MiR-202-3p Inhibits Foam Cell Formation and is Associated with Coronary Heart Disease Risk in a Chinese Population.
Authors: Li L, Wu F, Xie Y, Xu W, Xiong G, Xu Y, Huang S, Wu Y, Jiang X Abstract A previous study and a gene-annotation enrichment analysis for potential targets of the microRNA miR-202-3p both suggest that this microRNA might be implicated in cardiovascular and metabolic diseases. In the present study, the role of miR-202-3p in the pathogenesis of coronary heart disease (CHD) was explored. We conduct a case-control study to detect the expression levels of miR-202-3p in peripheral blood cells and found that miR-202-3p expression was significantly higher in CHD cases than in controls (P
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Alginate Oligosaccharide Alleviates Monocrotaline-Induced Pulmonary Hypertension via Anti-Oxidant and Anti-Inflammation Pathways in Rats.
Authors: Feng W, Hu Y, An N, Feng Z, Liu J, Mou J, Hu T, Guan H, Zhang D, Mao Y Abstract Pulmonary arterial hypertension (PAH) is a serious and fatal cardiovascular disorder characterized by increased pulmonary vascular resistance and progressive pulmonary vascular remodeling. The underlying pathological mechanisms of PAH are multi-factorial and multi-cellular. Alginate oligosaccharide (AOS), which is produced by depolymerizing alginate, shows better pharmacological activities and beneficial effects. The present study was undertaken to investigate the effects and potential mechanisms of AOS-mediated alleviation of ...
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

A Long-Term Complication Occurred After Transcatheter Closure of Large Atrial Septal Defect.
Authors: Zhao C, Xu J, Cui D, Liu K Abstract Transcatheter closure of ostium secondum atrial septal defect has become an alternative method to surgical closure. However, the incidence of complications and long-term results of using large size (> 40 mm) Amplatzer septal occluders are unknown. This case reported a 59 years old woman, whom received transcatheter closure of atrial septal defect (36 mm) with a 40 mm Amplatzer septal occluder 10 years ago and was diagnosed with heart failure. Transthroacic echocardiography showed severe mitral valve regurgitation. Intra-operatively, we confirmed and removed the large ...
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Influence of Percutaneous Occlusion of Atrial Septal Defect on Left Atrial Function Evaluated Using 2D Speckle Tracking Echocardiography.
Authors: Suzuki K, Kato T, Koyama S, Shinohara T, Inukai S, Sato J, Yamamoto H, Omori D, Yoshida S, Takeda S, Nishikawa H, Ohashi N, Sakurai H, Saitoh S Abstract Percutaneous occlusion of atrial septal defect (ASD) has recently become a standard therapeutic strategy, but little is known about left atrial (LA) function thereafter. The present study aimed to determine LA function in 43 children with ASD and 13 controls based on LA strain measured by two-dimensional echocardiographic speckle tracking (2DE-ST). Among these children, 12 underwent surgery (ASD-S), 31 had device closure (ASD-D), and 13 were included as co...
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Recovered Left Ventricular Ejection Fraction and Its Prognostic Impacts in Hospitalized Heart Failure Patients with Reduced Ejection Fraction.
Authors: Abe S, Yoshihisa A, Ichijo Y, Sato Y, Kanno Y, Takiguchi M, Yokokawa T, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Takeishi Y Abstract It has been recently recognized that recovery of left ventricular ejection fraction (EF), termed "recovered EF", occurs in a proportion of heart failure patients with reduced EF (HFrEF), and is associated with better prognosis. However, the clinical characteristics of "recovered EF" have not been fully examined.Consecutive 567 patients hospitalized due to HFrEF (EF
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Clinical Factors Associated with a Successful Catheter Ablation Outcome in Elderly Patients with Atrial Fibrillation.
Authors: Fujino T, Yuzawa H, Kinoshita T, Koike H, Shinohara M, Akitsu K, Yao S, Yano K, Suzuki T, Yamada M, Ikeda T Abstract Catheter ablation is currently an established treatment for symptomatic paroxysmal atrial fibrillation (AF). We focused on elderly patients with a high prevalence of AF and attempted to identify the clinical factors associated with unsuccessful ablation outcomes.Among 735 consecutive patients who underwent AF ablation procedures, 108 (14.7%, 66 men) aged ≥ 75 years were included. Of them, 80 had paroxysmal AF, and the remaining 28 non-paroxysmal AF. All patients underwent pulmonary vein (...
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Successful Ablation of Atrial Tachycardia Originating from Inside the Single Atrium and Conduit After a Fontan Operation.
Authors: Mori H, Sumitomo N, Muraji S, Imamura T, Iwashita N, Kobayashi T Abstract An 18-year-old male who had a past medical history of an intracardiac total cavopulmonary connection (TCPC) operation was referred to our hospital for radiofrequency catheter ablation (RFCA) of supraventricular tachycardia (SVT). Two types of SVTs were induced, and 3-dimensional (3D) maps were created using an ultra-high-density 3-dimensional mapping system (Rhythmia). The earliest atrial activation site (EAAS) of SVT1 was at the superior part of the conduit, and the EAAS of SVT2 was at the inferior part of the single atrium (SA). Th...
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Comparison of In-Hospital Clinical Outcomes of Acute Myocardial Infarction Between Nonagenarians and Octogenarians.
In conclusion, the in-hospital mortality of nonagenarians with AMI was comparable to that of octogenarians with AMI. In-hospital outcomes in nonagenarians with AMI may be acceptable as long as acute medical management including PCI to the culprit of AMI is performed. PMID: 31956138 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Elevated Plasma Adiponectin Levels Are Associated with Abnormal Corrected QT Interval in Patients with Stable Angina.
Authors: Wu CC, Chang CS, Hsu CC, Wang CP, Tsai IT, Lu YC, Houng JY, Chang CC, Chung FM, Lee YJ, Hung WC Abstract Low-circulating levels of adiponectin (ADPN) are associated with obesity, diabetes mellitus, and coronary artery disease. On the contrary, some studies have demonstrated a link between relatively high levels of plasma ADPN and heart failure, atrial fibrillation, and adverse outcome. However, little is known about the relationship between ADPN level and prolonged QT interval. The aim of this study was to investigate the association between plasma ADPN levels and prolonged QT interval in patients with sta...
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

The Relationship Between Circulating Neuregulin-1 and Coronary Collateral Circulation in Patients with Coronary Artery Disease.
Authors: Huang M, Zheng J, Chen Z, You C, Huang Q Abstract Coronary collateral circulation (CCC) plays a crucial role in myocardial blood supply, especially for ischemic myocardium. Previous study has shown that neuregulin-1 is a prominent angiogenic factor in diabetic cardiomyopathy, whereas the relationship between neuregulin-1 and CCC has not been investigated. Thus, we aimed to investigate relationship between circulating neuregulin-1 levels and CCC in stable coronary artery disease patients.Coronary artery disease patients with a stenosis of ≥ 90% as evidenced by coronary angiography were included in our st...
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Long-Term Performance of Right Ventricular Implantable Cardioverter-Defibrillator Leads in Arrhythmogenic Right Ventricular Cardiomyopathy and Hypertrophic Cardiomyopathy.
This study investigated ICD-lead intracardiac parameters over a long duration in patients with ARVC and HCM and compared these parameters with those of a control group. We included 50 patients (mean age, 55.2 ± 17.2 years; 26% female) with ICD leads in the right ventricular apex, and compared 7 ARVC and 14 HCM patients with 29 control patients without structural heart disease. ICD-lead parameters, including R-wave amplitude, pacing threshold, and impedance during follow-up, were compared. The difference in these parameters between the time of implantation and year 5 were also compared. There were no significant diff...
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Experimental Study with Regard to the Effects of Energy Titration of the Laserballoon on the Lesion Creation Using Porcine Myocardium.
Authors: Okishige K, Shigeta T, Nakamura RA, Hirao T, Yoshida H, Oda A, Yamauchi Y, Sasano T, Hirao K Abstract Laserballoon-based pulmonary vein isolation has proven to be safe and effective. However, the influence of the laser energy titration on the lesion formation has never been fully investigated. The aim of this study was to determine the relationship between the delivered laser energy and lesion size, as well as the incidence of steam pop.The whole porcine heart was excised, and the left ventricular myocardium was separated into four specimens. Myocardial specimens were embedded in a warm mattress to keep th...
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Perioperative Outcomes of Adjunctive Hypnotherapy Compared with Conscious Sedation Alone for Patients Undergoing Transfemoral Transcatheter Aortic Valve Implantation.
This study aimed to assess the perioperative outcomes of adjunctive hypnotherapy undergoing transfemoral TAVI with LACS.Consecutive patients (n = 143) with symptomatic severe aortic stenosis who underwent transfemoral TAVI with LACS only (n = 107) or with LACS and hypnotherapy (n = 36) between January 2015 and April 2016 were retrospectively included in the study. The clinical outcomes were compared between the two groups. The LACS with hypnotherapy group had a significantly shorter length of stay in the intensive care unit (ICU; LACS only versus LACS with hypnotherapy: 4.0 (4.0-5.5) days versus 3.0 (3.0-5.0) days, P
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

The Impact of Estrogen Supplementation to Autonomic and Sleep Modulations in Free-Moving Spontaneously Hypertensive Rats.
Authors: Liu SH, Lai CT, Chen HR, Lin WL, Yamada S, Lugtu IC, Chou YH, Yang CCH, Kuo TB, Chen SA, Lo LW Abstract Sleep and estrogen levels have an impact on neural regulation and are associated with cardiovascular (CV) events. We investigated the effects of estrogen on heart rate variability (HRV) and circadian cycle in spontaneously hypertensive rats (SHRs). Polysomnographic recording was performed in seven male and seven female SHRs during sleep. The electroencephalogram (EEG) and electromyogram (EMG) were evaluated to define active waking (AW), quiet sleep (QS), and paradoxical sleep (PS) stages. Cardiac activit...
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Impact of Bystander Cardiopulmonary Resuscitation and Dispatcher Assistance on Survival After Out-of-Hospital Cardiac Arrest Among Adult Patients by Location of Arrest.
Authors: Shimamoto T, Kiyohara K, Matsuyama T, Kitamura T, Kiguchi T, Nishiyama C, Kobayashi D, Okabayashi S, Kawamura T, Iwami T Abstract We investigated the impact of bystander-initiated cardiopulmonary resuscitation (CPR), dispatcher assistance (DA), and location of arrest on survival and outcomes after out-of-hospital cardiac arrest (OHCA).From a nationwide population-based registry of OHCA patients in Japan, we enrolled adult patients with bystander-witnessed OHCA of medical origin between 2013 and 2015. The primary outcome measure was a neurologically favorable outcome, defined by cerebral performance categor...
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Acute Myocardial Infarction Caused by Coronary Spasm and Dissection Treated with Medical Therapy.
We report the case of a 33-year-old woman with no history of coronary risk factors or chest pain who experienced intermittent chest pain at rest for several minutes from 2 PM. At 8 AM the next day, chest pain recurred and persisted for about 1 hour. She was transported to our hospital by ambulance, where electrocardiogram showed ST-elevation in the precordial leads, and blood tests showed elevation of cardiac markers. She was diagnosed with ST-elevation myocardial infarction. Because she was a young woman without any risk factors, coronary spastic angina was suspected. Coronary angiography without intracoronary nitrate adm...
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Percutaneous Simple Lead Traction Is a Feasible and Effective Method for Right Ventricular Lead Perforations.
Authors: Mori H, Kato R, Ikeda Y, Tsutsui K, Hasegawa S, Tanaka S, Iwanaga S, Nakano S, Muramatsu T, Sumitomo N, Matsumoto K Abstract Right ventricular (RV) lead perforations are relatively rare but a potentially life-threatening complication of surgical implantations of cardiac implantable electronic devices (CIEDs). The result of percutaneous simple lead traction after lead perforations in the Japanese population has not been well clarified.We retrospectively studied 1359 patients (pacemakers [PMs], 973 patients; implantable cardioverter defibrillators [ICD], 386 patients) from April 2007 to December 2018 who und...
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Exendin-4 Reduces Ventricular Arrhythmia Activity and Calcium Sparks-Mediated Sarcoplasmic Reticulum Ca Leak in Rats with Heart Failure.
Authors: Chen J, Xu S, Zhou W, Wu L, Wang L, Li W Abstract The aim of this study was to investigate the effect of exendin-4 (Ex-4) on ventricular arrhythmias and calcium sparks-mediated calcium leak in a myocardial infarction-heart failure model.We studied the influence of exendin-4 on ventricular arrhythmogenesis in a rat myocardial infarction-heart failure model. In vivo arrhythmia studies (electrocardiogram [ECG] telemetry studies), ex vivo arrhythmia studies calcium sparks tests, and analysis of total and phosphorylated ryanodine receptor (RyR) 2 and CaMK-II were carried out in sham group, myocardial infarction...
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Reduced Number of Platelets During Intra-Aortic Balloon Pumping Counterpulsation Predicts Higher Cardiovascular Mortality After Device Removal in Association with Systemic Inflammation.
The objective of this study is to evaluate the impact of the change in the platelet number during IABP use on the prognosis after device removal.This is a retrospective observational study. Patients in the intensive cardiac care unit at three Juntendo University hospitals who underwent percutaneous implantation of IABP with or without veno-arterial extracorporeal membrane oxygenation (V-A ECMO), since 2012-2016, were enrolled in the study (n = 439). Patients who died during mechanical circulatory support (n = 47) were excluded. We evaluated the prognostic impact of the ratio of platelet reduction from the baseline (% PLT r...
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Heart is the Target Organ of Endogenous Cardiac Natriuretic Peptides.
This study aimed to evaluate whether the heart is the target organ of endogenous atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in patients with heart failure (HF) with reduced ejection fraction (HFrEF).We measured the plasma levels of cyclic guanosine monophosphate (cGMP), which is a second messenger of ANP and BNP, in the aortic root (AO) and coronary sinus (CS) in 237 patients with HFrEF. Plasma levels of cGMP were significantly higher in the CS than those in the AO in 237 patients with HFrEF (10.0 ± 4.5 versus 10.5 ± 4.3 pmoL/mL, P
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Meta-Analysis of the Impact of Pre-Procedural Serum Albumin on Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement.
In conclusion, low albumin levels were associated with poor prognosis in patients after TAVR. Pre-procedural albumin can be used as a simple tool related to prognosis after TAVR. PMID: 31956151 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Serum Brain-Derived Neurotrophic Factor Levels Are Associated with Skeletal Muscle Function but Not with Muscle Mass in Patients with Heart Failure.
Authors: Nakano I, Kinugawa S, Hori H, Fukushima A, Yokota T, Takada S, Kakutani N, Obata Y, Yamanashi K, Anzai T Abstract Heart failure (HF) is associated with aberrant skeletal muscle impairments, which are closely linked to the severity of HF. A low level of brain-derived neurotrophic factor (BDNF), a myokine produced in the skeletal muscle, is known to be involved in reduced exercise capacity and poor prognosis in HF. However, little is known about the factors or conditions of skeletal muscle associated with BDNF levels. We investigated the association between serum BDNF levels and the skeletal muscle mass and ...
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Chemotherapy Improved Pulmonary Arterial Hypertension in a Patient with Chronic-Active Epstein-Barr Virus Infection.
Authors: Akagi S, Miki T, Sando Y, Fujii N, Sarashina T, Nakamura K, Ito H Abstract Chronic-active Epstein-Barr virus infection (CAEBV) is a rare disease that can lead to pulmonary arterial hypertension (PAH). However, the treatment for CAEBV-associated PAH has not been established. We discuss a case of improved pulmonary hypertension after chemotherapy in a patient with CAEBV-associated PAH. A 44-year old man was admitted to our hospital because of an abnormal electrocardiogram and liver dysfunction detected by annual medical examination. Echocardiography showed a dilated right ventricle and an estimated right ven...
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Association Between Waist Circumference and Carotid Intima-Media Thickness in the General Population.
In this study, we examined 1,182 subjects (658 men and 524 women, 62.3 ± 11.7 years on average) who underwent voluntary health check-ups and sought to determine the optimal cut-off value of WC for predicting carotid IMT thickness. Receiver operating characteristic curve analysis of WC was utilized to predict high carotid IMT (defined as carotid IMT ≥ 1.1 mm). We determined that the appropriate WC cut-off value was a WC ≥ 79 cm for men and women. There was a statistically significant difference in the prevalence of high carotid IMT between WC ≥ 79 cm and WC
Source: International Heart Journal - January 22, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Atypical Slow-Slow Atrioventricular Nodal Reentrant Tachycardia with Use of a Superior Slow Pathway.
We report a case of atypical slow-slow atrioventricular nodal reentrant tachycardia (AVNRT) utilizing a superior slow pathway as a retrograde limb. The standard electrophysiological criteria confirm the diagnosis of this AVNRT by successfully excluding a diagnosis of atrial tachycardia and atrioventricular reentrant tachycardia. The earliest atrial activation during tachycardia was found at the interatrial septum 17.5 mm superior to the site identified during retrograde conduction with the fast pathway. The tachycardia was not inducible after ablation at the right posterior septum, consistent with successful ablation of th...
Source: International Heart Journal - December 26, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

The Impact of Sacrubitril/Valsartan on Clinical Treatment and hs-cTnT and NT-ProBNP Serum Levels and the Left Ventricular Function in Patients with Chronic Heart Failure.
This study aims to observe the impact of sacrubitril/valsartan on clinical treatment and high-sensitivity cardiac troponin T (hs-cTnT), N-terminal pro-brain natriuretic peptide (NT-ProBNP) serum levels, the improvement of the left atrial diameter (LAD) and left ventricular end diastolic dimension (LVEDD), and the left ventricular ejection fraction (LVEF) in patients with CHF.120 patients were randomly divided into a sacrubitil/valsartan group and a valsantan group, with 60 cases in each. Patients in the sacrubitil/valsartan group were administered sacrubitril/valsartan; while in the valsantan group, they were administered ...
Source: International Heart Journal - December 26, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Biomarkers for Prediction of Cardiovascular Events in Community-Dwelling Adults Aged 40 or Older.
Authors: Chong Y, Ren Q, Li Y, Li C, Feng F, Zhou Y Abstract Lipoprotein-associated phospholipase A2 (Lp-PLA2) and high-sensitivity C-reactive protein (hs-CRP) have been reported to be associated with cardiovascular disease (CVD). However, whether the combination of these two markers can improve the prediction of CVD is unknown.A total of 1,921 participants without CVD, aged 40 years or older, were enrolled from 2010 to 2011. Plasma Lp-PLA2 and hs-CRP were measured at baseline. Participants were subsequently followed until December 2015. We identified a total of 148 cardiovascular events (myocardial infarction, str...
Source: International Heart Journal - December 26, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

The Novel Compound Heterozygous Mutations of GAA Gene in Mainland Chinese Patient with Classic Infantile-Onset Pompe Disease.
Authors: Li J, Cui Y, Wang X, Wang Q, Wang H, Yan B Abstract Pompe disease (PD) is a rare and fatal neuromuscular disease, which is an autosomal recessive disorder. This is the first study to report a case of the compound heterozygous c.1822C>T and c.2297A>C mutations of the GAA gene in mainland Chinese patient, which led to the classic infantile-onset Pompe disease (IOPD) characterized by hypertrophic cardiomyopathy. This case highlights that the detection of GAA activity in peripheral blood by dried blood spot and GAA gene analysis can clarify the diagnosis of IOPD and provides the genetic counseling to tho...
Source: International Heart Journal - December 26, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Rupture of Aortic Sinus Aneurysms Diagnosed by Left Ventricular Opacification.
Authors: Zhang YL, Wang XC, Li XD, Hu C, Pei LP, Yu W, Ma Y, Jiang S Abstract Rupture of aortic sinus aneurysms is a rare cardiac malformation that is commonly observed in the right coronary sinus but is rarely observed in the noncoronary sinus. Here, we report a case of aneurysm of the aortic sinus that ruptured into the left ventricular outflow tract and was diagnosed with left ventricular opacification. Left heart echocardiography can clearly demonstrate the structure of the heart and is one of the important diagnostic methods for diagnosing ruptured aortic sinus aneurysms. This observes the perfusion sequence o...
Source: International Heart Journal - December 26, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Exercise Preconditioning Protects against Acute Cardiac Injury Induced by Lipopolysaccharide Through General Control Nonderepressible 2 Kinase.
Authors: Sun ZG, Lu G, Zhao LL, Zhang LZ, Li A, Jing J, Xu X Abstract Exercise preconditioning may protect against cardiac injury induced by lipopolysaccharide (LPS), but the mechanism is unresolved. The aim of this study is to explore whether the general control nonderepressible 2 (GCN2) kinase gene is associated with the protective effect of exercise preconditioning. Eight-week-old male C57BL/6J (n = 40) and GCN2 knockout (KO) (n = 40) mice were divided into four groups: control, LPS (L), exercise preconditioning (E), and exercise preconditioning LPS (EL). Mice in the exercise groups performed exercise for eight ...
Source: International Heart Journal - December 26, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Relationship Between Brain Hemodynamic State, Autonomic Nerve Input, and Symptoms of Atrial Fibrillation.
Authors: Matsubara TJ, Fujiu K PMID: 31787631 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - December 5, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Appetite Status After Transcatheter Aortic Valve Implantation.
Authors: Itoh H, Kaneko H PMID: 31787632 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - December 5, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Announcement: UEDA Heart Awards for 2019.
Authors: Abstract We are pleased to announce that the following 3 articles have been selected for the UEDA Heart Awards for the Year 2019. FIRST PLACEA Novel Truncating LMNA Mutation in Patients with Cardiac Conduction Disorders and Dilated CardiomyopathyHiroshi Kawakami, Akiyoshi Ogimoto, Naohito Tokunaga, Kazuhisa Nishimura, Hideo Kawakami, Haruhiko Higashi, Chiharuko Iio, Tamami Kono, Jun Aono, Teruyoshi Uetani, Takayuki Nagai, Katsuji Inoue, Jun Suzuki, Shuntaro Ikeda, Takafumi Okura, Yasumasa Ohyagi, Yasuharu Tabara, Jitsuo HigakiInt Heart J 2018; 59 (3): 531-541. SECOND PLACEAssociation Between the Presence ...
Source: International Heart Journal - December 5, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Long-Term Patency Rate of Radial Artery Conduits in Chinese Patients Undergoing Off-Pump Coronary Artery Bypass Grafting.
This study aimed to evaluate long-term patency of the RA conduit compared to the SV conduit for off-pump CABG, and to screen the independent predictors of long-term RA graft failure.Patients
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Aortic Valve Replacement with Bovine Pericardium in Patients with Aortic Valve Regurgitation.
This study aimed to analyze the early and mid-term outcomes of aortic valve replacement with bovine pericardium in the treatment of aortic valve regurgitation.From January 2015 to March 2018, 36 patients (19 men; mean ± standard deviation [SD] age, 46.70 ± 16.60 years) underwent aortic valve replacement with bovine pericardium. The bovine pericardium was intraoperatively measured and shaped using an Ozaki template, according to the shape and size of the individual patient's aortic valve leaflets. Additional procedures were performed, including ventricular septal defect repair in 5 cases, mitral valve reconstr...
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Low Consultation Rate of General Population with Atrial Fibrillation.
In conclusion, about one-third of the patients with AF did not regularly see a doctor in a medical institution and most of them had a CHADS2 score of more than one point in a Japanese rural area. Educating the public about the risks of AF is required. PMID: 31735770 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Permanent Pacing in a Patient with Left Ventricular Mid-Cavity Obstruction and Apical Aneurysm.
Authors: Miura S, Okada T, Kuroda H, Yamaguchi K, Yoshitomi H, Watanabe N, Endo A, Tanabe K Abstract Hypertrophic cardiomyopathy with left ventricular (LV) mid-cavity obstruction and LV apical aneurysm is associated with high morbidity and mortality rates. However, consensus is lacking on the treatment modality for LV mid-cavity obstruction and LV apical aneurysm. Here, we report a case of reduced LV mid-cavity pressure gradient and symptoms, treated using permanent pacing. The effect of permanent pacing on pressure gradient and symptoms lasted for 4 years. As pacing is relatively non-invasive compared to surgical ...
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Predictors of Early Postoperative Supraventricular Tachyarrhythmias in Children After the Fontan Procedure.
This study aimed to evaluate the prevalence of arrhythmias and identify the predictors of early postoperative supraventricular tachyarrhythmias (SVTs) after the Fontan procedure.Data were analyzed from 80 pediatric patients who underwent Fontan procedures between April 2000 and December 2017 in a single-center retrospective study. Early postoperative SVTs were defined as arrhythmias within 30 days after the Fontan procedure. We divided the patients into two groups, with or without early postoperative arrhythmias, and the predictors of early postoperative arrhythmias were analyzed. A multivariate logistic regression analysi...
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Interleukin-34 Levels Were Associated with Prognosis in Patients with Acute Myocardial Infarction.
Authors: Fan Q, Tao R, Zhang H, Xie H, Xi R, Wang F, Xu Y, Zhang R, Yan X, Gu G Abstract Inflammatory factors have specific value in acute myocardial infarction (AMI). Our previous studies have identified the prognostic value of interleukin (IL)-34 during chronic heart failure. However, the potential impact of IL-34 on AMI remains unknown.Serum IL-34 was measured in 287 AMI patients, and they were followed up for the composite endpoint, including cardiovascular death, heart failure hospitalization, recurrent nonfatal myocardial infarction (MI), and nonfatal stroke.IL-34 levels were significantly associated with the...
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Vildagliptin, a DPP-4 Inhibitor, Attenuates Endothelial Dysfunction and Atherogenesis in Nondiabetic Apolipoprotein E-Deficient Mice.
Authors: Aini K, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M Abstract Dipeptidyl peptidase-4 (DPP-4) inhibitors are novel antidiabetic agents with possible vascular protection effects. Endothelial dysfunction is an initiation step in atherogenesis. The purpose of this study was to investigate whether vildagliptin (Vilda) attenuates the development of endothelial dysfunction and atherosclerotic lesions in nondiabetic apolipoprotein E-deficient (ApoE-/-) mice. Eight-week-old nondiabetic ApoE-/- mice fed a Western-type diet received Vilda (50 mg/kg/day) for 20 weeks or 8 ...
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Peak Work Rate during Exercise Could Detect Frailty Status in Elderly Patients with Stable Heart Failure.
Authors: Kawashima K, Hirashiki A, Nomoto K, Kokubo M, Shimizu A, Sakurai T, Kondo I, Washimi Y, Arai H, Toba K, Murohara T Abstract The Kihon Checklist (KCL) is a reliable tool for determining frailty status in the elderly. However, there is no information in the literature about the relationship between frailty status and exercise capacity. Here, we examined the associations between cardiopulmonary exercise testing parameters and frailty status in elderly patients with stable heart failure (HF).Ninety-two elderly patients with stable HF were evaluated using cardiopulmonary exercise testing and the KCL. A KCL scor...
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Determinants of Improvement of Mid-term Ejection Fraction in Patients with Acute Myocardial Infarction.
Authors: Ohashi J, Sakakura K, Yamamoto K, Taniguchi Y, Tsukui T, Seguchi M, Nanba-Sato H, Shibata K, Sasaki W, Ikeda T, Wada H, Momomura SI, Fujita H Abstract Persistent severe left ventricular (LV) systolic dysfunction after acute myocardial infarction (AMI) is associated with increased morbidity and mortality, whereas mid-term recovery of LV systolic function after AMI is associated with better long-term outcomes. The purpose of this study was to investigate the determinants of mid-term improvement of LV ejection fraction (EF) in AMI patients. We included 210 AMI patients who had modified Simpson EF both at the ...
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Real-World Antithrombotic Therapy in Atrial Fibrillation Patients with a History of Percutaneous Coronary Intervention.
Authors: Horiguchi A, Fukaya H, Oikawa J, Shirakawa Y, Kobayashi S, Arakawa Y, Nishinarita R, Nakamura H, Ishizue N, Igarashi G, Satoh A, Kishihara J, Niwano S, Ako J Abstract Optimal antithrombotic strategy for atrial fibrillation (AF) patients with a history of percutaneous coronary intervention (PCI) has been under debate. The actual prescription trend of antithrombotic therapy for these patients remains unclear, especially in chronic phase.Patients with AF having at least a 1-year history of PCI were retrospectively evaluated in 2010, 2012, 2014, and 2016. A total of 266 patients were finally enrolled in this s...
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

The Effective Contact Force to Minimize Edema Relative to Chronic Lesion Formation During Radiofrequency Ablation in Ventricular Wall.
Authors: Yamashita K, Ghafoori E, Silvernagel J, Ashton J, J Dosdall D, MacLeod R, Ranjan R Abstract Radiofrequency (RF) ablation results in creation of acute edema which can lead to temporary disruption of electrical propagation.The goal of this study was to find the effective contact force (CF) to minimize edema formation in comparison to the lesion size.Ventricular RF lesions (n = 49) were created by a CF-sensing catheter in a canine model (n = 10) with varying force for 30 seconds. Animals underwent T2-weighted (T2w) and late gadolinium enhancement MRI (LGE-MRI) immediately after ablation and at 12 weeks. Acute...
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Combination of Lesion Stenosis and Myocardial Supply Area Assessed by Coronary Computed Tomography Angiography for Prediction of Myocardial Ischemia.
This study aimed to investigate whether using CTA to assess myocardial supply area can improve the prediction of myocardial ischemia.We analyzed 201 vessels with moderate (luminal narrowing ≥ 50%,
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Feasibility of Uninterrupted Direct Oral Anticoagulants with Temporary Switching to Dabigatran ("Dabigatran Bridge") for Catheter Ablation of Atrial Fibrillation.
Feasibility of Uninterrupted Direct Oral Anticoagulants with Temporary Switching to Dabigatran ("Dabigatran Bridge") for Catheter Ablation of Atrial Fibrillation. Int Heart J. 2019 Nov 15;: Authors: Aoyama D, Miyazaki S, Hasegawa K, Kaseno K, Ishikawa E, Mukai M, Miyahara K, Aiki T, Matsui A, Yamaguchi J, Shiomi Y, Tama N, Ikeda H, Fukuoka Y, Morishita T, Ishida K, Uzui H, Tada H Abstract Uninterrupted anticoagulation therapy during atrial fibrillation (AF) ablation minimizes the risk of periprocedural thromboembolic events. Although the use of direct oral anticoagulants (DOACs) has rapidly d...
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

MYH7 Gene-Related Mutation p.V878L Identified in a Chinese Family with Hypertrophic Cardiomyopathy.
Authors: Du Y, Wang Y, Han X, Feng Z, Ma A Abstract Hypertrophic cardiomyopathy (HCM) is one of the most common inherited cardiovascular diseases and possesses a high risk for sudden cardiac death. Although mutations in more than 20 genes have been reported to be associated with HCM thus far, the genetic backgrounds of most HCM patients are not fully understood. We performed a genetic analysis in a Chinese family that presented with HCM using next-generation sequencing (NGS). Clinical data, family histories, and blood samples were collected from the proband and family members. Five patients showed typical clinical ...
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Effect of Pre-Procedural Beta-Blocker on Clinical Outcome after Percutaneous Coronary Intervention in Acute Coronary Syndrome.
Authors: Kim BS, Eom SY, Kim SH, Hwang HK, Park JS, Kim W, Lee JW, Rha SW, Kim GY, Lim SW, Lee SH, Chae JK, Woo SI, Bae JW, Kim HJ Abstract The efficacy of pre-procedural beta-blocker use in patients with acute coronary syndrome (ACS) is not well established in the current percutaneous coronary intervention (PCI) era. We investigate the effect of pre-procedural beta-blocker use on clinical outcomes in patients with ACS undergoing PCI. Among 44,967 consecutive cases of PCI enrolled in the nationwide, retrospective, multicenter registry (K-PCI registry), 31,040 patients with ACS were selected and analyzed. We classif...
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Senescence Marker Protein 30 Deficiency Exacerbates Pulmonary Hypertension in Hypoxia-Exposed Mice.
In this study, we examined the role of SMP30 in pulmonary vasculature using SMP30-deficient mice.We used female SMP30-deficient mice and wild-type littermate (WT) mice at the age of 12 to 18 weeks. The WT and SMP30-deficient mice were exposed to normoxia or hypoxia (10% oxygen for 4 weeks). In normoxia, the right ventricular systolic pressure (RVSP) was not different between the WT and SMP30-deficient mice, but in hypoxia, the RVSP was significantly higher in the SMP30-deficient mice compared to the WT mice (P
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Different Effects of Pulmonary Vein Isolation on Quality of Life Between Patients with Persistent and Paroxysmal Atrial Fibrillation.
This study was performed to compare the changes in QOL after extended PVI between patients with PerAF and paroxysmal AF (PAF).Patients with PAF (n = 38) and PerAF (n = 22) who underwent their first PVI and developed no AF recurrence 6 months after PVI were enrolled. QOL surveys were performed at baseline and 6 months post-ablation using Short Form-36 surveys.The mental component summary score (MCS) (53.4 ± 10.2 to 56.5 ± 7.1, P = 0.019) and physical component summary score (PCS) (46.1 ± 10.6 to 48.5 ± 8.3, P = 0.015) improved after PVI in the PAF group. The PCS, but not the MCS, improved after P...
Source: International Heart Journal - November 19, 2019 Category: Cardiology Tags: Int Heart J Source Type: research