Alterations of Cardiac KATP Channels and Autophagy Contribute in the Late Cardioprotective Phase of Exercise Preconditioning.
Authors: Lu J, Pan SS, Wang QT, Yuan Y Abstract The cardiac effects of exercise preconditioning (EP) are well established; however, the mechanisms involving cardiac ATP-sensitive potassium channel (KATP channel) subunits and autophagy are yet to be fully established. The present work aims to investigate the alterations of cardiac KATP channel subunits Kir6.2, SUR2A, and autophagy-related LC3 during the late cardioprotective phase of EP against exhaustive exercise-induced myocardial injury. Rats run on treadmill for four running time intervals, each with 10 minutes running and rest. Exhaustive exercise was performed...
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Utilization of Emergency and Hospitalization Care after Coronary Artery Bypass Surgery for Patients with Ischemic Heart Disease.
Authors: Tseng HS, Chao ZH, Huang SK, Tung TH, Chien CW Abstract This retrospective follow-up study explored the status of patients with myocardial infarction with regard to the likelihood of being readmitted to the hospital within 30 days after undergoing coronary artery bypass surgery (CABG) and their survival status within one year of the procedure.The rate of readmission within 30 days was 10.7% (167/1,575), primarily due to surgical wound infection (11.3% of readmission cases), ischemic heart disease (10.3%), and heart failure (8.7%). The readmission group consisted mainly of older males with a high comorbidit...
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Postoperative Lung Perfusion with Anomalous Origin of One Pulmonary Artery from the Aorta.
We describe a newborn patient with anomalous origin of the right pulmonary artery from the aorta who presented with significant lung perfusion at the anastomotic site 6 months postoperatively; the left/right perfusion ratio was 10:90 on a scintigram. The unbalanced left/right lung perfusion gradually improved over a number of years. In a newborn patient with anomalous origin of one pulmonary artery from the aorta, unbalanced lung perfusion may improve. PMID: 30101844 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

The Adaptive Remodeling of the Anterior Mitral Leaflet and Chordae Tendineae Is Associated with Mitral Valve Function in Advanced Ischemic and Nonischemic Dilated Cardiomyopathy.
Authors: Yoshida S, Fukushima S, Miyagawa S, Yoshikawa Y, Hata H, Saito S, Saito T, Domae K, Kashiyama N, Matsuura R, Toda K, Sawa Y Abstract The degree or nature of functional mitral regurgitation (MR) is not necessarily correlated with the size or function of the left ventricle (LV). We hypothesized that the anatomical structure of the mitral valve (MV) complex might play a role in functional MR in ischemic or nonischemic dilated cardiomyopathy (DCM).The structure of the LV and MV complex in DCM patients (n = 29) was assessed using electrocardiogram-gated 320-slice computed tomography and was compared with that i...
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Screening and Function Analysis of MicroRNAs Involved in Exercise Preconditioning-Attenuating Pathological Cardiac Hypertrophy.
In this study, we aimed to screen the miRNAs involved in EP-attenuating pathological cardiac hypertrophy. The histological and echocardiographic parameters assessment showed that pathological cardiac hypertrophy induced by transverse aortic constriction (TAC) was significantly alleviated in EP treated rats. The left ventricular tissues (n = 3) from Sham, TAC and EP + TAC groups were subjected to small RNA deep sequencing. A total of 570 known mature miRNAs and 530 putative novel miRNAs were detected. DEGseq analysis showed that there were 37 and 88 differentially expressed miRNAs in the comparisons of TAC versus Sham and E...
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Relationship Between Serum Sodium Level Within the Low-Normal Range on Admission and Long-Term Clinical Outcomes in Patients with Acute Decompensated Heart Failure.
Authors: Hiki M, Kasai T, Yatsu S, Murata A, Matsumoto H, Kato T, Suda S, Miyazaki T, Takagi A, Daida H Abstract Although hyponatremia during hospitalization for acute decompensated heart failure (ADHF) is reportedly related with poor prognosis, the available data regarding the impact of serum sodium level within the low-normal range at admission on clinical events in patients with ADHF is limited.We studied eligible patients admitted to our institution in 2007-2011. All the patients were categorized into 3 groups according to the admission serum sodium levels of
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Regular Treatment Strategy with a Large Amount of Carvedilol for Heart Failure Improves Biventricular Systolic Failure in a Patient with Repaired Tetralogy of Fallot.
Authors: Soma K, Yao A, Saito A, Inaba T, Ishikawa Y, Hirata Y, Komuro I Abstract It is widely known that β-blockers exert beneficial effects on non-ischemic and ischemic systolic heart failure (sHF) in nonstructural hearts. However, whether β-blockers exert similar effects on sHF associated with congenital heart disease (CHD), particularly in an anatomical right ventricle, remains under debate.Here we report the case of an adult man with repaired tetralogy of Fallot suffering from biventricular heart failure. Treatment with carvedilol directly improved the systolic function of the right and left ventricl...
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

The Comparison of Clinical Outcomes After Drug-Eluting Balloon and Drug-Eluting Stent Use for Left Main Bifurcation In-Stent Restenosis.
Authors: Lee WC, Hsueh SK, Chen CJ, Yang CH, Fang CY, Wu CJ, Fang HY Abstract Increasing evidence is available for the use of percutaneous coronary intervention (PCI) in selected patients with unprotected left main (LM) bifurcation coronary lesions. However, little data have been reported on recurrent in-stent restenosis (ISR) for LM bifurcation lesions. The aim of this study was to evaluate the efficacy of a drug-eluting balloon (DEB) for LM bifurcation ISR compared with that of a drug-eluting stent (DES).Between December 2011 and December 2015, 104 patients who underwent PCI for unprotected LM bifurcation ISR wer...
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Candidacy for a Subcutaneous Implantable Cardioverter Defibrillator in Patients with Cardiac Resynchronization Therapy.
Authors: Kawabata M, Goya M, Takahashi Y, Maeda S, Yagishita A, Shirai Y, Kaneko M, Shiohira S, Hirao K Abstract In patients requiring an implantable cardioverter defibrillator (ICD), the combined use of a prior pacemaker and a subcutaneous ICD (S-ICD) could be an alternative treatment option to implantation of new leads or upgrading of pacemakers to an ICD if vascular access is limited. Here, we assessed the prevalence of S-ICD's eligibility according to surface electrogram screening in those receiving cardiac resynchronization therapy (CRT). S-ICD's eligibility was assessed in patients with a CRT pacemaker or a C...
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Randomized Trial of Effect of Urate-Lowering Agent Febuxostat in Chronic Heart Failure Patients with Hyperuricemia (LEAF-CHF).
This study investigates the efficacy and safety of febuxostat in chronic heart failure patients with hyperuricemia. PMID: 30101851 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Chronic Pressure Overload Induces Cardiac Hypertrophy and Fibrosis via Increases in SGLT1 and IL-18 Gene Expression in Mice.
In conclusion, the results indicate that chronic pressure overload increases SGLT1 and IL-18 gene expressions, leading to the development of hypertrophic cardiomyopathy. These results make SGLT1 a potential candidate for the therapeutic target for hypertension-induced cardiomyopathy. PMID: 30101852 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

A Case of Aortic Stenosis with Serum IgG4 Elevation, and IgG4-Positive Plasmacytic Infiltration in the Aortic Valve, Epicardium, and Aortic Adventitia.
Authors: Hourai R, Kasashima S, Fujita SI, Sohmiya K, Daimon M, Hirose Y, Katsumata T, Kanki S, Ozeki M, Ishizaka N Abstract A 74-year-old man was admitted for preoperative screening of aortic stenosis. Five months before this admission, he was found to have elevated serum immunoglobulin G4 (IgG4; 2,010 mg/dL). Computed tomography (CT) showed a soft tissue mass surrounding the abdominal aorta, suggestive of IgG4-related periaortitis. CT coronary angiography showed perivascular thickening of the right coronary artery, and subsequent coronary angiography showed a multi-vessel disease. The patient underwent aortic val...
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Right Ventricular Stroke Work Index.
Authors: Ibe T, Wada H, Sakakura K, Ito M, Ugata Y, Yamamoto K, Taniguchi Y, Momomura SI, Fujita H Abstract Recently, long-term outcomes of pre-capillary pulmonary hypertension (PH) have been improved, whereas morbidity and mortality are still high because of right-sided heart failure (HF). Right-sided HF is closely related to right ventricular (RV) function and hemodynamics such as RV stroke work index (RVSWI). However, the association between RVSWI and long-term outcomes in pre-capillary PH has not been well investigated. The aims of this study were to compare clinical characteristics between low RVSWI and high R...
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Outcomes in Patients with Critical Limb Ischemia due to Arteriosclerosis Obliterans Who Did Not Undergo Arterial Reconstruction.
In this study, we investigate the comorbidities and survival rates of patients with CLI who receive conservative treatment. Thirty-five patients with CLI due to ASO, who had not undergone revascularization surgery (C group), were enrolled. As controls, 136 patients with CLI due to ASO who did undergo revascularization (R group), mainly via bypass surgery, were enrolled. Coronary artery disease, heart failure, and respiratory dysfunction were factors indicating conservative treatment. Limb salvage rates and survival rates were not significantly different between the two groups. Patients who had survived for less than two ye...
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

A Novel Bioabsorbable Sheet That Delivers NF- κB Decoy Oligonucleotide Restrains Abdominal Aortic Aneurysm Development in Rats.
A Novel Bioabsorbable Sheet That Delivers NF-κB Decoy Oligonucleotide Restrains Abdominal Aortic Aneurysm Development in Rats. Int Heart J. 2018 Aug 11;: Authors: Akimoto S, Suzuki JI, Aoyama N, Ikeuchi R, Watanabe H, Tsujimoto H, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I Abstract For the suppression of inflammation in the aneurysm development, we focused on inhibition of an important transcription factor, nuclear factor-kappa B (NF-κB), using a decoy strategy. We newly developed a novel bioabsorbable sheet that delivers NF-κB decoy oligodeoxynucleotide (ODN).We treated 5-we...
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

A Multiple Biomarker Approach in Patients with Cardiac Sarcoidosis.
Authors: Kiko T, Yoshihisa A, Kanno Y, Yokokawa T, Abe S, Miyata-Tatsumi M, Misaka T, Oikawa M, Kobayashi A, Ishida T, Takeishi Y Abstract Sarcoidosis is a systemic granulomatous disease including heart (cardiac sarcoidosis, CS). It has recently been reported that isolated CS, which presenting primarily cardiac symptoms without clinical evidence of sarcoid involvement in other organs. Diagnostic and prognostic biomarkers of CS, especially in isolated CS, have not yet been established.We studied plasma levels of angiotensin-converting enzyme (ACE), soluble interleukin-2 receptor (sIL-2R), B-type natriuretic peptide ...
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Phenotypic Screening Using Patient-Derived Induced Pluripotent Stem Cells Identified Pyr3 as a Candidate Compound for the Treatment of Infantile Hypertrophic Cardiomyopathy.
Authors: Sakai T, Naito AT, Kuramoto Y, Ito M, Okada K, Higo T, Nakagawa A, Shibamoto M, Yamaguchi T, Sumida T, Nomura S, Umezawa A, Miyagawa S, Sawa Y, Morita H, Lee JK, Shiojima I, Sakata Y, Komuro I Abstract Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by hypertrophy of the myocardium. Some of the patients are diagnosed for HCM during infancy, and the prognosis of infantile HCM is worse than general HCM. Nevertheless, pathophysiology of infantile HCM is less investigated and remains largely unknown. In the present study, we generated induced pluripotent stem cells (iPSCs) from tw...
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Three Novel Mutations in FBN1 and TGFBR2 in Patients with the Syndromic Form of Thoracic Aortic Aneurysms and Dissections.
Authors: Cao Y, Tan H, Li Z, Linpeng S, Long X, Liang D, Wu L Abstract There are many inherited disorders associated with thoracic aortic aneurysms and dissections (TAADs), like Marfan syndrome and Loeys-Dietz syndrome (LDS). The 4 patients in this study all had TAADs and were initially diagnosed with suspected Marfan syndrome. We collected peripheral blood samples from the patients and their family members and then attempted to identify the causal mutation using different methods including PCR, Sanger sequencing, and next generation sequencing. We identified 3 novel heterozygous mutations including 2 splicing muta...
Source: International Heart Journal - August 15, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Do the Roles of Fats from Different Depots Differ in the Coronary Artery?
Authors: Nakayama A PMID: 30068833 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - August 3, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Is It Possible to Distinguish Patients with Terminal Stage of Heart Failure by Analyzing Their Breathing Patterns?
Authors: Yamaoka-Tojo M PMID: 30068834 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - August 3, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

The Impact of Non-Cardiac Drugs on the Cardiac Repolarization Phase.
Authors: Oshima T, Fujiu K PMID: 30068835 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - August 3, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Periodontitis and Diabetes Mellitus.
Authors: Akazawa H PMID: 30068836 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - August 3, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Interleukin-18.
Authors: Wang S, Chen F, Yang S, Shi J Abstract A prospective observational study was conducted to evaluate the predictive value of interleukin-18 (IL-18) for major adverse cardiovascular events (MACEs) in hemodialysis patients. A total of 85 participants (45 hemodialysis patients and 40 healthy volunteers) with a mean age of 56.3 years were enrolled in this study. Demographic and clinical data were collected. MACE was used as the primary endpoint. Results showed that the hemodialysis patients had higher levels of IL-18 (701.6 ± 88.52 versus 152.0 ± 55.31 pg/mL, P
Source: International Heart Journal - July 21, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Prognostic Value of a Simple Echocardiographic Parameter, the Right Ventricular Systolic to Diastolic Duration Ratio, in Patients with Advanced Heart Failure with Non-Ischemic Dilated Cardiomyopathy.
Authors: Xu B, Kawata T, Daimon M, Kimura K, Nakao T, Lee SC, Hirokawa M, Yoshinaga A, Watanabe M, Yatomi Y, Komuro I Abstract The prognostic value of the right ventricular (RV) systolic to diastolic duration ratio (S/D ratio) in patients with advanced heart failure is not clear.We enrolled 45 patients with DCM (40 ± 13 years, 33 male) who were admitted to our hospital for evaluation or treatment of heart failure. The RV systolic and diastolic durations were measured using continuous Doppler imaging of tricuspid regurgitation, and the RV S/D ratio was calculated. Cardiac events were defined as cardiac death ...
Source: International Heart Journal - July 21, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Transcatheter Closure of a Huge Ductus Arteriosus in a Severely Ill Neonate.
Authors: Okada S, Muneuchi J, Nagatomo Y, Yokota C, Ohmura J, Yamamoto J, Watanabe M, Iida C, Shirouzu H, Takahashi Y Abstract Hemodynamically significant patent ductus arteriosus (PDA) in preterm infants increases morbidity and mortality. Here we describe a 12-day-old neonate with a huge PDA who developed pulmonary hemorrhage following disseminated intravascular clotting and multiple organ failure. Medical treatment or surgical ligation could not be performed because of the patient's poor condition. Transcatheter closure using a commercially available device (Amplatzer Vascular Plug II) successfully treated the hu...
Source: International Heart Journal - July 18, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Early Transfer of Patients with Acute Heart Failure from a Core Hospital to Collaborating Hospitals and Their Prognoses.
Authors: Yamaguchi T, Miyamoto T, Sekigawa M, Watanabe K, Hijikata S, Yamaguchi J, Iwai T, Sagawa Y, Miyazaki R, Masuda R, Miwa N, Hara N, Nagata Y, Obayashi T, Nozato T Abstract Japan is facing problems associated with "heart failure (HF) pandemics" and bed shortages in core hospitals that can accommodate patients with acute HF. The prognosis is currently unknown for acute HF patients who were transferred from core hospitals to collaborating hospitals during the very early treatment phase and whose treatment strategies are in place.We enrolled 166 acute HF patients who were hospitalized between January 1...
Source: International Heart Journal - July 18, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Successful Transcatheter Diagnosis and Medical Treatment of Right Atrial Involvement in IgG4-related Disease.
Authors: Yano T, Yamamoto M, Mochizuki A, Ogawa T, Nagano N, Fujito T, Nishida J, Nagahara D, Abe K, Miki T, Suzuki C, Takahashi H, Ishibashi-Ueda H, Miura T Abstract IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder characterized by lymphoplasmacytic infiltration of numerous IgG4-positive plasma cells, leading to fibrous thickening in the affected tissue. Typical cardiovascular manifestations of IgG4-RD are periaortitis, coronary arteritis, and pericarditis. Rare cases of myocardial involvement in IgG4-RD have been reported, but surgical resection or open biopsy was required for the diagnosis in thos...
Source: International Heart Journal - July 18, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

In-Stent Restenosis with "Inflammatory" Neointima Following Everolimus-Eluting Stent Implantation.
In-Stent Restenosis with "Inflammatory" Neointima Following Everolimus-Eluting Stent Implantation. Int Heart J. 2018 Jul 15;: Authors: Tsuji Y, Koide M, Katsura K, Fujita H, Ishibashi-Ueda H, Otsuka F Abstract A 53-year-old male presented with acute myocardial infarction and was subsequently implanted with a 4.0 × 28 mm everolimus-eluting platinum chromium stent in his proximal left anterior descending artery. Eight months after the implantation, he developed exertional angina and underwent coronary angiography, which revealed significant in-stent restenosis (ISR). Percutaneous coronary...
Source: International Heart Journal - July 18, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

A Case of Cardiogenic Stroke After Thoracoscopic Left Atrial Appendectomy.
We report this case to introduce how we evaluate the risk of postoperative cardiogenic stroke by means of contrast-enhanced cardiac computed tomography (CT), and how we formulate the postoperative patient management strategy including short-term oral anticoagulation therapy by using results of cardiac CT. PMID: 29937454 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - June 27, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease.
This study sought to evaluate the clinical benefit of valvular surgery in patients with concomitant CKD.We evaluated 349 patients with significant VHD who were referred for surgery. Patients were divided into those with CKD stage ≥ 3 (CKD patients; n = 88) and those with CKD stage 1 or 2 (no CKD patients; n = 261). 63 patients did not receive surgery, of which 20 patients had CKD and 43 had no CKD. Mortality and change in eGFR were assessed after a median follow-up of 21 months.In the whole study population, 25% of the patients had CKD and these patients had higher mortality than those with no CKD. The annual mortality ...
Source: International Heart Journal - June 24, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Impact of Genetic Variation in Aldehyde Dehydrogenase 2 and Alcohol Consumption on Coronary Artery Lesions in Chinese Patients with Stable Coronary Artery Disease.
Authors: Xu L, Zhao G, Wang J, Shen C, Li X, Lu F, Jiang H, Liu G, Hu K, Tang Y, Sun A, Ge J Abstract The aim of this study is to investigate the impact of aldehyde dehydrogenase 2 (ALDH2) genotype and alcohol consumption on coronary artery lesions in Chinese patients with stable coronary artery disease (CAD). A total of 753 Chinese patients (73.6% male) diagnosed with stable CAD by coronary angiography were included in the sample. The frequency of the mutated type ALDH2*2 (including ALDH2*1/*2 and ALDH2*2/*2) was 44.1% in CAD patients. The mutated ALDH2 carriers were more susceptible to multivessel lesions. Low to...
Source: International Heart Journal - June 9, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Association Between the Presence or Severity of Coronary Artery Disease and Pericardial Fat, Paracardial Fat, Epicardial Fat, Visceral Fat, and Subcutaneous Fat as Assessed by Multi-Detector Row Computed Tomography.
In conclusion, paracardial fat index may be a marker for evaluating the presence or severity of CAD. PMID: 29877298 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - June 9, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Ascending Aorta and Myocardial Mechanics in Patients with "Clinically Normal" Bicuspid Aortic Valve.
In conclusion, LV myocardial deformation properties are impaired among BAV patients. The impairment of LV systolic mechanics observed in BAV patients appears to be related only to the congenital abnormality of the aortic valve itself. PMID: 29877299 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - June 9, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Asymptomatic Reactive Hypoglycemia and Inflammatory Reaction in Patients with Coronary Artery Disease.
In this study, the incidence of RH and its effect on arteriosclerosis were examined in CAD patients with a lengthy oral glucose tolerance test (OGTT).We performed a prospective cross-sectional study on 116 nondiabetic CAD patients [70 ± 9 years, 70% male, HbA1c
Source: International Heart Journal - June 9, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

MicroRNA-208a Correlates Apoptosis and Oxidative Stress Induced by H2O2 through Protein Tyrosine Kinase/Phosphatase Balance in Cardiomyocytes.
Authors: Liu A, Sun Y, Yu B Abstract MicroRNAs, a class of small and non-encoding RNAs that transcriptionally or post-transcriptionally modulate the expression of their target genes, have been implicated as critical regulatory molecules in ischemia-/reperfusion-induced cardiac injury. In the present study, we report on the role of miR-208a in myocardial I/R injury and the underlying cardio-protective mechanism. The gain-of-function and loss-of-function were used to explore the effects of miR-208a on cardiac injury induced by H2O2 in cardiomyocytes. As predicted, knockdown of endogenous miR-208a significantly decrea...
Source: International Heart Journal - June 9, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Combined Surgical and Medical Therapy for Candida Prosthetic Endocarditis in a Patient with Repaired Tetralogy of Fallot.
Authors: Kubota K, Soma K, Uehara M, Inaba T, Saito A, Takeda N, Hatano M, Morita H, Inuzuka R, Hirata Y, Yao A, Komuro I Abstract Candida prosthetic endocarditis (CPE) is an uncommon and fatal complication in adults with congenital heart disease. The current guidelines for the management of fungal endocarditis recommend a combination of surgical and medical therapy. However, it still remains uncertain when surgical management in CPE patients should be performed. Therefore, the prognosis of CPE patients is very poor. Here we report a case of CPE in a 31-year-old woman who had undergone surgical repair for tetralogy...
Source: International Heart Journal - June 9, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Prognosis of Cancer Patients with Aortic Stenosis Under Optimal Cancer Therapies and Conservative Cardiac Treatments.
Authors: Okura Y, Ishigaki S, Sakakibara S, Yumoto C, Hashitate M, Sekine C, Fujita T, Takayama T, Ozaki K, Sato N, Minamino T Abstract Aortic stenosis (AS) is a life-threatening comorbidity of cancer patients. Aortic valve replacement (AVR) should be considered for some cancer patients, but neither the characteristics nor prognosis under conservative therapy is well known.We searched our echocardiography log (years 2005-2014) for cancer patients with AS, and 92 patients (54% female) were included in the study. To compare the survival curves, 470 control patients without AS were selected from our cancer registry.Me...
Source: International Heart Journal - June 9, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Clinical Significance of the Presence of Oscillatory Breathing Both at Rest and During Exercise in Cardiac Patients.
Authors: Himi T, Koike A, Nagayama O, Kato Y, Nishi I, Sato A, Yamashita T, Aonuma K Abstract Cardiac patients often experience nocturnal and daytime oscillatory breathing (OB). OB noted at rest sometimes becomes unclear or even disappears during exercise. We evaluated the physiological significance of OB by comparing the clinical characteristics of cardiac patients who manifested OB only at rest (group A), only during exercise (group B), and both at rest and during exercise (group C).Among 3,432 cardiac patients who underwent cardiopulmonary exercise testing (CPX), 114, 94, and 65 patients were identified as group...
Source: International Heart Journal - June 9, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Improved Propensity-Score Matched Long-Term Clinical Outcomes in Patients with Successful Percutaneous Coronary Interventions of Coronary Chronic Total Occlusion.
The objective of the study was to evaluate major adverse cardiovascular events (MACE) after successful versus failed percutaneous coronary intervention for chronic total occlusion (PCI-CTO).Limited data are available on long-term clinical follow-up in the treatment of chronic total occlusion (CTO).Between January 2009 and December 2010 PCI-CTO was attempted in 283 consecutive patients with 289 CTO lesions. Procedural success was 62.3% and clinical follow-up covered 83% (235/283) of the study population with a median follow-up of 66 months (range, 59-74).The total incidence of MACE was 57/235 (24.3%), and was significantly ...
Source: International Heart Journal - June 9, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

A Case of Left Ventricular Thrombus with Superior Mesenteric Vein Thrombosis Due to Atopic Dermatitis.
Authors: Ito S, Endo A, Okada T, Yoshitomi H, Hyakudomi R, Tajima Y, Tanabe K Abstract A 55-year-old man was presented to the emergency room because of abdominal pain for 4 days. He had a history of atopic dermatitis. Left ventricular (LV) asynergy and thrombus was detected on echocardiography, and superior mesenteric vein thrombosis was detected by computed tomography. There are no reported cases of this combination of thrombi. We hypothesized that the reason for this complication is the combination of coagulation disorder due to atopic dermatitis, silent myocardial infarction, and exacerbation of the coagulation ...
Source: International Heart Journal - June 9, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Relationship Between Serum Eicosapentaenoic Acid Levels and J-Waves in a General Population in Japan.
Authors: Kimura Y, Yamada M, Hanada K, Endo T, Narita N, Narita M, Senoo M, Yonekura M, Ichikawa H, Kurauchi S, Nakaji S, Okumura K, Tomita H Abstract We previously showed that J-waves were found more frequently in patients with low levels of serum eicosapentaenoic acid (EPA) in the acute phase of myocardial infarction, and were associated with the incidence of ischemia-related ventricular arrhythmias. However, the relationship between J-waves and serum EPA levels in a general population remains to be elucidated.The Iwaki Health Promotion Project is an ongoing community-based health promotion study in Iwaki, Hirosa...
Source: International Heart Journal - June 9, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Increased Oral Porphyromonas gingivalis Prevalence in Cardiovascular Patients with Uncontrolled Diabetes Mellitus.
Authors: Aoyama N, Suzuki JI, Kobayashi N, Hanatani T, Ashigaki N, Yoshida A, Shiheido Y, Sato H, Izumi Y, Isobe M Abstract The aim of this study was to determine the correlation between periodontopathic bacteria and diabetes mellitus (DM) status in cardiovascular disease (CVD) subjects.DM is associated with the progression of periodontitis. Several epidemiological studies have suggested that periodontitis may be a risk factor for CVD. However, no study has compared the periodontal condition between well-controlled and poorly-controlled DM patients with CVD.The subjects were well-controlled (n = 73) or poorly-contr...
Source: International Heart Journal - June 9, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Usefulness of Red Blood Cell Distribution Width to Predict Heart Failure Hospitalization in Patients with Hypertrophic Cardiomyopathy.
Authors: Yang HJ, Liu X, Qu C, Shi SB, Liang JJ, Yang B Abstract Red cell distribution width (RDW) has been associated with heart failure (HF) hospitalization in the general population, but the correlation to HF hospitalization in patients with hypertrophic cardiomyopathy (HCM) is unclear.Ninety-eight HCM patients without a history of HF were enrolled and RDW was assessed as a predictor.During a 16.8 ± 9.0 month follow-up period, 17 subjects were hospitalized due to HF. HF hospitalization patients had higher RDW than non-HF patients (14.7 ± 1.4% versus 13.0 ± 0.9%, P
Source: International Heart Journal - June 9, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Can Torsemide and Combination of Loop Diuretics Improve Mortality in Patients with Chronic Heart Failure After Discharge?
Authors: Yao Y, Zhang J, Zhang Y, Zhang R Abstract The aim of this study was to investigate the effect on mortality of torsemide and a combination of loop diuretics (furosemide + torsemide) in contemporary practice in patients with chronic heart failure (HF).We investigated patients with HF in the Heart Failure Center of Fuwai Hospital from 2009 to 2013 who were discharged on furosemide, torsemide, or a combination of the 2 drugs. Using inverse probability weighting (IPW) to account for nonrandom selection of diuretic strategies, we assessed the association between different diuretic strategies and mortality.Among ...
Source: International Heart Journal - June 9, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Systemic Inflammatory Stress Response During Cardiac Surgery.
Authors: Sugita J, Fujiu K PMID: 29848891 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - June 1, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Sinus Node Recovery Time Can Predict Maintenance of Sinus Rhythm After Catheter Ablation for Long-Standing Atrial Fibrillation.
Authors: Imai Y, Yokoyama Y, Watanabe T PMID: 29848892 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - June 1, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Cardiomyopathy with LMNA Mutation.
Authors: Ito M, Nomura S PMID: 29848893 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - June 1, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Targeting Vascular Inflammaging with Amlodipine for Atherosclerosis Prevention.
Authors: Harada M, Ishizuka M, Murakami H, Toko H PMID: 29848894 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - June 1, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Letter by Xiao and Song Regarding the Article "Relation Between Obesity, Metabolic Syndrome, Successful Long-Term Weight Reduction, and Right Ventricular Function".
Letter by Xiao and Song Regarding the Article "Relation Between Obesity, Metabolic Syndrome, Successful Long-Term Weight Reduction, and Right Ventricular Function". Int Heart J. 2018;59(3):668 Authors: Xiao CY, Song ZZ PMID: 29848895 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - June 1, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Reply to Letter by Xiao and Song Regarding the Article, "Relation between Obesity, Metabolic Syndrome, Successful Long-Term Weight Reduction, and Right Ventricular Function".
Reply to Letter by Xiao and Song Regarding the Article, "Relation between Obesity, Metabolic Syndrome, Successful Long-Term Weight Reduction, and Right Ventricular Function". Int Heart J. 2018;59(3):669 Authors: Baessler A, Zeller J PMID: 29848896 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - June 1, 2018 Category: Cardiology Tags: Int Heart J Source Type: research