Exercise intolerance in a man with ischaemic cardiomyopathy and biventricular pacing
Clinical introduction A patient in his 60s with a history of ischaemic cardiomyopathy and severely reduced left ventricular ejection fraction of 20% presents with worsening dyspnoea on exertion. He is tolerating therapeutic doses of guideline-directed medical therapy including sacubitril-valsartan, carvedilol, spironolactone and empagliflozin, and has a biventricular implantable cardiac defibrillator. He undergoes cardiopulmonary exercise testing (CPET) using the treadmill-modified Bruce protocol and is found to have a severely reduced peak oxygen consumption (VO2) (14.9 mL/kg/min) despite maximal effort. The test was stop...
Source: Heart - April 25, 2024 Category: Cardiology Authors: Bevan, G. H., Buber, J. Tags: Arrhythmias and sudden death Source Type: research
Presence and utility of electrocardiographic abnormalities in long-term childhood cancer survivors
Conclusion
A clinical prediction model with ECG data (left bundle branch block, left atrial enlargement, left heart axis, Cornell’s criteria for left ventricular hypertrophy and heart rate) may aid in ruling out LVEF <45%. (Source: Heart)
Source: Heart - April 25, 2024 Category: Cardiology Authors: de Baat, E. C., Merkx, R., Leerink, J. M., Boerhout, C., van der Pal, H. J. H., van Dalen, E. C., Loonen, J., Bresters, D., van Dulmen-den Broeder, E., van der Heiden-van der Loo, M., van den Heuvel, M. M., Kok, J. L., Louwerens, M., Neggers, S. J. C. M. Tags: Open access Heart failure and cardiomyopathies Source Type: research
Association of uncertain significance genetic variants with myocardial mechanics and morphometrics in patients with nonischemic dilated cardiomyopathy
Careful interpretation of the relation between phenotype changes of the heart and gene variants detected in dilated cardiomyopathy (DCM) is important for patient care and monitoring. (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - April 25, 2024 Category: Cardiology Authors: Karolina M ėlinytė-Ankudavičė, Marius Šukys, Gabrielė Kasputytė, Ričardas Krikštolaitis, Eglė Ereminienė, Grytė Galnaitienė, Vaida Mizarienė, Gintarė Šakalytė, Tomas Krilavičius and Renaldas Jurkevičius Tags: Research Source Type: research
Single-cell insights: pioneering an integrated atlas of chromatin accessibility and transcriptomic landscapes in diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) poses a growing health threat, elevating heart failure risk in diabetic individuals. Understanding DCM is crucial, with fibroblasts and endothelial cells playing pivotal roles in ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 25, 2024 Category: Cardiology Authors: Qiang Su, Wanzhong Huang, Yuan Huang, Rixin Dai, Chen Chang, Qiu-Yan Li, Hao Liu, Zhenhao Li, Yuxiang Zhao, Qiang Wu and Di-Guang Pan Tags: Research Source Type: research
Human umbilical cord-derived mesenchymal stromal cells improve myocardial fibrosis and restore miRNA-133a expression in diabetic cardiomyopathy
CONCLUSION: Intravenous injection of hUC-MSCs ameliorated key functional and structural features of DCM in male mice with diabetes of shorter and longer duration. Mechanistically, these effects were associated with restoration of intra-myocardial expression of miRNA-133a and its target mRNA COL1AI as well as suppression of systemic and localized inflammatory mediators.PMID:38659015 | DOI:10.1186/s13287-024-03715-2 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Boxin Liu Yan Wei Jingjing He Baofeng Feng Yimeng Chen Ruiyun Guo Matthew D Griffin Se án O Hynes Sanbing Shen Yan Liu Huixian Cui Jun Ma Timothy O'Brien Source Type: research
Perioperative management and outcomes for posterior spinal fusion in patients with Friedreich ataxia: A single-center, retrospective study
CONCLUSIONS: Patients with Friedreich ataxia are at high risk for perioperative complications when undergoing posterior spinal fusion and coordinated multidisciplinary care is required at each stage. Future research should focus on the utility of intraoperative echocardiography, optimal anesthetic agent selection, and targeted fluid management to reduce postoperative cardiac complications.PMID:38655751 | DOI:10.1111/pan.14896 (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - April 24, 2024 Category: Anesthesiology Authors: Elizabeth M O'Brien Natalie Neiswinter Kimberly Y Lin David Lynch Keith Baldwin Victoria Profeta John M Flynn Wallis T Muhly Source Type: research
Protective role of hydrogen sulfide against diabetic cardiomyopathy by inhibiting pyroptosis and myocardial fibrosis
In this study, a diabetic rat model was developed using intraperitoneal injections of streptozotocin (STZ), and hyperglycemia-stimulated cardiomyocytes were employed to replicate the cellular environment of DCM. There was a marked decline in the expression of cystathionine γ-lyase (CSE), a catalyst for H2S synthesis, in both the STZ-induced diabetic rats and hyperglycemia-stimulated cardiomyocytes. Experimental results in vivo indicated that H2S ameliorates MF and enhances cardiac functionality in diabetic rats by mitigating cardiomyocyte pyroptosis. In vitro assessments highlighted the induction of cardiomyocyte pyroptos...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 24, 2024 Category: Drugs & Pharmacology Authors: Maojun Liu Cheng Zeng Yifeng Zhang Ying Xin Simin Deng Xinqun Hu Source Type: research
Cardiomyopathy Without Amyloid Deposit in Systemic Light Chain Deposition Disease
Korean Circ J. 2024 Apr;54(4):221-222. doi: 10.4070/kcj.2024.0022.NO ABSTRACTPMID:38654569 | DOI:10.4070/kcj.2024.0022 (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Bo Eun Park Se Yong Jang Yoon Jung Park Myung Hwan Bae Jang Hoon Lee Dong Heon Yang Hun Sik Park Yongkeun Cho Source Type: research
A Rare Case of Overlapping Durvalumab-induced Myositis, Takotsubo-like Morphological Changes Caused by Myocarditis, and Myasthenia Gravis
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3028-23. Online ahead of print.ABSTRACTImmune checkpoint inhibitors can cause a range of immune-related adverse events, including myositis, Takotsubo cardiomyopathy, and myasthenia gravis. We herein report a rare case of a 78-year-old man with concurrent durvalumab-induced myositis, Takotsubo-like morphological changes caused by myocarditis, and myasthenia gravis. The patient initially required invasive ventilation and exhibited symptoms of myasthenia gravis after treatment with high-dose steroids. However, he subsequently achieved successful recovery after the adminis...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Shoichiro Saito Shigeto Hontsu Junya Hiraoka Ai Yamanaka Nobuhiro Fujioka Daisuke Shimada Yosuke Okuda Kazuma Sugie Shigeo Muro Source Type: research
Perioperative management and outcomes for posterior spinal fusion in patients with Friedreich ataxia: A single-center, retrospective study
CONCLUSIONS: Patients with Friedreich ataxia are at high risk for perioperative complications when undergoing posterior spinal fusion and coordinated multidisciplinary care is required at each stage. Future research should focus on the utility of intraoperative echocardiography, optimal anesthetic agent selection, and targeted fluid management to reduce postoperative cardiac complications.PMID:38655751 | DOI:10.1111/pan.14896 (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - April 24, 2024 Category: Anesthesiology Authors: Elizabeth M O'Brien Natalie Neiswinter Kimberly Y Lin David Lynch Keith Baldwin Victoria Profeta John M Flynn Wallis T Muhly Source Type: research
Protective role of hydrogen sulfide against diabetic cardiomyopathy by inhibiting pyroptosis and myocardial fibrosis
In this study, a diabetic rat model was developed using intraperitoneal injections of streptozotocin (STZ), and hyperglycemia-stimulated cardiomyocytes were employed to replicate the cellular environment of DCM. There was a marked decline in the expression of cystathionine γ-lyase (CSE), a catalyst for H2S synthesis, in both the STZ-induced diabetic rats and hyperglycemia-stimulated cardiomyocytes. Experimental results in vivo indicated that H2S ameliorates MF and enhances cardiac functionality in diabetic rats by mitigating cardiomyocyte pyroptosis. In vitro assessments highlighted the induction of cardiomyocyte pyroptos...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 24, 2024 Category: Drugs & Pharmacology Authors: Maojun Liu Cheng Zeng Yifeng Zhang Ying Xin Simin Deng Xinqun Hu Source Type: research
Cardiomyopathy Without Amyloid Deposit in Systemic Light Chain Deposition Disease
Korean Circ J. 2024 Apr;54(4):221-222. doi: 10.4070/kcj.2024.0022.NO ABSTRACTPMID:38654569 | DOI:10.4070/kcj.2024.0022 (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Bo Eun Park Se Yong Jang Yoon Jung Park Myung Hwan Bae Jang Hoon Lee Dong Heon Yang Hun Sik Park Yongkeun Cho Source Type: research
A Rare Case of Overlapping Durvalumab-induced Myositis, Takotsubo-like Morphological Changes Caused by Myocarditis, and Myasthenia Gravis
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3028-23. Online ahead of print.ABSTRACTImmune checkpoint inhibitors can cause a range of immune-related adverse events, including myositis, Takotsubo cardiomyopathy, and myasthenia gravis. We herein report a rare case of a 78-year-old man with concurrent durvalumab-induced myositis, Takotsubo-like morphological changes caused by myocarditis, and myasthenia gravis. The patient initially required invasive ventilation and exhibited symptoms of myasthenia gravis after treatment with high-dose steroids. However, he subsequently achieved successful recovery after the adminis...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Shoichiro Saito Shigeto Hontsu Junya Hiraoka Ai Yamanaka Nobuhiro Fujioka Daisuke Shimada Yosuke Okuda Kazuma Sugie Shigeo Muro Source Type: research
Cardiomyopathy Without Amyloid Deposit in Systemic Light Chain Deposition Disease
Korean Circ J. 2024 Apr;54(4):221-222. doi: 10.4070/kcj.2024.0022.NO ABSTRACTPMID:38654569 | PMC:PMC11040263 | DOI:10.4070/kcj.2024.0022 (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Bo Eun Park Se Yong Jang Yoon Jung Park Myung Hwan Bae Jang Hoon Lee Dong Heon Yang Hun Sik Park Yongkeun Cho Source Type: research
A Rare Case of Overlapping Durvalumab-induced Myositis, Takotsubo-like Morphological Changes Caused by Myocarditis, and Myasthenia Gravis
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3028-23. Online ahead of print.ABSTRACTImmune checkpoint inhibitors can cause a range of immune-related adverse events, including myositis, Takotsubo cardiomyopathy, and myasthenia gravis. We herein report a rare case of a 78-year-old man with concurrent durvalumab-induced myositis, Takotsubo-like morphological changes caused by myocarditis, and myasthenia gravis. The patient initially required invasive ventilation and exhibited symptoms of myasthenia gravis after treatment with high-dose steroids. However, he subsequently achieved successful recovery after the adminis...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Shoichiro Saito Shigeto Hontsu Junya Hiraoka Ai Yamanaka Nobuhiro Fujioka Daisuke Shimada Yosuke Okuda Kazuma Sugie Shigeo Muro Source Type: research
