Bernard Roubert, John A. Spertus, Stefan D. Anker Tags: Research Article Source Type: research

The price and value of impantable cardioverter defibrillators in hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) came to prominence in 1958 when Donald Teare described in the British Heart Journal its typical pathological features in 8 patients who died suddenly. The excessive risk of sudden cardiac death (SCD) dominated the early literature and contemporary 21st century studies suggest that the SCD rate is approximately 1% per year [1]. Ventricular arrhythmias are the primary cause of SCD and the development of the implantable cardioverter defibrillator (ICD) in 1980 was a significant milestone. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 2, 2020 Category: Cardiology Authors: Yang Chen, Constantinos O'Mahony Tags: Editorial Source Type: research

Minimal clinically important difference in quality of life scores for patients with heart failure and reduced ejection fraction
ABSTRACTAimsWhile the associations of health ‐related quality of life scores in heart failure (HF) [e.g. the Kansas City Cardiomyopathy Questionnaire (KCCQ)] with clinical outcomes are well established, their interpretation in the context of what magnitudes of change are clinically important to patients is less clear. The main objective of t his study was to correlate the changes in the KCCQ and Patient Global Assessment (PGA) in patients with HF with reduced ejection fraction (HFrEF) to determine minimal clinically important difference (MCID).Methods and resultsWe analysed data from 459 patients of the FAIR ‐HF trial....
Source: European Journal of Heart Failure - April 2, 2020 Category: Cardiology Authors: Javed Butler, Muhammad Shahzeb Khan, Claudio Mori, Gerasimos S. Filippatos, Piotr Ponikowski, Josep Comin ‐Colet, Bernard Roubert, John A. Spertus, Stefan D. Anker Tags: Research Article Source Type: research

Left-ventricular non-compaction-comparison between different techniques of quantification of trabeculations: Should the diagnostic thresholds be modified?
Abstract BACKGROUND: Diagnosis of left ventricular non-compaction (LVNC) is challenging, and different imaging techniques propose different criteria. AIM: To compare the value of two-dimensional transthoracic echocardiography (2D-TTE) and cardiac magnetic resonance (CMR) criteria in diagnosing LVNC, and to test a new trabecular quantification method obtained by 2D-TTE, exploring its relationship with CMR non-compacted mass quantification. METHODS: From a multicentre French study, we selected 48 patients with LVNC and 20 with dilated cardiomyopathy (DCM) who underwent 2D-TTE and CMR. Current 2D-TTE (Jenni...
Source: Archives of Cardiovascular Diseases - April 2, 2020 Category: Cardiology Authors: Donghi V, Tradi F, Carbone A, Viala M, Gaubert G, Nguyen K, Reant P, Donal E, Eicher JC, Selton-Suty C, Huttin O, Resseguier N, Michel N, Guazzi M, Jacquier A, Habib G Tags: Arch Cardiovasc Dis Source Type: research

NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy
Publication date: Available online 30 March 2020Source: Redox BiologyAuthor(s): Cheng Zeng, Fengqi Duan, Jia Hu, Bin Luo, Binlong Huang, Xiaoying Lou, Xiuting Sun, Hongyu Li, Xuanhong Zhang, Shengli Yin, Hongmei Tan (Source: Redox Biology)
Source: Redox Biology - April 1, 2020 Category: Biology Source Type: research

Understanding the Relationships of Cardiac Diagnostics in Patients with Amyloid Transthyretin Cardiac Amyloidosis
Amyloid transthyretin (ATTR) cardiac amyloidosis (CA) is an increasingly recognized cause of restrictive cardiomyopathy and associated heart failure with preserved ejection fraction (HFpEF). Despite improved diagnostic techniques to identify this condition, many patients experience delayed diagnosis. Interpretation of routine cardiac biomarkers (i.e. troponins and brain natriuretic peptide (BNP)) and echocardiography in ATTR-CA is limited, particularly in relation to pyrophosphate (PYP) scintigraphy. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2020 Category: Transplant Surgery Authors: B. Di Giovanni, D. Gustafson, M.B. Adamson, K. Runeckles, D.H. Delgado Tags: (64) Source Type: research

Single-Cell RNA-seq of Human Cardiomyocytes Revealed DNA Damage Response as a Novel Predictor for Therapeutic Prognosis in Heart Failure Patients with Dilated Cardiomyopathy
Patients with dilated cardiomyopathy (DCM) who achieved left ventricular reverse remodeling (LVRR) have a favorable prognosis, but it is still difficult to precisely predict LVRR in the clinical setting. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2020 Category: Transplant Surgery Authors: T. Ko, M. Hatano, I. Komuro Tags: (27) Source Type: research