Ponatinib-Related Vasospastic Angina
We report 3 cases of Ponatinib-related vasospastic angina, in which prophylactic administration of nitrates or calcium channel blockers was effective.PMID:38556342 | DOI:10.1536/ihj.23-355 (Source: International Heart Journal)
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Michiho Shindo Chinatsu Komiyama Tetsuo Yamaguchi Kosei Kageyama Hisashi Yamamoto Yo Fujimoto Naoyuki Uchida Takahide Kodama Source Type: research
A Case of Ventricular Fibrillation in Masked Long-QT Syndrome Coexisting with Coronary Vasospasm
Int Heart J. 2024;65(2):354-358. doi: 10.1536/ihj.23-397.ABSTRACTAlthough long-QT syndrome (LQTS) with a normal range QT interval at rest leads to fatal ventricular arrhythmias, it is difficult to diagnose. In this article, we present a rare case of a patient who suffered a cardiac arrest and was recently diagnosed with LQTS and coronary vasospasm. A 62-year-old man with no syncopal episodes had a cardiopulmonary arrest while running. During coronary angiography, vasospasm was induced and we prescribed coronary vasodilators, including calcium channel blockers. An exercise stress test was performed to evaluate the effect of...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Atsumasa Kurozumi Yoshinari Enomoto Hisao Hara Norihiro Kato Yukio Hiroi Source Type: research
Congenital Pulmonary Lymphangiectasia Masked by Postoperative Pulmonary Venous Obstruction in an Infant with Total Anomalous Pulmonary Venous Connection
Int Heart J. 2024;65(2):363-366. doi: 10.1536/ihj.23-232.ABSTRACTCongenital pulmonary lymphangiectasia (CPL) is associated with fetal pulmonary venous obstructive physiology. The precise morbidity of CPL is unknown as CPL is generally fatal in neonates. Here, we report an infant with secondary CPL in total anomalous pulmonary venous connection (TAPVC). He developed severe pulmonary hypertension (PH) after corrective surgery for TAPVC. However, cardiac catheterization showed mild left pulmonary venous obstruction (PVO), which was deemed unnecessary for re-intervention. He died at 11 months-old due to an exacerbation of PH. ...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Yoshiko Nawata Daisuke Toyomura Seigo Okada Yasuo Suzuki Narumi Honda-Nakada Yuji Ohnishi Yuichiro Sugitani Naoki Kawaguchi Rui Tokitaka-Okada Naoki Masaki Eiji Ikeda Shunji Hasegawa Source Type: research
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Int Heart J. 2024;65(2):371. doi: 10.1536/ihj.65.371.NO ABSTRACTPMID:38556345 | DOI:10.1536/ihj.65.371 (Source: International Heart Journal)
Source: International Heart Journal - March 31, 2024 Category: Cardiology Source Type: research
Errata: Effect of Thimerosal on Arrhythmia Induced by Coronary Ligation: The Involvement of ATP-dependent Potassium Channels
Int Heart J. 2024;65(2):372. doi: 10.1536/ihj.65-2_Errata.ABSTRACTSeveral errors (shown with underlines) in the following list appeared in the article "Effect of Thimerosal on Arrhythmia Induced by Coronary Ligation: The Involvement of ATP-dependent Potassium Channels" by Ömer Bozdogan, Ersöz Gonca, Melih Nebigil, Eylem Suveren Tiryaki (Vol. 46 No.4, 711-721, 2005).PMID:38556346 | DOI:10.1536/ihj.65-2_Errata (Source: International Heart Journal)
Source: International Heart Journal - March 31, 2024 Category: Cardiology Source Type: research
Characteristics of Shoshin Beriberi, a Fulminant Cardiovascular Type of Beriberi
Int Heart J. 2024;65(2):171-172. doi: 10.1536/ihj.24-034.NO ABSTRACTPMID:38556327 | DOI:10.1536/ihj.24-034 (Source: International Heart Journal)
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Eisuke Amiya Hiroyuki Morita Source Type: research
Recent Advances on Selenium Nutrition and Keshan Disease
Int Heart J. 2024;65(2):173-179. doi: 10.1536/ihj.23-628.ABSTRACTKeshan disease (KD) is a type of endemic cardiomyopathy with an unknown cause. It is primarily found in areas in China with low selenium levels, from northeast to southwest. The nutritional biogeochemical etiology hypothesis suggests that selenium deficiency is a major factor in KD development. Selenium is important in removing free radicals and protecting cells and tissues from peroxide-induced damage. Thus, low environmental selenium may affect the selenium level within the human body, and selenium level differences are commonly observed between healthy peo...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Shu-Juan Li An-Wei Wang Kai-Lian Huang Ying Yang Source Type: research
Clinical Significance of the Triglyceride-Glucose Index in Patients Requiring Nonsurgical Intensive Care
Int Heart J. 2024;65(2):180-189. doi: 10.1536/ihj.23-409.ABSTRACTThe evaluation of triglyceride-glucose (TyG) index has not been sufficient in patients requiring nonsurgical intensive care.A total of 3,906 patients who required intensive care were enrolled. We computed the TyG index using the value on admission by the following formula: ln [triglyceride (mg/dL) × glucose (mg/dL) /2]. Patients were divided into three groups according to the TyG index quartiles: low (quartile 1 [Q1]; TyG index ≤ 8.493, n = 977), middle (Q2/Q3; 8.494 ≤ TyG index ≤ 9.536, n = 1,953), and high (Q4; TyG index > 9.537, n = 976). The med...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Suguru Nishigoori Akihiro Shirakabe Hirotake Okazaki Masato Matsushita Yusaku Shibata Shota Shigihara Tomofumi Sawatani Kenichi Tani Kazutaka Kiuchi Nobuaki Kobayashi Kuniya Asai Source Type: research
Impact of Red Blood Cell Transfusion on Subsequent Cardiovascular Events in Patients with Acute Heart Failure and Anemia
In conclusion, this study suggests that RBC transfusions for anemia may not improve clinical outcomes in patients with AHF.PMID:38556330 | DOI:10.1536/ihj.23-596 (Source: International Heart Journal)
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Yukihiro Watanabe Shuhei Tara Takuya Nishino Katsuhito Kato Yoshiaki Kubota Daisuke Hayashi Kosuke Mozawa Junya Matsuda Hideki Miyachi Yukichi Tokita Yu-Ki Iwasaki Masahiro Yasutake Kuniya Asai Source Type: research
Impact of Hemoglobin Level, White Blood Cell Count, Renal Dysfunction, and Staphylococcus as the Causative Organism on Prediction of In-Hospital Mortality from Infective Endocarditis
In this study, a total of 162 patients who were admitted to our hospital during the period from 2009 to 2021, who were suspected of having IE according to the modified Duke classification, and for whom IE was confirmed by transesophageal echocardiography were retrospectively analyzed. Patients were observed for a mean-period of 43.7 days with the primary endpoint being in-hospital death. The in-hospital death group had a lower level of hemoglobin (Hb), higher white blood cell (WBC) count, lower level of estimated glomerular filtration rate (eGFR), and higher frequency of Staphylococcus being the causative agent than those ...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Masamichi Koike Takahiro Doi Koki Morishita Kosuke Uruno Mirei Kawasaki-Nabuchi Kaoru Komuro Hiroyuki Iwano Syuichi Naraoka Daigo Nagahara Satoshi Yuda Source Type: research
Efficacy and Tolerability of Ivabradine for Cardiomyopathy in Patients with Duchenne Muscular Dystrophy
Int Heart J. 2024;65(2):211-217. doi: 10.1536/ihj.23-563.ABSTRACTDuchenne muscular dystrophy (DMD) is an intractable X-linked myopathy caused by dystrophin gene mutations. Patients with DMD suffer from progressive muscle weakness, inevitable cardiomyopathy, increased heart rate (HR), and decreased blood pressure (BP). The aim of this study was to clarify the efficacy and tolerability of ivabradine treatment for DMD cardiomyopathy.A retrospective analysis was performed in 11 patients with DMD, who received ivabradine treatment for more than 1 year. Clinical results were analyzed before (baseline), 6 months after, and 12 mon...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Akiko Wakisaka Koichi Kimura Hiroyuki Morita Koki Nakanishi Masao Daimon Masanori Nojima Hideki Itoh Atsuhito Takeda Ruriko Kitao Tomihiro Imai Tetsuhiko Ikeda Takashi Nakajima Chigusa Watanabe Toshihiro Furukawa Ichiro Ohno Chiho Ishida Norihiko Takeda K Source Type: research
Clinical Value of Troponin Levels to Cardiac Function and Prognosis in Patients with Fulminant Myocarditis
This study aimed to investigate the association between cardiac Tn levels and the course of cardiac function, and prognosis in patients with fulminant myocarditis (FM) receiving percutaneous mechanical circulatory support (MCS).We used data from a multicenter retrospective registry, CHANGE PUMP 2, which included 216 patients with FM who required MCS. Among them, 141 patients whose Tn levels were available were analyzed. The patients were divided into low and high Tn groups according to the median values of TnT and TnI.The median age was 54 years, and 59.6% were male. The TnT and TnI on day 1 (at MCS initiation) were 3.8 (1...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Naoki Shibata Toru Kondo Takahiro Okumura Takahiro Imaizumi Kaoru Dohi Hideo Izawa Nobuyuki Ohte Tetsuya Amano Toyoaki Murohara CHANGE PUMP 2 investigators Source Type: research
U-Shaped Association between Serum Chloride Levels and In-Hospital Mortality in Patients with Congestive Heart Failure in Intensive Care Units
This study comprised 15,983 participants. When compared with the reference group (Q5), the groups with the highest (Q7) and lowest (Q1) blood chloride levels exhibited increased in-hospital mortality, with fully adjusted odds ratios (ORs) of 1.36 [95% confidence interval (CI): 1.08-1.71] and 1.25 (95% CI: 1-1.56), respectively. A U-shaped relationship was observed between blood chloride levels and in-hospital mortality, with the lowest risk observed at a threshold of 105.017 mmol/L. The effect sizes and corresponding CIs below and above the threshold were 0.969 (95% CI: 0.957-0.982) and 1.039 (95% CI: 1.002-1.076), respect...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Kai Zhang Yu Han Fangming Gu Zhaoxuan Gu JiaYu Zhao Jianguo Chen Bowen Chen Min Gao Zhengyan Hou Xiaoqi Yu Tianyi Cai Yafang Gao Rui Hu Jinyu Xie Tianzhou Liu Bo Li Source Type: research
Causal Relationship Between Immune Cells/Cytokines and Dilated Cardiomyopathy
This study aimed to investigate the causal relationship between the levels of various types of immune cells/cytokines and DCM. Herein, two-sample Mendelian randomization (MR) (TSMR) using R software was conducted. Single nucleotide polymorphisms (SNPs) related to the levels of various types of immune cells/cytokines and DCM were screened based on the genome-wide association studies (GWAS) obtained from open-source databases. The TSMR was conducted using inverse variance weighted (IVW), method, MR-Egger regression, weighted median method, and simple estimator based on mode to explore the causal association between the level...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Bin Qi Nan Huang Zhi-Jie Yang Wen-Bo Zheng Chun Gui Source Type: research
lncRNA CCAT2 Protects Against Cardiomyocyte Injury After Myocardial Ischemia/Reperfusion by Regulating BMI1 Expression
Int Heart J. 2024;65(2):279-291. doi: 10.1536/ihj.23-569.ABSTRACTMyocardial ischemia/reperfusion (I/R) decreases cardiac function and efficiency. Accumulating evidence suggests that long noncoding RNAs (lncRNAs) have been linked to the cellular processes of myocardial I/R injury. The present investigation elucidated the function of lncRNA colon cancer-associated transcript 2 (CCAT2) in myocardial I/R injury and the related mechanisms.AC16 cardiomyocytes were exposed to hypoxia (16 hours) /reoxygenation (6 hours) (H/R) to mimic myocardial I/R models in vitro. CCAT2 and microRNA (miR) -539-3p expressions in AC16 cardiomyocyt...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Mengli Zhang Bei Xu Wei Li Bo Yu Huan Peng Feng Gui Fen Ai Zhen Chen Source Type: research
