Pathogen manipulation of antigen-specific T cell responses
Immunology Interest Group Seminar Series Although protective immunity to intracellular pathogens depends on T cell responses, most studies focus on events related to T cell priming and differentiation in secondary lymphoid tissues. However, effector T cells must act at sites of infection, generally in non-lymphoid tissues, to control pathogen growth and limit tissue damage. Tuberculosis, in addition to being a major problem of global health, is a chronic infection characterized by induction of apparently-appropriate T cell responses in which T cells are routinely unable to clear the pathogen (Mycobacterium tuberculosis). This presentation will focus on mechanisms that limit the efficacy of antigen-specific CD4+ T cells in mice and humans infected with M. tuberculosis. In particular, the presentation will describe multiple mechanisms exploited by the bacteria to modulate antigen presentation in vivo, to promote persistence of the pathogen, and chronic infection. It will also discuss evidence that the success of evasion of human T cell responses can be assessed through long-term evolutionary studies of the bacteria.Air date: 1/11/2017 4:15:00 PM
Tuberculosis (TB) is highly prevalent worldwide, and it affects children and adults equally, causing significant morbidity and mortality. Imaging plays a crucial role in diagnosis and management. Knowledge of imaging modalities available, imaging manifestations of both pulmonary and extrapulmonary tuberculosis, is vital for the radiologist for timely diagnosis among children with TB.
[Govt of SA] Western Cape Government launches first-of-a-kind public facing TB dashboard to help monitor the province's TB response
CONCLUSION: According to our study, tuberculin skin test is a reliable and sensitive test for diagnosis of latent tuberculosis in liver transplant candidates. Isoniazid prophylaxis is well tolerated in patients with end stage liver diseases and liver transplant recipients.PMID:34540155 | PMC:PMC8408033 | DOI:10.18502/ijm.v13i2.5981
CONCLUSION: Although the NTM species has a small portion in TB suspected patients, their prevalence has increased, mainly in elderly patients. Moreover, M. simiae was the most prevalent NTM species in our region. Therefore, identification of common species in each region is recommended and clinicians should pay more attention to them in each region.PMID:34540154 | PMC:PMC8408032 | DOI:10.18502/ijm.v13i2.5980
by Narendran Gopalan, Vignes Anand Srinivasalu, Ponnuraja Chinnayan, Banurekha Velayutham, Adhin Bhaskar, Ramesh Santhanakrishnan, Thirumaran Senguttuvan, Sridhar Rathinam, Mahilmaran Ayyamperumal, Kumar Satagopan, Dhanalakshmi Rajendran, Tamizhselvan Manoharan, Sekar Lakshmanan, Paulkumaran Paramasivam, Dhanalakshmi Angamuthu, Mangalambal Ganesan, John Washington Easudoss Arockia, Ramesh Babu Venkatesan, Venkatesan Lakshmipathy, Shivakumar Shanmugham, Balaji Subramanyam, Shakila Shankar, Jawahar Mohideen Shaheed, Baskaran Dhanaraj, Narayanan Paranji Ramiyengar, Soumya Swaminathan, Padmapriyadarsini Chandrasekaran Introduc...
ConclusionsECMO has won the opportunity for the diagnosis and treatment of this young patient who suffered from a rare cause of cardiac arrest and finally achieved a good prognosis.
In conclusion, our preliminary data suggest a diagnostic and prognostic role for rLiHyQ against leishmaniasis.PMID:34537185 | DOI:10.1016/j.actatropica.2021.106126
Purpose of review Analyses of the host transcriptional response to infection has proved to be an alternative diagnostic strategy to standard direct pathogen detection. This review summarizes the value of applying blood and mucosal transcriptome analyses for the diagnosis and management of children with viral and bacterial infections. Recent findings Over the years, studies have validated the concept that RNA transcriptional profiles derived from children with infectious diseases carry a pathogen-specific biosignature that can be qualitatively and quantitively measured. These biosignatures can be translated into ...