A Survey of Direct Oral Anticoagulant Cessation in General Surgery and Outcomes in Patients with Nonvalvular Atrial Fibrillation.
Authors: Kawabata M, Goya M, Maeda S, Yagishita A, Takahashi Y, Sasano T, Hirao K Abstract There is little data on management and outcomes of atrial fibrillation (AF) patients on direct oral anticoagulants (DOAC) undergoing general surgery.We retrospectively assessed 98 surgeries in 85 nonvalvular AF patients aged 73 ± 8 (59 men) receiving DOACs. Cardiac, emergency, and minimally invasive surgeries were excluded.The CHA2DS2-VASc score ranged from 0 to 8. The DOACs being given were: dabigatran, 16; rivaroxaban, 25; apixaban, 28; and edoxaban, 16. While the DOACs were not suspended in 11 cases, they were inter...
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Pulmonary Hypertension Following Increased Dosing of Diazoxide in an Infant.
We report a case of an infant with HH, subsequently complicated by diazoxide-induced PH. When diazoxide was introduced, PH did not appear initially, but it developed during increased dosing. We monitored PH via regular echocardiography examinations. PH gradually improved with tapering of the diazoxide dose and disappeared after drug discontinuation. Our case suggests a diazoxide dose threshold might induce PH. Therefore, close echocardiography examinations should accompany diazoxide treatment. PMID: 32921661 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Risk Factors for Mid-Term Liver Disease After the Fontan Procedure.
Authors: Oka N, Miyamoto T, Tomoyasu T, Hayashi H, Miyaji K Abstract The Fontan procedure is a palliative surgery performed for patients with complex congenital heart disease who exhibit functional single ventricular physiology. Although clinical outcomes of the Fontan procedure have improved in recent years and most patients who undergo the procedure reach adulthood, Fontan-associated liver disease (FALD) is a noncardiovascular complication that has become increasingly common; its risk factors remain unknown.A total of 95 patients who underwent the Fontan procedure and who were followed up for at least three years...
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Ivabradine-Induced Torsade de Pointes in Patients with Heart Failure Reduced Ejection Fraction.
Authors: Jang JH, Kwon SW, Lee MJ, Ko KY, Park JH, Yoon GS, Choi SH, Beak YS, Park SD, Shin SH, Woo SI, Kim DH, Kwan J Abstract Ivabradine is a selective inhibitor of the sinoatrial node "funny" current, prolonging the slow diastolic depolarization. As it has the ability to block the heart rate selectively, it is more effective at a faster heart rate. It is recommended for the treatment of heart failure reduced ejection fraction in the presence of beta-blocker therapy for the further reduction of the heart rate. However, previous reports have shown the association of Torsade de pointes (TdP) with concurre...
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Balloon Valvuloplasty to Treat Adult Symptomatic Pulmonary Valve Stenosis with Sequential Follow-Up Using Cardiac Magnetic Resonance Imaging in Combination with Echocardiography.
In conclusion, cMRI in combination with echocardiography was sufficiently informative to follow-up this PVS patient both before and after BPV. cMRI is easily reproducible in adult patients; therefore, cMRI should be recommended for long-term follow-up in adult PVS patients. PMID: 32921664 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Randomized, Open-Label, Cross-Over Comparison of the Effects of Benzbromarone and Febuxostat on Endothelial Function in Patients with Hyperuricemia.
Authors: Nakata T, Ikeda S, Koga S, Yonekura T, Tsuneto A, Doi Y, Fukae S, Minami T, Kawano H, Maemura K Abstract Uric acid is generated with reactive oxygen species via xanthine oxidase (XO), and hyperuricemia, which is identified as the excess of uric acid in the blood, has been associated with vascular endothelial dysfunction. However, the effects of urate-lowering medicines on endothelial function have not been fully elucidated. Thus this study determined and compared the effects of benzbromarone (urate transporter 1 inhibitor) and febuxostat (XO inhibitor) on endothelial function.This randomized, cross-over, o...
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Evolut Self-Expanding Transcatheter Aortic Valve Replacement in Patients with Extremely Horizontal Aorta (Aortic Root Angle ≥ 70°).
Evolut Self-Expanding Transcatheter Aortic Valve Replacement in Patients with Extremely Horizontal Aorta (Aortic Root Angle ≥ 70°). Int Heart J. 2020 Sep 12;: Authors: Kaneko U, Hachinohe D, Kobayashi K, Shitan H, Mitsube K, Furugen A, Kawamura T, Koshima R, Fujita T Abstract Because of its rigidity and non-steerability, the presence of a horizontal aortic root poses a major anatomical issue during transcatheter aortic valve replacement (TAVR) with Evolut self-expanding valve. Previous studies have elucidated the difficulties of coaxial implantation of the self-expanding valve in patients with h...
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Mid-term Clinical Outcomes of Immediate Protamine Use Following Elective Percutaneous Coronary Interventions.
In conclusion, immediate protamine use following elective PCI did not increase mid-term ischemia-driven TVR or stent thrombosis. However, immediate protamine use after PCI should be discussed further for the safety of the patient. PMID: 32921667 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Myopotential Oversensing Is a Major Cause of Inappropriate Shock in Subcutaneous Implantable Defibrillator in Japan.
This study highlights the fact that IAS continues to occur due to myopotential noise oversensing instead of T-wave oversensing. To minimize the risk of IAS, it is desirable to search and secure high R-wave voltage. PMID: 32921668 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Incidence and Predictors of Neoatherosclerosis in Patients with Early In-Stent Restenosis Determined Using Optical Coherence Tomography.
Authors: Meng L, Liu X, Yu H, Wei G, Gu X, Chang X, Xie M, Qu W, Peng X, Sun Y, Tian J, Yu B Abstract In-stent restenosis (ISR) still exists after drug-eluting stent (DES) implantation, even up to one year. The incidence and risk factors for neoatherosclerosis in patients with early ISR have not yet been elucidated. Here, we used optical coherence tomography (OCT) to evaluate the incidence and predictors of neoatherosclerosis in patients with early ISRs.OCT was performed on ISR lesions in 185 patients in order to detect neoatherosclerosis. The median follow-up was 180 days, and neoatherosclerosis was detected in 37...
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Significance of Ventricular Arrhythmia Based on Stored Electrogram Analysis in a Pacemaker Population.
This study included 302 consecutive patients with a dual-chamber pacemaker. A total of 1024 EGMs stored in pacemakers as ventricular high-rate episodes were analyzed. The definition of NSVT was ≥ 5 consecutive ventricular beats at ≥ 150 bpm lasting
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

How to Safely Prevent Venous Thromboembolism in Severe Trauma Patients.
This study aimed to assess the efficacy and safety of our new anticoagulation therapy protocol using unfractionated heparin (UFH) plus intermittent pneumatic compression (IPC) to prevent post-traumatic VTE in high-risk trauma patients.This study enrolled 70 trauma patients who were admitted to the emergency medical center of Nagasaki University Hospital and had Risk Assessment Profile (RAP) scores ≥ 5. After stopping bleeding at the trauma site, all patients received intravenous UFH (10,000 U/day) plus IPC, which was continued for 14 days or until the patients could walk. On days 7 and 14, all patients underwent lower e...
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Sex-Related Differences in Cardiac Remodeling and Reverse Remodeling After Transcatheter Aortic Valve Implantation in Patients with Severe Aortic Stenosis in a Japanese Population.
This study aims to determine whether any sex-related differences in LV or reverse remodeling after TAVI exist in the context of severe AS.Of 208 patients who received TAVI for severe AS in our institution, 100 (men, 42; mean age, 83.0 ± 4.9 years) underwent transthoracic echocardiography before and 3 months after TAVI. Despite similar valvular gradients, women with severe AS had lower indexed LV mass (LVMi) than did men (152.3 ± 35.4 versus 173.2 ± 44.6 g/m2, P = 0.005), with smaller indexed LV end-diastolic (LVEDVi) (50.2 ± 13.3 versus 61.4 ± 20.7 mL/m2, P = 0.001) and end-systolic (LVES...
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

A Fatal Case of Myocarditis Following Myositis Induced by Pembrolizumab Treatment for Metastatic Upper Urinary Tract Urothelial Carcinoma.
In conclusion, we found that myositis and myocarditis developed in a patient with advanced urothelial carcinoma after pembrolizumab treatment. A routine follow-up of CK and cardiac troponin I, as well as an ECG, should be performed to identify any possible ICI-induced myocarditis and myositis quickly. PMID: 32921673 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Determinants of In-Hospital Death Among the Very Elderly with Acute Myocardial Infarction.
In conclusion, in-hospital outcomes of the very elderly with AMI were still poor in the current PCI era. Poor pre-admission ADL as well as cardiogenic shock and anemia were determined to be strongly associated with in-hospital death. PMID: 32921674 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Prognostic Impact of B-Type Natriuretic Peptide on Long-Term Clinical Outcomes in Patients with Non-ST-Segment Elevation Acute Myocardial Infarction Without Creatine Kinase Elevation.
Authors: Takahashi N, Ogita M, Suwa S, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Tobaru T, Saku K, Oshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M, J-MINUET investigators Abstract Although B-type natriuretic peptide (BNP) has gradually gained recognition as an indicator in risk stratification for patients with acute myocardial infarction (AMI), the prognostic impact on long-term clinical outcomes in patie...
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Novel Cardiocerebral Channelopathy Associated with a KCND3 V392I Mutation.
We report two teenage siblings exhibiting both cardiac (early repolarization syndrome and paroxysmal atrial fibrillation) and cerebral phenotypes (epilepsy and intellectual disability), in whom we identified the KCND3 V392I mutation. We propose a link between the KCND3 mutation with a mixed electrophysiological phenotype and cardiocerebral phenotypes, which may be defined as a novel cardiocerebral channelopathy. PMID: 32921676 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Comparison of Landiolol and Digoxin as an Intravenous Drug for Controlling the Heart Rate in Patients with Atrial Fibrillation and Severely Depressed Left Ventricular Function.
Authors: Shinohara M, Wada R, Yano K, Akitsu K, Koike H, Kinoshita T, Suzuki T, Fujino T, Ikeda T Abstract Clinical experience with landiolol use in patients with atrial fibrillation (AF) and a severely depressed left ventricular (LV) function is limited. We compared the efficacy and safety of landiolol with that of digoxin as an intravenous drug in controlling the heart rate (HR) during AF associated with a very low LV ejection fraction (LVEF).We retrospectively analyzed 53 patients treated with landiolol (n = 34) or digoxin (n = 19) for AF tachycardias with an LVEF ≤ 25. The landiolol dose was adjusted between...
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Suspected Hydroxychloroquine-Induced Sinus Bradycardia and QTc Prolongation in a Patient with COVID-19.
Authors: Kang Y, Wang H, Chen H, Wang B, Yang Y, Zhao X, Ran Q, Wei J Abstract An 84-year-old woman with hypertension, Alzheimer's disease, and chronic kidney disease presented with fever and was diagnosed with corona virus disease 2019 (COVID-19). During the hospitalization, she experienced unexpected sinus bradycardia with prolonged QTc, which was thought to be closely related to the short-term use of hydroxychloroquine (HCQ), an old drug used to treat malaria and autoimmune diseases, but now used against COVID-19. The cardiac side effects of HCQ were rare, seen with short-term and low-dose use. With the COVID-19...
Source: International Heart Journal - September 15, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Does Quicker Mean Better? Comparison of Rapid Deployment Versus Conventional Aortic Valve Replacement.
Authors: Lu Y, Wang J, Chen Z, Wei J, Li F, Cai Z Abstract The aim of this meta-analysis was to compare the clinical outcomes in patients who underwent rapid deployment aortic valve replacement (RDAVR) and conventional bio prosthetic aortic valve replacement (CAVR).We performed a literature search by August 2018. The primary outcomes were hospital and 1-year mortality, and the secondary endpoints included the aortic cross-clamp (ACC), cardiopulmonary bypass (CPB) time, and postoperative and valve-related complications.Two randomized controlled trials and 13 propensity score-matched studies were included. There was ...
Source: International Heart Journal - September 5, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Decreases in Circulating Concentrations of Short-Chain Acylcarnitines are Associated with Systolic Function Improvement After Decompensated Heart Failure.
This study recruited 79 HF patients hospitalized because of acute decompensation with a left ventricular ejection fraction (LVEF) of
Source: International Heart Journal - September 5, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

18-Year Follow-Up After Coronary Stenting for Left Main Coronary Artery Lesions.
Authors: Bai J, Dong Z, Pan L, Xia X, Zhang B Abstract The current treatment of radiation-induced coronary artery disease (RCAD) is comparable to that of generic coronary artery disease (CAD); however, the outcomes of these treatment measures have not been fully examined in RCAD. A 33-year-old woman, without conventional cardiovascular risk factors, presented with left main coronary artery (LMCA) lesions. At the age of 26, she received mediastinal radiation therapy (RT) to treat mixed cellularity Hodgkin lymphoma. One BiodivYsio 3.5 × 18 mm stent was implanted at the LMCA site. At the age of 38, the patient w...
Source: International Heart Journal - September 5, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Prediction of Lethal Arrhythmic Events Through Remote Monitoring Using Heart Rate Variability Analysis in Patients with an Implantable Cardioverter Defibrillator.
The objective was to identify the predictors of lethal arrhythmic events (VT/VF).Thirty-three patients (mean age: 50 years) with ICDs [with functionality of heart rate variability (HRV) analysis] were divided into two groups [VT/VF (+), VT/VF (-) ]. Clinical, device (ventricular lead impedance; amplitude of ventricular electrogram), and HRV data were compared between the two groups. The NN interval-index (SDNNi) was calculated for every 5 minutes, and the mean, maximum, minimum, and standard deviation of SDNNi during the 24-hour period were used.During the observation period of 13 ± 10 months, 10 patients experience...
Source: International Heart Journal - September 5, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Sudden Unexpected Death of Infantile Dilated Cardiomyopathy with JPH2 and PKD1 Gene Variants.
Authors: Miura A, Kondo H, Yamamoto T, Okumura Y, Nishio H Abstract A Japanese girl with polycystic kidney disease (PKD) developed normally, but at 8 months of age, she was hospitalized for acute onset dyspnea. On the day after admission to hospital, her general condition suddenly became worse. An echocardiogram showed left ventricular dilatation with thin walls, severe mitral valve regurgitation, and a reduced ejection fraction. She died of acute cardiac failure 3 hours after the sudden change. Postmortem analysis with light microscopy showed disarray of cardiomyocytes without obvious infiltration of lymphocytes, ...
Source: International Heart Journal - September 5, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Redefining the Blanking Period by a Long-Term Follow-Up after Atrial Fibrillation Ablation Using Second-Generation Cryoballoon.
Authors: Xia Y, Liu J, Jia Y, Zhang H, Yu M, Li X, Fang P Abstract On the basis of radiofrequency ablation of atrial fibrillation (AF), some studies suggested that early recurrences of atrial tachyarrhythmia (ERATs) were associated with late AF recurrence (LAFR), and some also suspected and challenged the current recommended 90 day blanking period. We aim to evaluate the impact of ERAT on long-term success and to determine the optimum blanking period after AF ablation using second-generation cryoballoon (sg-CB). From August 2016 to October 2018, 369 consecutive patients who successfully underwent initial AF ablatio...
Source: International Heart Journal - September 5, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Homocysteine as a Key Player in Lifestyle Management of Arrhythmia.
Authors: Shimizu Y, Fujiu K PMID: 32727997 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - August 1, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Glucose Fluctuation and Cardiovascular Diseases.
Authors: Fujiwara T, Takeda N PMID: 32727998 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - August 1, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Elevated Homocysteine Levels Associated with Atrial Fibrillation and Recurrent Atrial Fibrillation.
Authors: Rong H, Huang L, Jin N, Hong J, Hu J, Wang S, Xie Y, Pu J Abstract There is increasing evidence linking plasma homocysteine levels and atrial fibrillation (AF). The association between an elevated level of plasma homocysteine and AF was examined by meta-analysis in this study.The PubMed and ScienceDirect databases until August 2019 were utilized to collect previous literature on homocysteine and the potential relation to AF. The pooled effects were evaluated depending on standardized mean differences (SMDs) or odds ratios (ORs) with 95% confidence intervals (CIs), and the calculation was performed using St...
Source: International Heart Journal - August 1, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

The Clinical Efficacy of Endothelin Receptor Antagonists in Patients with Pulmonary Arterial Hypertension.
Authors: Maki H, Hara T, Tsuji M, Saito A, Minatsuki S, Inaba T, Amiya E, Hosoya Y, Hatano M, Morita H, Yao A, Kinugawa K, Komuro I Abstract Therapeutic strategies for pulmonary arterial hypertension (PAH) have made remarkable progress over the last two decades. Currently, 3 types of drugs can be used to treat PAH; prostacyclins, phosphodiesterase 5 inhibitors, and endothelin receptor antagonists (ERA). In Japan, the first generation ERA bosentan was reimbursed in 2005, following which the 2nd generation ERAs ambrisentan and macitentan were reimbursed in 2009 and 2015, respectively. The efficacy of each ERA on hemo...
Source: International Heart Journal - August 1, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

MiR-24 Protects Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Injury Through Regulating Mitogen-Activated Protein Kinase 14.
This study aimed to explore the function of miR-24 in hypoxia/reoxygenation (H/R) -induced cardiomyocyte injury.We constructed a cardiomyocyte model of H/R using the primary cardiomyocytes isolated from Sprague-Dawley rats. To explore the role of miR-24, cells were transfected with a miR-24 mimic or miR-24 inhibitor. The RNA expression levels of miR-24 and Mapk14 were determined using qRT-PCR. The proliferation and apoptosis of cells were determined using a CCK8 assay and a flow cytometer. The TargetScan website was used to predict the targets of miR-24. A dual-luciferase reporter gene assay was conducted to verify whethe...
Source: International Heart Journal - August 1, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Ventricular Septal Rupture After Recent Myocardial Infarction in the Very Elderly.
Authors: Arai R, Fukamachi D, Akutsu N, Okumura Y, Tanaka M Abstract Ventricular septal rupture (VSR) is one of the fatal complications of myocardial infarction in the percutaneous coronary intervention era. A rapid diagnosis, medical and mechanical support, and surgical intervention are required for recovery and survival. In such a situation, the risk of complications associated with surgery is very high, especially in very elderly patients, in which any therapeutic strategy should be carefully discussed by the heart team. Herein, we describe two cases of VSRs after recent myocardial infarction (RMI) in very elder...
Source: International Heart Journal - August 1, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Veno-venous Extracorporeal Membrane Oxygenation for Right Ventricular Failure with Atrial Septostomy After Corrective Repair of Tetralogy of Fallot.
Authors: Wu SJ, Fan YF Abstract Right ventricular (RV) dysfunction may occur after cardiac surgery and it is not rare after corrective repair of tetralogy of Fallot (TOF). If traditional treatments with volume management, infusion of inotropic agents, and use of pulmonary vasodilators cannot stabilize the patient, extracorporeal membrane oxygenation (ECMO) or a ventricular assist device (VAD) will be considered as the last resort. Here, we report a young infant patient with RV failure after corrective repair of TOF and without closure of an atrial septal defect (ASD), who was rescued by veno-venous (VV) -ECMO. ...
Source: International Heart Journal - August 1, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Steroid-Refractory Protein-Losing Enteropathy with Gastrointestinal Bleeding in a Patient with Fontan Circulation.
We report a 7-year-old steroid-refractory post-Fontan PLE case suggesting the latter pathogenesis together with a literature review. PMID: 32728004 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - August 1, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Erratum: Differential Atrial Pacing to Detect Reconnection Gaps After Pulmonary Vein Isolation in Atrial Fibrillation.
Authors: Tahara M, Kato R, Ikeda Y, Goto K, Asano S, Mori H, Iwanaga S, Muramatsu T, Matsumoto K Abstract The errors in the following list appeared in the article entitled "Differential Atrial Pacing to Detect Reconnection Gaps After Pulmonary Vein Isolation in Atrial Fibrillation" by Mai Tahara, Ritsushi Kato, Yoshifumi Ikeda, Koji Goto, So Asano, Hitoshi Mori, Shiro Iwanaga, Toshihiro Muramatsu, and Kazuo Matsumoto (Vol. 61, No. 3, 503-509, 2020). PMID: 32728005 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - August 1, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Association Between R353Q (rs6046) Polymorphism in Factor VII with Coronary Heart Disease.
We examined all eligible studies using the Newcastle-Ottawa Quality Assessment Scale (NOS). The odds ratio (OR) and its corresponding 95% confidence interval (CI) were adopted to evaluate the relationship between the R353Q (rs6046) polymorphism and CHD. Stata version 14.0 (Stata Corporation, USA) was used in all statistical tests.There were at least 28 eligible studies, including 14626 cases and 17994 controls, included in our meta-analysis. R353Q (rs6046) polymorphism was associated with the reduced risk of CHD in four genetic models: allele model (Q versus R: OR = 0.79, 95% CI: 0.69 to 0.90, P
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

MiR-134-5p Regulates Myocardial Apoptosis and Angiogenesis by Directly Targeting KDM2A After Myocardial Infarction.
In this study, MI mouse model was established. Quantitative real-time PCR (qRT-PCR) and western blot were used to measure the expression of miR-134-5p, lysine demethylase 2A (KDM2A), and vascular endothelial growth factor (VEGF). Dual-Luciferase reporter (DLR) assay was used to explore the relationship between miR-134-5p and KDM2A. The influence of miR-134-5p on cardiomyocytes apoptosis was detected using methyl thiazolyl tetrazolium (MTT) assay. The results revealed that miR-134-5p was highly expressed in infarction tissues of MI mice. Knockdown of miR-134-5p inhibited hypoxia/reoxygenation (H/R) -induced cardiomyocyte ap...
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Late Migration of a Paravalvular Leak Closure Device.
We present a case of a seventy-year-old gentleman with rheumatic heart disease and multiple previous mechanical aortic and mitral valve replacements. After repeated admissions for decompensated heart failure, secondary to paravalvular mitral regurgitation, a percutaneous paravalvular leak closure was performed with successful reduction of the leak. He represented 30 days later with cardiogenic shock and multiorgan failure secondary to torrential central mitral regurgitation caused by late displacement of the closure device with mitral prosthesis impingement. Due to an excessively high surgical risk, his case was successful...
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Clinical Manifestation, Timing Course, Precipitating Factors, and Protective Factors of Ventricular Free Wall Rupture Following ST-Segment Elevation Myocardial Infarction.
This study provides evidence for a better understanding of FWR. PMID: 32684590 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

General Anesthesia or Conscious Sedation for Transfemoral Aortic Valve Replacement with the SAPIEN 3 Transcatheter Heart Valve.
Authors: Neumann FJ, Redwood S, Abdel-Wahab M, Lefèvre T, Frank D, Eltchaninoff H, Caussin C, Stella PR, Hovorka T, Baumgartner H, Tarantini G, Wendler O, Treede H Abstract Differences in the benefits of conscious sedation (CS) and general anesthesia (GA) during transfemoral aortic valve implantation (TAVI) are unclear.We aimed to assess differences in procedural and clinical outcomes based on the type of anesthesia received during TAVI.We analyzed SOURCE 3 Registry data for patients who received the SAPIEN 3 valve by type of anesthesia used during TAVI.Of the 1694 TAVI patients, 1027 received CS and 667 rec...
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Preoperative Clinical Features and High Pulmonary Wedge Pressure with a Discordant Pattern as Prognostic Factor in Hemodialysis Patients with Severe Aortic Valve Stenosis.
Authors: Ueda M, Kubo T, Ochi Y, Takahashi A, Miyagawa K, Baba Y, Noguchi T, Hirota T, Yamasaki N, Yamamoto M, Nishimori H, Sasaguri S, Orihashi K, Kitaoka H Abstract Hemodialysis (HD) is one of the important risks for the development of cardiovascular disease, including aortic valve stenosis (AS). Although aortic valve replacement (AVR) is a beneficial treatment for AS, HD patients are known to show a high rate of mortality after AVR than non-HD patients.We retrospectively studied 109 patients who underwent AVR for severe AS, 18 of which were HD patients. Survival rate after AVR, preoperative clinical data, and su...
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Quality of Life in Adults Undergoing Percutaneous Device Closure of Atrial Septal Defect.
Authors: Huang ST, Sun KP, Xu N, Chen Q, Cao H Abstract To assess changes in the quality of life in adult patients undergoing percutaneous device closure of atrial septal defect (ASD).We used a standard Medical Outcome Study Short Form 36 (SF-36) that includes psychological and physiological aspects to assess and analyze the quality of life of 73 adult patients who underwent percutaneous device closure of ASD.Of the 73 patients who were investigated in this study, 67 completed questionnaires successfully. The following findings were revealed after analyzing the preoperative results and postoperative results. In som...
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Comparison of Neointimal Response between Durable-Polymer Everolimus-Eluting Stent and Bioabsorbable-Polymer Everolimus-Eluting Stent for Severely Calcified Lesions Requiring Rotational Atherectomy.
Authors: Matsuda Y, Ashikaga T, Sasaoka T, Hatano Y, Umemoto T, Lee T, Yonetsu T, Maejima Y, Sasano T Abstract Clinical outcomes after percutaneous coronary intervention (PCI) for severely calcified lesions remain poor. The purpose of this study was to investigate the neointimal response after everolimus-eluting stents (EES) for severely calcified lesions treated with rotational atherectomy (RA) using optical coherence tomography (OCT).We retrospectively analyzed 34 lesions in which PCI was performed with EES deployment following RA and OCT was performed immediately after PCI and at follow-up (nine months). The EES...
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Comparison of Durable-Polymer- and Biodegradable-Polymer-Based Newer-Generation Drug-Eluting Stents in Patients with Acute Myocardial Infarction and Prediabetes After Successful Percutaneous Coronary Intervention.
Authors: Kim YH, Her AY, Jeong MH, Kim BK, Hong SJ, Kim S, Ahn CM, Kim JS, Ko YG, Choi D, Hong MK, Jang Y Abstract Hyperglycemia is an important risk factor for poor clinical outcomes in patients with acute myocardial infarction (AMI). The relative superiority of the long-term clinical outcomes of durable-polymer (DP) -based and biodegradable-polymer (BP) -based newer-generation drug-eluting stents (DESs) after successful percutaneous coronary intervention (PCI) in patients with AMI and prediabetes is not well established. We compared the clinical outcomes in such patients between DP-based and BP-based newer-genera...
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

MiR-182-5p Inhibits the Proliferation of Vascular Smooth Muscle Cells Induced by ox-LDL Through Targeting PAPPA.
This study aims to analyze the expression level and correlation of miR-182-5p and its target gene PAPPA in coronary atherosclerosis (CAD).Real time PCR, ELISA, and Western blotting methods were used to detect the expression levels. Dual-luciferase reporter gene assays were used to analyze the interaction between the 3'-UTR of PAPPA and miR-182-5p.The expression level of miR-182-5p in CAD was significantly lower than that in normal population, while the content of serum PAPPA was significantly increased, and the expression level of miR-182-5p was negatively correlated with the PAPPA content. The expression level of miR-182-...
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Diagnosing Heart Failure from Chest X-Ray Images Using Deep Learning.
Authors: Matsumoto T, Kodera S, Shinohara H, Ieki H, Yamaguchi T, Higashikuni Y, Kiyosue A, Ito K, Ando J, Takimoto E, Akazawa H, Morita H, Komuro I Abstract The development of deep learning technology has enabled machines to achieve high-level accuracy in interpreting medical images. While many previous studies have examined the detection of pulmonary nodules in chest X-rays using deep learning, the application of this technology to heart failure remains rare. In this paper, we investigated the performance of a deep learning algorithm in terms of diagnosing heart failure using images obtained from chest X-rays. We...
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Prognostic Value of Left Ventricular Dyssynchrony Assessed with Nuclear Cardiology in Patients with Known or Suspected Stable Coronary Artery Disease with Preserved Left Ventricular Ejection Fraction.
Authors: Hatta T, Yoda S, Hayase M, Monno K, Hori Y, Fujito H, Suzuki Y, Matsumoto N, Okumura Y Abstract Left ventricular (LV) mechanical dyssynchrony assessed with phase analysis of electrocardiogram (ECG) -gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is useful for predicting major cardiac events (MCEs) in patients with cardiac dysfunction. However, there is no report on its usefulness in Japanese patients with known or suspected stable coronary artery disease (CAD) with preserved LV ejection fraction (LVEF).We retrospectively investigated 3,374 consecutive patients w...
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Prevalence and Predictors of Atherosclerotic Peripheral Arterial Obstructive Disease in Severe Heart Valve Diseases.
This study aims to investigate the prevalence and predictors of PAOD in HVDs.In this study, a total of 245 consecutive patients were examined: 153 with severe aortic valve stenosis (AS), 66 with severe primary mitral valve regurgitation (MR), and 26 with severe pure native aortic valve regurgitation (AR). All patients underwent ultrasound scan of the carotid artery to ascertain the presence of internal carotid artery stenosis (ICAS). ICAS was defined as a peak systolic velocity ≥ 125 cm/second and/or ≥ 50% reduction in diameter. In addition, we measured the ankle-brachial index in each leg using a volume plethysmogra...
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Usefulness of Plasma Branched-Chain Amino Acid Analysis in Predicting Outcomes of Patients with Nonischemic Dilated Cardiomyopathy.
This study enrolled 39 NIDCM patients, who underwent plasma amino acid (AA) analysis. The ratio of BCAAs to total AAs was calculated. All patients were divided into two groups at the median of BCAA/total AA ratio; high BCAA/total AA group (≥ 0.15, n = 20) and low BCAA/total AA group (
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Precise Signals with a High-Density Grid Mapping Catheter Are Useful for an Entrainment Study.
Authors: Oikawa J, Fukaya H, Niwano S, Saito D, Sato T, Matsuura G, Arakawa Y, Shirakawa Y, Kobayashi S, Horiguchi A, Nishinarita R, Ishizue N, Kishihara J, Ako J Abstract Complex atrial tachycardias (ATs) after catheter ablation or a MAZE procedure is sometimes difficult to determine the circuits of the tachycardia. A high-density, grid-shapes mapping catheter has been launched, which can be useful for detecting the detail circuits of tachycardias on three-dimensional mapping systems. The signal quality is also important for performing electrophysiological studies (EPSs), such as entrainment mapping, to identify t...
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Association between Sarcopenia/Lower Muscle Mass and Short-Term Regression of Deep Vein Thrombosis Using Direct Oral Anticoagulants.
We examined the association with DVT regression following direct oral anticoagulants (DOACs) treatment.The prospective cohort study period was between October 2017 and August 2018. We enrolled 46 patients diagnosed with DVT by ultrasonography, who were aged>60 years old and treated with DOACs. Sarcopenia was evaluated using the Asian Working Group for Sarcopenia flowchart. The average DOACs treatment period was 94 days, and 29 patients exhibited thrombus regression. On univariate logistic regression analysis, sarcopenia, average GCM diameter index, and gastrocnemius integrated backscatter index were significantly associ...
Source: International Heart Journal - July 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research