B-Type Natriuretic Peptide Inhibits the Expression and Function of SERCA2a in Heart Failure
Int Heart J. 2024;65(2):292-299. doi: 10.1536/ihj.23-144.ABSTRACTB-type natriuretic peptide (BNP) possesses protective cardiovascular properties; however, there has not been sufficient serious consideration of the side effects of BNP. As for sarcoplasmic/endoplasmic reticulum calcium ATPase 2a (SERCA2a), it was once considered a new target for the treatment of heart failure (HF). Nevertheless, clinical trials of SERCA2a gene therapy in HF have finally become unsuccessful. Research has found that elevated BNP levels and decreased SERCA2a expression are two important HF characteristics, which are always negatively correlated...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Yuting Zhai Junhong Chen Rongsheng Kan Haochen Xuan Chaofan Wang Dongye Li Tongda Xu Source Type: research
MiR-522-3p Attenuates Cardiac Recovery by Targeting FOXP1 to Suppress Angiogenesis
Int Heart J. 2024;65(2):300-307. doi: 10.1536/ihj.23-269.ABSTRACTAngiogenesis is crucial for blood supply reconstitution after myocardial infarction in patients with acute coronary syndrome (ACS). MicroRNAs are recognized as important epigenetic regulators of endothelial angiogenesis. The purpose of this study is to determine the roles of miR-522-3p in angiogenesis after myocardial infarction. The expression levels of miR-522-3p in rats' plasma and in the upper part of the ligation of the heart tissues at 28 days after myocardial infarction were significantly higher than those of the sham group. miR-522-3p mimics inhibited...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Chunyu Li Yanan Pu Di Wang Rong Cheng Rui Xu Qingyun Gong Yi Jiang Cheng Zhang Yan Chen Source Type: research
Hydroxycitric Acid Tripotassium Hydrate Attenuates Monocrotaline and Hypoxia-Induced Pulmonary Hypertension in Rats
CONCLUSIONS: This study shows that hydroxycitric acid tripotassium hydrate can alleviate pulmonary hypertension caused by hypoxia and monocycloline in rats, improve remodeling of the right ventricle and pulmonary artery, and inhibit pulmonary artery smooth muscle cell proliferation and migration. The protective effects may be achieved by regulating inflammation and oxidative stress through the p65 signaling pathway.PMID:38556339 | DOI:10.1536/ihj.23-350 (Source: International Heart Journal)
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Shunjun Wang Huayang Li Quan Liu Husai Ma Lin Huang Laishun Yu Zhongkai Wu Source Type: research
Platelet Microparticle-Derived MiR-320b Inhibits Hypertension with Atherosclerosis Development by Targeting ETFA
This study aimed to explore the role and mechanism of platelet microparticle (PMP) -derived microRNA-320b (miR-320b) in patients with hypertension accompanied by atherosclerosis.We collected samples from 13 controls without hypertension and atherosclerosis and 20 patients who had hypertension accompanied by atherosclerosis. In vitro, platelets were activated by Thrombin receptor-activating peptide to produce PMPs. HUVECs were induced by CoCl2 to mimic a hypoxic environment in vitro. RT-qPCR was employed to detect the expression levels of CD61, miR-320b, and ETFA. The protein expression level of ETFA was evaluated via Weste...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Yongcong He Yangyang Jiang Fan Wu Xiaoxue Zhang Shaolan Liang Zebing Ye Source Type: research
Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway
This study aims to elucidate the effect of Chemokine (C C motif) receptor-like 2 (CCRL2) in experimental autoimmune myocarditis (EAM) occurrence and its potential regulatory mechanisms.EAM was simulated in a mouse model injected with α-myosin-heavy chain. The changes on EAM were assessed through histological staining of heart tissues, including measuring cardiac troponin I (cTnI), proinflammatory cytokines, transferase-mediated dUTP nick end labeling (TUNEL) assay, and cardiac function. Then, the heart tissues from the EAM mouse model and control groups were analyzed through transcriptome sequencing to identify the differ...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Lin Chen Jing Meng Jia Zheng Tingting Zhao Qi Li Chengzhi Lu Source Type: research
Ponatinib-Related Vasospastic Angina
We report 3 cases of Ponatinib-related vasospastic angina, in which prophylactic administration of nitrates or calcium channel blockers was effective.PMID:38556342 | DOI:10.1536/ihj.23-355 (Source: International Heart Journal)
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Michiho Shindo Chinatsu Komiyama Tetsuo Yamaguchi Kosei Kageyama Hisashi Yamamoto Yo Fujimoto Naoyuki Uchida Takahide Kodama Source Type: research
A Case of Ventricular Fibrillation in Masked Long-QT Syndrome Coexisting with Coronary Vasospasm
Int Heart J. 2024;65(2):354-358. doi: 10.1536/ihj.23-397.ABSTRACTAlthough long-QT syndrome (LQTS) with a normal range QT interval at rest leads to fatal ventricular arrhythmias, it is difficult to diagnose. In this article, we present a rare case of a patient who suffered a cardiac arrest and was recently diagnosed with LQTS and coronary vasospasm. A 62-year-old man with no syncopal episodes had a cardiopulmonary arrest while running. During coronary angiography, vasospasm was induced and we prescribed coronary vasodilators, including calcium channel blockers. An exercise stress test was performed to evaluate the effect of...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Atsumasa Kurozumi Yoshinari Enomoto Hisao Hara Norihiro Kato Yukio Hiroi Source Type: research
Congenital Pulmonary Lymphangiectasia Masked by Postoperative Pulmonary Venous Obstruction in an Infant with Total Anomalous Pulmonary Venous Connection
Int Heart J. 2024;65(2):363-366. doi: 10.1536/ihj.23-232.ABSTRACTCongenital pulmonary lymphangiectasia (CPL) is associated with fetal pulmonary venous obstructive physiology. The precise morbidity of CPL is unknown as CPL is generally fatal in neonates. Here, we report an infant with secondary CPL in total anomalous pulmonary venous connection (TAPVC). He developed severe pulmonary hypertension (PH) after corrective surgery for TAPVC. However, cardiac catheterization showed mild left pulmonary venous obstruction (PVO), which was deemed unnecessary for re-intervention. He died at 11 months-old due to an exacerbation of PH. ...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Yoshiko Nawata Daisuke Toyomura Seigo Okada Yasuo Suzuki Narumi Honda-Nakada Yuji Ohnishi Yuichiro Sugitani Naoki Kawaguchi Rui Tokitaka-Okada Naoki Masaki Eiji Ikeda Shunji Hasegawa Source Type: research
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Int Heart J. 2024;65(2):371. doi: 10.1536/ihj.65.371.NO ABSTRACTPMID:38556345 | DOI:10.1536/ihj.65.371 (Source: International Heart Journal)
Source: International Heart Journal - March 31, 2024 Category: Cardiology Source Type: research
Errata: Effect of Thimerosal on Arrhythmia Induced by Coronary Ligation: The Involvement of ATP-dependent Potassium Channels
Int Heart J. 2024;65(2):372. doi: 10.1536/ihj.65-2_Errata.ABSTRACTSeveral errors (shown with underlines) in the following list appeared in the article "Effect of Thimerosal on Arrhythmia Induced by Coronary Ligation: The Involvement of ATP-dependent Potassium Channels" by Ömer Bozdogan, Ersöz Gonca, Melih Nebigil, Eylem Suveren Tiryaki (Vol. 46 No.4, 711-721, 2005).PMID:38556346 | DOI:10.1536/ihj.65-2_Errata (Source: International Heart Journal)
Source: International Heart Journal - March 31, 2024 Category: Cardiology Source Type: research
Characteristics of Shoshin Beriberi, a Fulminant Cardiovascular Type of Beriberi
Int Heart J. 2024;65(2):171-172. doi: 10.1536/ihj.24-034.NO ABSTRACTPMID:38556327 | DOI:10.1536/ihj.24-034 (Source: International Heart Journal)
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Eisuke Amiya Hiroyuki Morita Source Type: research
Recent Advances on Selenium Nutrition and Keshan Disease
Int Heart J. 2024;65(2):173-179. doi: 10.1536/ihj.23-628.ABSTRACTKeshan disease (KD) is a type of endemic cardiomyopathy with an unknown cause. It is primarily found in areas in China with low selenium levels, from northeast to southwest. The nutritional biogeochemical etiology hypothesis suggests that selenium deficiency is a major factor in KD development. Selenium is important in removing free radicals and protecting cells and tissues from peroxide-induced damage. Thus, low environmental selenium may affect the selenium level within the human body, and selenium level differences are commonly observed between healthy peo...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Shu-Juan Li An-Wei Wang Kai-Lian Huang Ying Yang Source Type: research
Clinical Significance of the Triglyceride-Glucose Index in Patients Requiring Nonsurgical Intensive Care
Int Heart J. 2024;65(2):180-189. doi: 10.1536/ihj.23-409.ABSTRACTThe evaluation of triglyceride-glucose (TyG) index has not been sufficient in patients requiring nonsurgical intensive care.A total of 3,906 patients who required intensive care were enrolled. We computed the TyG index using the value on admission by the following formula: ln [triglyceride (mg/dL) × glucose (mg/dL) /2]. Patients were divided into three groups according to the TyG index quartiles: low (quartile 1 [Q1]; TyG index ≤ 8.493, n = 977), middle (Q2/Q3; 8.494 ≤ TyG index ≤ 9.536, n = 1,953), and high (Q4; TyG index > 9.537, n = 976). The med...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Suguru Nishigoori Akihiro Shirakabe Hirotake Okazaki Masato Matsushita Yusaku Shibata Shota Shigihara Tomofumi Sawatani Kenichi Tani Kazutaka Kiuchi Nobuaki Kobayashi Kuniya Asai Source Type: research
Impact of Red Blood Cell Transfusion on Subsequent Cardiovascular Events in Patients with Acute Heart Failure and Anemia
In conclusion, this study suggests that RBC transfusions for anemia may not improve clinical outcomes in patients with AHF.PMID:38556330 | DOI:10.1536/ihj.23-596 (Source: International Heart Journal)
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Yukihiro Watanabe Shuhei Tara Takuya Nishino Katsuhito Kato Yoshiaki Kubota Daisuke Hayashi Kosuke Mozawa Junya Matsuda Hideki Miyachi Yukichi Tokita Yu-Ki Iwasaki Masahiro Yasutake Kuniya Asai Source Type: research
Impact of Hemoglobin Level, White Blood Cell Count, Renal Dysfunction, and Staphylococcus as the Causative Organism on Prediction of In-Hospital Mortality from Infective Endocarditis
In this study, a total of 162 patients who were admitted to our hospital during the period from 2009 to 2021, who were suspected of having IE according to the modified Duke classification, and for whom IE was confirmed by transesophageal echocardiography were retrospectively analyzed. Patients were observed for a mean-period of 43.7 days with the primary endpoint being in-hospital death. The in-hospital death group had a lower level of hemoglobin (Hb), higher white blood cell (WBC) count, lower level of estimated glomerular filtration rate (eGFR), and higher frequency of Staphylococcus being the causative agent than those ...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Masamichi Koike Takahiro Doi Koki Morishita Kosuke Uruno Mirei Kawasaki-Nabuchi Kaoru Komuro Hiroyuki Iwano Syuichi Naraoka Daigo Nagahara Satoshi Yuda Source Type: research
