SPTLC3 Is Essential for Complex I Activity and Contributes to Ischemic Cardiomyopathy
CONCLUSIONS: Our findings suggest a novel essential role for SPTLC3 in electron transport chain function and a contribution to ischemic injury by regulating complex I activity.PMID:38660786 | DOI:10.1161/CIRCULATIONAHA.123.066879 (Source: Circulation)
Source: Circulation - April 25, 2024 Category: Cardiology Authors: Anna Kovilakath Adolfo G Mauro Yolander Valentine Frank Raucci Maryam Jamil Christiane Carter Jeremy Thompson Qun Chen Beutner Gisela Yang Yue Jeremy Allegood Xiaoxin X Wang Jordan Dail Teja Devarakonda Komuraiah Myakala Jolene J Windle Mark A Subler Davi Source Type: research
Effects of a Global < em > Rab27a < /em > Null Mutation on Murine PVAT and Cardiovascular Function
CONCLUSIONS: Global RAB27A loss impacted perivascular adipose tissue and thoracic aorta proteomic signatures, altered vasocontractile responses, and decreased left ventricular ejection fraction in mice.PMID:38660803 | DOI:10.1161/ATVBAHA.124.320969 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Ashley Soucy Christian Potts Abigail Kaija Anne Harrington Marissa McGilvrey George L Sutphin Ron Korstanje Benjamin Tero Jacob Seeker Ilka Pinz Calvin Vary Larisa Ryzhova Lucy Liaw Source Type: research
A young patient with Graves' disease presenting with a triad of heart failure, pancytopenia, and jaundice: A case report
We describe a case of a young man who presented with progressive cough, increased abdominal girth and ankle swelling for a few months. On examination, he had jaundice, bilateral exophthalmos, diffuse goiter, ascites, and significant lower limb edema. Laboratory investigations showed increased Thyroxin level with a suppressed thyroid stimulating hormone and positive anti-thyrotropin receptor antibodies. Also, the patient had pancytopenia, coagulopathy and cholestatic pattern of elevated liver enzymes. Echocardiography demonstrated mildly reduced left ventricular function with diastolic dysfunction, but electrocardiogram did...
Source: Clinical Case Reports - April 25, 2024 Category: General Medicine Authors: Mohamed Kamal Sabra,
Anwar Joudeh,
Mahmoud Al Niserat,
Riyadh Hammamy Tags: CASE REPORT Source Type: research
Exercise intolerance in a man with ischaemic cardiomyopathy and biventricular pacing
Clinical introduction A patient in his 60s with a history of ischaemic cardiomyopathy and severely reduced left ventricular ejection fraction of 20% presents with worsening dyspnoea on exertion. He is tolerating therapeutic doses of guideline-directed medical therapy including sacubitril-valsartan, carvedilol, spironolactone and empagliflozin, and has a biventricular implantable cardiac defibrillator. He undergoes cardiopulmonary exercise testing (CPET) using the treadmill-modified Bruce protocol and is found to have a severely reduced peak oxygen consumption (VO2) (14.9 mL/kg/min) despite maximal effort. The test was stop...
Source: Heart - April 25, 2024 Category: Cardiology Authors: Bevan, G. H., Buber, J. Tags: Arrhythmias and sudden death Source Type: research
Presence and utility of electrocardiographic abnormalities in long-term childhood cancer survivors
Conclusion
A clinical prediction model with ECG data (left bundle branch block, left atrial enlargement, left heart axis, Cornell’s criteria for left ventricular hypertrophy and heart rate) may aid in ruling out LVEF <45%. (Source: Heart)
Source: Heart - April 25, 2024 Category: Cardiology Authors: de Baat, E. C., Merkx, R., Leerink, J. M., Boerhout, C., van der Pal, H. J. H., van Dalen, E. C., Loonen, J., Bresters, D., van Dulmen-den Broeder, E., van der Heiden-van der Loo, M., van den Heuvel, M. M., Kok, J. L., Louwerens, M., Neggers, S. J. C. M. Tags: Open access Heart failure and cardiomyopathies Source Type: research
Association of uncertain significance genetic variants with myocardial mechanics and morphometrics in patients with nonischemic dilated cardiomyopathy
Careful interpretation of the relation between phenotype changes of the heart and gene variants detected in dilated cardiomyopathy (DCM) is important for patient care and monitoring. (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - April 25, 2024 Category: Cardiology Authors: Karolina M ėlinytė-Ankudavičė, Marius Šukys, Gabrielė Kasputytė, Ričardas Krikštolaitis, Eglė Ereminienė, Grytė Galnaitienė, Vaida Mizarienė, Gintarė Šakalytė, Tomas Krilavičius and Renaldas Jurkevičius Tags: Research Source Type: research
Human umbilical cord-derived mesenchymal stromal cells improve myocardial fibrosis and restore miRNA-133a expression in diabetic cardiomyopathy
CONCLUSION: Intravenous injection of hUC-MSCs ameliorated key functional and structural features of DCM in male mice with diabetes of shorter and longer duration. Mechanistically, these effects were associated with restoration of intra-myocardial expression of miRNA-133a and its target mRNA COL1AI as well as suppression of systemic and localized inflammatory mediators.PMID:38659015 | DOI:10.1186/s13287-024-03715-2 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Boxin Liu Yan Wei Jingjing He Baofeng Feng Yimeng Chen Ruiyun Guo Matthew D Griffin Se án O Hynes Sanbing Shen Yan Liu Huixian Cui Jun Ma Timothy O'Brien Source Type: research
Perioperative management and outcomes for posterior spinal fusion in patients with Friedreich ataxia: A single-center, retrospective study
CONCLUSIONS: Patients with Friedreich ataxia are at high risk for perioperative complications when undergoing posterior spinal fusion and coordinated multidisciplinary care is required at each stage. Future research should focus on the utility of intraoperative echocardiography, optimal anesthetic agent selection, and targeted fluid management to reduce postoperative cardiac complications.PMID:38655751 | DOI:10.1111/pan.14896 (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - April 24, 2024 Category: Anesthesiology Authors: Elizabeth M O'Brien Natalie Neiswinter Kimberly Y Lin David Lynch Keith Baldwin Victoria Profeta John M Flynn Wallis T Muhly Source Type: research
Protective role of hydrogen sulfide against diabetic cardiomyopathy by inhibiting pyroptosis and myocardial fibrosis
In this study, a diabetic rat model was developed using intraperitoneal injections of streptozotocin (STZ), and hyperglycemia-stimulated cardiomyocytes were employed to replicate the cellular environment of DCM. There was a marked decline in the expression of cystathionine γ-lyase (CSE), a catalyst for H2S synthesis, in both the STZ-induced diabetic rats and hyperglycemia-stimulated cardiomyocytes. Experimental results in vivo indicated that H2S ameliorates MF and enhances cardiac functionality in diabetic rats by mitigating cardiomyocyte pyroptosis. In vitro assessments highlighted the induction of cardiomyocyte pyroptos...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 24, 2024 Category: Drugs & Pharmacology Authors: Maojun Liu Cheng Zeng Yifeng Zhang Ying Xin Simin Deng Xinqun Hu Source Type: research
Cardiomyopathy Without Amyloid Deposit in Systemic Light Chain Deposition Disease
Korean Circ J. 2024 Apr;54(4):221-222. doi: 10.4070/kcj.2024.0022.NO ABSTRACTPMID:38654569 | DOI:10.4070/kcj.2024.0022 (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Bo Eun Park Se Yong Jang Yoon Jung Park Myung Hwan Bae Jang Hoon Lee Dong Heon Yang Hun Sik Park Yongkeun Cho Source Type: research
Randomized investigation of the MitraClip device in heart failure: Design and rationale of the RESHAPE ‐HF2 trial design
ConclusionsThe RESHAPE-HF2 trial will provide sound evidence on the MitraClip device and its effects in HF patients with FMR. The recruitment was recently completed with 506 randomized patients. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - April 24, 2024 Category: Cardiology Authors: Stefan D. Anker,
Tim Friede,
Ralph Stephan von Bardeleben,
Javed Butler,
Kaneez Fatima,
Monika Diek,
Jutta Heinrich,
Gerd Hasenfu ß,
Wolfgang Schillinger,
Piotr Ponikowski Tags: Study Design Source Type: research
Pulsed Field Ablation for Incessant Scar-Related Ventricular Tachycardia: First U.S. Report
70 y/o woman with a history of ischemic cardiomyopathy with ejection fraction of 20% due to a large healed anteroapical infarction. She had previously undergone three prior endocardial radiofrequency ablations for scar-related ventricular tachycardia (VT) with the most recent procedure at our center 4 months prior to the current hospital presentation. During that procedure, three zones of deceleration were identified, and ablation terminated two VT morphologies along the septal aspect of the scar and the patient was rendered noninducible from multiple sites of stimulation within the left ventricle. (Source: Heart Rhythm)
Source: Heart Rhythm - April 24, 2024 Category: Cardiology Authors: Praneeth Katrapati, J. Peter Weiss, David Baning, Michael Zawaneh, Wilber Su, Roderick Tung Source Type: research
Chagas Cardiomyopathy and Myocardial Sympathetic Denervation
AbstractPurpose of ReviewMore than a century since its discovery, the pathogenesis of Chagas heart disease (CHD) remains incompletely understood. The role of derangements in the autonomic control of the heart in triggering malignant arrhythmia before the appearance of contractile ventricular impairment was reviewed.Recent FindingsAlthough previous investigations had demonstrated the anatomical and functional consequences of parasympathetic dysautonomia upon the heart rate control, only recently, coronary microvascular disturbances and sympathetic denervation at the ventricular level have been reported in patients and exper...
Source: Current Cardiology Reports - April 24, 2024 Category: Cardiology Source Type: research
Integrated machine learning and multimodal data fusion for patho-phenotypic feature recognition in iPSC models of dilated cardiomyopathy
Biol Chem. 2024 Apr 24. doi: 10.1515/hsz-2024-0023. Online ahead of print.ABSTRACTIntegration of multiple data sources presents a challenge for accurate prediction of molecular patho-phenotypic features in automated analysis of data from human model systems. Here, we applied a machine learning-based data integration to distinguish patho-phenotypic features at the subcellular level for dilated cardiomyopathy (DCM). We employed a human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model of a DCM mutation in the sarcomere protein troponin T (TnT), TnT-R141W, compared to isogenic healthy (WT) control iPSC-CMs. ...
Source: Biological Chemistry - April 23, 2024 Category: Chemistry Authors: Ruheen Wali Hang Xu Cleophas Cheruiyot Hafiza Nosheen Saleem Andreas Janshoff Michael Habeck Antje Ebert Source Type: research
Types of Septic Cardiomyopathy: Prognosis and Influencing Factors - A Clinical Study
(Source: Risk Management and Healthcare Policy)
Source: Risk Management and Healthcare Policy - April 23, 2024 Category: Health Management Tags: Risk Management and Healthcare Policy Source Type: research
