Aire: new tricks from an old dog

Immunology Interest Group Seminar Series Aire is a transcriptional regulator that controls immunological tolerance. Its primary modus operandi is the induction – specifically in thymic medullary epithelial cells – of a battery of transcripts encoding proteins characteristic of terminally differentiated peripheral cell-types, and consequently negative selection of T cells that recognize these proteins. After briefly reviewing the classical findings, this presentation will focus on more recently discovered facets of Aire function, including positive selection of a perinatal population of regulatory T cells, inhibition of the generation of IL-17-producing “ early-responder ” γ : δ T cell populations, and activation of MEC superenhancers. Dr. Mathis obtained a PhD from the University of Rochester, and performed postdoctoral studies at the Laboratoire de G é n é tique Mol é culaire des Eucaryotes in Strasbourg, France and at Stanford University Medical Center. She returned to Strasbourg at the end of 1983, establishing a laboratory at the LGME [later the Institut de Genetique et de Biologie Moleculare et Cellulaire (IGBMC)] in conjunction with Dr. Christophe Benoist. The lab moved to the Joslin Diabetes Center, Boston in 1999. Through 2008, Dr. Mathis was a Professor of Medicine at Brigham and Women ’ s Hospital and Harvard Medical School, and Associate Research Director and Head of the Section on Immunology and Immunogenetics at Joslin. Dr. Mathis is currently a Pr...
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