Curing HIV infection: going beyond N=1
Immunology Interest Group Seminar Series
The latent reservoir for HIV is a major barrier to curing HIV
infection. This talk will discuss recent studies of the mechanism by
which the reservoir arises, the mechanism by which it is maintained, and
approaches for measuring the reservoir in patients participating in HIV
cure trials.
Dr. Robert F. Siliciano is a Professor of Medicine and Molecular Biology and Genetics at the Johns Hopkins University School of Medicine and a member of the Howard Hughes Medical Institute. In 1995, his laboratory provided the first demonstration that latently infected memory CD4+ T cells were p...
Source: Videocast - All Events - January 26, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Division of Allergy, Immunology and Transplantation Subcommittee - January 2017
Report from Division Director and Division StaffAir date: 1/30/2017 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 25, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Is the Right Flavor of Inflammation the Key to Successful Cancer Therapy?
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Romina Goldszmid received her Ph.D. working on dendritic cell-based vaccines for melanoma immunotherapy from the University of Buenos Aires, Argentina, part of which was performed as a visiting scholar in the laboratory of Dr. Ralph Steinman at the Rockefeller University. She then did her postdoctoral training in infectious diseases immunology with Dr. Alan Sher in the Laboratory of Parasitic Diseases (LPD) at NIAID. There, Dr. Goldszmid focused on the interplay between dendritic cells and natural killer cells during the early response to Toxoplasma gondii infecti...
Source: Videocast - All Events - January 23, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Group 1 innate lymphoid cells in metabolic disease
Immunology Interest Group Seminar Series
Innate lymphoid cells (ILCs) are the most recently identified arm of the innate immune system that function to protect epithelial barriers against pathogens and maintain tissue homeostasis. Although ILCs can also promote pathology at mucosal sites such as the gut or lung, it remains unknown whether aberrant activation of tissue-resident ILCs can contribute to disease in non-barrier tissues. Here, we identify a subset of long-term adipose-resident ILC1 that are dependent on the transcription factors Nfil3 and T-bet, but phenotypically and functionally distinct from circulating mature...
Source: Videocast - All Events - January 17, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Demystifying Medicine 2017: Glycoproteins, Allergy, and Other Diseases
The Demystifying Medicine Lecture Series is designed to help bridge the gap between advances in biology and their applications to major human diseases. Each lecture will feature a presentation on a major disease, including current research and advancements on treatments.For more information go tohttps://demystifyingmedicine.od.nih.gov/Air date: 1/31/2017 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 17, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
The multi-faceted role of the IgG glycan
Immunology Interest Group Seminar Series
Beyond their role in pathogen neutralization, antibodies mediate pathogen control and clearance via the recruitment of innate immune effector functions including phagocytosis and cytotoxicity but also via the homeostatic regulation of the immune activation. Two modifications to the constant domain of the IgG antibody control this biological activity: 1) the irreversible genomic selection of isotype/subclass and 2) a more subtle alteration in Fc-glycosylation, that together provide instructions to the innate immune system . Because glycosylation alters the affinity of antibodies for ...
Source: Videocast - All Events - January 12, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Pathogen manipulation of antigen-specific T cell responses
Immunology Interest Group Seminar Series
Although protective immunity to intracellular pathogens depends on T cell responses, most studies focus on events related to T cell priming and differentiation in secondary lymphoid tissues. However, effector T cells must act at sites of infection, generally in non-lymphoid tissues, to control pathogen growth and limit tissue damage. Tuberculosis, in addition to being a major problem of global health, is a chronic infection characterized by induction of apparently-appropriate T cell responses in which T cells are routinely unable to clear the pathogen (Mycobacterium tuberculosis).
T...
Source: Videocast - All Events - January 3, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Secrets and Lyase: New Roles of S1P Signaling in the Immune System
Immunology Interest Group Seminar Series
Sphingosine 1-phosphate (S1P) signaling plays critical roles in the cardiovascular and immune systems. We have recently characterized a mouse that lacks the S1P transporter SPNS2. SPNS2-deficient mice have only a minor reduction in blood S1P and hence grossly normal vascular permeability, but a dramatic reduction in lymph S1P and hence severely disrupted lymphocyte trafficking. These mice have revealed unexpected functions of S1P gradients in positioning immune cells within lymphoid organs, as well as in supporting lymphocyte survival.
Dr. Susan Schwab is Associate Professor at the ...
Source: Videocast - All Events - December 8, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Modeling Zika virus in mice: What have we learned so far?
Immunology Interest Group Seminar Series
The recent spread of Zika virus (ZIKV) and its association with increased rates of Guillain Barre and other neurological disorders as well as congenital defects that include microcephaly has created an urgent need to develop animal models to examine the pathogenesis of the disease and explore the efficacy of potential therapeutics and vaccines. Recently developed infection models for ZIKV utilize mice defective in interferon responses. This talk will describe a new model of peripheral ZIKV infection using immunocompetent neonatal C57BL/6 mice and compare its clinical progression, vi...
Source: Videocast - All Events - December 1, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
2016 Kinyoun Lecture - Structure-Based Vaccine Design and B-cell Ontogeny in the Modern Era of Vaccinology
2016 Joseph J. Kinyoun Memorial Lecture
Dr. John Mascola, director of the Dale and Betty Bumpers Vaccine Research Center at NIAID, will deliver the 2016 Joseph J. Kinyoun Memorial Lecture.
His talk, titled “ Structure-Based Vaccine Design and B-cell Ontogeny in the Modern Era of Vaccinology, ” will include an overview of the challenges facing the development of effective vaccines against viruses, including HIV, respiratory syncytial virus and influenza virus. Mascola will describe how researchers can use structural information about viral proteins and antiviral antibodies to design new vaccines. He also will discuss ho...
Source: Videocast - All Events - November 29, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Unraveling T Cell Dysfunction: from Co-Inhibitory Receptors to Molecular Programs
Immunology Interest Group Seminar Series
In chronic diseases such as cancer and chronic viral infections, T cells acquire a dysfunctional state characterized by variable loss of effector functions. Dysfunctional T cells express multiple co-inhibitory receptors, such as CTLA-4 and PD-1, and blockade of these receptors has been harnessed to improve T cell responses and clinical outcome in multiple cancer indications. Unfortunately, the current therapies directed against CTLA-4 and PD-1 do not reach all patients and resistance to these therapies is increasing. This has prompted intense investigation into gaining a deeper unde...
Source: Videocast - All Events - November 29, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
How to Hit HIV Where It Hurts
Immunology Interest Group Seminar Series
No medical procedure has saved more lives than vaccination. But, today, some pathogens have evolved which have defied successful vaccination using the empirical paradigms pioneered by Pasteur and Jenner. One characteristic of many pathogens for which successful vaccines do not exist is that they present themselves in various guises. HIV is an extreme example because of its high mutability. This highly mutable virus can evade natural or vaccine induced immune responses, often by mutating at multiple sites linked by compensatory interactions. I will first describe how by bringing to t...
Source: Videocast - All Events - November 10, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Strategies for an HIV Cure 2016 (Day 3)
This scientific meeting is focused on innovative and collaborative research strategies to cure HIV infection. Investigators from NIH-funded Martin Delaney Collaboratories and other programs related to HIV persistence and cure, investigators in complementary disciplines, and community members will share scientific results and engage in active discussion about the merits of various approaches under investigation. These discussions are intended to stimulate new collaborations and ideas for future research. The meeting is sponsored by the Division of AIDS at the National Institute of Allergy and Infectious Diseases (NIAID), Na...
Source: Videocast - All Events - November 8, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Strategies for an HIV Cure 2016 (Day 2)
This scientific meeting is focused on innovative and collaborative research strategies to cure HIV infection. Investigators from NIH-funded Martin Delaney Collaboratories and other programs related to HIV persistence and cure, investigators in complementary disciplines, and community members will share scientific results and engage in active discussion about the merits of various approaches under investigation. These discussions are intended to stimulate new collaborations and ideas for future research. The meeting is sponsored by the Division of AIDS at the National Institute of Allergy and Infectious Diseases (NIAID), Na...
Source: Videocast - All Events - November 8, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Strategies for an HIV Cure 2016 (Day 1)
This scientific meeting is focused on innovative and collaborative research strategies to cure HIV infection. Investigators from NIH-funded Martin Delaney Collaboratories and other programs related to HIV persistence and cure, investigators in complementary disciplines, and community members will share scientific results and engage in active discussion about the merits of various approaches under investigation. These discussions are intended to stimulate new collaborations and ideas for future research. The meeting is sponsored by the Division of AIDS at the National Institute of Allergy and Infectious Diseases (NIAID), Na...
Source: Videocast - All Events - November 8, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
