Efficacy and Tolerability of Ivabradine for Cardiomyopathy in Patients with Duchenne Muscular Dystrophy
Int Heart J. 2024;65(2):211-217. doi: 10.1536/ihj.23-563.ABSTRACTDuchenne muscular dystrophy (DMD) is an intractable X-linked myopathy caused by dystrophin gene mutations. Patients with DMD suffer from progressive muscle weakness, inevitable cardiomyopathy, increased heart rate (HR), and decreased blood pressure (BP). The aim of this study was to clarify the efficacy and tolerability of ivabradine treatment for DMD cardiomyopathy.A retrospective analysis was performed in 11 patients with DMD, who received ivabradine treatment for more than 1 year. Clinical results were analyzed before (baseline), 6 months after, and 12 mon...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Akiko Wakisaka Koichi Kimura Hiroyuki Morita Koki Nakanishi Masao Daimon Masanori Nojima Hideki Itoh Atsuhito Takeda Ruriko Kitao Tomihiro Imai Tetsuhiko Ikeda Takashi Nakajima Chigusa Watanabe Toshihiro Furukawa Ichiro Ohno Chiho Ishida Norihiko Takeda K Source Type: research
Clinical Value of Troponin Levels to Cardiac Function and Prognosis in Patients with Fulminant Myocarditis
This study aimed to investigate the association between cardiac Tn levels and the course of cardiac function, and prognosis in patients with fulminant myocarditis (FM) receiving percutaneous mechanical circulatory support (MCS).We used data from a multicenter retrospective registry, CHANGE PUMP 2, which included 216 patients with FM who required MCS. Among them, 141 patients whose Tn levels were available were analyzed. The patients were divided into low and high Tn groups according to the median values of TnT and TnI.The median age was 54 years, and 59.6% were male. The TnT and TnI on day 1 (at MCS initiation) were 3.8 (1...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Naoki Shibata Toru Kondo Takahiro Okumura Takahiro Imaizumi Kaoru Dohi Hideo Izawa Nobuyuki Ohte Tetsuya Amano Toyoaki Murohara CHANGE PUMP 2 investigators Source Type: research
U-Shaped Association between Serum Chloride Levels and In-Hospital Mortality in Patients with Congestive Heart Failure in Intensive Care Units
This study comprised 15,983 participants. When compared with the reference group (Q5), the groups with the highest (Q7) and lowest (Q1) blood chloride levels exhibited increased in-hospital mortality, with fully adjusted odds ratios (ORs) of 1.36 [95% confidence interval (CI): 1.08-1.71] and 1.25 (95% CI: 1-1.56), respectively. A U-shaped relationship was observed between blood chloride levels and in-hospital mortality, with the lowest risk observed at a threshold of 105.017 mmol/L. The effect sizes and corresponding CIs below and above the threshold were 0.969 (95% CI: 0.957-0.982) and 1.039 (95% CI: 1.002-1.076), respect...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Kai Zhang Yu Han Fangming Gu Zhaoxuan Gu JiaYu Zhao Jianguo Chen Bowen Chen Min Gao Zhengyan Hou Xiaoqi Yu Tianyi Cai Yafang Gao Rui Hu Jinyu Xie Tianzhou Liu Bo Li Source Type: research
Causal Relationship Between Immune Cells/Cytokines and Dilated Cardiomyopathy
This study aimed to investigate the causal relationship between the levels of various types of immune cells/cytokines and DCM. Herein, two-sample Mendelian randomization (MR) (TSMR) using R software was conducted. Single nucleotide polymorphisms (SNPs) related to the levels of various types of immune cells/cytokines and DCM were screened based on the genome-wide association studies (GWAS) obtained from open-source databases. The TSMR was conducted using inverse variance weighted (IVW), method, MR-Egger regression, weighted median method, and simple estimator based on mode to explore the causal association between the level...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Bin Qi Nan Huang Zhi-Jie Yang Wen-Bo Zheng Chun Gui Source Type: research
lncRNA CCAT2 Protects Against Cardiomyocyte Injury After Myocardial Ischemia/Reperfusion by Regulating BMI1 Expression
Int Heart J. 2024;65(2):279-291. doi: 10.1536/ihj.23-569.ABSTRACTMyocardial ischemia/reperfusion (I/R) decreases cardiac function and efficiency. Accumulating evidence suggests that long noncoding RNAs (lncRNAs) have been linked to the cellular processes of myocardial I/R injury. The present investigation elucidated the function of lncRNA colon cancer-associated transcript 2 (CCAT2) in myocardial I/R injury and the related mechanisms.AC16 cardiomyocytes were exposed to hypoxia (16 hours) /reoxygenation (6 hours) (H/R) to mimic myocardial I/R models in vitro. CCAT2 and microRNA (miR) -539-3p expressions in AC16 cardiomyocyt...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Mengli Zhang Bei Xu Wei Li Bo Yu Huan Peng Feng Gui Fen Ai Zhen Chen Source Type: research
B-Type Natriuretic Peptide Inhibits the Expression and Function of SERCA2a in Heart Failure
Int Heart J. 2024;65(2):292-299. doi: 10.1536/ihj.23-144.ABSTRACTB-type natriuretic peptide (BNP) possesses protective cardiovascular properties; however, there has not been sufficient serious consideration of the side effects of BNP. As for sarcoplasmic/endoplasmic reticulum calcium ATPase 2a (SERCA2a), it was once considered a new target for the treatment of heart failure (HF). Nevertheless, clinical trials of SERCA2a gene therapy in HF have finally become unsuccessful. Research has found that elevated BNP levels and decreased SERCA2a expression are two important HF characteristics, which are always negatively correlated...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Yuting Zhai Junhong Chen Rongsheng Kan Haochen Xuan Chaofan Wang Dongye Li Tongda Xu Source Type: research
MiR-522-3p Attenuates Cardiac Recovery by Targeting FOXP1 to Suppress Angiogenesis
Int Heart J. 2024;65(2):300-307. doi: 10.1536/ihj.23-269.ABSTRACTAngiogenesis is crucial for blood supply reconstitution after myocardial infarction in patients with acute coronary syndrome (ACS). MicroRNAs are recognized as important epigenetic regulators of endothelial angiogenesis. The purpose of this study is to determine the roles of miR-522-3p in angiogenesis after myocardial infarction. The expression levels of miR-522-3p in rats' plasma and in the upper part of the ligation of the heart tissues at 28 days after myocardial infarction were significantly higher than those of the sham group. miR-522-3p mimics inhibited...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Chunyu Li Yanan Pu Di Wang Rong Cheng Rui Xu Qingyun Gong Yi Jiang Cheng Zhang Yan Chen Source Type: research
Hydroxycitric Acid Tripotassium Hydrate Attenuates Monocrotaline and Hypoxia-Induced Pulmonary Hypertension in Rats
CONCLUSIONS: This study shows that hydroxycitric acid tripotassium hydrate can alleviate pulmonary hypertension caused by hypoxia and monocycloline in rats, improve remodeling of the right ventricle and pulmonary artery, and inhibit pulmonary artery smooth muscle cell proliferation and migration. The protective effects may be achieved by regulating inflammation and oxidative stress through the p65 signaling pathway.PMID:38556339 | DOI:10.1536/ihj.23-350 (Source: International Heart Journal)
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Shunjun Wang Huayang Li Quan Liu Husai Ma Lin Huang Laishun Yu Zhongkai Wu Source Type: research
Platelet Microparticle-Derived MiR-320b Inhibits Hypertension with Atherosclerosis Development by Targeting ETFA
This study aimed to explore the role and mechanism of platelet microparticle (PMP) -derived microRNA-320b (miR-320b) in patients with hypertension accompanied by atherosclerosis.We collected samples from 13 controls without hypertension and atherosclerosis and 20 patients who had hypertension accompanied by atherosclerosis. In vitro, platelets were activated by Thrombin receptor-activating peptide to produce PMPs. HUVECs were induced by CoCl2 to mimic a hypoxic environment in vitro. RT-qPCR was employed to detect the expression levels of CD61, miR-320b, and ETFA. The protein expression level of ETFA was evaluated via Weste...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Yongcong He Yangyang Jiang Fan Wu Xiaoxue Zhang Shaolan Liang Zebing Ye Source Type: research
Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway
This study aims to elucidate the effect of Chemokine (C C motif) receptor-like 2 (CCRL2) in experimental autoimmune myocarditis (EAM) occurrence and its potential regulatory mechanisms.EAM was simulated in a mouse model injected with α-myosin-heavy chain. The changes on EAM were assessed through histological staining of heart tissues, including measuring cardiac troponin I (cTnI), proinflammatory cytokines, transferase-mediated dUTP nick end labeling (TUNEL) assay, and cardiac function. Then, the heart tissues from the EAM mouse model and control groups were analyzed through transcriptome sequencing to identify the differ...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Lin Chen Jing Meng Jia Zheng Tingting Zhao Qi Li Chengzhi Lu Source Type: research
Ponatinib-Related Vasospastic Angina
We report 3 cases of Ponatinib-related vasospastic angina, in which prophylactic administration of nitrates or calcium channel blockers was effective.PMID:38556342 | DOI:10.1536/ihj.23-355 (Source: International Heart Journal)
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Michiho Shindo Chinatsu Komiyama Tetsuo Yamaguchi Kosei Kageyama Hisashi Yamamoto Yo Fujimoto Naoyuki Uchida Takahide Kodama Source Type: research
A Case of Ventricular Fibrillation in Masked Long-QT Syndrome Coexisting with Coronary Vasospasm
Int Heart J. 2024;65(2):354-358. doi: 10.1536/ihj.23-397.ABSTRACTAlthough long-QT syndrome (LQTS) with a normal range QT interval at rest leads to fatal ventricular arrhythmias, it is difficult to diagnose. In this article, we present a rare case of a patient who suffered a cardiac arrest and was recently diagnosed with LQTS and coronary vasospasm. A 62-year-old man with no syncopal episodes had a cardiopulmonary arrest while running. During coronary angiography, vasospasm was induced and we prescribed coronary vasodilators, including calcium channel blockers. An exercise stress test was performed to evaluate the effect of...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Atsumasa Kurozumi Yoshinari Enomoto Hisao Hara Norihiro Kato Yukio Hiroi Source Type: research
Congenital Pulmonary Lymphangiectasia Masked by Postoperative Pulmonary Venous Obstruction in an Infant with Total Anomalous Pulmonary Venous Connection
Int Heart J. 2024;65(2):363-366. doi: 10.1536/ihj.23-232.ABSTRACTCongenital pulmonary lymphangiectasia (CPL) is associated with fetal pulmonary venous obstructive physiology. The precise morbidity of CPL is unknown as CPL is generally fatal in neonates. Here, we report an infant with secondary CPL in total anomalous pulmonary venous connection (TAPVC). He developed severe pulmonary hypertension (PH) after corrective surgery for TAPVC. However, cardiac catheterization showed mild left pulmonary venous obstruction (PVO), which was deemed unnecessary for re-intervention. He died at 11 months-old due to an exacerbation of PH. ...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Yoshiko Nawata Daisuke Toyomura Seigo Okada Yasuo Suzuki Narumi Honda-Nakada Yuji Ohnishi Yuichiro Sugitani Naoki Kawaguchi Rui Tokitaka-Okada Naoki Masaki Eiji Ikeda Shunji Hasegawa Source Type: research
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Int Heart J. 2024;65(2):371. doi: 10.1536/ihj.65.371.NO ABSTRACTPMID:38556345 | DOI:10.1536/ihj.65.371 (Source: International Heart Journal)
Source: International Heart Journal - March 31, 2024 Category: Cardiology Source Type: research
Errata: Effect of Thimerosal on Arrhythmia Induced by Coronary Ligation: The Involvement of ATP-dependent Potassium Channels
Int Heart J. 2024;65(2):372. doi: 10.1536/ihj.65-2_Errata.ABSTRACTSeveral errors (shown with underlines) in the following list appeared in the article "Effect of Thimerosal on Arrhythmia Induced by Coronary Ligation: The Involvement of ATP-dependent Potassium Channels" by Ömer Bozdogan, Ersöz Gonca, Melih Nebigil, Eylem Suveren Tiryaki (Vol. 46 No.4, 711-721, 2005).PMID:38556346 | DOI:10.1536/ihj.65-2_Errata (Source: International Heart Journal)
Source: International Heart Journal - March 31, 2024 Category: Cardiology Source Type: research
