Normal and excessive muscle sympathetic nerve activity in heart failure: implications for future trials of therapeutic autonomic modulation
ConclusionBurst frequency and incidence exceeded normative values in only ~53% and ~33% of patients. Such diversity encourages selective deployment of sympatho-modulatory therapies. Clinical characteristics can highlight individuals who may benefit from future personalized interventions targeting pathological sympathetic activation. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - December 3, 2022 Category: Cardiology Authors: Mark B. Badrov, Daniel A. Keir, George Tomlinson, Catherine F. Notarius, Philip J. Millar, Derek S. Kimmerly, J. Kevin Shoemaker, Evan Keys, John S. Floras Tags: Research Article Source Type: research

Cardiac amyloidosis —An underdiagnosed cause of heart failure: A case report and review of literature
Cardiac amyloidosis should be considered in patients with diastolic heart failure and nephrotic syndrome. Strain analysis is a specific finding. A high index of suspicion is required and early initiation of therapy improves outcomes. AbstractRestrictive cardiomyopathy secondary to cardiac amyloidosis is an underdiagnosed, but treatable, cause of heart failure involving an extracellular deposition of misfolded protein. Hereby, we report a case of a female patient with history of nephrotic syndrome for 1 year who subsequently presented with symptoms of heart failure. The findings on cardiac imaging supported the suspicion of...
Source: Clinical Case Reports - December 3, 2022 Category: General Medicine Authors: Kanak Parmar, Juthipong Benjanuwattra, Pooja Sethi, Lukman Tijani, Philip Hurst, Gaspar Del ‐Rio Pertuz, Erwin Argueta‐Sosa Tags: CASE REPORT Source Type: research

Heart rate reduction as a marker to optimize carvedilol treatment and enhance myocardial recovery in pediatric dilated cardiomyopathy
Conclusion: This study demonstrates that HRR is safe and improvement in LVEF is related to the degree of HRR. The magnitude of LVEF improvement was enhanced by a major reduction in HR. It provides evidence that HRR could be used as a clinical marker to treat HF in children. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - December 2, 2022 Category: Physiology Source Type: research

The interplay between cardiac dyads and mitochondria regulated the calcium handling in cardiomyocytes
Calcium mishandling and mitochondrial dysfunction have been increasingly recognized as significant factors involved in the progression procedure of cardiomyopathy. Ca2+ mishandling could cause calcium-triggered arrhythmias, which could enhance force development and ATP consumption. Mitochondrial disorganization and dysfunction in cardiomyopathy could disturb the balance of energy catabolic and anabolic procedure. Close spatial localization and arrangement of structural among T-tubule, sarcoplasmic reticulum, mitochondria are important for Ca2+ handling. So that, we illustrate the regulating network between calcium handling...
Source: Frontiers in Physiology - December 2, 2022 Category: Physiology Source Type: research

Maternal cardiomyopathy increases the risk of perinatal adverse outcomes
(Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 2, 2022 Category: OBGYN Authors: Elizabeth J. Eggleton, Kate J. Mcmurrugh, Catherine E. Aiken Source Type: research

Perinatal outcomes in pregnancies complicated by maternal cardiomyopathy: a letter
(Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 2, 2022 Category: OBGYN Authors: Avir Sarkar, Manish Gupta, Bhumika Jesingh, Ramesh Chandra Source Type: research

A Case of Neonatal Lupus Presenting with Myocardial Dysfunction in the Absence of Congenital Heart Block (CHB): Clinical Management and Brief Literature Review of Neonatal Cardiac Lupus
AbstractNeonatal lupus (NLE) is a rare acquired autoimmune disorder caused by transplacental passage of maternal autoantibodies to Sjogren ’s Syndrome A or B (SSA-SSB) autoantigens (Vanoni et al. in Clin Rev Allerg Immunol 53:469–476, 2017) which target fetal and neonatal tissues for immune destruction. The cardiac trademark of NLE is autoimmune heart block, which accounts for more than 80% of cases of complete atrioventricular hea rt block (AVB) in newborns with a structurally normal heart (Martin in Cardiol Young 24: 41–46, 2014). NLE presenting with cardiac alterations not involving rhythm disturbances are describ...
Source: Pediatric Cardiology - December 2, 2022 Category: Cardiology Source Type: research

The value of CMR Left ventricular strain analysis in evaluating ICM
AbstractThe purpose of this article is to investigate the value of cardiac magnetic resonance imaging (CMR) derived left ventricular strain parameters in evaluation of ischemic cardiomyopathy (ICM). Thirty-one ICM patients and nineteen non-cardiomyopathy (non-CM) patients who performed CMR examinations during the same period were selected for this retrospective study. The basic clinical data, CMR left ventricular function parameters, left ventricular strain parameters were compared among the left ventricular ejection fraction (LVEF) preserved ICM group, the LVEF impaired ICM group and the non-CM group. The differences of M...
Source: The International Journal of Cardiovascular Imaging - December 2, 2022 Category: Radiology Source Type: research

A Narrative Review of the Pathophysiology and Treatment of Hypertrophic Cardiomyopathy
South Med J. 2022 Dec;115(12):926-929. doi: 10.14423/SMJ.0000000000001478.NO ABSTRACTPMID:36455903 | DOI:10.14423/SMJ.0000000000001478 (Source: Southern Medical Journal)
Source: Southern Medical Journal - December 1, 2022 Category: General Medicine Authors: Lee M Gelpi Acevedo Alexandra Lizette Salinas Juan Sebastian Polanco Hamasah Nizami Denise Marsh Meet Patel Kinna Parikh Rahul Jain Rohit Jain Source Type: research

Genome Editing and Diabetic Cardiomyopathy
Adv Exp Med Biol. 2023;1396:103-114. doi: 10.1007/978-981-19-5642-3_7.NO ABSTRACTPMID:36454462 | DOI:10.1007/978-981-19-5642-3_7 (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - December 1, 2022 Category: Research Authors: Tyler N Kambis Paras K Mishra Source Type: research

Cardiovascular magnetic resonance imaging characteristics in patients with methamphetamine-associated cardiomyopathy
Methamphetamine-associated cardiomyopathy (MA-CMP) is an increasingly recognised aetiology of cardiomyopathy. Cardiovascular magnetic resonance (CMR) is a specialised cardiac imaging modality commonly used in ... (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - December 1, 2022 Category: Radiology Authors: Michael B. Stokes, Fiona Thoi, Daniel J. Scherer, Kyi T. H. Win, David M. Kaye, Karen S. Teo and Prashanthan Sanders Tags: Research Source Type: research

Left ventricular assist device in cardiac amyloidosis: friend or foe?
AbstractThe prevalence of cardiac amyloidosis has progressively increased over the last years, being recognized as a significant cause of heart failure. In fact, the management of advanced heart failure is a cornerstone treatment of amyloid cardiomyopathy due to the frequent delay in its diagnosis. Left ventricular assist devices (LVADs) have been gaining importance in the scenario of end-stage heart failure, representing an alternative to heart transplant. However, only few studies have investigated the role of LVAD in restrictive cardiomyopathies such as cardiac amyloidosis, since there are several problems to consider. ...
Source: Heart Failure Reviews - December 1, 2022 Category: Cardiology Source Type: research

Cardiopulmonary Exercise Test Could Provide Prognostic Value of 1-year Mortality in Patients with Newly Diagnosed Idiopathic Pulmonary Fibrosis: A Real-World Experience
Conclusion: CPET may provide prognostic value of 1-year mortality in patients with newly diagnosed IPF. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Fu, P., Cheng, Y. Tags: 12.01 - Idiopathic interstitial pneumonias Source Type: research

Cardioprotective medication in Duchenne muscular dystrophy: a single-centre cohort study
Duchenne’s muscular dystrophy (DMD) is a neuromuscular disorder characterised by progressive muscle wasting impacting mobility, ventilation and cardiac function. Associated neuromuscular cardiomyopathy remains a major cause of morbidity and mortality. We investigated the effects of cardioprotective medications (ACE-inhibitors(ACE-I), beta-blockers) on clinical outcomes in DMD patients.This was a retrospective cohort study (reference:2021/12469) of DMD patients at a tertiary centre between 1993-2001 screening the electronic records for demographics, comorbidities, medication, disease specific features, echocardiograph...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Kisel, J., Ballard, E., Eui-Sik, S., Hart, N., Srivastava, S., Murphy, P., Marino, P., Kapetanakis, S., Steier, J. Tags: 01.01 - Clinical problems - no related to asthma or COPD Source Type: research

Implicating biological pathways in lung function and COPD by variant-to-gene mapping of novel signals from a multi-ancestry meta-analysis of genome-wide association studies
Genome-wide association studies (GWAS) of lung function and COPD have identified approximately 300 genetic signals and 100 putative causal genes. We hypothesised that a larger, multi-ancestry meta-analysis with improved coverage of genomes would improve the detection of genetic signals and the mapping to relevant causal genes and biological pathways.We performed a multi-ancestry meta-analysis of GWAS summary statistics for association results for FEV1, FVC, FEV1/FVC and Peak Expiratory Flow across from 39 European ancestry cohorts, four African ancestry, three American ancestry, two East Asian ancestry and one South Asian ...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Tobin, M. D., Shrine, N., Izquierdo, A., Chen, J., Guyatt, A. L., Packer, R., Batini, C., Pozarickij, A., Walters, R. G., London, S., Morris, A. P., Wain, L. V., Hall, I. P. Tags: 03.01 - Molecular pathology and functional genomics Source Type: research