Tripartite Left Bundle Branch Area Pacing.
Authors: Hasumi E, Fujiu K PMID: 33518650 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Rate Versus Rhythm Control in Tachycardia-Induced Cardiomyopathy Patients with Persistent Atrial Flutter.
Authors: Oka S, Kai T, Hoshino K, Watanabe K, Nakamura J, Abe M, Watanabe A Abstract Tachycardia-induced cardiomyopathy (TIC) is a potentially reversible cardiomyopathy caused by tachyarrhythmia. For atrial flutter (AFL) -induced TIC, a rhythm control strategy, such as catheter ablation, has been recommended. However, the efficacy of rate control has remained unclear due to the difficulty of achieving control using arrhythmic medications.We prospectively assessed 47 symptomatic heart failure (HF) patients with left ventricular ejection fraction (LVEF)
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Prediction of Serious Adverse Events of Patients with Hypertrophic Cardiomyopathy by Magnetic Resonance.
Authors: Komuro J, Iguchi N, Utanohara Y, Takayama M, Umemura J, Tomoike H Abstract Although it is well known that patients with hypertrophic cardiomyopathy (HCM) have serious adverse events, such as life-threatening arrhythmia and heart failure, the prediction of such evens is still difficult. Recently, it has been reported that one of the causes of these serious adverse events is microvascular dysfunction, which can be noninvasively evaluated by employing cardiac magnetic resonance (CMR) imaging.We analyzed 32 consecutive HCM patients via CMR imaging and myocardial scintigraphy and divided them into two groups: v...
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Cardiac Biomarker Abnormalities Are Closely Related to Prognosis in Patients with COVID-19.
This study aims to delineate the relationship of cardiac biomarkers and outcomes in severe cases of corona virus disease 2019 (COVID-19). One hundred forty-eight critically ill adult patients with COVID-19 were enrolled. From these patients, the demographic data, symptoms, cardiac biomarkers, treatments, and clinical outcomes were collected. Data were compared between survivors and non-survivors. Four patients in the non-survivor group were selected, and their cardiac biomarkers were collected and analyzed. Among the 148 patients, the incidence of cardiovascular complications was 19 (12.8%). Five of them were survivors (5....
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

BIRC5, GAJ5, and lncRNA NPHP3-AS1 Are Correlated with the Development of Atrial Fibrillation-Valvular Heart Disease.
Authors: Zhao Z, Liu G, Zhang H, Ruan P, Ge J, Liu Q Abstract The aim of this study was to explore the pivotal genes or lncRNAs involved in the progression of atrial fibrillation (AF) -valvular heart disease (VHD). The mRNA profiling GSE113013 was obtained from the Gene Expression Omnibus database. The identification of differentially expressed genes (DEGs) and differentially expressed long non-coding RNAs (DElncRNAs) was performed. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were carried out for DEGs. Then, the construction of the protein-protein interaction (PPI) network ...
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Randomized Controlled Comparison of Optimal Medical Therapy with Percutaneous Recanalization of Chronic Total Occlusion (COMET-CTO).
Authors: Juricic SA, Tesic MB, Galassi AR, Petrovic ON, Dobric MR, Orlic DN, Vukcevic VD, Stankovic GR, Aleksandric SB, Tomasevic MV, Nedeljkovic MA, Beleslin BD, Jelic DD, Ostojic MC, Stojkovic SM Abstract The aim of this randomized prospective study was to evaluate the quality of life (QoL) using the "Seattle Angina Questionnaire" (SAQ) in patients with chronic total occlusion (CTO) in coronary arteries treated with either percutaneous coronary intervention (PCI) or optimal medical therapy (OMT), or only with OMT.The potential benefits of recanalization of CTO by PCI have been controversial because of t...
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Silence Is Golden.
We presented a case of focal AT that could be triggered by speech and terminated with the cessation of conversation. An electrophysiological study showed that the outbreak was associated with left atrial pressure rose. Radiofrequency ablation at the left atrial posterior-superior wall (earliest activation site) resulted in the immediate termination of AT. These electrophysiological characteristics indicated that the cardiac autonomic nervous system and/or left atrial pressure might play essential roles in the occurrences of speech-induced AT. PMID: 33518656 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Mitral Valve Repair for Isolated Libman-Sacks Endocarditis in a Patient with Primary Antiphospholipid Syndrome.
Authors: Ye T, Wang J, Liao S Abstract Libman-Sacks endocarditis, characterized by verrucous vegetations formation, is a typical cardiac manifestation of autoimmune diseases such as systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). Although typically mild and asymptomatic, Libman-Sacks endocarditis can lead to serious complications, including thromboembolic events, superimposed bacterial endocarditis, and severe valvular regurgitation and/or stenosis, and valve surgery may be required. Here, we report a case of mitral valve repair for a large Libman-Sacks vegetation in a 29-year-old woman with...
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Subclinical Cardiomyopathy in Miyoshi Myopathy Detected by Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging.
We present a case of a patient with MM incidentally diagnosed with concomitant cardiomyopathy. PMID: 33518658 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Electron Microscopy Revealed Massive Lipid Droplets in Cardiomyocytes in a Patient with Cardiogenic Shock Following a Fulminant Type 1 Diabetes Mellitus.
Authors: Sugawara R, Sugiyama H, Nakamura K, Tohgi K, Hongo T, Tsuchiya M, Momoki N, Nose S, Yutani C, Ikeda Y, Ikeda T, Ito H Abstract A 52-year-old man with consciousness disorder following a 2-day history of general fatigue, diarrhea, vomiting and excessive thirst was admitted to our hospital. Severe hyperglycemia (1,739 mg/dL) with a slightly elevated HbA1c level (6.9%), ketonuria and low C-peptide level (0.07 ng/mL) confirmed the diagnosis of fulminant type 1 diabetes mellitus (FT1DM). Following sudden unexplained cardiogenic shock shortly after the initiation of insulin therapy with no evidence of myocardial ...
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Fracture of a Temporary Inferior Vena Cava Filter.
We report the case of a 70-year-old woman who developed non-massive PE and proximal DVT, which were treated using an IVC filter; two filters were placed owing to the fracture of the filters. Few previous reports have discussed IVC fractures and the difficulty in detecting such fractures on computed tomography before retrieval. Based on our experience, we suggest that a temporary IVC filter for DVT treatment should be considered carefully. PMID: 33518660 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Erratum: Ueda Heart Awards for 2020.
Authors: Abstract There were errors in the announcement of the UEDA Heart Awards for the Year 2020 in the November 2020 issue. We would therefore like to officially announce that the following 6 articles have been selected for the UEDA Heart Awards for 2020. PMID: 33518661 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Identification of SLED1 as a Potential Predictive Biomarker and Therapeutic Target of Post-Infarct Heart Failure by Bioinformatics Analyses.
Authors: Zhang J, Wang J, Wu Y, Li W, Gong K, Zhao P Abstract The aim of this study was to explore potential predictive biomarkers and therapeutic targets of post-infarct heart failure (HF) using bioinformatics analyses.CEL raw data of GSE59867 and GSE62646 were downloaded from the GEO database. Differentially expressed genes (DEGs) between patients with ST-segment elevation myocardial infarction (STEMI) and those with stable coronary artery disease (CAD) at admission and DEGs between admission and 6 months after myocardial infarction (MI) in patients with STEMI were analyzed. A gene ontology (GO) analysis and a ge...
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Comparison of Clinical Characteristics of Acute Myocardial Infarction Between Young ( < 55 Years) and Older (55 to < 70 Years) Patients.
Comparison of Clinical Characteristics of Acute Myocardial Infarction Between Young (
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Percutaneous Mitral Valve Intervention Using MitraClip for Functional Mitral Regurgitation and Heart Failure.
Authors: Kaneko H, Kiriyama H, Kamon T, Itoh H, Kodera S, Fujiu K, Daimon M, Morita H, Hatano M, Komuro I Abstract Functional mitral regurgitation (FMR) frequently coexists with left ventricular systolic dysfunction and advanced heart failure, and typically has poor clinical outcomes. Although various therapeutic options including cardiac resynchronization therapy and surgical mitral intervention, have been proposed, an optimal treatment strategy for functional mitral regurgitation has not yet been established. Over the last decade, transcatheter mitral valve repair using MitraClip has emerged as a novel alternativ...
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Early Vascular Response to Ultrathin Biodegradable Polymer Sirolimus-Eluting Stents for the Treatment of ST-Elevation Myocardial Infarction After Plaque Rupture.
We examined this response in 20 patients with STEMI caused by plaque rupture using frequency-domain optical coherence tomography (OCT) to understand the underlying mechanisms. Plaque rupture was diagnosed by OCT before PCI with BP-SES implantation was performed. OCT was again performed before the final angiography (post-PCI) and after 2 weeks (2W-OCT).BP-SES placement caused protrusion of atherothrombotic material into the stent lumen and incomplete stent apposition in all patients. After 2 weeks, incomplete stent apposition was significantly reduced (% malapposed struts: post-PCI 4.7 ± 3.3%; 2W-OCT 0.9 ± 1.2%; P
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Handgrip Strength Is an Independent Predictor of Cardiovascular Outcomes in Diabetes Mellitus.
This study examined this relationship and investigated the predictors of cardiovascular events in this population.This study enrolled 161 patients with DM and no history of cardiovascular diseases who were admitted to our hospital for the treatment of DM between September 2012 and December 2015. Patients were divided into sarcopenia and non-sarcopenia groups, and were followed until March 2019. The primary endpoint was major adverse cardiovascular events (MACE).The mean age was 65.9 ± 1.8 years old and the mean follow-up period was 4.1 ± 0.8 years. The log-rank test indicated that MACE differed significantly ...
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Role of Intracardiac Defibrillation During the Ablation Procedure as a Predictor of Atrial Fibrillation Recurrence After Catheter Ablation.
This study aimed to investigate the change in the IDF threshold before and after RFCA during the ablation procedure and determine whether the IDF threshold after RFCA was associated with the AF substrate and AF recurrence. A total of 141 consecutive patients with drug-refractory persistent AF (age 62.5 ± 10.3 years, 84.4% male) were enrolled in this study. Before RFCA, we initially performed IDF with an output of 1 J. When IDF failed to restore SR, the output was gradually increased to 30 J. After RFCA, we attempted pacing-induced AF to provoke other focuses of AF. When AF was induced, we performed IDF again to term...
Source: International Heart Journal - February 2, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Relationship Between Mitral Leaflet Size and Coaptation and Their Associated Factors in Patients with Normal Left Ventricular Size and Systolic Function.
Authors: Xu B, Daimon M, Kawata T, Nakao T, Hirokawa M, Sawada N, Kimura K, Yamanaka Y, Morita H, Komuro I, Yatomi Y Abstract Enlargement of the mitral valve (MV) has gained attention as a compensatory mechanism for functional mitral regurgitation (FMR). We aimed to determine if MV leaflet area is associated with MV coaptation-zone area and identify the clinical factors associated with MV leaflet size and coaptation-zone area in patients with normal left ventricle (LV) systolic function and size using real-time 3D echocardiography (RT3DE).We performed RT3DE in 135 patients with normal LV size and ejection fraction....
Source: International Heart Journal - January 20, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Atrioventricular Block after Tricuspid Valve Surgery.
Authors: Herrmann FEM, Graf H, Wellmann P, Sadoni S, Hagl C, Juchem G Abstract Tricuspid valve (TV) surgery is associated with a high risk of postoperative pacemaker requirement. We set out to identify the incidence of atrioventricular block (AVB) after TV surgery and determine whether atrioventricular conduction recovers within time.We investigated pre/intra- and postoperative predictors of AVB in patients who underwent tricuspid valve surgery (not only isolated TV surgery) at our institution between 2004 and 2017. Patients who had pacemakers prior to surgery were excluded.One year after surgery, 5.8% of the survi...
Source: International Heart Journal - January 20, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Quantification of Left Atrial Fibrosis in Patients After Pulmonary Vein Isolation Using the Second-Generation Cryoballoon.
This study examined the extent of low-voltage areas in patients with recurrence of atrial tachyarrhythmia (ATA) after CB-based pulmonary vein isolation (PVI).Sixty patients (mean age 67 ± 10 years, n = 32 female; n = 34 paroxysmal AF) who received radiofrequency redo-procedure due to recurrence of ATA within 6 months after CB-based PVI were included. A point-by point 3D-map was performed, and low-voltage sites were delineated based on bipolar voltage 50%).The median area of LA low-voltage sites was 28.9 (9; 50.3) cm2, corresponding to 17.4 (6; 30.6) % of the LA wall surface. 17/60 (28.3%) patients were categorized a...
Source: International Heart Journal - January 20, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Late Stent Thrombosis After Drug-Coated Balloon Coronary Angioplasty for In-Stent Restenosis.
Authors: Wang W, Wang B, Chen Y, Wei S Abstract A 41-year-old woman with chest pain for 6 hours was admitted to our chest pain center, presenting with acute myocardial infarction. Coronary angiography showed acute total occlusion in the proximal left anterior descending artery due to late stent thrombosis. After thrombus aspiration and intracoronary administration of 0.5 mg tirofiban, repeated angiography showed that no obvious residual stenosis remained. The patient underwent drug-coated balloon angioplasty 69 days ago and was then administered dual antiplatelet treatment (aspirin and clopidogrel) uninterruptedly....
Source: International Heart Journal - January 20, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

FLNC and MYLK2 Gene Mutations in a Chinese Family with Different Phenotypes of Cardiomyopathy.
Authors: Qin X, Li P, Qu HQ, Liu Y, Xia Y, Chen S, Yang Y, Huang S, Wen P, Zhou X, Li X, Wang Y, Tian L, Hakonarson H, Wu Y, Zhuang J Abstract Mutations in the sarcomeric protein filamin C (FLNC) gene have been linked to hypertrophic cardiomyopathy (HCM), as they have been determined to increase the risk of ventricular arrhythmia and sudden death. Thus, in this study, we identified a novel missense mutation of FLNC in a Chinese family with HCM, and, interestingly, a second novel truncating mutation of MYLK2 was discobered in one family member with different phenotype.We performed whole-exome sequencing in a Chinese...
Source: International Heart Journal - January 20, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Angiotensin II Increases HMGB1 Expression in the Myocardium Through AT1 and AT2 Receptors When Under Pressure Overload.
Authors: Zhang L, Zhang B, Yu Y, Wang J, Wu J, Su Y, Jiang H, Zou Y, Ge J Abstract High-mobility group box 1 (HMGB1) is increased in the myocardium under pressure overload (PO) and is involved in PO-induced cardiac remodeling. The mechanisms of the upregulation of cardiac HMGB1 expression have not been fully elucidated. In the present study, a mouse transverse aortic constriction (TAC) model was used, and an angiotensin II (Ang II) type 1 (AT1) receptor inhibitor (losartan) or Ang II type 2 (AT2) receptor inhibitor (PD123319) was administrated to mice for 14 days. Cardiac myocytes were cultured and treated with Ang...
Source: International Heart Journal - January 20, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Incidence, Risk Factors, and Outcomes of Coronary Obstruction Following Valve-in-Valve Transcatheter Aortic Valve Replacement.
Authors: Gao Z, Wang Y, Qian D, Jin J Abstract There is scant information about the incidence, risk factors, and outcomes of coronary obstruction (CO) following valve-in-valve transcatheter aortic valve replacement (VIV-TAVR). A meta-analysis of the published studies from January 2000 to April 2020 was conducted, and the endpoint was CO. A total of 2858 patients were enrolled in this study. The mean age was 77.7 ± 9.8, and 39.9% of them were female. The Society of Thoracic Surgeons (STS) score, European System for Cardiac Operative Risk Evaluation (EuroSCORE), and Logistic EuroSCORE were 8.9 ± 7.8, 16...
Source: International Heart Journal - January 20, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Risk Stratification of Percutaneous Edge-to-Edge Repair by MitraClip in Patients with Mitral Regurgitation.
Authors: Tanaka S, Imamura T, Ushijima R, Fukuda N, Ueno H, Kinugawa K Abstract Edge-to-edge repair using the MitraClip system is indicated in patients with severe mitral regurgitation (MR) who are at high risk for open-heart surgery due to comorbidity or reduced cardiac function. However, less is known about pre-procedural risk factors for mortality and morbidity following MitraClip implantation. Consecutive 25 patients with severe MR who underwent MitraClip therapy (mean age, 77 years old, 14 males) were included. Right heart catheterization and echocardiographic data before and after the procedure were collected...
Source: International Heart Journal - January 20, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Intravenous Mineralocorticoid Receptor Antagonist Use in Acutely Decompensated Heart Failure with Diuretic Resistance.
We report the well-tolerated use of intravenous MRAs as a rescue procedure in 3 patients admitted for ADHF with important diuretic resistance. Undertaking trials evaluating the effect of this therapeutic strategy in ADHF could represent a promising avenue. PMID: 33455988 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - January 20, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Predictors of AVNRT Recurrence After Slow Pathway Modification.
Authors: Wegner FK, Habbel P, Schuppert P, Frommeyer G, Ellermann C, Lange PS, Leitz P, Köbe J, Wasmer K, Eckardt L, Dechering DG Abstract Atrioventricular nodal reentry tachycardia (AVNRT) is the most common regular supraventricular tachycardia (SVT). Slow pathway modification (SPM) is the accepted first line treatment with reported success rates around 95%. Information regarding possible predictors of AVNRT recurrence is scarce.Out of 4170 consecutive patients with SPM in our department from 1993-2018, we identified 78 patients (1.9%) receiving> 1 SPM (69% female, median age 50 years) with a recurrence of...
Source: International Heart Journal - January 20, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Basilar Artery Dissection Complicated with Infective Endocarditis.
Authors: Kawano A, Masutani S, Inui A, Honma H, Igarashi T, Tsuneoka H, Sakamoto W, Sakurai Y, Dembo T, Imanaka K Abstract A 14 year-old boy developed infective endocarditis of the mitral valve caused by Methicillin-sensitive Staphylococcus aureus and became comatose. Isolated basilar artery dissection was initially observed on the 3rd day by magnetic resonance imaging (MRI), ie, it did not exist on day 1. He underwent successful urgent mitral valve repair on the 5th day because of highly mobile vegetations and a newly emerged brain infarction under optimal antibiotic administration. Postoperatively, he recovered w...
Source: International Heart Journal - January 20, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Use of Impella CP Device in Off-Pump Coronary Artery Bypass Graft Surgery.
We report a case of a 66-year-old male with multiple comorbidities and low cardiac output undergoing OPCABG. Impella CP device was deployed for "in-pump" support during surgical coronary revascularization resulting in intraoperative stability and uncomplicated post-operative recovery.Previous reports have described the use of the Impella Recover LP 5.0 device for use during OPCABG. We describe the successful and safe perioperative use of the Impella CP device. Despite lower flow rates, adequate support was achieved and the transfemoral cannulation and smaller outer diameter than the Impella 5.0 device may decreas...
Source: International Heart Journal - January 20, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Mid-Aortic Syndrome in Williams-Beuren Syndrome with an Atypical Small-Sized Deletion of Chromosome 7q11.23 Misdiagnosed as Takayasu Arteritis.
We report a case of incidentally diagnosed MAS caused by WBS without typical manifestations caused by an atypical small-sized deletion in chromosome 7q11.23, which was initially misdiagnosed as Takayasu arteritis. PMID: 33455992 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - January 20, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Hypertrophic Cardiomyopathy Complicated by Cardiac Sarcoidosis Diagnosed by Both the Morphological Abnormalities and the Time Course of the Disease.
In this study, we report a patient who had initially been diagnosed with hypertrophic obstructive cardiomyopathy (HOCM). The patient developed complete atrioventricular block (CAVB) and morphological abnormalities, which led to his primary diagnosis being re-conducted. Moreover, we made a definite diagnose of isolated CS (ICS) based on the guideline for the diagnosis and treatment using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT)1) and performed tailor-made treatment including immunosuppressive therapy. PMID: 33455993 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - January 20, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Increased Circulating Cathepsin L in Patients with Coronary Artery Disease.
This study investigated the hypothesis that plasma CatL is associated with the prevalence of coronary artery disease (CAD). Between February May 2011 and January 2013, 206 consecutive subjects were enrolled from among patients who underwent coronary angiography and percutaneous coronary intervention treatment. Age-matched subjects (n = 215) served as controls. Plasma CatL and high-sensitive C-reactive protein (hs-CRP) and high-density lipoprotein cholesterol were measured. The patients with CAD had significantly higher plasma CatL levels compared to the controls (1.4 ± 0.4 versus 0.4 ± 0.2 ng/mL, P
Source: International Heart Journal - January 6, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

Electrophysiological Insights into Three Modalities of Left Bundle Branch Area Pacing in Patients Indicated for Pacing Therapy.
Authors: Zhang J, Sheng X, Pan Y, Wang M, Fu G Abstract Left bundle branch pacing (LBBP) has been adopted as a new pacing therapy whether in routine pacing or patients with heart failure, but the criteria for a completely captured LBBP are too complicated and have a low success rate in routine clinical practice.Consecutive patients with pacing therapy indications were enrolled. Left bundle branch area pacing (LBBAP) was conducted, and the presence of LBB potential, paced QRS duration, stimulus to left ventricular activation time (Stim-LVAT), and LBB potential to left ventricular activation time (LBB po-LVAT) were d...
Source: International Heart Journal - January 6, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

The Clinical Efficacy of N-Acetylcysteine in the Treatment of ST Segment Elevation Myocardial Infarction.
Authors: Jiang SJ, Huang CH Abstract The aim of this study was to evaluate the clinical efficacy of N-acetylcysteine (NAC) in the treatment of ST segment elevation myocardial infarction (STEMI).PubMed, EMBASE, Cochrane Library, and Web of Science were searched systematically from the establishment of the database to June 2020. Two researchers independently completed literature screening and data extraction and conducted a meta-analysis.Nine articles including 1419 patients were enrolled. Meta-analysis showed that all-cause mortality [RR = 0.56, 95%CI (0.33, 0.93), P = 0.02], occurrence of major adverse cardiovascul...
Source: International Heart Journal - January 6, 2021 Category: Cardiology Tags: Int Heart J Source Type: research

The New Target of Vulnerable Plaque.
Authors: Oshima T, Fujiu K PMID: 33250484 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - December 1, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Most Cited Articles in 2019.
Authors: PMID: 33250485 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - December 1, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Announcement: UEDA Heart Awards for 2020.
Authors: Abstract We are pleased to announce that the following 6 articles have been selected for the UEDA Heart Awards for the Year 2020.FIRST PLACEActivation of DNA Damage Response and Cellular Senescence in Cardiac Fibroblasts Limit Cardiac Fibrosis After Myocardial InfarctionMasato Shibamoto, Tomoaki Higo, Atsuhiko T. Naito, Akito Nakagawa, Tomokazu Sumida, Katsuki Okada, Taku Sakai, Yuki Kuramoto, Toshihiro Yamaguchi, Masamichi Ito, Yuki Masumura, Shuichirou Higo, Jong-Kook Lee, Shungo Hikoso, Issei Komuro, Yasushi SakataInt Heart J 2019; 60 (4): 944-957.SECOND PLACEPressure Overload Impairs Cardiac Function ...
Source: International Heart Journal - December 1, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

MiR-324/SOCS3 Axis Protects Against Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury and Regulates Myocardial Ischemia via TNF/NF- κB Signaling Pathway.
MiR-324/SOCS3 Axis Protects Against Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury and Regulates Myocardial Ischemia via TNF/NF-κB Signaling Pathway. Int Heart J. 2020 Nov 13;: Authors: Han X, Chen X, Han J, Zhong Y, Li Q, An Y Abstract We aimed at exploring the function of microRNA-324/cytokine signaling 3 (miR-324/SOCS3) axis in hypoxia/reoxygenation (H/R) -induced cardiomyocyte injury and its underlying mechanism. The differential expression genes were analyzed based on the GSE83500 and GSE48060 datasets from the Gene Expression Omnibus (GEO) database. Then, to conduct the function enrichm...
Source: International Heart Journal - November 17, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Efficacy of Fractional Flow Reserve-Guided Percutaneous Cornary Intervention for Patients with Angina Pectoris.
This study was performed to confirm whether FFR-guided PCI improves the prognosis compared with other treatments. Multiple databases were searched for studies published from 2000 to 2018, and a network meta-analysis (NMA) was performed to compare outcomes of FFR-guided PCI, non-FFR-guided PCI, coronary artery bypass grafting (CABG), and medical treatment (MT) for AP based on estimated odds ratios (ORs). The study included 18,093 patients from 15 randomized controlled trials (RCTs). No evidence of inconsistency was observed among the studies. The NMA showed that the all-cause mortality of FFR-guided PCI was not significantl...
Source: International Heart Journal - November 17, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Comparison of Measured Data between Pre- and Post-Radiotherapy in a Patient with Cardiac Resynchronization Therapy Defibrillator.
Authors: Kubo T, Iida K, Tamai S Abstract Although some researches proved the influence of radiation therapy (RT) on pacemakers and implantable cardioverter defibrillators, little has been reported on cardiac resynchronization therapy defibrillators (CRTDs). We experienced a case of RT on CRTD and had a new finding.A patient with CRTD implanted for dilated cardiomyopathy was diagnosed with lung squamous cell carcinoma and started receiving RT. All the implanted devices, including the main body of CRTD, left ventricular lead (LV), right ventricular lead with high-voltage conductor, and right atrial lead, were from t...
Source: International Heart Journal - November 17, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Time-Dependent Changes in Porcelain Aorta and Aortic Stenosis in a Patient with Systemic Lupus Erythematosus.
Authors: Hirose K, Kodera S, Daimon M, Komuro I Abstract Porcelain aorta, defined as extensive calcification of the ascending aorta or aortic arch, is a reported risk factor for embolic stroke during cardiac surgery. However, the time course of the progression of aortic calcification leading to porcelain aorta has not been elucidated. We herein describe a 70-year-old woman who was followed up for systemic lupus erythematosus and antiphospholipid syndrome for approximately 20 years. A routine computed tomography scan revealed progression of ascending aortic calcification to porcelain aorta. The calcification was abs...
Source: International Heart Journal - November 17, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Long-Term Prognosis of Patients Who Underwent Percutaneous Transvenous Mitral Commissurotomy for Mitral Stenosis.
We examined 77 of 93 patients (83%) with MS and who underwent PTMC from 1989 to 2002 at our institute, as well as the occurrence of either one of the following clinical endpoints until September 1, 2018: all-cause death or repeat intervention for the mitral valve.The mean follow-up duration was 20.5 ± 7.3 years. The mean age was 51 ± 11 years. Overall, the 20-year survival rate was 71% ± 5%; without any intervention, the 20-year survival rate was 40% ± 6%. In patients who achieved good immediate results (i.e., mitral valve area (MVA) of ≥ 1.5 cm2 without mitral regurgitation (MR) of> 2/4 a...
Source: International Heart Journal - November 17, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Serum Dickkopf-3 Level Is Inversely Associated with Significant Coronary Stenosis in an Asymptomatic Chinese Cohort.
Authors: Wang L, Liu S, Niu J, Zhao Z, Xu M, Lu J, Li M, Wang T, Chen Y, Wang S, Dai M, Bi Y, Wang W, Ning G, Xu Y Abstract Dickkopp-3 (DKK3) has been identified to play a protection role against atherosclerosis. However, little is known about the relationship between serum DKK3 levels and subclinical coronary atherosclerosis. We aimed to investigate the association of serum DKK3 with coronary stenosis in an asymptomatic Chinese population. A total of 550 Chinese adults aged 40-60 years and without symptoms or histories of cardiovascular diseases were randomly selected to undergo coronary computed tomography angiog...
Source: International Heart Journal - November 17, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Comparison of Health-Related Quality of Life in Adults Undergoing Transthoracic and Transcatheter Device Closure for Ventricular Septal Defects.
This study aims to compare and analyze the health-related quality of life (HRQoL) of adult patients with ventricular septal defects (VSDs) who underwent transthoracic or transcatheter device closure.The HRQoL data of 30 patients who underwent transthoracic device closure for VSDs and 30 who underwent transcatheter device closure for VSDs were retrospectively evaluated before and one year after the procedure. The Medical Outcomes Study 36-Item Short-Form (SF-36), the Hospital Anxiety and Depression Scale (HADS), and a self-designed questionnaire were used as evaluation tools.After treatment, both groups showed significant i...
Source: International Heart Journal - November 17, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Transcatheter Closure of Large Coronary-Cameral Fistulas Using the Patent Ductus Arteriosus Occluder or Amplatzer Vascular Plugs.
Authors: Tang L, Wang ZJ, Tang JJ, Fang ZF, Hu XQ, Tai S, Xing ZH, Shen XQ, Zhao YS, Zhou SH Abstract Transcatheter closure (TCC) has emerged as the first-line treatment for coronary artery fistulas. However, limited data exist regarding the long-term outcomes and technical aspects of this procedure. We aimed to report the long-term outcomes and technical aspects of TCC of large coronary-cameral fistulas (CCFs).All patients with large CCFs who underwent attempted TCC using the patent ductus arteriosus (PDA) occluder or Amplatzer vascular plug (AVP), from June 2002 to December 2017, were retrospectively reviewed. A ...
Source: International Heart Journal - November 17, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Higher Pulmonary Arterial Pressure Was Related to Non-Pulmonary Vein Atrial Tachyarrhythmia.
This study aimed to explore the clinical outcome of recurrent ATA ablation after PVI and the difference between patients with and without non-PV ATA.A total of 49 patients without structural heart diseases who received catheter ablation for recurrent AF between January 2014 and December 2018 were recruited (prior ablation with PVI only 71.4% and PVI with cavotricuspid isthmus line ablation 28.6%). Patients were divided into two groups according to the presence or absence of non-PV ATA.Most patients (53.1%) experienced very late recurrence with a median duration of 15 months. A total of 15 patients had non-PV ATA and receiv...
Source: International Heart Journal - November 17, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Determinants of Periprocedural Myocardial Infarction in Current Elective Percutaneous Coronary Interventions.
Authors: Mizuno Y, Sakakura K, Yamamoto K, Taniguchi Y, Tsukui T, Seguchi M, Wada H, Momomura SI, Fujita H Abstract Periprocedural myocardial infarction (PMI) is closely associated with long-term cardiovascular events. The factors associated with PMI are not fully understood. The purpose of this study was to investigate the determinants of PMI in contemporary elective percutaneous coronary intervention (PCI). Overall, 731 elective PCI was divided into the PMI (n = 27) and non-PMI (n = 704) groups. Univariate and multivariate logistic regression analysis was used to find factors associated with PMI. In the univariat...
Source: International Heart Journal - November 17, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Anticoagulation in Patients with Heart Failure and Sinus Rhythm.
Authors: Li X, Yang J, Xu D Abstract The risk of thromboembolic events is significantly increased among patients with heart failure, even in those without atrial fibrillation. However, it is still unclear whether patients with heart failure and sinus rhythm can benefit from prophylactic anticoagulant therapy.This was a retrospective review of the pathophysiological mechanisms, epidemiological studies, and clinical trials on anticoagulation in patients with heart failure and sinus rhythm.Some subgroup analyses of clinical trials found that prophylactic anticoagulant therapy could reduce the incidence of stroke in pa...
Source: International Heart Journal - November 17, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Responses to Treatment According to the Cytokine Profiles of Pericardial Effusion in Two Children with Idiopathic Pericarditis.
Authors: Motonaga T, Furuta T, Okada S, Ohnishi Y, Suzuki Y, Yasudo H, Hasegawa S Abstract Acute pericarditis is inflammation of the pericardium with or without pericardial effusion. In the pediatric population, most patients with acute pericarditis are diagnosed with idiopathic pericarditis. Herein, we present two children with idiopathic pericarditis who underwent immunological assessment of pericardial effusion for the first time. Both patients showed equally high levels of interleukin-6 in the pericardial effusion. However, they had different treatment responses, in accordance with the pericardial effusion and ...
Source: International Heart Journal - November 17, 2020 Category: Cardiology Tags: Int Heart J Source Type: research