Unraveling the complexities of tryptase form and function in humans
Immunonology IG Seminar
Dr. Jonathan Lyons received his undergraduate education from Pomona College, and a Doctorate of Medicine from the University of Southern California in 2007. Dr. Lyons completed residency training in Internal Medicine at the University of California, San Diego, in 2010, remaining an additional year as a Chief Medical Resident. He concluded his formal medical training as a clinical fellow in Allergy and Immunology at NIAID in 2014. Following completion of fellowship, Jonathan was selected for the NIAID Transition Program in Clinical Research, and he is currently an Assistant Clinical Investigator in t...
Source: Videocast - All Events - November 14, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Transcriptional Regulation of Neuroinflammation
NCI's Center for Cancer Research (CCR) Grand Rounds
Dr. Lazarevic received her B.Sc. Microbiology degree from the University of Nottingham (UK) and Ph.D. degree in Molecular Virology and Microbiology from the University of Pittsburgh. Following her post-doctoral training in the laboratory of Dr. Laurie Glimcher at Harvard School of Public Health, Dr. Lazarevic was recruited as a tenure-track investigator in the Experimental Immunology Branch, CCR. Her laboratory is interested in how transcription factors regulate differentiation and effector function of CD4+ T helper (Th) cells in the context of autoimmune disorders with e...
Source: Videocast - All Events - November 13, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Loss of Type I Interferon Negative Regulation – Lessons from Human Genetics
Immunonology IG Seminar
Dr. Dusan Bogunovic is an Assistant Professor in the Department of Microbiology, Department of Pediatrics at Mindich Child Health and Development Institute at the Icahn School of Medicine at Mount Sinai in New York. He obtained his PhD in Immunology at NYU Medical School where he studied innate immune signaling in dendritic cells as a function of their ability to mount an adaptive immune response against melanoma. That work has inspired two clinical trials. He did his postdoctoral fellowship at The Rockefeller University with Jean-Laurent Casanova where he studied how host genetics contribute to inf...
Source: Videocast - All Events - November 2, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Office of AIDS Research Advisory Council Meeting - November 2017
OAR Director ’ s Report, updates for the DHHS HIV Treatment and Prevention Guidelines, OAR Task Force on Cost Sharing, plans for the Clinical Trials Networks from the National Institute of Allergy and Infectious Diseases, and updates on the HIV/AIDS research activities from Institutes at the NIH.Air date: 11/16/2017 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - October 26, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Innate Immunity in Neurodegeneration
NCI's Center for Cancer Research (CCR) Grand Rounds
Dr. Marco Colonna received his medical degree with honors from the School of Medicine at Parma University in 1983, and completed his specialization in Internal Medicine at Parma University in 1988. He began his postdoctoral training as a Research Fellow at the Istituto Nazionale per la Ricerca sul Cancro in Genova, Italy, followed by work as a Research Affiliate in the Department of Molecular Immunology at Roswell Park Memorial Institute in Buffalo, New York and as a Research Fellow in Pathology at Dana Farber Cancer Institute and Harvard Medical School. He then became a ...
Source: Videocast - All Events - September 25, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
The development and Function of Regulatory T cells
Immunology Interest Group Seminar Series
Dr. Chen ’ s research focuses on elucidating mechanisms of T-cell immunity and tolerance and manipulating T-cell immunity versus tolerance in animal models to understand the pathogenesis of and develop immunotherapy for autoimmunity, cancer and infectious diseases. Among his many scientific contributions to biomedical research, Dr. Chen is the first to discover that TGF-beta induces Foxp3 gene in naive CD4+ T cells and converts them into regulatory T cells (iTregs, pTregs). The paper describing this finding has been cited for more than 4000 times. He has also demonstrated that TGF...
Source: Videocast - All Events - September 25, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Mechanisms of self versus non-self discrimination in the innate immune system
Immunology Interest Group Seminar SeriesAir date: 9/27/2017 2:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 18, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Division of Allergy, Immunology and Transplantation Subcommittee - September 2017
Report from Division Director and Division StaffAir date: 9/11/2017 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - August 14, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Cancer Immunology and Immunotherapy: From Conception to Delivery (Day 2)
This two-day national symposium addresses recent advances in the field and should be an exciting forum for discussion and debate on the current understanding of cancer and immunology and immunotherapy.
Sessions will include:
-Fundamentals of CAR-based Therapies I& II-The Basis of Tumor Recognition-Checkpoint Modulators-Fundamental Biology of T Lymphocytes-Cancer Vaccines and Their ContextFor more information go tohttps://ncifrederick.cancer.gov/events/CancerImmunology2017/default.aspAir date: 10/13/2017 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - August 9, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Cancer Immunology and Immunotherapy: From Conception to Delivery (Day 1)
This two-day national symposium addresses recent advances in the field and should be an exciting forum for discussion and debate on the current understanding of cancer and immunology and immunotherapy.
Sessions will include:
-Fundamentals of CAR-based Therapies I& II-The Basis of Tumor Recognition-Checkpoint Modulators-Fundamental Biology of T Lymphocytes-Cancer Vaccines and Their ContextFor more information go tohttps://ncifrederick.cancer.gov/events/CancerImmunology2017/default.aspAir date: 10/12/2017 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - August 9, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Screening of Discovery's First in Human
Between September 2015 and June 2016, Discovery film crews followed patients, their families, doctors and researchers, and NIH clinical and care staff to provide a personal and realistic look at the challenges of carrying out cutting edge, experimental medicine. The endeavor was a massive undertaking, with Discovery crews capturing over 1,000 hours of footage in the hospital. More than 1,000 staff members consented to be filmed.
The film is a shining moment for the NIH as a whole and the Clinical Center in particular, and provides an unprecedented glimpse into the triumphs and setbacks that are part of being at the forefro...
Source: Videocast - All Events - August 3, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Law of STAT fives, root orchestrators of lymphocyte homeostasis and function
Immunology Interest Group Seminar Series
The transcription factor STAT5 is fundamental to the mammalian immune system. Operating downstream of cytokines and growth factors, it impacts all aspects of lymphocyte biology, from general cellular processes like proliferation and apoptosis, to specialized immunological programs like effector and regulatory T cell differentiation. Genetic studies in humans underscore its widespread influence as mutations of STAT5 or upstream activators manifest varied Alejandro Villarino, NIAMS, NIHimmunological phenotypes including immunodeficiency, autoimmunity and hematological malignancies. Mo...
Source: Videocast - All Events - June 20, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
NETting the web in systemic autoimmunity
Immunology Interest Group Seminar Series
Mariana Kaplan, M.D. is Senior Investigator and Chief of the Systemic Autoimmunity Branch at NIAMS/NIH. Prior to her appointment, she was Professor of Medicine in the Division of Rheumatology at the University of Michigan. Dr. Kaplan obtained her medical degree at the National Autonomous University of Mexico and did her Internal Medicine Residency at the National Institute of Medical Sciences and Nutrition in Mexico City. Dr. Kaplan did her Rheumatology Fellowship and postdoctoral training at the University of Michigan, where she was a member of the faculty for 15 years, and an acti...
Source: Videocast - All Events - June 19, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Interferon-induced transmembrane proteins block Zika virus infection and prevent a non-apoptotic, paraptosis-like cell death pathway
We report that ZIKV induces massive vacuolization followed by “ implosive ” cell death in human epithelial cells, primary skin fibroblasts and astrocytes, a phenomenon which is exacerbated when IFITM3 levels are low. It is reminiscent of paraptosis, a caspase-independent, non-apoptotic form of cell death associated with the formation of large cytoplasmic vacuoles. We further show that ZIKV-induced vacuoles are derived from the endoplasmic reticulum (ER) and dependent on the PI3K/Akt signaling axis. Inhibiting the Sec61 ER translocon in ZIKV-infected cells blocked vacuole formation and viral production. Our results prov...
Source: Videocast - All Events - June 12, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
The plasticity and migratory responses of innate lymphoid cells: more similarity to T cells than you thought
Immunology Interest Group Seminar Series
The identification of innate lymphoid cells (ILCs) was a major step forward in developing a better understanding of host defense. Although ILC lack the capacity for antigen recognition, they show striking similarities with T cell subsets in both the transcription factors that govern their differentiation and the effector cytokines they produce. One major difference in the existing concepts of ILC and adaptive T cell responses is that the former are considered to act largely as tissue resident effectors whereas T cells migrate from secondary lymphoid tissues of activation to peripher...
Source: Videocast - All Events - May 30, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
