Recent Advances on Selenium Nutrition and Keshan Disease
Int Heart J. 2024;65(2):173-179. doi: 10.1536/ihj.23-628.ABSTRACTKeshan disease (KD) is a type of endemic cardiomyopathy with an unknown cause. It is primarily found in areas in China with low selenium levels, from northeast to southwest. The nutritional biogeochemical etiology hypothesis suggests that selenium deficiency is a major factor in KD development. Selenium is important in removing free radicals and protecting cells and tissues from peroxide-induced damage. Thus, low environmental selenium may affect the selenium level within the human body, and selenium level differences are commonly observed between healthy peo...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Shu-Juan Li An-Wei Wang Kai-Lian Huang Ying Yang Source Type: research
Causal Relationship Between Immune Cells/Cytokines and Dilated Cardiomyopathy
This study aimed to investigate the causal relationship between the levels of various types of immune cells/cytokines and DCM. Herein, two-sample Mendelian randomization (MR) (TSMR) using R software was conducted. Single nucleotide polymorphisms (SNPs) related to the levels of various types of immune cells/cytokines and DCM were screened based on the genome-wide association studies (GWAS) obtained from open-source databases. The TSMR was conducted using inverse variance weighted (IVW), method, MR-Egger regression, weighted median method, and simple estimator based on mode to explore the causal association between the level...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Bin Qi Nan Huang Zhi-Jie Yang Wen-Bo Zheng Chun Gui Source Type: research
Efficacy and Tolerability of Ivabradine for Cardiomyopathy in Patients with Duchenne Muscular Dystrophy
Int Heart J. 2024;65(2):211-217. doi: 10.1536/ihj.23-563.ABSTRACTDuchenne muscular dystrophy (DMD) is an intractable X-linked myopathy caused by dystrophin gene mutations. Patients with DMD suffer from progressive muscle weakness, inevitable cardiomyopathy, increased heart rate (HR), and decreased blood pressure (BP). The aim of this study was to clarify the efficacy and tolerability of ivabradine treatment for DMD cardiomyopathy.A retrospective analysis was performed in 11 patients with DMD, who received ivabradine treatment for more than 1 year. Clinical results were analyzed before (baseline), 6 months after, and 12 mon...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Akiko Wakisaka Koichi Kimura Hiroyuki Morita Koki Nakanishi Masao Daimon Masanori Nojima Hideki Itoh Atsuhito Takeda Ruriko Kitao Tomihiro Imai Tetsuhiko Ikeda Takashi Nakajima Chigusa Watanabe Toshihiro Furukawa Ichiro Ohno Chiho Ishida Norihiko Takeda K Source Type: research
Recent Advances on Selenium Nutrition and Keshan Disease
Int Heart J. 2024;65(2):173-179. doi: 10.1536/ihj.23-628.ABSTRACTKeshan disease (KD) is a type of endemic cardiomyopathy with an unknown cause. It is primarily found in areas in China with low selenium levels, from northeast to southwest. The nutritional biogeochemical etiology hypothesis suggests that selenium deficiency is a major factor in KD development. Selenium is important in removing free radicals and protecting cells and tissues from peroxide-induced damage. Thus, low environmental selenium may affect the selenium level within the human body, and selenium level differences are commonly observed between healthy peo...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Shu-Juan Li An-Wei Wang Kai-Lian Huang Ying Yang Source Type: research
Causal Relationship Between Immune Cells/Cytokines and Dilated Cardiomyopathy
This study aimed to investigate the causal relationship between the levels of various types of immune cells/cytokines and DCM. Herein, two-sample Mendelian randomization (MR) (TSMR) using R software was conducted. Single nucleotide polymorphisms (SNPs) related to the levels of various types of immune cells/cytokines and DCM were screened based on the genome-wide association studies (GWAS) obtained from open-source databases. The TSMR was conducted using inverse variance weighted (IVW), method, MR-Egger regression, weighted median method, and simple estimator based on mode to explore the causal association between the level...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Bin Qi Nan Huang Zhi-Jie Yang Wen-Bo Zheng Chun Gui Source Type: research
Efficacy and Tolerability of Ivabradine for Cardiomyopathy in Patients with Duchenne Muscular Dystrophy
Int Heart J. 2024;65(2):211-217. doi: 10.1536/ihj.23-563.ABSTRACTDuchenne muscular dystrophy (DMD) is an intractable X-linked myopathy caused by dystrophin gene mutations. Patients with DMD suffer from progressive muscle weakness, inevitable cardiomyopathy, increased heart rate (HR), and decreased blood pressure (BP). The aim of this study was to clarify the efficacy and tolerability of ivabradine treatment for DMD cardiomyopathy.A retrospective analysis was performed in 11 patients with DMD, who received ivabradine treatment for more than 1 year. Clinical results were analyzed before (baseline), 6 months after, and 12 mon...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Akiko Wakisaka Koichi Kimura Hiroyuki Morita Koki Nakanishi Masao Daimon Masanori Nojima Hideki Itoh Atsuhito Takeda Ruriko Kitao Tomihiro Imai Tetsuhiko Ikeda Takashi Nakajima Chigusa Watanabe Toshihiro Furukawa Ichiro Ohno Chiho Ishida Norihiko Takeda K Source Type: research
Recent Advances on Selenium Nutrition and Keshan Disease
Int Heart J. 2024;65(2):173-179. doi: 10.1536/ihj.23-628.ABSTRACTKeshan disease (KD) is a type of endemic cardiomyopathy with an unknown cause. It is primarily found in areas in China with low selenium levels, from northeast to southwest. The nutritional biogeochemical etiology hypothesis suggests that selenium deficiency is a major factor in KD development. Selenium is important in removing free radicals and protecting cells and tissues from peroxide-induced damage. Thus, low environmental selenium may affect the selenium level within the human body, and selenium level differences are commonly observed between healthy peo...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Shu-Juan Li An-Wei Wang Kai-Lian Huang Ying Yang Source Type: research
Causal Relationship Between Immune Cells/Cytokines and Dilated Cardiomyopathy
This study aimed to investigate the causal relationship between the levels of various types of immune cells/cytokines and DCM. Herein, two-sample Mendelian randomization (MR) (TSMR) using R software was conducted. Single nucleotide polymorphisms (SNPs) related to the levels of various types of immune cells/cytokines and DCM were screened based on the genome-wide association studies (GWAS) obtained from open-source databases. The TSMR was conducted using inverse variance weighted (IVW), method, MR-Egger regression, weighted median method, and simple estimator based on mode to explore the causal association between the level...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Bin Qi Nan Huang Zhi-Jie Yang Wen-Bo Zheng Chun Gui Source Type: research
Efficacy and Tolerability of Ivabradine for Cardiomyopathy in Patients with Duchenne Muscular Dystrophy
Int Heart J. 2024;65(2):211-217. doi: 10.1536/ihj.23-563.ABSTRACTDuchenne muscular dystrophy (DMD) is an intractable X-linked myopathy caused by dystrophin gene mutations. Patients with DMD suffer from progressive muscle weakness, inevitable cardiomyopathy, increased heart rate (HR), and decreased blood pressure (BP). The aim of this study was to clarify the efficacy and tolerability of ivabradine treatment for DMD cardiomyopathy.A retrospective analysis was performed in 11 patients with DMD, who received ivabradine treatment for more than 1 year. Clinical results were analyzed before (baseline), 6 months after, and 12 mon...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Akiko Wakisaka Koichi Kimura Hiroyuki Morita Koki Nakanishi Masao Daimon Masanori Nojima Hideki Itoh Atsuhito Takeda Ruriko Kitao Tomihiro Imai Tetsuhiko Ikeda Takashi Nakajima Chigusa Watanabe Toshihiro Furukawa Ichiro Ohno Chiho Ishida Norihiko Takeda K Source Type: research
Recent Advances on Selenium Nutrition and Keshan Disease
Int Heart J. 2024;65(2):173-179. doi: 10.1536/ihj.23-628.ABSTRACTKeshan disease (KD) is a type of endemic cardiomyopathy with an unknown cause. It is primarily found in areas in China with low selenium levels, from northeast to southwest. The nutritional biogeochemical etiology hypothesis suggests that selenium deficiency is a major factor in KD development. Selenium is important in removing free radicals and protecting cells and tissues from peroxide-induced damage. Thus, low environmental selenium may affect the selenium level within the human body, and selenium level differences are commonly observed between healthy peo...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Shu-Juan Li An-Wei Wang Kai-Lian Huang Ying Yang Source Type: research
Causal Relationship Between Immune Cells/Cytokines and Dilated Cardiomyopathy
This study aimed to investigate the causal relationship between the levels of various types of immune cells/cytokines and DCM. Herein, two-sample Mendelian randomization (MR) (TSMR) using R software was conducted. Single nucleotide polymorphisms (SNPs) related to the levels of various types of immune cells/cytokines and DCM were screened based on the genome-wide association studies (GWAS) obtained from open-source databases. The TSMR was conducted using inverse variance weighted (IVW), method, MR-Egger regression, weighted median method, and simple estimator based on mode to explore the causal association between the level...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Bin Qi Nan Huang Zhi-Jie Yang Wen-Bo Zheng Chun Gui Source Type: research
Efficacy and Tolerability of Ivabradine for Cardiomyopathy in Patients with Duchenne Muscular Dystrophy
Int Heart J. 2024;65(2):211-217. doi: 10.1536/ihj.23-563.ABSTRACTDuchenne muscular dystrophy (DMD) is an intractable X-linked myopathy caused by dystrophin gene mutations. Patients with DMD suffer from progressive muscle weakness, inevitable cardiomyopathy, increased heart rate (HR), and decreased blood pressure (BP). The aim of this study was to clarify the efficacy and tolerability of ivabradine treatment for DMD cardiomyopathy.A retrospective analysis was performed in 11 patients with DMD, who received ivabradine treatment for more than 1 year. Clinical results were analyzed before (baseline), 6 months after, and 12 mon...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Akiko Wakisaka Koichi Kimura Hiroyuki Morita Koki Nakanishi Masao Daimon Masanori Nojima Hideki Itoh Atsuhito Takeda Ruriko Kitao Tomihiro Imai Tetsuhiko Ikeda Takashi Nakajima Chigusa Watanabe Toshihiro Furukawa Ichiro Ohno Chiho Ishida Norihiko Takeda K Source Type: research
Recent Advances on Selenium Nutrition and Keshan Disease
Int Heart J. 2024;65(2):173-179. doi: 10.1536/ihj.23-628.ABSTRACTKeshan disease (KD) is a type of endemic cardiomyopathy with an unknown cause. It is primarily found in areas in China with low selenium levels, from northeast to southwest. The nutritional biogeochemical etiology hypothesis suggests that selenium deficiency is a major factor in KD development. Selenium is important in removing free radicals and protecting cells and tissues from peroxide-induced damage. Thus, low environmental selenium may affect the selenium level within the human body, and selenium level differences are commonly observed between healthy peo...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Shu-Juan Li An-Wei Wang Kai-Lian Huang Ying Yang Source Type: research
Causal Relationship Between Immune Cells/Cytokines and Dilated Cardiomyopathy
This study aimed to investigate the causal relationship between the levels of various types of immune cells/cytokines and DCM. Herein, two-sample Mendelian randomization (MR) (TSMR) using R software was conducted. Single nucleotide polymorphisms (SNPs) related to the levels of various types of immune cells/cytokines and DCM were screened based on the genome-wide association studies (GWAS) obtained from open-source databases. The TSMR was conducted using inverse variance weighted (IVW), method, MR-Egger regression, weighted median method, and simple estimator based on mode to explore the causal association between the level...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Bin Qi Nan Huang Zhi-Jie Yang Wen-Bo Zheng Chun Gui Source Type: research
Efficacy and Tolerability of Ivabradine for Cardiomyopathy in Patients with Duchenne Muscular Dystrophy
Int Heart J. 2024;65(2):211-217. doi: 10.1536/ihj.23-563.ABSTRACTDuchenne muscular dystrophy (DMD) is an intractable X-linked myopathy caused by dystrophin gene mutations. Patients with DMD suffer from progressive muscle weakness, inevitable cardiomyopathy, increased heart rate (HR), and decreased blood pressure (BP). The aim of this study was to clarify the efficacy and tolerability of ivabradine treatment for DMD cardiomyopathy.A retrospective analysis was performed in 11 patients with DMD, who received ivabradine treatment for more than 1 year. Clinical results were analyzed before (baseline), 6 months after, and 12 mon...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Akiko Wakisaka Koichi Kimura Hiroyuki Morita Koki Nakanishi Masao Daimon Masanori Nojima Hideki Itoh Atsuhito Takeda Ruriko Kitao Tomihiro Imai Tetsuhiko Ikeda Takashi Nakajima Chigusa Watanabe Toshihiro Furukawa Ichiro Ohno Chiho Ishida Norihiko Takeda K Source Type: research
