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Off-Pump Coronary Artery Bypass Grafting with Mini-Sternotomy in the Treatment of Triple-Vessel Coronary Artery Disease.
Authors: Su P, Gu S, Liu Y, Zhang X, Yan J, An X, Gao J, Xin Y, Zhou J Abstract We have developed off-pump coronary artery bypass approach with lower distal mini-sternotomy (TM-OPCAB) for multivessel coronary revascularization. The aim of this retrospective study is to provide evidence for the feasibility and safety of this technique in the treatment of triple-vessel diseases.Two hundred eighty-eight patients with triple-vessel coronary artery disease who underwent TM-OPCAB or standard off-pump coronary artery bypass surgery (S-OPCAB) were included in this study after propensity-score matching. We retrospectively r...
Source: International Heart Journal - April 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Recovery of Endothelial Function after Minor-to-Moderate Surgery Is Impaired by Diabetes Mellitus, Obesity, Hyperuricemia and Sevoflurane-Based Anesthesia.
Authors: Ohno S, Kohjitani A, Miyata M, Tohya A, Yamashita K, Hashiguchi T, Ohishi M, Sugimura M Abstract Endothelial dysfunction is observed in several cardiovascular diseases, where endothelium-dependent vasodilation is impaired by oxidative stress. However, the time course of endothelial function during the perioperative period of a minor-to-moderate surgery, and the effects of atherosclerotic risk factors and employed general anesthetics on recovery of endothelial function, are unknown. Endothelial function of 30 patients was evaluated as the reactive hyperemia index (RHI) of reactive hyperemia peripheral arter...
Source: International Heart Journal - April 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

MicroRNA-208a Regulates H9c2 Cells Simulated Ischemia-Reperfusion Myocardial Injury via Targeting CHD9 through Notch/NF-kappa B Signal Pathways.
In conclusion, miR-208a was a cardiac-enriched miRNA and CHD9 is a direct target of miR-208a, which was also related with Notch/NFB signal pathway during I/R injury. miR-208a has potential to be a biomarker for early diagnosis of I/R injury and might be used as a treatment target in clinical treatment of ischemic heart disease. PMID: 29681568 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - April 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

The Intra-Pericardial Paraganglioma Presenting as Ascites and Hemopericardium with Impending Tamponade.
Authors: Huang WC, Huang MH, Lu TM, Hsu CP Abstract The intra-pericardial paraganglioma is very rare and most of them present with hypertension or palpitations. Here we reported an extraordinarily rare case of intra-pericardial paraganglioma presenting as faint, pitting edema, abdominal fullness with ascites, and hemopericardium with impending tamponade, which was treated successfully by emergent pericardiocentesis and surgical resection. PMID: 29681569 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - April 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Single Femoral Venous Drainage Versus Both Vena Cava Drainage in Isolated Repeat Tricuspid Valve Surgery.
Authors: Peng R, Shi H, Ba J, Wang C Abstract To assess the potential advantages of minimally invasive surgery using a single femoral venous drainage method versus femoral venous and superior vena cava or jugular venous drainage method during repeat tricuspid valve surgery.From January 2010 to December 2016, 50 repeat tricuspid valve procedures were performed using a minimally invasive approach without aortic cross-clamping at our institution. The arterial cannula was inserted into the femoral artery, and at the same time, the venous cannula was placed in the femoral vein in 28 patients (FV group) during cardiopulm...
Source: International Heart Journal - April 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

The Outcome of Percutaneous Coronary Intervention for Significant Atherosclerotic Lesions in Segment Proximal to Myocardial Bridge at Left Anterior Descending Coronary Artery.
This study aimed to evaluate the efficacy of percutaneous coronary intervention (PCI) for significant atherosclerosis lesions proximal to myocardial bridge (MB) at left anterior descending coronary artery (LAD).A total of 330 consecutive patients with LAD significant stenosis, diagnosed as acute coronary syndrome (ACS), were included. Based on whether combined with MB, the patients were divided into the MB group (MB, n = 48) and non-MB group (NMB, n = 282). Drug eluting stents (DES) were successfully implanted in the stenostic segments prior to MB. All patients were followed up during the hospital stay, 30 days and 12 mont...
Source: International Heart Journal - April 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Improved Diagnosis of Detection of Late Enhancement in Left Ventricular Myocardium Using 2nd Generation 320-Slice CT Reconstructed with FIRST in Non-Ischemic Cardiomyopathy.
Authors: Takaoka H, Funabashi N, Ozawa K, Uehara M, Sano K, Komuro I, Kobayashi Y Abstract Forward Projected Model-based Iterative Reconstruction SoluTion (FIRST) is a new reconstruction technique using CT, which provides successful reconstruction of high-quality CT images, especially in low contrast imaging. To evaluate improvements in the diagnostic accuracy of the detection of abnormal late enhancement (LE) in left-ventricular myocardium (LVM) using 320-slice CT with FIRST, we compared this modality with previous CT methods in patients with non-ischemic cardiomyopathy or a cardiac tumor.This was a retrospective ...
Source: International Heart Journal - April 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Amlodipine Inhibits Vascular Cell Senescence and Protects Against Atherogenesis Through the Mechanism Independent of Calcium Channel Blockade.
Authors: Kayamori H, Shimizu I, Yoshida Y, Hayashi Y, Suda M, Ikegami R, Katsuumi G, Wakasugi T, Minamino T Abstract Vascular cells have a finite lifespan and eventually enter irreversible growth arrest called cellular senescence. We have previously suggested that vascular cell senescence contributes to the pathogenesis of human atherosclerosis. Amlodipine is a mixture of two enantiomers, one of which (S- enantiomer) has L-type channel blocking activity, while the other (R+ enantiomer) shows ~1000-fold weaker channel blocking activity than S- enantiomer and has other unknown effects. It has been reported that amlod...
Source: International Heart Journal - April 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Effect of Palliative Care for Patients with Heart Failure.
Authors: Xu Z, Chen L, Jin S, Yang B, Chen X, Wu Z Abstract Palliative care might be beneficial to heart failure. However, the results remain controversial. We conducted a systematic review and meta-analysis to explore the effect of palliative care on heart failure.PubMed, Embase, Web of Science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of palliative care versus usual care on heart failure were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies. The primary outco...
Source: International Heart Journal - April 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Sinus Standstill in a Patient after Intracoronary Papaverine Administration for a Coronary Fractional Flow Reserve.
Authors: Nauchi M, Sakai T, Yamawaki M, Ito Y Abstract A 78-year-old woman had paroxysmal atrial fibrillation and effort angina. Two months before she was admitted for a coronary angiography, she had been feeling dizzy. A Holter 24-hour electrocardiography monitor exhibited an asymptomatic episode of 2.9 seconds of RR interval. She underwent a coronary angiography, which showed intermediate stenosis in the left descending artery. Fractional flow reserve (FFR) measurement using intracoronary papaverine administration was performed. After intracoronary papaverine (12 mg) administration, pause of 4 seconds led to poly...
Source: International Heart Journal - April 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Clinical Meaning of the Ratio of Brachial Pre-Ejection Period to Brachial Ejection Time in Patients with Left Ventricular Systolic Dysfunction.
Authors: Park KH, Park WJ, Han SJ, Kim HS, Jo SH, Kim SA, Suh SW Abstract An increase in the ratio of the brachial pre-ejection period to brachial ejection time [pre-ejection period (PEP)/ET] is correlated with a decrease of left ventricular ejection fraction (LVEF). The current study was designed to test the hypothesis that the change value (Δ) of PEP/ET is a useful indicator of Δ LVEF in patients with left ventricular systolic dysfunction.We consecutively enrolled 104 patients with left ventricular systolic dysfunction (LVEF
Source: International Heart Journal - April 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Carotid Artery Stenting Versus Carotid Endarterectomy for Treatment of Asymptomatic Carotid Artery Stenosis.
Authors: Yuan G, Zhou S, Wu W, Zhang Y, Lei J, Huang B Abstract Asymptomatic carotid stenosis is common and is associated with increased risk of stroke. The relative efficacy and safety of carotid endarterectomy (CEA) and carotid stenting (CAS) in patients with asymptomatic carotid stenosis remain unclear. Five studies that recruited patients with asymptomatic but significant carotid stenosis, who underwent CEA or CAS, were included in this systematic review and meta-analysis. The analyzed outcomes included risks of stroke, myocardial infarction (MI), and death. Risk ratio (RR) and 95% confidence interval (95% CI) ...
Source: International Heart Journal - April 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Spontaneous Reduction in Abnormal Myocardial Uptake of Fluorine-18 Fluorodeoxygluose in a Patient with Cardiac Sarcoidosis.
Authors: Terasaki F, Fujita SI, Kanzaki Y, Hirose Y, Ishizaka N Abstract Fluorine-18 fluorodeoxygluose (18F-FDG) positron emission tomography (PET) is a useful tool for evaluating disease activity in sarcoidosis including cardiac involvement. A 67-year-old patient who developed atrioventricular block requiring permanent pacemaker implantation was diagnosed with cardiac sarcoidosis. The patient did not undergo steroid or immunosuppressive therapy but underwent serial 18F-FDG PET examination, which showed spontaneous reduction in the myocardial FDG uptake, indicating the remission of immune-inflammatory activity. Alt...
Source: International Heart Journal - April 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Calcified Nodules Projecting into the Popliteal Artery Successfully Treated Through the Use of Myocardial Biopsy Forceps.
We report a case of critical limb ischemia with calcified nodules projecting into the popliteal artery, in which the use of myocardial biopsy forceps led to good results. PMID: 29628469 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - April 11, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

A Rare Case of Rush Progression of Purulent Pericarditis by Escherichia coli in a Patient with Malignant Lymphoma.
We report an old male case of purulent pericarditis by Escherichia coli. He came to our hospital suffering from leg edema for 3 months. Echocardiography revealed the large amount of pericardial effusion, and he was admitted to test the cause of pericardial effusion without high fever, tachycardia, and shock vital signs. On the third day, he suddenly presented vital shock. We performed emergency cardiopulmonary resuscitation and pericardiocentesis. Appearance of pericardial effusion was hemorrhagic and purulent. The gram stain revealed remarkable E. coli invasion to pericardial space. Antibiotic therapy was immediately star...
Source: International Heart Journal - April 11, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

A Case of a Cardiac Resynchronization Therapy-Defibrillator Exhibiting a Lower and Alternately Variable Basic Rate.
Authors: Iwazaki K, Kojima T, Murasawa T, Yokota J, Tanimoto H, Matsuda J, Fukuma N, Matsubara T, Shimizu Y, Oguri G, Hasumi E, Kubo H, Chang K, Fujiu K, Komuro I Abstract A cardiac resynchronization therapy defibrillator (CRT-D) (Medtronic Inc. Protecta XT) was implanted in a 67-year-old man who had cardiac sarcoidosis with extremely low cardiac function. He had ventricular tachycardia which was controlled by catheter ablation, medication and pacing. The programmed mode was DDI, lower rate was 90 beats/minute, paced AV delay was 150 ms, and the noncompetitive atrial pacing (NCAP) function was programmed as 300 ms....
Source: International Heart Journal - April 11, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

HCN4-Overexpressing Mouse Embryonic Stem Cell-Derived Cardiomyocytes Generate a New Rapid Rhythm in Rats with Bradycardia.
Authors: Saito Y, Nakamura K, Yoshida M, Sugiyama H, Takano M, Nagase S, Morita H, Kusano KF, Ito H Abstract A biological pacemaker is expected to solve the persisting problems of an artificial cardiac pacemaker including short battery life, lead breaks, infection, and electromagnetic interference. We previously reported HCN4 overexpression enhances pacemaking ability of mouse embryonic stem cell-derived cardiomyocytes (mESC-CMs) in vitro. However, the effect of these cells on bradycardia in vivo has remained unclear. Therefore, we transplanted HCN4-overexpressing mESC-CMs into bradycardia model animals and investi...
Source: International Heart Journal - April 11, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Acute Inferior Wall ST Segment Elevation Myocardial Infarction Caused Atrial Lead Dysfunction Reversed by Primary Percutaneous Coronary Intervention.
We report and discuss a 76-year-old female who had atrial lead dysfunction caused by acute myocardial infarction and who was recovered after primary percutaneous coronary intervention. The sequential electrocardiographic changes were demonstrated and the possible mechanisms were discussed. PMID: 29628473 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - April 11, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Preoperative Simulation Using CT Virtual Endoscopy for Minimally Invasive Surgery of Hypertrophic Obstructive Cardiomyopathy.
Authors: Totsugawa T, Tsunoda M, Kagiyama N, Otsuki Y, Yoshitaka H, Sakaguchi T Abstract Transaortic septal myectomy is a procedure that involves a learning curve for surgeons because the bulging interventricular septum usually interferes with the visualization of the deep parts of the left ventricular chamber. In this case report, we demonstrate computed tomography virtual endoscopy for preoperative simulation, which enabled us to clearly image the relationship among the bulging septum, the expected myectomy area, and the structures deep in the left ventricle, such as the papillary muscle and abnormal muscular bun...
Source: International Heart Journal - April 11, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Prognostic Improvement of Acute Necrotizing Eosinophilic Myocarditis (ANEM) Through a Rapid Pathological Diagnosis and Appropriate Therapy.
We present the case of a patient with acute necrotizing eosinophilic myocarditis (ANEM) who rapidly recovered after receiving high-dose corticosteroid therapy. A previously healthy 29-year-old woman presented to our hospital with abdominal pain, nausea, and fever that had lasted for two days. Her clinical condition progressively declined and she ultimately presented with cardiogenic shock due to fulminant heart failure and atrioventricular dissociation due to sinus bradycardia, which required inotropic and ventilatory support. Endomyocardial biopsy results were consistent with ANEM. High-dose corticosteroids were promptly ...
Source: International Heart Journal - April 11, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

A Novel Truncating LMNA Mutation in Patients with Cardiac Conduction Disorders and Dilated Cardiomyopathy.
Authors: Kawakami H, Ogimoto A, Tokunaga N, Nishimura K, Kawakami H, Higashi H, Iio C, Kono T, Aono J, Uetani T, Nagai T, Inoue K, Suzuki J, Ikeda S, Okura T, Ohyagi Y, Tabara Y, Higaki J Abstract The cardiac phenotype of laminopathies is characterized by cardiac conduction disorders (CCDs) and dilated cardiomyopathy (DCM). Although laminopathies have been considered monogenic, they exhibit a remarkable degree of clinical variability. This case series aimed to detect the causal mutation and to investigate the causes of clinical variability in a Japanese family with inherited CCD and DCM.Of the five family members i...
Source: International Heart Journal - April 11, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Rapid Desensitization to Overcome Contrast Allergy Prior to Urgent Coronary Angiography.
Authors: Uppal S, DeCicco AE, Intini A, Josephson RA Abstract Allergic reactions to contrast media are a frequently reported complication of coronary angiography. The majority of patients experience mild, self-limited episodes, but in rare cases patients may experience severe, persistent symptoms. A strategy of premedication with corticosteroids and anti-histamines and an optimal selection of contrast agent is almost always successful in averting contrast reactions, yet a select few patients will continue to have breakthrough events. This is a case of recurrent, severe allergy to contrast media despite standard pre...
Source: International Heart Journal - April 11, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Arrhythmogenic Right Ventricular Cardiomyopathy with Multiple Thrombi and Ventricular Tachycardia of Atypical Left Branch Bundle Block Morphology.
Authors: Gong S, Wei X, Liu G, Wu F, Chen X Abstract A 61-year-old male patient was admitted to our hospital with recurrent palpitations and syncope. Electrocardiography, echocardiography, and contrast-enhanced computed tomography were performed. The patient was diagnosed with arrhythmogenic right ventricular cardiomyopathy (ARVC) complicated by multiple thrombi, and ventricular tachycardia (VT) without typical left bundle branch block (LBBB) morphology. This case suggests that VT is not always the sole contributor to syncope and death in patients with ARVC, and pulmonary embolism should be considered. Furthermore,...
Source: International Heart Journal - April 11, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Hcm.
HCM. Int Heart J. 2018;59(2):243-244 Authors: Mano T PMID: 29607979 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - April 4, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Correlation between Nutritional State and Prognosis of Heart Failure, with a Focus on the Immune System.
Authors: Matsubara TJ, Fujiu K PMID: 29607980 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - April 4, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

The Future of Women in Japanese Cardiology.
Authors: Hosoya Y PMID: 29607981 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - April 4, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Erratum: Shorter Heart Failure Duration Is a Predictor of Left Ventricular Reverse Remodeling During Adaptive Servo-Ventilator Treatment in Patients With Advanced Heart Failure.
Authors: Imamura T, Kinugawa K, Nitta D, Komuro I Abstract An error appeared in the article entitled "Shorter Heart Failure Duration Is a Predictor of Left Ventricular Reverse Remodeling During Adaptive Servo-Ventilator Treatment in Patients With Advanced Heart Failure" by Teruhiko Imamura, Koichiro Kinugawa, Daisuke Nitta, and Issei Komuro (Vol. 57, No. 2, 198-203, 2016). The Figure 1 on page 201 should be replaced by the following figure. PMID: 29607982 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - April 4, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Best Reviewers for 2017.
Authors: PMID: 29607884 [PubMed - in process] (Source: International Heart Journal)
Source: International Heart Journal - April 4, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Fatal Cardiac Hemochromatosis in a Patient with Hereditary Spherocytosis.
Authors: Fujino T, Inoue S, Katsuki S, Higo T, Ide T, Oda Y, Tsutsui H Abstract A 31-year-old man was admitted to our hospital with atrial tachycardia and cardiogenic shock. He had been diagnosed with hereditary spherocytosis (HS) during childhood, but he never received any red blood cell transfusions. Right ventricular endomyocardial biopsy revealed multiple myocardial hemosiderin deposits, and he was diagnosed with cardiac hemochromatosis. In addition to the iron deposition in the heart, the loss of myocyte and severe interstitial fibrosis were present. His cardiac function did not improve even after the cardiove...
Source: International Heart Journal - March 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Early Recurrence after Longstanding Persistent Atrial Fibrillation Ablation.
Authors: Takayama K, Hachiya H, Iesaka Y, Hirao K, Isobe M Abstract Early recurrence (ER) of atrial fibrillation (AF) is common after ablation of longstanding persistent AF. However, optimal timing for repeat ablation has yet to be established.Two-hundred-four patients (mean age 62 ± 9 years) with longstanding persistent AF underwent catheter ablation including pulmonary vein (PV) isolation and substrate modification. ER defined as AF recurrence within 60 days, occurred in 115 patients (56.4%) 9 ± 1 days after the procedure. Analysis showed optimal blanking period to be 15 days. At 426 ± 224 da...
Source: International Heart Journal - March 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Two Patients with Coincident Noncompacted Myocardium and Hypertrophic Cardiomyopathy.
Authors: Tang X, Yu S, Yin L, Gong L Abstract To our knowledge, left ventricular noncompaction (LVNC) and hypertrophic cardiomyopathy (HCM) commonly occur as separate disorders in different patients; however, LVNC associated with HCM, which is called hypertrophic LVNC, is relatively rare.1) Here we report two sporadic cases of hypertrophic LVNC which were diagnosed by echocardiography and cardiac magnetic resonance (CMR). PMID: 29563375 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - March 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Combining Percutaneous Ultrasound-Guided Hematoma Aspiration and Compression Repair to Treat Femoral Artery Pseudoaneurysm after Cardiac Catheterization.
This study aimed to prospectively evaluate the safety and efficacy of a new developed method that uses percutaneous ultrasound-guided hematoma aspiration followed by targeted localized manual compression for treatment of femoral artery pseudoaneurysm after cardiac catheterization, which obviates thrombin use, surgery, and long-time compression.From January 2007 to July 2014, 32 patients (17 women; mean age, 55.3 ± 11.5 years) out of 8,725 consecutive cases undergoing cardiac catheterization via femoral access developed one pseudoaneurysm each ranging in size from 21 × 11 mm to 72 × 39 mm. Under ultrasoun...
Source: International Heart Journal - March 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Exploration of Bivalirudin Use during Percutaneous Coronary Intervention for High Bleeding Risk Patients with Chronic Total Occlusion.
Authors: Li C, Shen Y, Xu R, Dai Y, Chang S, Lu H, Ge L, Ma J, Qian J, Ge J Abstract The safety and efficacy of bivalirudin during percutaneous coronary intervention (PCI) in high bleeding risk patients with chronic total occlusion lesions (CTO) has not been studied till date. The use of bivalirudin may increase the thrombotic events during CTO-PCI.Between May 2013 and April 2014, a total of 117 high bleeding risk patients with CTOs underwent PCI. Bivalirudin was used in 89 cases with different strategies, including standard usage, combination of heparin, and additional bolus of bivalirudin on the basis of standard...
Source: International Heart Journal - March 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Infective Endocarditis Associated with Atopic Dermatitis.
We report a case of aortic valve infective endocarditis (IE) in a 24-year-old man with atopic dermatitis (AD). He had a history of balloon valvuloplasty for a stenotic bicuspid aortic valve, and had dental caries but no invasive dental procedure before the onset of IE. On admission, skin lesions of AD with itching and scratches were found on the neck, trunk, and extremities. Echocardiography showed a vegetation on the aortic valve with mild steno-regurgitation, but extension of IE to the annulus was not detected. Magnetic resonance imaging identified fresh cerebral infarction without neurological dysfunction, leading us to...
Source: International Heart Journal - March 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Rapid Healing of a Spontaneous Coronary Artery Dissection Detected by Computed Tomography Angiography.
Authors: Sakai K, Kobayashi Y, Shirai S, Ando K Abstract Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome and little is known about characteristics, treatment, and follow-up of patients with SCAD. Computed tomography angiography (CTA) plays an important role in the diagnosis and management of SCAD. Herein, we describe a case of a patient with SCAD who underwent successful conservative management, and in whom CTA was able to detect rapid healing of the dissection, 4.5 hours post-dissection. PMID: 29563379 [PubMed - as supplied by publisher] (Source: International Heart Journal)
Source: International Heart Journal - March 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

A Pitfall in the Diagnosis of Bilateral Deep Vein Thrombosis in a Young Man.
Authors: Adachi Y, Sakakura K, Okochi T, Mase T, Matsumoto M, Wada H, Fujita H, Momomura SI Abstract A 32-year-old man with a history of bronchial asthma was referred for low back pain and bilateral femur pain. Vascular sonography revealed bilateral deep vein thrombosis (DVT) from the femoral veins to the popliteal veins. Computed tomography revealed hypoplasia of the inferior vena cava (IVC) and dilated lumbar veins, ascending lumbar veins, and azygos vein as collaterals. There was no evidence of malignant neoplasm. The results of the thrombophilia tests were within normal limits. Hypoplasia of the IVC is a rare c...
Source: International Heart Journal - March 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Diagnostic Approach to Cardiac Involvement in Idiopathic Inflammatory Myopathies.
Authors: Chen F, Peng Y, Chen M Abstract Cardiac involvement in idiopathic inflammatory myopathies (IIMs) attracts more attention than it ever did because of its morbidity and impact on worse prognosis, although the accurate information needs further epidemiological studies. Early identification and intervention for the diseased heart may help improve the clinical outcomes of IIMs with cardiac involvement. Cardiac troponin assays, allowing for sensitive detection of minor myocardium injury, may provide a new way for early detection for heart involvement in IIMs. While elevated cardiac troponin I (cTnI) specifically...
Source: International Heart Journal - March 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Predictive Value of Mean Platelet Volume/Platelet Count for Prognosis in Acute Myocardial Infarction.
Authors: Tian C, Song J, He D, Wu J, Sun Z, Sun Z Abstract Increased mean platelet volume (MPV) has been associated with adverse clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). We aim to assess whether MPV/platelet count (MPV/PC) ratio is a useful marker to predict long-term prognosis in patients with STEMI undergoing PCI. Moreover, the prognostic accuracy of MPV/PC ratio is compared with MPV. 962 consecutive patients with STEMI treated with P-PCI were considered. According to the admission MPV/PC values, the population was d...
Source: International Heart Journal - March 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

The Role of FAK in the Secretion of MMP9 after CD147 Stimulation in Macrophages.
Authors: Yu C, Lixia Y, Ruiwei G, Yankun S, Jinshan Y Abstract To investigate whether focal adhesion kinase (FAK) can participate in the secretion of matrix metalloproteinase 9 (MMP9) after CD147 stimulation in THP-1 induced macrophages; thus, to explore the potential treatment perspectives for acute coronary syndrome (ACS).Phorbol-12-myristate-13-acetate (PMA) was used to induce THP-1 cells to differentiate into macrophages. To confirm the peak mRNA and protein expression of FAK and MMP9 after the stimulation of CD147, the macrophages were divided into 5 groups (0, 3, 6, 9, and 12 hours), with 0 hours group as con...
Source: International Heart Journal - March 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Coronary Artery Bypass Surgery versus Percutaneous Coronary Intervention for Left Main Coronary Artery Disease with Chronic Kidney Disease.
Authors: Lin TC, Lu TM, Huang FC, Hsu PF, Shih CC, Lin SJ, Hsu CP Abstract Percutaneous coronary intervention (PCI) has emerged as an alternative treatment to coronary artery bypass grafting (CABG) in patients with unprotected left main coronary artery disease (ULMCAD). However, the optimal treatment for ULMCAD concomitant with chronic kidney disease (CKD) was rarely addressed. Herein, we compare the long-term outcomes of these patients treated with CABG or PCI.From January 2004 to December 2010, 185 patients with ULMCAD and CKD undergoing PCI (n = 84) or CABG (n = 101) were matched for the selection criteria. The ...
Source: International Heart Journal - March 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Contribution of Poststent Irregular Protrusion to Subsequent In-Stent Neoatherosclerosis after the Second-Generation Drug-Eluting Stent Implantation.
This study aimed to assess the relationship between IP and in-stent neoatheroscrerosis formation using OCT. We evaluated 83 patients (101 lesions) who underwent second-generation DES implantation and 8-month follow-up (8M-FU) using OCT. Lesions were divided into two groups in presence of IP (IP: n = 43, non-IP: n = 58). At prepercutaneous coronary intervention (pre-PCI), lipid-rich plaque, lesions with positive remodeling, and in-stent thrombus formation were more frequent in IP than in non-IP. On multivariate analysis, the thrombus at pre-PCI and the lesions with positive remodeling were independent predictors of IP. At 8...
Source: International Heart Journal - March 25, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

The Impact of Respiratory Events on the Autonomic Nervous System during Sleep.
Authors: Liang J, Zhang X, Luo Y, Wang T, Sun L, Huang S Abstract Sleep apnea hypopnea syndrome (SAHS) is an independent risk factor for cardiovascular diseases. However, the pathophysiology between them is not yet clear. This paper seeks to understand how respiratory events impact the cardiovascular system by heart rate variability. We compared the differences between successional pathological respiratory events (PR) and pure normal respiration (NR) during sleep. The transitions between normal and pathological respiration (TR) were also analyzed. Thirteen patients who suffered moderate or severe SAHS were enrolled...
Source: International Heart Journal - March 14, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Congenital Absence of Left Atrial Appendage Diagnosed by Multimodality Imaging.
Authors: Enomoto Y, Hashimoto G, Sahara N, Hashimoto H, Niikura H, Nakamura K, Iijima R, Hara H, Suzuki M, Noro M, Moroi M, Sugi K, Nakamura M Abstract A 70-years-old male with a history of hypertension and drug resistant paroxysmal atrial fibrillation (AF) presented to our hospital for catheter ablation to his symptomatic AF. He had no prior surgical or percutaneous procedure to close or exclude the left atrial appendage (LAA). A transesophageal echocardiography (TEE) was performed to rule out intra-cardiac thrombus prior to the ablation procedure. Although the TEE imaging at multiple acquisition angles was obtain...
Source: International Heart Journal - March 14, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Variation in Patient Backgrounds, Practice Patterns, and Outcomes of High-Risk Pulmonary Embolism in Japan.
We examined variation in patient backgrounds, procedures, and outcomes in this population.We identified 361 patients were eligible. Among those, including 266 received thrombolysis and 95 received embolectomy. The 30-day mortality was 41.4% in 266 patients with thrombolysis, and 14 patients died in 95 patients with embolectomy. Among the thrombolysis group, 30-day mortality was 35% in 187 patients without CPA thrombolysis and was 56% in 79 patients with CPA. Among the embolectomy group, 30-day mortality was 14% in 81 patients without CPA, and 21% patients died in 14 patients with CPA.The present nationwide study showed tha...
Source: International Heart Journal - March 6, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

A Vaginal Stillbirth after Aortic Surgery of Type B Aortic Dissection in a Pregnant Woman.
Authors: Zhu C, Zheng X, Zhu Z, Li D, Wang T, Xu R, Liu K Abstract Acute aortic dissection occurring during pregnancy poses great danger to both the mother and fetus. Cesareans are usually performed before or after the aortic repair depending on the conditions of the mother and fetus. Here we report our experience in treating a 32-week pregnant woman with a type B aortic dissection, whose baby had died before admission. A cesarean section was initially arranged after emergency aortic repair. However, the patient started to deliver the fetus vaginally after the aortic surgery and the stillborn baby was delivered vag...
Source: International Heart Journal - March 6, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Pulmonary Tumor Thrombotic Microangiopathy due to Advanced Gastric Cancer with Virchow's Node Metastasis.
Authors: Sato T, Mori M, Aoki J, Tanabe K Abstract Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal cancer-related complication characterized by severe progressive pulmonary hypertension. Antemortem diagnosis is difficult owing to the rapid progression of the condition, especially when the patient has no known malignancies and initially presents with pulmonary hypertension. Here we report a case of PTTM due to occult gastric cancer with metastasis in the left supraclavicular lymph node, also known as Virchow's node. Enlarged Virchow's node is an important indicator of advanced gastric cancer. In patient...
Source: International Heart Journal - March 6, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Rationale and Design of Randomized Evaluation of Aggressive or Moderate Lipid Lowering Therapy with Pitavastatin in Coronary Artery Disease (REAL-CAD) Trial.
Authors: Miyauchi K, Kimura T, Shimokawa H, Daida H, Iimuro S, Iwata H, Ozaki Y, Sakuma I, Nakagawa Y, Hibi K, Hiro T, Fukumoto Y, Hokimoto S, Ohashi Y, Ohtsu H, Saito Y, Matsuzaki M, Nagai R, REAL-CAD Trial Investigaters Abstract Large-scale clinical trials in patients in Western countries with coronary artery disease (CAD) have found that aggressive lipid-lowering therapy using high-dose statins reduces cardiovascular (CV) events further than low-dose statins. However, such evidence has not yet been fully established in Asian populations, including in Japan. The Randomized Evaluation of Aggressive or Moderate Lip...
Source: International Heart Journal - March 6, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Novel Understanding of Takotsubo Syndrome.
Authors: Watanabe M, Izumo M, Akashi YJ Abstract Takotsubo cardiomyopathy is described as a transient reversible cardiomyopathy which typically occurs in older women after emotional or physical stress. This cardiomyopathy is also recognized as a "syndrome" because it develops in conjunction with various diseases. Since the clinical presentation of takotsubo syndrome (TTS) is similar to acute coronary syndrome (ACS), TTS should be distinguished from ischemic heart disease. Although the pathophysiology of TTS has not well been established, a number of its specific features have been suggested. The predictor...
Source: International Heart Journal - March 6, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Endocardial Fibrotic Lesions Have a Greater Effect on Peak Longitudinal Strain than Epicardial Fibrotic Lesions in Hypertrophic Cardiomyopathy Patients.
Authors: Funabashi N, Takaoka H, Ozawa K, Kobayashi Y Abstract Peak longitudinal strain (PLS) of the left ventricular (LV) myocardium by transthoracic echocardiogram (TTE) is useful to detect LV myocardial damage. We hypothesized that myocardial fibrosis (MF) in the LV myocardium may influence PLS. Eighteen hypertrophic cardiomyopathy (HCM) patients (14 males; 58 ± 17 years old) underwent 1.5 Tesla cardiac magnetic resonance (CMR) and TTE. Patients with previous myocardial infarction were excluded. We used TTE to assess whole-layer PLS in an American Heart Association-defined 17-segment LV model. Whole-layer...
Source: International Heart Journal - February 27, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Morphological Determinants of Obstructive Hypertrophic Cardiomyopathy Obtained Using Echocardiography.
Authors: Nara I, Iino T, Watanabe H, Sato W, Watanabe K, Shimbo M, Umeta Y, Ito H Abstract The morphological determinants of left ventricular outflow tract (LVOT) obstruction in hypertrophic cardiomyopathy (HCM) are not completely understood. We aimed to identify the anatomical risks of the obstruction using echocardiography.Fifty patients with untreated HCM were classified into two groups: those with LVOT pressure gradient (LVOTPG) ≥ 30 mmHg (obstructive HCM [HOCM] group) and those with LVOTPG
Source: International Heart Journal - February 27, 2018 Category: Cardiology Tags: Int Heart J Source Type: research