Targeting immune cell metabolism with a view to altering disease outcome
By training I am an immunologist with expertise in infection biology. Over time, the research focus of my laboratory has remained immunology-based, but has evolved to encompass an interest in autoimmunity and cancer. Over the last 15 years we have increasingly focused on understanding the relationship between basic aspects of cell-intrinsic metabolism and cell function and fate in immune cells. In general, immune cells are responsive to stimulation through receptors that recognize signals from pathogens, other immune cells and stromal cells. Responses to these signals encompass marked changes in cellular metabolism that se...
Source: Videocast - All Events - November 22, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
How does the Plasma Membrane Participate in Receptor-Mediated Cell Signaling?
Cells are poised to respond to their physical environment and must distinguish specific stimuli from biological noise. Specific response mechanisms depend on collective molecular interactions that are regulated in time and space by the plasma membrane and its connections with the cytoskeleton and intracellular structures. Molecular stimuli engage their specific receptors to initiate a transmembrane signal, and the surrounding system efficiently rearranges to amplify this nanoscale interaction to microscale assemblies, yielding a cellular response that often reaches to longer length scales within the organism. A striking ex...
Source: Videocast - All Events - November 21, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Designing Nanoparticles to Probe and Cross Biological Barriers to Immunotherapy
The Mucosal Associated Immune System Engineering and Lymphatics (MAISEL) Lab ’ s research integrates nanotechnology, materials science, and tissue engineering with physiology, medicine, and immunology to probe lymphatics and extracellular barriers via novel ex vivo and in vitro models and nanoparticles. We are particularly focused on studying mucosal barriers to the therapeutic path from the mucosal lumen to the downstream lymph nodes and integrating the newly created knowledge to design immune modulatory therapeutic interventions. We have made significant progress in understanding how nanoparticle material properties li...
Source: Videocast - All Events - November 14, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
The role of early life origin B cells in adult immunity
The adult immune system is a mosaic of short-lived cells that are continuously replenished by ongoing hematopoiesis and self-sustaining cells that originated from times long gone. Using lineage tracing mediated by CD79aCreERT2 induced at various time points during ontogeny we have identified a neonatal wave of B cell output that is remarkably well preserved into adulthood. In addition to B-1 cells, early-life time-stamped B cells contributed substantially to IgA plasma cells. These were actively maintained by B cell memory within gut chronic germinal centers and contained commensal microbiota reactivity. Interestingly, neo...
Source: Videocast - All Events - November 14, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Clinical Center Grand Rounds: Development of a CMV Vaccine: From Bench to Congress
Sallie Permar, MD, PhDNancy C. Paduano Professor and ChairDepartment of Pediatrics, Weill Cornell MedicinePediatrician-in-ChiefNew York-Presbyterian/Weill Cornell Medical CenterProfessor of Immunology and Microbial PathogenesisWeill Cornell Graduate School of Medical SciencesAir date: 11/8/2023 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 30, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS: Dissecting The Human Immune Response: Useful, Basic and Surprising Findings
Antonio Lanzavecchia is an immunologist recognized for his work on antigen presentation by B cells and dendritic cells, for his studies on T cell activation and on the cellular basis of immunological memory, and for the development of novel methods to isolate human monoclonal antibodies. Lanzavecchia was born in Italy and obtained a medical degree from the University of Pavia, where he specialized in pediatrics and in infectious diseases.For more information go tohttps://oir.nih.gov/wals/nih-directors-wednesday-afternoon-lecture-series-2023-2024/dissecting-human-immune-response-useful-basic-surprising-findingsAir date: 1/2...
Source: Videocast - All Events - October 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Grand Rounds: Immunotherapy of Liver Cancer: From Bench to Bedside and Back to the Bench
CCR Grand Rounds“ Immunotherapy of Liver Cancer: From Bench to Bedside and Back to the Bench ”
Tim F. Greten, M.D.
Deputy Chief, Thoracic and GI Malignancies Branch
Co-Director, NCI CCR Liver Cancer Program
Center for Cancer Research, NCI
Dr. Greten is a physician-scientist who uses his medical expertise in gastroenterology, hepatology and medical oncology along with his research expertise in tumor immunology to develop novel treatments for patients with cancer. He heads a research team to study the tumor microenvironment in the li ver in the context of hepatocellular carcinoma, cholangiocarcinoma and liver metasta...
Source: Videocast - All Events - September 13, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Strategies for an HIV Cure (Day 2)
The National Institute of Allergy and Infectious Diseases (NIAID) will host the sixth biennial Strategies for an HIV Cure meeting on October 12-13, 2023. This is a programmatic meeting to review research progress by awardees funded through the NIH Martin Delaney Collaboratories (MDCs) for HIV Cure Research program, foster communication and collaboration between the ten MDCs, and to collect feedback from representatives from each individual MDC Scientific Advisory Board (SAB) and Community Advisory Board (CAB).
The two-day in-person meeting will feature presentations from the ten NIH Martin Delaney Collaboratories for HIV...
Source: Videocast - All Events - September 11, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Strategies for an HIV Cure (Day 1)
The National Institute of Allergy and Infectious Diseases (NIAID) will host the sixth biennial Strategies for an HIV Cure meeting on October 12-13, 2023. This is a programmatic meeting to review research progress by awardees funded through the NIH Martin Delaney Collaboratories (MDCs) for HIV Cure Research program, foster communication and collaboration between the ten MDCs, and to collect feedback from representatives from each individual MDC Scientific Advisory Board (SAB) and Community Advisory Board (CAB).
The two-day in-person meeting will feature presentations from the ten NIH Martin Delaney Collaboratories for HIV...
Source: Videocast - All Events - September 11, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Immunology Interest Group: Immunity, hematopoiesis and cancer through the prism of the gut mycobiome
Weekly Seminar Series for the NIH-FDA Immunology Interest GroupAir date: 9/13/2023 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 7, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar: Microbiome, metabolites and mucosal immunity
NIH-FDA Immunology Interest Group Seminar Series.Air date: 9/6/2023 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 5, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
2023 Frontiers in Basic Immunology (Day 2)
The Center for Cancer Research at the National Cancer Institute is hosting a two-day international symposium on September 27-28, 2023 entitled 2023 Frontiers in Basic Immunology. The program includes recent advances in the field and should be an exciting forum for discussion and debate on the current understanding of basic immunological mechanisms.Air date: 9/28/2023 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - August 28, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
2023 Frontiers in Basic Immunology (Day 1)
The Center for Cancer Research at the National Cancer Institute is hosting a two-day international symposium on September 27-28, 2023 entitled 2023 Frontiers in Basic Immunology. The program includes recent advances in the field and should be an exciting forum for discussion and debate on the current understanding of basic immunological mechanisms.Air date: 9/27/2023 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - August 28, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Division of Allergy, Immunology, and Transplantation Subcommittee - September 2023
Report from Division Director and Division StaffAir date: 9/11/2023 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - August 28, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
GVIRF Webinar: Vaccine Adjuvants for Global Health
The biennial Global Vaccine and Immunization Research Forum (GVIRF) and the associated GVIRF webinar series are global convenings that bring together the entire Vaccine and Immunization Research community, from basic immunology to implementation research, and from low to high income countries to address research challenges, innovations, and opportunities to facilitate vaccine research and development and maximize the benefit of immunization. Both the GVIRF and the webinars are co-organized by the US National Institute of Allergy& Infectious Diseases (NIAID), the Bill& Melinda Gates Foundation, and the World Health Organiza...
Source: Videocast - All Events - August 24, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
