IIG Seminar - MHC-II heterozygosity limits T1D susceptibility through non-cognate negative selection.
The ability of T cells to distinguish highly similar peptide ligands bound to a specific class of MHC proteins is the underlying basis for a functioning adaptive immune system. Why TCRs - which are structurally very similar to antibodies - only bind MHC proteins is poorly understood. The Huseby lab is focused on the molecular and cellular pathways that govern the generation, maintenance and function of a self-tolerant T cell repertoire and the autoimmune consequences of self-tolerance failure. To understand how T cell repertoires develop and how defects in the process lead to autoimmune disease, Dr. Huseby ’ s group has ...
Source: Videocast - All Events - May 11, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Heterologous Immunity: How Infection History affects Inflammatory Diseases
Our understanding of host-pathogen interaction is primarily derived from studying how the immune system protects us from a single pathogen. In contrast, it is largely unknown how this response alters the body ’ s ability to respond to a second infectious agent or the susceptibility to autoimmunity or cancer. Nicole Joller and her group investigate the long-term effects of pathogenic challenges on future responses. Currently, they are focusing on changes in the regulatory compartment of the adaptive immune system. The Joller laboratory employs in-vivo animal models, cellular assays and genome-scale approaches to investiga...
Source: Videocast - All Events - May 9, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Multimodal decoding of liver regeneration and repair
Neil Henderson, Professor of Tissue Repair and Regeneration at the University of Edinburgh, is an academic hepatologist with an international profile in defining cellular interactions and molecular pathways driving organ fibrosis. Organ fibrosis (scarring) is a major cause of morbidity and mortality worldwide, and as yet there are no effective anti-fibrotic treatments. Dr. Henderson is primarily interested in the cellular and molecular mechanisms that drive organ fibrosis, and the pathways which are responsible for efficient wound healing and healthy tissue regeneration following injury. Dr. Henderson and his group have de...
Source: Videocast - All Events - May 9, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Advances in Aging, Immunity and Chronic Inflammatory Diseases (Day 2)
The National Institute on Aging (NIA), National Institute of Allergy and Infectious Diseases (NIAID), and National Institute of Dental and Craniofacial Research (NIDCR) will host a workshop on Advances in Aging, Immunity and Chronic Inflammatory Diseases at Rockledge 2, Room 160 (1st level) on May 9-10, 2023. • May 9: 9:00 AM – 5:40 PM (EST) • May 10: 8:30 AM – 5:15 PM (EST)
This workshop will focus on recent advances (biological and technological) in our knowledge of immunosenescence, aging, and their impact on chronic disease development The past few years have seen major advances in our knowledge of immune f...
Source: Videocast - All Events - May 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Advances in Aging, Immunity and Chronic Inflammatory Diseases (Day 1)
The National Institute on Aging (NIA), National Institute of Allergy and Infectious Diseases (NIAID), and National Institute of Dental and Craniofacial Research (NIDCR) will host a workshop on Advances in Aging, Immunity and Chronic Inflammatory Diseases at Rockledge 2, Room 160 (1st level) on May 9-10, 2023. • May 9: 9:00 AM – 5:40 PM (EST) • May 10: 8:30 AM – 5:15 PM (EST)
This workshop will focus on recent advances (biological and technological) in our knowledge of immunosenescence, aging, and their impact on chronic disease development The past few years have seen major advances in our knowledge of immune f...
Source: Videocast - All Events - May 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar
Michail Lionakis combines groundbreaking studies of murine candidiasis models with clinical and genomic insight from his stewardship of the world ’ s largest APECED patient cohort to generate radical, transformative discoveries of fungal infection at the intersection of colonization, invasion, and host defense. Dr. Lionakis has achieved many “ firsts ” , including identification of new AIRE and CARD9 mutations, redefinition of disease clinical spectra, and discovery of effective treatment regimens. He leverages his candidiasis mouse models to advance mechanistic insight, including how Card9 deficiency causes CNS-spec...
Source: Videocast - All Events - April 25, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH/FDA IIG Seminar - Enfu Hui
Dr. Hui is an associate professor at UCSD, leading a research laboratory on investigating the mechanisms of immune checkpoints, using cell-free membrane reconstitution, time-resolved live cell microscopy and cutting-edge cell biology approaches. Dr. Hui ’ s laboratory recently uncovered two novel aspects of PD-L1/PD-1 signaling. Intracellularly, Dr. Hui and his group showed that the T cell costimulatory receptor CD28 is a primary target of PD-1 associated phosphatases. Extracellularly, they discovered that PD-L1, a key weapon of tumor cells, can be neutralized in cis by PD-1 expressed on the same cells. Dr. Hui continues...
Source: Videocast - All Events - April 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Gwendalyn Randolph
Dr. Randolph ’ s research integrates the study of monocytes, monocyte-derived cells, and dendritic cells with vascular and lymphatic vessel biology. Dr. Randolph and her team have pioneered assays to study migration of these immune cells to lymph nodes in various tissues, and their work on tracking monocytes has led to advances in understanding the relationship of monocytes to the dendritic cell system in vivo. This work has led to identification of a core set of genes that define macrophages, while revealing striking tissue-specific profiles for resident macrophages in different organs. Her group has also developed assa...
Source: Videocast - All Events - April 3, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Grand Rounds: Studying Precision Oncology Past by Mining a Clinical Trials Database and Identifying Future Opportunities from Single-Cell Analysis
CCR Grand Rounds“ Studying Precision Oncology Past by Mining a Clinical Trials Database and Identifying Future Opportunities from Single-Cell Analysis ”
Alejandro A. Sch ä ffer, Ph.D.
Staff Scientist, Cancer Data Science Laboratory
Center for Cancer Research, NCI
Friday, March 31, 2023
12:00 – 1:00 p.m.
Lipsett Amphitheater
(Masks required)
Also available to view via NIH Videocast.
Alejandro Sch ä ffer, Ph.D., was born in Montevideo, Uruguay, and emigrated with his parents to the United States. He received his B.S. in Applied Mathematics and his M.S. in Mathematics from Carnegie Mellon University in 1983. He re...
Source: Videocast - All Events - March 24, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar: NIH/FDA - Tobias Hohl
All people encounter, inhale, and ingest fungi on a daily basis. Although only several hundred of the estimated five million species of fungi worldwide cause disease in humans, advances in medical technologies and the global AIDS pandemic have dramatically increased our susceptibility to fungal disease. In cancer and bone marrow transplant patients, the filamentous mold Aspergillus fumigatus and the commensal fungus Candida albicans represent significant causes of infection-related morbidity and mortality. At present, no fungal vaccines have been licensed for clinical use, and contemporary antifungal therapies for systemic...
Source: Videocast - All Events - March 3, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Pathogenic communications between the mouth and gut
Dr. Kamada ’ s laboratory is interested in understanding how the gut microbiota and host immunity interact in gastrointestinal health and disease. Specifically, they have focused on the mechanisms by which certain pathogenic members of commensal bacteria promote chronic intestinal inflammation that leads to the development of inflammatory bowel disease. Dr. Kamada and his group are investigating how potentially pathogenic members of commensal bacteria accumulate the gut and activate host immune cells. Likewise, Dr. Kamada is studying how beneficial commensal bacteria compete with these pathogenic bacteria and regulate in...
Source: Videocast - All Events - March 1, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - The tumor antigenic landscape associated with T cell infiltration and immunoediting.
The Bassani-Sternberg lab focuses on identifying clinically relevant cancer-specific Human Leukocyte Antigen (HLA) ligands that will guide the development of personalized cancer immunotherapy using mass-spectrometry (MS), currently the only methodology to identify unbiasedly HLA binding peptides that are presented in vivo to cytotoxic T cells. Her group has developed proteogenomics and MS-based immunopeptidomics analytical and computational approaches to identify HLA ligands derived from tumor-associated proteins, mutated neoantigens, non-canonical ORFs and post translationally modified peptides. In the clinic, the Bassani...
Source: Videocast - All Events - March 1, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Clinical Center Grand Rounds: Regulatory B cells and Exosomes: Emerging Immunotherapies for Uveitis, Multiple Sclerosis and Graft-Versus-Host Disease
Charles E. Egwuagu, MPH, PhD, Chief, Molecular Immunology Section, Laboratory of Immunology National Eye Institute, NEIFor more information go tohttps://clinicalcenter.nih.gov/about/news/grcurrent.htmlAir date: 4/19/2023 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 24, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Clinical Center Grand Rounds: Air Makes Me Flare – The Role Of The Environment In Atopic Dermatitis
Air Makes Me Flare – The Role Of The Environment In Atopic Dermatitis
Ian Myles, MD, MPH
Chief, Epithelial Therapeutics Unit
Chief Medical Research Officer, U.S. Public Health Service Commissioned Corps
National Institute of Allergy and Infectious Diseases, NIAIDFor more information go tohttps://clinicalcenter.nih.gov/about/news/grcurrent.htmlAir date: 3/1/2023 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 23, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Mini-Symposium on Spectral Flow cytometry
Our goal is to spur conversations about the technology, including best practice to design panels, new pipelines to process data and new prospects for immunology!
For that reason, this symposium will be for in-person participation only. Seminars will be recorded for archival and for scientists who cannot attend.
We are planning a combination of presentations (seminars and/or posters) from users of the technique in the NIH/FDA communiaty, as well as updates from commercial suppliers.
Novice/curious scientists as well as expert users are encouraged to participate.Air date: 2/24/2023 9:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 22, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
