Hypertrophic Cardiomyopathy Patients Have More Adverse Hemodynamic Profiles on Pre-Transplant Cardiopulmonary Exercise Testing
Purpose: Non-invasive cardiopulmonary exercise testing (CPET) is useful for predicting transplant-free survival in patients with advanced heart failure (HF). We sought to investigate the differences in CPET parameters in patients with hypertrophic cardiomyopathy (HCM) compared to other etiologies of HF. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C. Lee, A. Fernandez Valledor, R. Goldsmith, G. Sayer, N. Uriel Source Type: research
Mavacamten Use for Obstructive Hypertrophic Cardiomyopathy and Effect on Beta-Blocker Therapy in an Academic Institution
Purpose: Mavacamten is the first and only cardiac myosin inhibitor approved for the management of obstructive hypertrophic cardiomyopathy (oHCM). While it has been shown to decrease left ventricular outflow tract (LVOT) obstruction in landmark trials, studies on real-world use of mavacamten are still ongoing. First-line therapy includes β-blocker and calcium channel blockers (CCB), with disopyramide as an option for refractory patients. In the EXPLORER-HCM trial, 76% of patients (n = 94) on mavacamten were also on beta-blocker, with only 17% (n= 16) requiring adjustments to the dose of β-blocker therapy. (Source: The Jou...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C.K. Cornelio, R. Wu, A.C. Miranda Source Type: research
Genotype Analysis of LVOT Gradient Measurements in Patients Receiving Mavacamten for Obstructive Hypertrophic Cardiomyopathy?
Purpose: Hypertrophic cardiomyopathy (HCM) is the most common genetically inherited cardiac condition encountered. Recent utilization of cardiac myosin inhibitors has altered the management of obstructive symptoms. In this retrospective analysis, we compare the response to therapy in patients with obstructive HCM being treated with mavacamten based on genetic positivity. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C.K. Cornelio, A.C. Miranda, R. Wu Source Type: research
A Case of Takotsubo Cardiomyopathy in a Bilateral Lung Transplant Recipient
Introduction: Takotsubo cardiomyopathy (TTC) is a stress induced, temporary decrease in systolic function within the left ventricle ’s apical area, often resembling myocardial infarction (MI). In patients with EKG or troponin findings indicative of MI, it is often discovered upon coronary angiography with nonocclusive vasculature. Diagnosis can be confirmed by apical ballooning on echocardiogram. Here we report a case of a lun g transplant recipient who developed Takotsubo cardiomyopathy after bronchoscopy. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: A. Shajihan, O. Shlobin, , S. Aryal Source Type: research
Genetic Signatures in Heart Transplant and LVAD Patients: Unraveling Their Association with Hypertrophic and Dilated Cardiomyopathy Subtypes
This study evaluates genetic testing outcomes in a cohort of 40 HTx patients and 20 LVAD patients for bridge to transplantation, with a focus on hypertrophic cardiomyopathy (HCMP) and dilated cardiomyopathy (DCMP) subgroups. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: K. Kim Source Type: research
Decreased Cardiac Mass in Cancer Survivors with Anthracycline Induced Cardiotoxicity Undergoing Heart Transplantation
In this study we examined actual cardiac mass of the explanted heart at the time of heart transplantation (HT) in CS with AIC and compared it to patients with other causes of non-ischemic cardiomyopathy (NICM). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C. Lee, M. Regan, K. Clerkin, J. Fried, K. Axsom, D. Majure, Y. Naka, Y. Kaku, K. Takeda, F. Latif, G. Sayer, N. Uriel Source Type: research
Bi-Atrial Inflow Cannulation with BVAD: A Novel Approach for Bridging Restrictive Cardiomyopathy Patients to Heart Transplantation
Introduction: Restrictive cardiomyopathy (RCM) poses a significant challenge in utilizing mechanical circulatory devices (MCD) as a bridge to heart transplantation (HT). Bi-atrial inflow cannulation can be feasible approach for MCD implantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Hussain, A. Al Ghamdi, A. Arifi, A. Hussanat, N. Selimovic Source Type: research
Genome-Wide DNA Methylation Profiling in Human Dilated Cardiomyopathy
Purpose: DNA methylation controls transcriptional expression. The role of DNA methylation in heart failure (HF) and response to left ventricular assist devices (LVAD) is unknown. Here, we examined genome-wide DNA methylation in end stage dilated cardiomyopathy (DCM) and response to LVAD therapy. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , D. Liescheski, M. Urban, A. Burdorf, J. Um, B. Lowes Source Type: research
The Long-Term Outcomes of Patients with Chemotherapy-Induced Cardiomyopathy Undergoing Heart Transplantation
Purpose: Chemotherapy-induced cardiomyopathy (CCMP) is observed in up to 10% of cancer survivors. Progression into end-stage heart failure occurs in 2-4% of those patients. In individuals in complete remission who develop end-stage heart failure an orthotopic heart transplantation (OHT) is a viable option. The data on the contemporary long-term post-OHT outcomes in CCMP patients is scarce. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Carmona Rubio, J. Herrmann, K. Meleveedu, O. Ali, W. Tang Source Type: research
Role of KCCQ Overall Summary Score in Predicting Mortality in Heart Failure Patients
Purpose: Heart failure (HF) is a complex clinical syndrome associated with morbidity and mortality. Identification of independent predictors of risk in HF patients is crucial for guiding proper management strategies. The Kansas City Cardiomyopathy Questionnaire (KCCQ) is a validated tool that assesses the quality of life and functional status in HF patients. Therefore, we aimed to assess the KCCQ ’s Overall Summary Score (KCCQ-OSS) and independent parameters such as demographics, ejection fraction (EF), and other KCCQ-related variables as predictors of outcome in the study population. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Patel, M. Kittleson, M. White, A. Velleca, I. Kim, E. Kransdorf, L. Czer, F. Esmailian, J. Kobashigawa Source Type: research
Exception Requests and Approval Rates After Implementation of the National Heart Review Board for Pediatrics
Purpose: The OPTN Guidance for pediatric heart transplant exception requests addresses dilated cardiomyopathy (DCM), hypertrophic or restrictive cardiomyopathy (HCM/RCM), single ventricle congenital heart disease (1V CHD), and cardiac allograft vasculopathy (CAV). The purpose of our study was to evaluate the use and approval rates of exception requests after the implementation of the National Heart Review Board (NHRB) for Pediatrics. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , D. Bearl, L. Wright Source Type: research
To the Editor — Risk of atrial arrhythmias in arrhythmogenic right ventricular cardiomyopathy patients undergoing ventricular tachycardia ablation
The objective of this study was to determine the type, prevalence, outcome, and risk correlates of atrial arrhythmias in arrhythmogenic right ventricular cardiomyopathy in patients undergoing ventricular tachycardia ablation. The risk score for typical atrial flutter was determined from univariate logistic regression analysis. They then found that the risk score for typical flutter included age>40 years, ≥moderate right ventricular dysfunction, ≥moderate tricuspid regurgitation, ≥moderate right atrial dilation, and right ventricular volume>250 mL, with score>4 identifying 50% prevalence of typical flutter. (Source: Heart Rhythm)
Source: Heart Rhythm - April 1, 2024 Category: Cardiology Authors: Yun Cheng, Qinggang Zhang Source Type: research
Causal Relationship Between Immune Cells/Cytokines and Dilated Cardiomyopathy
This study aimed to investigate the causal relationship between the levels of various types of immune cells/cytokines and DCM. Herein, two-sample Mendelian randomization (MR) (TSMR) using R software was conducted. Single nucleotide polymorphisms (SNPs) related to the levels of various types of immune cells/cytokines and DCM were screened based on the genome-wide association studies (GWAS) obtained from open-source databases. The TSMR was conducted using inverse variance weighted (IVW), method, MR-Egger regression, weighted median method, and simple estimator based on mode to explore the causal association between the level...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Bin Qi Nan Huang Zhi-Jie Yang Wen-Bo Zheng Chun Gui Source Type: research
Efficacy and Tolerability of Ivabradine for Cardiomyopathy in Patients with Duchenne Muscular Dystrophy
Int Heart J. 2024;65(2):211-217. doi: 10.1536/ihj.23-563.ABSTRACTDuchenne muscular dystrophy (DMD) is an intractable X-linked myopathy caused by dystrophin gene mutations. Patients with DMD suffer from progressive muscle weakness, inevitable cardiomyopathy, increased heart rate (HR), and decreased blood pressure (BP). The aim of this study was to clarify the efficacy and tolerability of ivabradine treatment for DMD cardiomyopathy.A retrospective analysis was performed in 11 patients with DMD, who received ivabradine treatment for more than 1 year. Clinical results were analyzed before (baseline), 6 months after, and 12 mon...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Akiko Wakisaka Koichi Kimura Hiroyuki Morita Koki Nakanishi Masao Daimon Masanori Nojima Hideki Itoh Atsuhito Takeda Ruriko Kitao Tomihiro Imai Tetsuhiko Ikeda Takashi Nakajima Chigusa Watanabe Toshihiro Furukawa Ichiro Ohno Chiho Ishida Norihiko Takeda K Source Type: research
Recent Advances on Selenium Nutrition and Keshan Disease
Int Heart J. 2024;65(2):173-179. doi: 10.1536/ihj.23-628.ABSTRACTKeshan disease (KD) is a type of endemic cardiomyopathy with an unknown cause. It is primarily found in areas in China with low selenium levels, from northeast to southwest. The nutritional biogeochemical etiology hypothesis suggests that selenium deficiency is a major factor in KD development. Selenium is important in removing free radicals and protecting cells and tissues from peroxide-induced damage. Thus, low environmental selenium may affect the selenium level within the human body, and selenium level differences are commonly observed between healthy peo...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Shu-Juan Li An-Wei Wang Kai-Lian Huang Ying Yang Source Type: research
