IIG Seminar - Tissue-Resident Memory T cells in cancer.
The Mami-Choua ï b laboratory has identified several constitutive elements of the tumor environment (TME) involved in the regulation of antitumor T-cell response. In particular: the influence of TGF- β on the expression and signaling of CD103 in CD8+ resident memory T cells (TRM), and the role of this integrin to sustain specific cytotoxicity and to promote T-cell recruitment within epithelial tumor regions; the role of hypoxia, epithelial-mesenchymal transition (EMT) and p53 in controlling tumor cell susceptibility to T-cell-mediated killing; and the effect of Von Hippel-Lindau (VHL) gene mutations in promoting PD-L1 ex...
Source: Videocast - All Events - January 9, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Clonal dynamics of the recall antibody response
Immunology Interest Group
Victora studies the basic biology of how antibodies are generated in response to infection and immunization. This includes the evolutionary process of affinity maturation in germinal centers, which is essential to improve antibodies ’ powerful targeting capabilities, and the dynamics with which the diversity of antibody responses are pruned and focused on subsequent exposures. To gain a deeper understanding of how high-affinity antibodies are generated and evolve during this complex process, the Victora lab is exploring three complementary perspectives: those of molecules, cells, and whole organ...
Source: Videocast - All Events - January 9, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Mammalian DNases and their role in the tug of war between Staphylococcus aureus and the host
Immunology Interest Group
Victor J. Torres is a microbiologist investigating how multidrug-resistant bacteria cause disease and identifying new therapies to fight and prevent infection. Torres uses a diverse range of techniques spanning genetics, molecular biology, immunology, and bioinformatics to study the bacteria Staphylococcus aureus (S. aureus). S. aureus causes a wide range of diseases, from mild skin infections to life-threatening blood infections. Highly virulent and, in some instances, resistant to antibiotics (known as methicillin-resistant S. aureus, or MRSA), S. aureus is responsible for millions of illnesses ...
Source: Videocast - All Events - January 9, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Division of Allergy, Immunology and Transplantation Subcommittee
Report from Division Director and Division StaffAir date: 1/30/2023 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - December 21, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH-FDA Immunology Interest Group 1.25.23
Victora studies the basic biology of how antibodies are generated in response to infection and immunization. This includes the evolutionary process of affinity maturation in germinal centers, which is essential to improve antibodies ’ powerful targeting capabilities, and the dynamics with which the diversity of antibody responses are pruned and focused on subsequent exposures. To gain a deeper understanding of how high-affinity antibodies are generated and evolve during this complex process, the Victora lab is exploring three complementary perspectives: those of molecules, cells, and whole organs. On the molecular scale,...
Source: Videocast - All Events - December 13, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH-FDA Immunology Interest Group 1.18.23
Victor J. Torres is a microbiologist investigating how multidrug-resistant bacteria cause disease and identifying new therapies to fight and prevent infection. Torres uses a diverse range of techniques spanning genetics, molecular biology, immunology, and bioinformatics to study the bacteria Staphylococcus aureus (S. aureus). S. aureus causes a wide range of diseases, from mild skin infections to life-threatening blood infections. Highly virulent and, in some instances, resistant to antibiotics (known as methicillin-resistant S. aureus, or MRSA), S. aureus is responsible for millions of illnesses and tens of thousands of d...
Source: Videocast - All Events - December 13, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH-FDA Immunology Interest Group 1.11.23
Klaus Fr ü h ’ s research focuses on understanding the molecular interaction between viral pathogens and their hosts, particularly the identification and characterization of viral gene products that modulate the innate and adaptive immune responses. This knowledge is translated into the development and improvement of cytomegalovirus (CMV)-vectored vaccines which are unique in their ability to persistently maintain an immune shield of so called effector memory T cells, including highly unconventional (MHC-II and MHC-E) restricted CD8+ T cells. CMV vectored vaccines have shown protection in non-human primate models of AID...
Source: Videocast - All Events - December 13, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH-FDA Immunology Interest Group Seminar
All immune system cells develop from a common hematopoietic stem cell (HSC) whose differentiation pathway is controlled in part by the activation and repression of lineage specific gene programs. Our laboratory is interested in understanding how these transcriptional programs are wired and how alterations in these pathways lead to disease such as autoimmunity, asthma and acute leukemia. ID2 and ID3 control the development and effector fate of innate lymphoid cells including NK cells, ILCs and NKT cells. Our laboratory has focused on understanding how ID protein expression is regulated in innate lymphoid cells and how the t...
Source: Videocast - All Events - December 12, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Bids Dr. Fauci Farewell
Virtual farewell event to celebrate the remarkable career of Dr. Anthony Fauci, Director of the National Institute of Allergy and Infectious Diseases. For more information, please visit: https://employees.nih.gov/pages/farewell-dr-fauci.aspxGuest of Honor:Anthony Fauci, M.D., Director, NIAIDModerator:John Burklow, Acting Chief of Staff, NIHSpeakers:Lawrence Tabak, D.D.S., Ph.D., Performing the Duties of the Director of the NIHJohn Gallin, M.D., Associate Director for Clinical Research, NIHCliff Lane, M.D., Deputy Director for Clinical Research, NIAIDFrancis Collins, M.D., Ph.D., Special Projects Advisor to the President of...
Source: Videocast - All Events - December 5, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
2022 Immunology Interest Group Workshop (Day 1)
The 2022 NIH/FDA Immunology Interest Group Training Workshop will be held as a hybrid meeting on December 8 and 9, 2022. The workshop is comprised of short talks selected from abstracts submitted by IIG members from NIH and FDA; two plenary talks provided by renowned speakers designated as workshop " gurus; " and two professional development sessions. The IIG workshop particularly provides opportunities for trainees to present their studies and to receive valuable feedback.For more information go tohttps://events.cancer.gov/eib/iigAir date: 12/8/2022 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - November 28, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
2022 Immunology Interest Group Workshop (Day 2)
The 2022 NIH/FDA Immunology Interest Group Training Workshop will be held as a hybrid meeting on December 8 and 9, 2022. The workshop is comprised of short talks selected from abstracts submitted by IIG members from NIH and FDA; two plenary talks provided by renowned speakers designated as workshop " gurus; " and two professional development sessions. The IIG workshop particularly provides opportunities for trainees to present their studies and to receive valuable feedback.For more information go tohttps://events.cancer.gov/eib/iigAir date: 12/9/2022 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - November 28, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Immunology Interest Group: Chemokines and anionic phospholipids: new binding partners for microbial killing and apoptotic cell clearance
Virologist and biochemist studying the immune evasion strategies deployed by viruses to gain new insights into the mechanisms of the immune system and identify new targets for anti-microbial, anti-viral and anti-inflammatory therapies.For more information go tohttps://www.niaid.nih.gov/research/immunology-seminarsAir date: 12/21/2022 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 28, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Immunology Interest Group: Initiation and Regulation of Innate Immunity
Dr. Kagan's research focuses on understanding the organization of signal transduction pathways within cells of the mammalian immune system. As a model, he focuses his attention on members of the Toll-like Receptor family (TLR) family of proteins. TLRs play a critical role in the detection and elimination of infectious microorganisms that enter the human body. Signaling events that occur downstream from TLR-mediated microbial detection are the primary source of interest to the Kagan lab. Understanding the assembly and regulation of these signaling complexes is directly relevant to the study of human infections, autoimmunity...
Source: Videocast - All Events - November 28, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Immunology Interest Group: Balancing tolerance and immunity downstream of the antigen receptor
This reporter serves as an in vivo sensor of both self and foreign antigen encounter, and serves to unmask enormous clonal heterogeneity among superficially uniform populations of B cells. Recent work has focused on dissecting the distinct roles of the IgM and IgD B cell receptor isotypes in regulating the immune responses of self-reactive B cells.For more information go tohttps://www.niaid.nih.gov/research/immunology-seminarsAir date: 12/7/2022 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 28, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Sergio Pontejo - Chemokines and anionic phospholipids: new binding partners for microbial killing and apoptotic cell clearance.
Virologist and biochemist studying the immune evasion strategies deployed by viruses to gain new insights into the mechanisms of the immune system and identify new targets for anti-microbial, anti-viral and anti-inflammatory therapies.For more information go tohttps://www.niaid.nih.gov/research/immunology-seminarsAir date: 12/21/2022 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 23, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
