Innate allergy

Immunology Interest Group Seminar Series Despite clear roles for classical arms of immunity in maintenance of a healthy commensal microbial flora and protection from invasive pathogenic organisms, the purpose of allergic immunity, which underlies increasingly prevalent diseases like food allergy, asthma and atopic dermatitis, remains puzzling. The discovery of innate lymphoid cells that are programmed to produce cytokines associated with allergic immunity has provided new opportunities to assess basal physiologic processes that involve this canonical tissue response, and may reveal opportunities for re-tuning this arm of immunity to enhance health and well-being. Richard Locksley is the Sandler Distinguished Professor, a Howard Hughes Medical Institute Investigator, and Director of the Sandler Asthma Basic Research Center at the University of California San Francisco (UCSF). He obtained his A.B. from Harvard, M.D. from the University of Rochester, Internal Medicine Residency at UCSF, and Infectious Diseases Fellowship at the University of Washington. His lab studies innate and adaptive immunity using infectious and inflammatory disease models, focusing on cytokines as critical mediators of biology. His salient contributions have elucidated the roles of cytokines as regulators of adaptive and innate immunity, and he pioneered the development of mice containing incorporated reporter systems that have enabled interrogation of the immune system in vivo. He has focused on Th2-rela...
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