Heart Transplant Outcomes in Adults with Hypertrophic Cardiomyopathy: A Contemporary Analysis
Purpose: Heart transplant (HT) is the definitive therapy for adults with end stage symptomatic hypertrophic cardiomyopathy (HCM). Post-transplant outcomes are uncertain with few reports of inferior findings compared with other heart failure (HF) etiologies. Using adult HT listings and transplants, we compared outcomes between those with HCM, ischemic cardiomyopathies (ICM) or other HF etiologies in the contemporary era in the United States. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , I. Konstantinidis, N. Patel, K. Singh, A. Pillai, W. Baker, A. Jaiswal Source Type: research
Impact of the UNOS Donor Heart Allocation System in Adult Heart Transplant Recipients with Hypertrophic Cardiomyopathy in the United States
Purpose: The latest donor heart allocation system in the United States favors transplant for patients receiving temporary mechanical circulatory support (MCS). However, such a system could be disadvantageous to patients with hypertrophic cardiomyopathy (HCM) awaiting heart transplant (HT). We sought to examine the trends and outcomes in HT in patients with HCM. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , N. Patel, I. Konstantinidis, A. Pillai, K. Singh, W. Baker, A. Jaiswal Source Type: research
Heart Transplant in Transthyretin Cardiac Amyloidosis: A Single-Center Experience
Purpose: To review our center ’s experience with heart transplant in patients with transthyretin amyloid cardiomyopathy (ATTR-CM). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: M. Chedid El Helou, M. Jacob, K. James, T. Martyn, M. Mountis, Z. Taimeh, W. Tang, N. Brozzi, C. Sheffield, E. Soltesz, M. Tong, S. Unai, J. Estep, R. Starling, E. Hsich, Source Type: research
Have Heart Transplant Allocation Policy Changes Brought Improvements in Mortality for Children and Adults with Cardiomyopathy? A UNOS Database Analysis
Purpose: The United Network of Organ Sharing (UNOS) made changes to the priority for allocation of hearts for transplantation (HT) in 2016 for children and 2018 for adult patients. There are limited data describing the association of these changes with waitlist outcomes in patients with cardiomyopathy. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. O'Connor, X. Zhang, C. Mavroudis, K. Maeda, H. Ahmed, J. Edwards, K.Y. Lin, C. Wittlieb-Weber, J. Rossano, J. Edelson Source Type: research
Impact of the New 2018 US Donor Heart Allocation System on the Long-Term Outcomes in Patients with Hypertrophic Cardiomyopathy
Purpose: The introduction of the new heart allocation system in the US in October 2018 resulted in an increase in the number of orthotopic heart transplants (OHT) performed among patients with hypertrophic cardiomyopathy (HCM). However, whether that affected long-term (>1 year) post-transplant outcomes in these patients remains unknown. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Carmona Rubio, E. Popjes, G. Bhat, R. Dowling, H. Eisen Source Type: research
Accuracy of Clinical Diagnosis in Advanced Heart Failure Patients Undergoing Transplantation and Impact of Genetic Testing
Purpose: Genetic testing in cardiomyopathy patients can improve diagnostic precision, tailor therapeutic interventions and aid prognostication. Results may have implications for relatives. Cardiomyopathy genetic testing was commissioned in 2018 in the UK. In heart transplant patients, we examined concordance between clinical and histological phenotype, yield of genetic testing and impact of pathogenic mutation on diagnosis. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Mathai, C. Papadopoulou, S. Preston, M. Goddard, S. Bhagra, C. Lewis, L. Martinez Marin, S. Pettit, J. Parameshwar, A. Kydd Source Type: research
Hybrid Palliation as Bridge to Heart Transplantation in Neonatal Dilated Cardiomyopathy
We present an infant with DCM successfully palliated with hybrid procedure as a bridge to heart transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , R.K. Singh, M. Argilla, S. Chakravarti, A. Ludomirsky, M. Martinez, J. McKinstry, R.S. Mosca, R.M. Rogoff, S. Saharan, T. Kumar Source Type: research
To VAD or Not VAD? How to Get to Heart Transplant in a Child with Duchenne Muscular Dystrophy
We present a clinical case dilemma of a 9-year-old child with DMD and dilated cardiomyopathy. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Joong, K. Gambetta, M. Monge, P. Thrush Source Type: research
HeartWare ™ HVAD Support Without Anticoagulation
Introduction: Ventricular assist devices (VAD) are increasingly utilized in pediatric patients as bridge to heart transplant (HTx). In the setting of concomitant disease processes such as cancer, it can be challenging to balance anticoagulation in these patients. Here, we report a pediatric case of anthracycline-induced cardiomyopathy requiring HeartWare ™ Left Ventricular Assist Device (HVAD) who was managed without thrombotic or thromboembolic complications while off anticoagulant/antiplatelet agents for over one hundred days. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , E. Greengard, J.N. Johnson, R. Ameduri Source Type: research
Outcomes of Pediatric Chemotherapy Induced Cardiomyopathy Needing Heart Transplant- An Multi-Institutional Analysis of UNOS Database
This study was aimed to evaluate outcomes of CIC patients needing heart transplantation using the multi-institutional UNOS database. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: K. Raja, S. Lunos, S.M. Peer, S. Deshpande, T. Alexy, N. Rodgers, Source Type: research
Perception vs. Reality: Reported and Objective Measures of Physical Activity in Children with Hypertrophic Cardiomyopathy (HCM)
Purpose: Physical activity (PA) is a pillar of cardiovascular health. However, those with hypertrophic cardiomyopathy (HCM) are often counselled to limit PA due to potential risk of sudden cardiac death (SCD). No clear data exists on how active youth with HCM are and what they perceive as barriers to increasing PA. We therefore aimed to quantify the level of PA in this population and assess the barriers to a heart healthy lifestyle. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Jeewa, S. Lemaire-Paquette, T. Pidborochynski, M. Khoury, C. Cunningham, S. Dhillon, N. Alami Laroussi, L. Vaujois, F. Dallaire, K. Armstrong, D. Schantz, W. Mawad, T. Bradley, J. Conway Source Type: research
Practice Variation in Anticoagulation Management of Outpatient Pediatric Cardiomyopathy Patients: Survey of ACTION Providers
Purpose: Anticoagulation is frequently utilized in children with cardiomyopathy for primary prevention of thrombosis. However, there is limited evidence to support prophylactic anticoagulation and data regarding practice variation and management strategy for children with cardiomyopathy are scarce. The aim of this study was to evaluate practice variation in the management of outpatient prophylactic anticoagulation of children with cardiomyopathy cared for at Advanced Cardiac Therapies Improving Outcomes Network (ACTION) centers. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M.J. O'Connor, J.A. Spinner, S. Amdani, J. Conway Source Type: research
Triheptanoin Use for Severe Neonatal Cardiomyopathy Secondary to Mitochondrial Trifunctional Protein Deficiency- A First Report
Introduction: Mitochondrial trifunctional protein deficiencies (MTFPD) are rare and lead to incomplete oxidation of fatty acids, causing an energy deficit affecting the heart, skeletal muscle, brain, and liver, as well as accumulation of potentially toxic fatty acid intermediates. The clinical manifestations include rhabdomyolysis, hypoglycemia, and in severe cases cardiomyopathy. Treatment of these disorders is limited and include avoidance of fasting, implementation of high carbohydrate and low long chain fatty acid diets and supplementation with medium chain fatty acids (MCFA). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. Boothe, A. McGuinness, Y. Lo Yau, M. Brock, G. Peek, M. Bleiweis, H. Blanchette, J. Rackley, E. Martin, L. Coleman, F. Fricker, B. Pietra, D. Gupta Source Type: research
Complex Management of a Young Cardiomyopathy Patient Leading to Durable LVAD
We report the complex case of a 26-year-old male suffering from chronic cardiomyopathy exacerbated by recent COVID infection. He had an extended hospital course and despite numerous challenges, the patient eventually received a durable left ventricular assist device (LVAD). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T. Malik, N. Hendren, E. Hardin, S. Teotia, S. Reznik, M. Farr, M. Peltz Source Type: research
Isolated Right Heart Stress-Induced Cardiomyopathy After Lung Transplant
Introduction: Stress-induced, or Takotsubo, cardiomyopathy (SIC) is a syndrome of rapid and severe regional systolic dysfunction in the left ventricle (LV), and in 10% of cases, simultaneous involvement of the right ventricle (RV). Recognizing SIC in patients with risk factors of extreme physical stress is crucial to reducing in-hospital mortality. Our case details an isolated RV SIC after a lung transplant. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T. Kaiho, A. Bharat, C. Kurihara Source Type: research
