Emerging concepts in inflammatory cardiomyopathy
All truths are easy to understand once they are discovered; the point is to discover them [Galileo Galilei]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 16, 2024 Category: Cardiology Authors: Nisha A. Gilotra, Enrico Ammirati Source Type: research
Genetically predicted biomarkers of iron homeostasis and risk of non-ischemic cardiomyopathy: A Mendelian randomization study
Both iron overload and iron deficiency have been associated with cardiovascular diseases in observational studies. Previous Mendelian Randomization (MR) studies discovered a protective effect of higher iron status on coronary atrial disease, while a neutral effect on all-cause heart failure. Using two-sample MR, we evaluated how genetically predicted systemic iron status affects the risk of non-ischemic cardiomyopathy and different phenotypes. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 16, 2024 Category: Nutrition Authors: Hao Huang, Xueying Wang, Yu Yu, Sijing Cheng, Tianxin Long, Hongxia Niu, Wei Hua Source Type: research
Unusual cerebral intraventricular hemorrhage and cardiomyopathy related to congenital cytomegalovirus from non-primary maternal infection: a case report
Congenital cytomegalovirus (cCMV) infection, resulting from non-primary maternal infection or reactivation during pregnancy, can cause serious fetal abnormalities, complications in the immediate neonatal perio... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - April 16, 2024 Category: Pediatrics Authors: Victoria Malherbe, Stefanie Celen, Katherine Carkeek, Evelina Carapancea, Cinzia Auriti and Fiammetta Piersigilli Tags: Case report Source Type: research
Correction to: Pediatric takotsubo cardiomyopathy: A review and insights from a National Multicentric Registry
(Source: Heart Failure Reviews)
Source: Heart Failure Reviews - April 16, 2024 Category: Cardiology Source Type: research
Correlation of Extent of Left Ventricular Endocardial Unipolar Low Voltage Zones with Ventricular Tachycardia in Non-ischemic Cardiomyopathy
Endocardial electrogram (EGM) characteristics in non-ischemic cardiomyopathy (NICM) have not been explored adequately for prognostication. (Source: Heart Rhythm)
Source: Heart Rhythm - April 16, 2024 Category: Cardiology Authors: Deep Chandh Raja, Jenish Shroff, Anugrah Nair, Sreevilasam P. Abhilash, Lukah Q. Tuan, Abhinav Mehta, Walter P. Abhayaratna, Prashanthan Sanders, David S. Frankel, Francis E. Marchlinski, Rajeev Kumar Pathak Source Type: research
Unusual cerebral intraventricular hemorrhage and cardiomyopathy related to congenital cytomegalovirus from non-primary maternal infection: a case report
ConclusionAlthough uncommon, congenital cytomegalovirus infection should be included in the differential diagnosis of intraventricular hemorrhage and cardiomyopathy. Furthermore, this case highlights the possible severity of congenital cytomegalovirus infection, even in cases of previous maternal immunity. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - April 16, 2024 Category: Pediatrics Source Type: research
Incremental value of diastolic wall strain in predicting heart failure events in patients with atrial fibrillation
This study aims to assess DWS as a predictor of HF in AF patients with preserved ejection fraction. We analysed a prospective database of AF patients undergoing transthoracic echocardiography. AF patients with reduced left ventricular ejection fraction (< 50%), posterior wall motion abnormality, hypertrophic cardiomyopathy, valvular heart disease, pericardial disease, congenital heart disease, or history of pacemaker/implantable cardioverter-defibrillator implantation or cardiac surgery were excluded. The study followed patients until HF developme nt, death, or last visit. Follow-up for patients who underwent cathete...
Source: Heart and Vessels - April 16, 2024 Category: Cardiology Source Type: research
Genetic predisposition in chemotherapy ‐induced cardiomyopathy in a 65‐year‐old female with metastatic breast cancer
We present a case of a 65-year-old woman with breast cancer who developed recurrent CTRCD following low-dose chemotherapy, despite lacking conventional cardiovascular risk factors. Her medical history included anthracycline-associated cardiomyopathy, and her condition deteriorated significantly after treatment with HER2-targeted therapies. Through the use of multimodal imaging, we detected severe left ventricular systolic dysfunction. Further investigation with genetic testing revealed a likely pathogenic variant in theTNNT2 gene, suggesting a genetic predisposition to CTRCD. This case implies the potential role of genetic...
Source: ESC Heart Failure - April 15, 2024 Category: Cardiology Authors: So ‐Young Lee,
Hoon Seok Kim,
Mi‐Hyang Jung,
Suyon Chang,
Myungshin Kim,
Jong‐Chan Youn,
Woo‐Baek Chung,
Hae Ok Jung Tags: Case Report Source Type: research
The role of cardiac magnetic resonance in sports cardiology: results from a large cohort of athletes
ConclusionCMR is more efficient in identifying a pathologic cardiac substrate in athletes in case of VAs (i.e., polymorphic beats), abnormal ECG repolarisation (negative T-waves in inferolateral leads), and borderline echocardiographic findings (LV hypertrophy, mildly depressed LV function). On the other hand, CMR is associated with a large proportion of negative results. Therefore, a careful clinical selection is needed to indicate CMR in athletes appropriately.Graphical AbstractClinical indications for CMR and positive CMR findings.The left panel shows clinical indications for CMR in our athletic cohort and the percentag...
Source: Clinical Research in Cardiology - April 15, 2024 Category: Cardiology Source Type: research
On the role of dysferlin in striated muscle: membrane repair, t-tubules and Ca < sup > 2+ < /sup > handling
J Physiol. 2024 Apr 14. doi: 10.1113/JP285103. Online ahead of print.ABSTRACTDysferlin is a 237 kDa membrane-associated protein characterised by multiple C2 domains with a diverse role in skeletal and cardiac muscle physiology. Mutations in DYSF are known to cause various types of human muscular dystrophies, known collectively as dysferlinopathies, with some patients developing cardiomyopathy. A myriad of in vitro membrane repair studies suggest that dysferlin plays an integral role in the membrane repair complex in skeletal muscle. In comparison, less is known about dysferlin in the heart, but mounting evidence suggests t...
Source: The Journal of Physiology - April 14, 2024 Category: Physiology Authors: C J Quinn E J Cartwright A W Trafford K M Dibb Source Type: research
On the role of dysferlin in striated muscle: membrane repair, t-tubules and Ca < sup > 2+ < /sup > handling
J Physiol. 2024 Apr 14. doi: 10.1113/JP285103. Online ahead of print.ABSTRACTDysferlin is a 237 kDa membrane-associated protein characterised by multiple C2 domains with a diverse role in skeletal and cardiac muscle physiology. Mutations in DYSF are known to cause various types of human muscular dystrophies, known collectively as dysferlinopathies, with some patients developing cardiomyopathy. A myriad of in vitro membrane repair studies suggest that dysferlin plays an integral role in the membrane repair complex in skeletal muscle. In comparison, less is known about dysferlin in the heart, but mounting evidence suggests t...
Source: The Journal of Physiology - April 14, 2024 Category: Physiology Authors: C J Quinn E J Cartwright A W Trafford K M Dibb Source Type: research
Carnitine palmitoyltransferase II (CPT II) deficiency responsible for refractory cardiac arrhythmias, acute multiorgan failure and early fatal outcome
ConclusionsCPTII deficiency may be suspected in newborns showing cardiac arrhythmias, associated or not with hypertrophic cardiomyopathy, polycystic kidneys, brain malformations, hepatomegaly. Its diagnosis should be even more suspected and investigated in cases of increased plasmatic levels of creatine phosphokinase and acylcarnitines in addition to kidney, heart and liver dysfunctions, as occurred in the present patient. Accurate family history, extended metabolic screening, and multidisciplinary approach are necessary for diagnosis and adequate management of affected subjects. Next generation sequencing (NGS) techniques...
Source: Italian Journal of Pediatrics - April 14, 2024 Category: Pediatrics Source Type: research
Transthyretin amyloid cardiomyopathy among patients with heart failure and preserved ejection fraction: the AMY score
ConclusionsA score based on basic clinical and echocardiographic features helps to distinguish ATTRwt-CM from typical HFpEF. This could facilitate the diagnostic work-up for these patients and enable earlier disease screening on a large scale. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 13, 2024 Category: Cardiology Authors: Guglielmo Gioia,
Lore Schrutka,
Joanna Jozwiak ‐Nozdrzykowska,
Karl‐Patrik Kresoja,
Hilka Gunold,
Karin Klingel,
Holger Thiele,
Diana Bonderman,
Philipp Lurz,
Karl‐Philipp Rommel Tags: Original Article Source Type: research
The NEDD8 activating enzyme inhibitor MLN4924 mitigates doxorubicin-induced cardiotoxicity in mice
Free Radic Biol Med. 2024 Apr 11:S0891-5849(24)00400-3. doi: 10.1016/j.freeradbiomed.2024.04.221. Online ahead of print.ABSTRACTDoxorubicin (Dox) is a widely utilized chemotherapeutic agent in clinical oncology for treating various cancers. However, its clinical use is constrained by its significant side effects. Among these, the development of cardiomyopathy, characterized by cardiac remodeling and eventual heart failure, stands as a major concern following Dox chemotherapy.In our current investigation, we have showcased the efficacy of MLN4924 in mitigating doxorubicin-induced cardiotoxicity through direct inhibition of ...
Source: Free Radical Biology and Medicine - April 13, 2024 Category: Biology Authors: KangHui Chen JianMin Sun Li Lin JianWen Liu XinYue Liu GuangDuo Chen Hang Chen ZhaoYang Chen Source Type: research
