Division of Allergy, Immunology and Transplantation Subcommittee - June 2017
Report from Division Director and Division StaffAir date: 6/5/2017 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - May 23, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Myeloid-derived Trefoil Factor 2 (TFF2) controls epithelial regeneration at the mucosal interface
Immunology Interest Group Seminar Series
Trefoil factor proteins, an enigmatic family of mucosal cytokines, are known to promote tissue repair. Despite being discovered decades ago, not much was known until recently about how Trefoil proteins work. Dr. Herbert ’ s laboratory has discovered that these proteins regulate immune responses in allergic asthma and hookworm infection, and that they trigger the regeneration of epithelial cells.
De ’ Broski Herbert is an Associate Professor of Immunology at the University of Pennsylvania School of Veterinary Medicine. He received his B.S. in microbiology from Xavier University i...
Source: Videocast - All Events - May 17, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
The Abscopal Effect: Optimal Radiation Dose and Fractionation
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Formenti is the Chair of Radiation Oncology at Weill Cornell Medical College and the Associate Director of the Cancer Center. Trained as a medical and radiation oncologist she devoted her career to translate novel preclinical information to the clinic. Key to her formation was a year spent in Malcolm Mitchell ’ s laboratory at USC, in cancer immunology. Her initial research on how to best combine radiation and systemic therapy, both pre-clinically and clinically evolved on focusing on the systemic effects of radiotherapy, particularly on the immune system. Her l...
Source: Videocast - All Events - May 15, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Epithelial molecules shaping immunosurveillance by local T cells
Immunology Interest Group Seminar Series
The thesis of conventional immunology is centralized control whereby responses to infection within tissues are decided within lymph nodes, from which effector T lymphocytes are dispatched to quell regional disturbances. But this cannot explain the observation that many tissues at steady state are T cell-rich. Do such cells simply provide responses to infection or do they provide more generalized means to sustain tissue integrity and organ function? Likewise, how are such cells able to respond to acute stress but not drive constitutive tissue inflammation? And, how do immune cell –...
Source: Videocast - All Events - May 8, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Hijacking of immune regulatory mechanisms in lymphoid malignancies
Immunology Interest Group Seminar Series
Signalling through the B cell receptor (BCR) is central to the development and maintenance of B cells. In light of the numerous proliferative and survival pathways activated downstream of the BCR, it comes as no surprise that malignant B cells would co-opt this receptor to promote their own growth and survival. However, direct evidence for BCR signalling in human lymphoma has only come to light recently. Roles for antigen-dependent and antigen-independent, or tonic, BCR signalling have now been described for several different lymphoma subtypes. Furthermore, correlative data implicat...
Source: Videocast - All Events - April 17, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Innate allergy
Immunology Interest Group Seminar Series
Despite clear roles for classical arms of immunity in maintenance of a healthy commensal microbial flora and protection from invasive pathogenic organisms, the purpose of allergic immunity, which underlies increasingly prevalent diseases like food allergy, asthma and atopic dermatitis, remains puzzling. The discovery of innate lymphoid cells that are programmed to produce cytokines associated with allergic immunity has provided new opportunities to assess basal physiologic processes that involve this canonical tissue response, and may reveal opportunities for re-tuning this arm of i...
Source: Videocast - All Events - March 30, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
The gut microbiome: a master regulator of metabolism
Immunology Interest Group Seminar Series
Humans and many other animals are home to enormous numbers of beneficial bacteria that profoundly influence health. The existence of beneficial resident microorganisms was first recognized in the late 1800's by Louis Pasteur, who founded the field of medical microbiology. However, we ’ ve only recently begun to acquire a molecular understanding of how resident microorganisms contribute to our health. The Hooper lab has spent more than a decade studying how resident bacteria of the gut communicate with our own cells to shape our physiology, our development, and our ability to fight...
Source: Videocast - All Events - March 27, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Human T cells in immunity, autoimmunity and immunodeficiencies
Immunology Interest Group Seminar Series
Dr. Sallusto''s laboratory is focused on the understanding of the mechanisms that control T cell priming and regulate cytokine production and homing capacities. These questions are addressed primarily in the human system, combining the ex vivo analysis of memory T cell subsets with in vitro priming of naive T cells. This approach has led to the identification of chemokine receptors expressed in human Th17 and Th22 cells, and to the dissection of the cytokines that drive naive T cells polarization and modulate T cells effector functions. In parallel, Dr. Sallusto''s laboratory has us...
Source: Videocast - All Events - March 16, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Elucidating the regulation of antiviral immune responses in humans
Director's Seminar Series
Research in the laboratory headed by Dr. Su is aimed at understanding the molecular regulation of human immune responses in vivo. The laboratory aims to identify the genetic underpinnings of patients who have rare inherited immunodeficiencies that present with virus infections. These patients serve as " experiments of nature " who can more broadly inform us as to what is happening in the healthy immune system. Viruses of particular interest include those that infect the skin such as herpes simplex virus, as well as systemic viruses such as Epstein-Barr virus, and more recently respiratory tract vi...
Source: Videocast - All Events - March 14, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Myeloid-derived Trefoil Factor 2 (TFF2) controls epithelial regeneration at the mucosal interface
Immunology Interest Group Seminar Series
Trefoil factor proteins, an enigmatic family of mucosal cytokines, are known to promote tissue repair. Despite being discovered decades ago, not much was known until recently about how Trefoil proteins work. Dr. Herbert ’ s laboratory has discovered that these proteins regulate immune responses in allergic asthma and hookworm infection, and that they trigger the regeneration of epithelial cells.
De ’ Broski Herbert is an Associate Professor of Immunology at the University of Pennsylvania School of Veterinary Medicine. He received his B.S. in microbiology from Xavier University i...
Source: Videocast - All Events - March 13, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Genetics and immunology of alopecia areata
NIH Director ’ s Wednesday Afternoon Lecture Series
For the past 20 years, Dr. Christiano's research has focused on understanding the molecular processes that lead to inherited skin and hair disorders in humans. Her research career began with the discovery of genetic mutations associated with epidermolysis bullosa, a skin disease that causes severe blistering. Dr. Christiano's recent work has focused on the investigation of the underlying genetic causes of and identification of potential therapies for alopecia areata, an autoimmune form of hair loss.For more information go tohttps://oir.nih.gov/walsAir date: 3/1/2017 3...
Source: Videocast - All Events - February 27, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Aire: new tricks from an old dog
Immunology Interest Group Seminar Series
Aire is a transcriptional regulator that controls immunological tolerance. Its primary modus operandi is the induction – specifically in thymic medullary epithelial cells – of a battery of transcripts encoding proteins characteristic of terminally differentiated peripheral cell-types, and consequently negative selection of T cells that recognize these proteins. After briefly reviewing the classical findings, this presentation will focus on more recently discovered facets of Aire function, including positive selection of a perinatal population of regulatory T cells, inhibition of...
Source: Videocast - All Events - February 22, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Shared Pathways Controlling the Development of Innate and Innate-Like Lymphocytes
Immunology Interest Group Seminar Series
I will present our current understanding of the PLZF-driven molecular mechanisms underlying the development of Innate and Innate-Like Lymphocytes, highlighting recent findings regarding the upstream events leading to PLZF induction and the downsteeam targets of PLZF. Ultimately, these findings shed light on a fundamental dichotomy between conventional lymphocytes, which acquire effector function after encounter with pathogens, and innate lymphocytes which acquire their effector programs during development.
Dr Bendelac obtained his MD and PhD in Paris, France and joined Ronald Schwar...
Source: Videocast - All Events - February 22, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Control of T Helper Type 2 Responses by Dendritic Cells
Immunology Interest Group Seminar Series
In my laboratory the focus will be on two main areas of research: (1) the mechanisms determining the commitment and plasticity of memory follicular helper CD4 T cells (Tfh) cells and their role in allergy, and (2) the roles that dendritic cell (DC) subpopulations play in the induction of T Helper 2 (Th2) responses to common allergens that trigger allergic asthma. Our data indicate that IL-4-committed Tfh cells are precursors of house dust mite (HDM)-specific Th2 cells and reveal an unexpected role of B cells and Tfh cells in the pathogenesis of allergic asthma. In addition, new data...
Source: Videocast - All Events - February 7, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Oh to be seventeen again: IL-17 signaling in fungal immunity and autoimmune disease
Immunology Interest Group Seminar Series
The IL-17 family constitutes a distinct subclass of pro-inflammatory cytokines with unique structures and signaling properties. Signals from IL-17 mediate immunity to extracellular pathogens, particularly the commensal fungus Candida albicans. Conversely, dysregulated IL-17 signal transduction drives pathogenesis in autoimmune conditions, including psoriasis. This talk will discuss both sides of this dual-acting cytokine, from the perspective of IL-17 receptor-induced signal transduction mechanisms.
Biography: Dr. Sarah Gaffen received her BS in Biological Sciences from Carnegie Mel...
Source: Videocast - All Events - February 3, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
