Left Ventricle Assist Device as a Treatment for Burned Out Hypertrophic Obstructive Cardiomyopathy
Introduction: LVAD is a promising treatment for severe burned-out hypertrophic obstructive cardiomyopathy(HOCM)with refractory HF (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: R. Sadraldin, , A. Alkhaldi, M. Bin Hudhud Source Type: research
Initial Experience of Sodium-Glucose Cotransporter 2 Inhibitors in Adolescents with Heart Failure Due to Muscular Dystrophy
Introduction: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are novel agents in the management of adult heart failure (HF) with proven mortality benefit in large, randomized control trials. Now the standard of care in adult guideline-directed medical therapy (GDMT), SGLT2i are increasingly being used off-label in pediatric patients. Patients with Duchene muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), progressive X-linked myopathies that primarily affect males in their early teenage years, can develop HF secondary to dilated cardiomyopathy (DCM). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , E. Kramer, D. Weber, H. Ahmed, M.J. O'Connor, J.B. Edelson, J.J. Edwards, K.Y. Lin, J.W. Rossano, C.A. Wittlieb-Weber, J.H. Berger Source Type: research
Two Successful Unplanned Pregnancies in a 33-Year-Old Woman After Heart Transplantation for Peripartum Cardiomyopathy
We report a case of two successful unplanned pregnancies in a woman 12 years after heart transplantation (HT) for peripartum cardiomyopathy (PPCM). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , E. Garcia Romero, L. Gali án Gay, M. Goya, L. Herrador-Galindo, C. Diez-Lopez, F. de Frutos, J. Gonzalez-Costello Source Type: research
Successful Simultaneous Heart-Kidney Transplant in a Patient with MT-TL1 Melas Cardiomyopathy
Introduction: Mitochondrial diseases encompass diverse disorders affecting energy-producing mitochondria. They often affect vital organ systems, including the cardiovascular, neurological, renal, hepatic, musculoskeletal, auditory, and visual systems. This communication focuses on a successful simultaneous heart-kidney transplant in a patient with MELAS syndrome, associated with a m.3243A>G mutation in the MT-TL1 gene. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: J. Arriola-Montenegro, , R. Cogswell, T. Alexy, R. John, R. Voeller, V. Humphreville, A. Aggarwal, V. Maharaj Source Type: research
Cardiac Recovery and Improved Outcomes During Left Ventricular Assist Device Support: The First Heart-Mate 3 in Argentina
We present the first case of Heart-Mate 3 (HM3) implantation in Argentina, with cardiac recovery in a patient with non-compaction cardiomyopathy and its evolution after a four-year follow-up. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: C.B. Putaro, , G. Ganum, F. Soto Arevalo, L. Favaloro, M.F. Renedo, R.R. Favaloro Source Type: research
Hypertrophic Cardiomyopathy and Rare Genetic Mutations
Introduction: Hypertrophic cardiomyopathy (HCM) is a genetic disorder of cardiomyocytes, whose prevalence is approximately 1:500 in the general adult population, with a wide spectrum of clinical and morphological presentation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , G. Campos, S. Mangini, S. Moraes, F. Bacal Source Type: research
Between Metrics and Measures: KCCQ, CPET, and HF Prognosis
Introduction: Various tools and measurements are thoroughly used to assess the impact of Heart Failure (HF) therapy prognosis. Cardiopulmonary Exercise Test (CPET) is an objective assessment used to assess patients ’ response to exercise by measuring many cardiac parameters. Kansas City Cardiomyopathy Questionnaire (KCCQ) in the same vein provides a useful tool to evaluate treatment effectiveness through comparison of scores before and after therapy. This case is reported about a patient with HFrEF, whose co ndition was assessed using KCCQ and CPET. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. Abu Suailiek, H. Alkharabsheh, D. Al-Khatib, O. Asad, A.Z. Turk Source Type: research
The Great Masquerader: Lymphocytic Myocarditis Masking as Cardiac Sarcoidosis: A Case of Severe Non-Ischemic Cardiomyopathy and Ventricular Tachycardia Storm
Introduction: Among the several etiologies leading to non-ischemic cardiomyopathies, lymphocytic myocarditis and cardiac sarcoidosis may be particularly difficult to distinguish due to similarities in clinical presentation and associated findings in advanced imaging modalities. Here, we discuss a case of severe non-ischemic cardiomyopathy caused by lymphocytic myocarditis initially diagnosed and managed as cardiac sarcoidosis. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Doddi, J. Avalon, M. Awad, J.D. Mills, M. Caccamo Source Type: research
Identification and Clinical Course of Novel Pathogenic Variant of Transthyretin Amyloid Cardiomyopathy: P.arg54lys
Introduction: Here we describe a novel TTR gene mutation, which manifested as a mixed phenotype of polyneuropathy and cardiomyopathy. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Kim, , J. Youn Source Type: research
One of a Kind: A Rare Case of Cardiac Transplantation in a Patient with Eosinophilic Endomyocardial Fibrosis
Introduction: Eosinophilic myocarditis is an inflammatory cardiomyopathy characterized by eosinophilic infiltration of the myocardium leading to fibrosis. It can be seen in malignancy and immune-mediated disorders. Patients can present acutely with myocarditis or chronically as restrictive cardiomyopathy (RC), known as Loeffler ’s endocarditis (eosinophilic endomyocardial fibrosis). The symptoms may be non-specific, and a definitive diagnosis is made with cardiac Magnetic Resonance Imaging (cMRI) or endomyocardial biopsy. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , K. Girgis, J. Celenza-Salvatore, C. Gidea, F. Ali, M. Montgomery, N. Hochbaum, B. Fyfe-Kirschner, S. Kapoor Source Type: research
Impact of Neighborhood Factors on Exercise Capacity in Children with Hypertrophic Cardiomyopathy
Purpose: Interventions to improve exercise capacity in children with hypertrophic cardiomyopathy (HCM) may be a critical way to improve cardiovascular risk and quality of life. However, there is limited data on the environmental determinants of exercise capacity in children with HCM. Understanding this potential link is a vital step in designing effective and equitable interventions (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , L. Wang, A.L. Roberts, H. Stanley, J. Rossano, M. O'Connor, K. Lin, C. Wittlieb-Weber, H. Ahmed, J. Edwards, V. Tam, J.B. Edelson Source Type: research
Hypertrophic Cardiomyopathy Patients Have More Adverse Hemodynamic Profiles on Pre-Transplant Cardiopulmonary Exercise Testing
Purpose: Non-invasive cardiopulmonary exercise testing (CPET) is useful for predicting transplant-free survival in patients with advanced heart failure (HF). We sought to investigate the differences in CPET parameters in patients with hypertrophic cardiomyopathy (HCM) compared to other etiologies of HF. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C. Lee, A. Fernandez Valledor, R. Goldsmith, G. Sayer, N. Uriel Source Type: research
Mavacamten Use for Obstructive Hypertrophic Cardiomyopathy and Effect on Beta-Blocker Therapy in an Academic Institution
Purpose: Mavacamten is the first and only cardiac myosin inhibitor approved for the management of obstructive hypertrophic cardiomyopathy (oHCM). While it has been shown to decrease left ventricular outflow tract (LVOT) obstruction in landmark trials, studies on real-world use of mavacamten are still ongoing. First-line therapy includes β-blocker and calcium channel blockers (CCB), with disopyramide as an option for refractory patients. In the EXPLORER-HCM trial, 76% of patients (n = 94) on mavacamten were also on beta-blocker, with only 17% (n= 16) requiring adjustments to the dose of β-blocker therapy. (Source: The Jou...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C.K. Cornelio, R. Wu, A.C. Miranda Source Type: research
Genotype Analysis of LVOT Gradient Measurements in Patients Receiving Mavacamten for Obstructive Hypertrophic Cardiomyopathy?
Purpose: Hypertrophic cardiomyopathy (HCM) is the most common genetically inherited cardiac condition encountered. Recent utilization of cardiac myosin inhibitors has altered the management of obstructive symptoms. In this retrospective analysis, we compare the response to therapy in patients with obstructive HCM being treated with mavacamten based on genetic positivity. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C.K. Cornelio, A.C. Miranda, R. Wu Source Type: research
A Case of Takotsubo Cardiomyopathy in a Bilateral Lung Transplant Recipient
Introduction: Takotsubo cardiomyopathy (TTC) is a stress induced, temporary decrease in systolic function within the left ventricle ’s apical area, often resembling myocardial infarction (MI). In patients with EKG or troponin findings indicative of MI, it is often discovered upon coronary angiography with nonocclusive vasculature. Diagnosis can be confirmed by apical ballooning on echocardiogram. Here we report a case of a lun g transplant recipient who developed Takotsubo cardiomyopathy after bronchoscopy. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: A. Shajihan, O. Shlobin, , S. Aryal Source Type: research
