The changing landscape of heart failure treatment in transthyretin amyloid cardiomyopathy: Is the time ripe for clinical use of sodium –glucose cotransporter 2 inhibitors?
(Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - April 16, 2024 Category: Cardiology Authors: Aldostefano Porcari,
Marianna Fontana Tags: Invited Editorial Source Type: research
Prevalence and Predictors of Readmissions Among Patients with Hypertrophic Cardiomyopathy and Atrial Fibrillation/Flutter
Atrial fibrillation/flutter (AF) is the most common dysrhythmia in patients with hypertrophic cardiomyopathy (HCM). Unexplained left ventricular hypertrophy and left ventricular outflow tract (LVOT) obstruction are integral components of HCM pathology which can cause increased left atrial pressure and atrial myopathy contributing to the substrate for AF. Our aim was to determine the impact of AF on hospital readmissions in patients with HCM. We conducted a retrospective analysis using the 2015 - 2019 Nationwide Readmission Database to analyze the effect of AF on 30-day readmission and causes of 30-day readmission in patien...
Source: The American Journal of Cardiology - April 16, 2024 Category: Cardiology Authors: Muhammad Usman Almani, Khawaja Muhammad Talha, Laibah Arhsad Khan, Ishaque Hameed, Zain Ul Abideen Asad, Marat Fudim, Richard Krasuski, Muhammad Shahzeb Khan Source Type: research
Emerging concepts in inflammatory cardiomyopathy
All truths are easy to understand once they are discovered; the point is to discover them [Galileo Galilei]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 16, 2024 Category: Cardiology Authors: Nisha A. Gilotra, Enrico Ammirati Source Type: research
Genetically predicted biomarkers of iron homeostasis and risk of non-ischemic cardiomyopathy: A Mendelian randomization study
Both iron overload and iron deficiency have been associated with cardiovascular diseases in observational studies. Previous Mendelian Randomization (MR) studies discovered a protective effect of higher iron status on coronary atrial disease, while a neutral effect on all-cause heart failure. Using two-sample MR, we evaluated how genetically predicted systemic iron status affects the risk of non-ischemic cardiomyopathy and different phenotypes. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 16, 2024 Category: Nutrition Authors: Hao Huang, Xueying Wang, Yu Yu, Sijing Cheng, Tianxin Long, Hongxia Niu, Wei Hua Source Type: research
Unusual cerebral intraventricular hemorrhage and cardiomyopathy related to congenital cytomegalovirus from non-primary maternal infection: a case report
Congenital cytomegalovirus (cCMV) infection, resulting from non-primary maternal infection or reactivation during pregnancy, can cause serious fetal abnormalities, complications in the immediate neonatal perio... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - April 16, 2024 Category: Pediatrics Authors: Victoria Malherbe, Stefanie Celen, Katherine Carkeek, Evelina Carapancea, Cinzia Auriti and Fiammetta Piersigilli Tags: Case report Source Type: research
Correction to: Pediatric takotsubo cardiomyopathy: A review and insights from a National Multicentric Registry
(Source: Heart Failure Reviews)
Source: Heart Failure Reviews - April 16, 2024 Category: Cardiology Source Type: research
Correlation of Extent of Left Ventricular Endocardial Unipolar Low Voltage Zones with Ventricular Tachycardia in Non-ischemic Cardiomyopathy
Endocardial electrogram (EGM) characteristics in non-ischemic cardiomyopathy (NICM) have not been explored adequately for prognostication. (Source: Heart Rhythm)
Source: Heart Rhythm - April 16, 2024 Category: Cardiology Authors: Deep Chandh Raja, Jenish Shroff, Anugrah Nair, Sreevilasam P. Abhilash, Lukah Q. Tuan, Abhinav Mehta, Walter P. Abhayaratna, Prashanthan Sanders, David S. Frankel, Francis E. Marchlinski, Rajeev Kumar Pathak Source Type: research
Unusual cerebral intraventricular hemorrhage and cardiomyopathy related to congenital cytomegalovirus from non-primary maternal infection: a case report
ConclusionAlthough uncommon, congenital cytomegalovirus infection should be included in the differential diagnosis of intraventricular hemorrhage and cardiomyopathy. Furthermore, this case highlights the possible severity of congenital cytomegalovirus infection, even in cases of previous maternal immunity. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - April 16, 2024 Category: Pediatrics Source Type: research
Incremental value of diastolic wall strain in predicting heart failure events in patients with atrial fibrillation
This study aims to assess DWS as a predictor of HF in AF patients with preserved ejection fraction. We analysed a prospective database of AF patients undergoing transthoracic echocardiography. AF patients with reduced left ventricular ejection fraction (< 50%), posterior wall motion abnormality, hypertrophic cardiomyopathy, valvular heart disease, pericardial disease, congenital heart disease, or history of pacemaker/implantable cardioverter-defibrillator implantation or cardiac surgery were excluded. The study followed patients until HF developme nt, death, or last visit. Follow-up for patients who underwent cathete...
Source: Heart and Vessels - April 16, 2024 Category: Cardiology Source Type: research
Prevalence and Predictors of Readmissions in Patients With Hypertrophic Cardiomyopathy and Atrial Fibrillation/Flutter
Atrial fibrillation/flutter (AF) is the most common dysrhythmia in patients with hypertrophic cardiomyopathy (HCM). Unexplained left ventricular hypertrophy and left ventricular outflow tract obstruction are integral components of HCM pathology which can cause increased left atrial pressure and atrial myopathy contributing to the substrate for AF. We aimed to determine the impact of AF on hospital readmissions in patients with HCM. We conducted a retrospective analysis using the 2015 to 2019 Nationwide Readmission Database to analyze the effect of AF on 30-day readmission and causes of 30-day readmission in patients with H...
Source: The American Journal of Cardiology - April 16, 2024 Category: Cardiology Authors: Muhammad Usman Almani, Khawaja Muhammad Talha, Laibah Arhsad Khan, Ishaque Hameed, Zain Ul Abideen Asad, Marat Fudim, Richard Krasuski, Muhammad Shahzeb Khan Source Type: research
Genetic predisposition in chemotherapy ‐induced cardiomyopathy in a 65‐year‐old female with metastatic breast cancer
We present a case of a 65-year-old woman with breast cancer who developed recurrent CTRCD following low-dose chemotherapy, despite lacking conventional cardiovascular risk factors. Her medical history included anthracycline-associated cardiomyopathy, and her condition deteriorated significantly after treatment with HER2-targeted therapies. Through the use of multimodal imaging, we detected severe left ventricular systolic dysfunction. Further investigation with genetic testing revealed a likely pathogenic variant in theTNNT2 gene, suggesting a genetic predisposition to CTRCD. This case implies the potential role of genetic...
Source: ESC Heart Failure - April 15, 2024 Category: Cardiology Authors: So ‐Young Lee,
Hoon Seok Kim,
Mi‐Hyang Jung,
Suyon Chang,
Myungshin Kim,
Jong‐Chan Youn,
Woo‐Baek Chung,
Hae Ok Jung Tags: Case Report Source Type: research
The role of cardiac magnetic resonance in sports cardiology: results from a large cohort of athletes
ConclusionCMR is more efficient in identifying a pathologic cardiac substrate in athletes in case of VAs (i.e., polymorphic beats), abnormal ECG repolarisation (negative T-waves in inferolateral leads), and borderline echocardiographic findings (LV hypertrophy, mildly depressed LV function). On the other hand, CMR is associated with a large proportion of negative results. Therefore, a careful clinical selection is needed to indicate CMR in athletes appropriately.Graphical AbstractClinical indications for CMR and positive CMR findings.The left panel shows clinical indications for CMR in our athletic cohort and the percentag...
Source: Clinical Research in Cardiology - April 15, 2024 Category: Cardiology Source Type: research
On the role of dysferlin in striated muscle: membrane repair, t-tubules and Ca < sup > 2+ < /sup > handling
J Physiol. 2024 Apr 14. doi: 10.1113/JP285103. Online ahead of print.ABSTRACTDysferlin is a 237 kDa membrane-associated protein characterised by multiple C2 domains with a diverse role in skeletal and cardiac muscle physiology. Mutations in DYSF are known to cause various types of human muscular dystrophies, known collectively as dysferlinopathies, with some patients developing cardiomyopathy. A myriad of in vitro membrane repair studies suggest that dysferlin plays an integral role in the membrane repair complex in skeletal muscle. In comparison, less is known about dysferlin in the heart, but mounting evidence suggests t...
Source: The Journal of Physiology - April 14, 2024 Category: Physiology Authors: C J Quinn E J Cartwright A W Trafford K M Dibb Source Type: research
On the role of dysferlin in striated muscle: membrane repair, t-tubules and Ca < sup > 2+ < /sup > handling
J Physiol. 2024 Apr 14. doi: 10.1113/JP285103. Online ahead of print.ABSTRACTDysferlin is a 237 kDa membrane-associated protein characterised by multiple C2 domains with a diverse role in skeletal and cardiac muscle physiology. Mutations in DYSF are known to cause various types of human muscular dystrophies, known collectively as dysferlinopathies, with some patients developing cardiomyopathy. A myriad of in vitro membrane repair studies suggest that dysferlin plays an integral role in the membrane repair complex in skeletal muscle. In comparison, less is known about dysferlin in the heart, but mounting evidence suggests t...
Source: The Journal of Physiology - April 14, 2024 Category: Physiology Authors: C J Quinn E J Cartwright A W Trafford K M Dibb Source Type: research
